Mapk8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: Mapk8 (mitogen-activated protein kinase 8) Mus musculus
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Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 732272
MGI Page MGI
Description: Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including JNK cascade; generation of neurons; and positive regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is expressed in several structures, including central nervous system; genitourinary system; oral region epithelium; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; INTERACTS WITH (-)-anisomycin; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI849689; c-Jun N-terminal kinase 1; JNK; JNK1; JNK1 beta1 protein kinase; MAP kinase 8; MAPK 8; mitogen activated protein kinase 8; Prk; Prkm8; protein kinase mitogen-activated 8; SAPK1; stress-activated protein kinase JNK1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,099,855 - 33,169,215 (-)NCBIGRCm39mm39
GRCm39 Ensembl1433,099,855 - 33,169,115 (-)Ensembl
GRCm381433,377,898 - 33,447,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,377,898 - 33,447,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371434,191,084 - 34,260,344 (-)NCBIGRCm37mm9NCBIm37
MGSCv361432,211,101 - 32,276,249 (-)NCBImm8
Celera1429,636,611 - 29,705,910 (-)NCBICelera
Cytogenetic Map14BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-taxifolin  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R)-Salsolinol  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-Dinitropyrene  (EXP)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4,6-trinitrobenzene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (EXP)
1-nitropyrene  (EXP)
17beta-estradiol  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
2-trans,6-trans-farnesyl diphosphate  (EXP)
3',5'-cyclic GMP  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
acetaldehyde  (ISO)
acetic acid  (ISO)
acetylleucyl-leucyl-norleucinal  (EXP)
Aciculatin  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
ADP  (ISO)
afimoxifene  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-Chaconine  (EXP)
alpha-mangostin  (ISO)
alvocidib  (ISO)
amidotrizoic acid  (ISO)
amiloride  (EXP)
amino acid  (EXP)
ammonium chloride  (ISO)
amodiaquine  (ISO)
amphetamine  (ISO)
anethole  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
Antimony trioxide  (EXP,ISO)
ANTIMYCIN  (EXP)
apigenin  (ISO)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
asbestos  (EXP)
asiatic acid  (EXP)
atrazine  (ISO)
atropine  (ISO)
aureusidin  (ISO)
Azaspiracid  (EXP)
bafilomycin A1  (EXP)
baicalein  (ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (ISO)
benomyl  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzyl isothiocyanate  (ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (ISO)
bicuculline  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
Bisphenol A diglycidyl ether  (ISO)
bortezomib  (ISO)
bufalin  (ISO)
bupropion  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (EXP,ISO)
Calcimycin  (ISO)
calcipotriol  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
candesartan  (EXP)
cantharidic acid  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carnosic acid  (EXP,ISO)
carnosine  (EXP)
celecoxib  (EXP,ISO)
chalcone  (EXP)
chenodeoxycholic acid  (EXP)
chlordecone  (EXP)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cholate  (EXP)
choline  (EXP)
chromium atom  (EXP)
chromium(6+)  (EXP,ISO)
chrysophanol  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP,ISO)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
D-mannitol  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
delphinidin  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
diethylstilbestrol  (EXP)
diltiazem  (ISO)
dimethylarsinic acid  (EXP,ISO)
Dinitramine  (EXP)
dinophysistoxin 1  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
diphenhydramine  (ISO)
dipyridamole  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP,ISO)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (ISO)
emetine  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
erastin  (EXP)
eriodictyol  (EXP)
esculetin  (ISO)
Estragole  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
Ethyl pyruvate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
Evodiamine  (ISO)
farnesyl diphosphate  (EXP)
fenvalerate  (ISO)
ferrosoferric oxide  (ISO)
ferulic acid  (EXP,ISO)
flubendazole  (ISO)
flufenoxuron  (EXP)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fomepizole  (EXP)
formononetin  (ISO)
formoterol fumarate  (ISO)
fructose  (ISO)
gallic acid  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
Gastrodin  (ISO)
gefitinib  (ISO)
Geniposide pentaacetate  (ISO)
gentamycin  (ISO)
ginkgolide B  (ISO)
ginsenoside Rg1  (ISO)
gliclazide  (ISO)
gliotoxin  (ISO)
glucose  (ISO)
glutathione  (EXP,ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
haloperidol  (ISO)
hemin  (ISO)
hesperetin  (EXP,ISO)
hesperidin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
icatibant  (ISO)
ifosfamide  (ISO)
indoxyl sulfate  (EXP,ISO)
iomeprol  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (ISO)
Isorhapontigenin  (ISO)
ivermectin  (EXP,ISO)
kaempferol  (ISO)
kanamycin A  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
kojic acid  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-methionine  (EXP,ISO)
lactacystin  (EXP,ISO)
lead diacetate  (ISO)
lead(II) chloride  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP)
lithium atom  (ISO)
lithium hydride  (ISO)
Longikaurin A  (ISO)
lovastatin  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
Magnolol  (EXP)
malonaldehyde  (ISO)
Malonoben  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
manumycin A  (EXP)
marimastat  (ISO)
masoprocol  (ISO)
mebendazole  (ISO)
Mecamylamine  (ISO)
mechlorethamine  (EXP)
melatonin  (ISO)
menadione  (ISO)
mercaptoethanol  (ISO)
mercury dichloride  (EXP)
Mesna  (EXP)
metam  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylglyoxal  (EXP,ISO)
methylmercury chloride  (EXP)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
miconazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (EXP)
monosodium L-glutamate  (ISO)
morin  (ISO)
muscimol  (EXP)
mycophenolic acid  (ISO)
myricitrin  (ISO)
N(6),N(6)-dimethyladenine  (ISO)
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-Nitroso-N-methylurethane  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
Narciclasine  (EXP)
naringin  (EXP)
neocuproine  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nitroprusside  (ISO)
nocodazole  (ISO)
notoginsenoside R1  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
olmesartan  (EXP)
osthole  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
parthenolide  (ISO)
PD 168393  (ISO)
pentanal  (ISO)
Pentoxifylline  (ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perifosine  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (EXP)
phosgene  (ISO)
phthalic anhydride  (ISO)
pipoxolan  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
plitidepsin  (ISO)
potassium atom  (ISO)
potassium chromate  (ISO)
pramipexole  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (ISO)
procyanidin B3  (EXP)
prodigiosin  (ISO)
progesterone  (ISO)
prostaglandin E2  (EXP)
prostaglandin F2alpha  (EXP)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quinoline  (ISO)
ramipril  (ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rimonabant  (EXP)
Ro 31-8220  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salubrinal  (ISO)
Salvianolic acid A  (EXP)
sanguinarine  (ISO)
sappanchalcone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
SCH772984  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP,ISO)
Soman  (ISO)
sorafenib  (ISO)
spermine  (ISO)
SR 144528  (EXP)
stavudine  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP)
sucrose  (ISO)
sulforaphane  (ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
syringic acid  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (EXP)
taurine  (ISO)
taurocholic acid  (EXP)
TEMPO  (EXP)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetracaine  (ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (ISO)
thapsigargin  (EXP,ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
trans-anethole  (ISO)
trans-chalcone  (EXP)
tributylstannane  (ISO)
tricetin  (ISO)
trichostatin A  (ISO)
trifluoperazine  (EXP,ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (ISO)
trimethyltin  (EXP)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (ISO)
U-73122  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
Vernodalin  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
wogonin  (EXP)
wortmannin  (EXP,ISO)
Yessotoxin  (EXP)
zearalenone  (EXP)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid starvation  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to hydrogen peroxide  (IDA)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nitric oxide  (IMP)
cellular response to reactive oxygen species  (ISO)
dendrite morphogenesis  (IMP)
determination of dorsal identity  (ISO)
glial cell apoptotic process  (ISO)
inflammatory response  (ISO)
intracellular signal transduction  (IBA)
JNK cascade  (IBA,IDA,ISO)
JUN phosphorylation  (IMP,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of protein binding  (ISO)
neuron development  (ISO)
neuron migration  (IMP)
neuron projection development  (ISO)
neuronal stem cell population maintenance  (ISO)
ossification  (IMP)
peptidyl-serine phosphorylation  (IDA,IMP,ISO)
peptidyl-threonine phosphorylation  (IMP,ISO)
phosphorylation  (IEA)
positive regulation of apoptotic process  (IBA,ISO)
positive regulation of apoptotic signaling pathway  (IGI)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cyclase activity  (ISO)
positive regulation of deacetylase activity  (ISO)
positive regulation of determination of dorsal identity  (IDA)
positive regulation of DNA replication  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell apoptotic process  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron migration  (ISO)
positive regulation of podosome assembly  (IMP)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein ubiquitination  (IMP)
positive regulation of transcription factor catabolic process  (IMP)
programmed necrotic cell death  (IMP)
protein localization to tricellular tight junction  (IMP)
protein phosphorylation  (IDA,IMP,ISO)
regulation of centrosome cycle  (ISO)
regulation of circadian rhythm  (IMP)
regulation of dense core granule transport  (ISO)
regulation of DNA replication origin binding  (ISO)
regulation of gene expression  (IMP)
regulation of neuron differentiation  (ISO)
regulation of protein localization  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to cadmium ion  (IGI)
response to heat  (ISO)
response to hydrogen peroxide  (ISO)
response to mechanical stimulus  (IBA)
response to osmotic stress  (ISO)
response to oxidative stress  (ISO)
response to steroid hormone  (ISO)
response to UV  (ISO)
rhythmic process  (IEA)
signal transduction  (ISO)
stress-activated MAPK cascade  (ISO)
type B pancreatic cell apoptotic process  (ISO)

Cellular Component
axon  (IMP,ISO)
basal dendrite  (IMP)
cell junction  (IEA)
cytoplasm  (IBA,IDA,IMP,ISO)
cytosol  (IDA,TAS)
dendrite cytoplasm  (ISO)
mitochondrion  (IDA,ISO)
nucleus  (IBA,IDA,ISO)
perikaryon  (ISO)
podosome  (IDA)
synapse  (ISO)
vesicle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
adenosine signaling pathway  (ISO)
c-Jun N-terminal kinases MAPK signaling pathway  (ISO)
ceramide signaling pathway  (IEA,ISO)
Chagas disease pathway  (IEA)
colorectal cancer pathway  (IEA)
Endoplasmic Reticulum-associated degradation pathway  (IEA)
endothelin signaling pathway  (ISO)
ephrin - ephrin receptor bidirectional signaling axis  (ISO)
epidermal growth factor/neuregulin signaling pathway  (IEA)
erythropoietin signaling pathway  (ISO)
FasL mediated signaling pathway  (ISO)
Fc epsilon receptor mediated signaling pathway  (ISO)
glypican signaling pathway  (ISO)
gonadotropin-releasing hormone signaling pathway  (IEA)
hepatitis C pathway  (IEA)
inflammatory response pathway  (ISO)
influenza A pathway  (IEA)
insulin signaling pathway  (IEA)
interleukin-1 signaling pathway  (ISO)
interleukin-2 signaling pathway  (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
N-cadherin signaling pathway  (ISO)
neurotrophic factor signaling pathway  (IEA)
NOD-like receptor signaling pathway  (IEA)
p53 signaling pathway  (ISO)
pancreatic cancer pathway  (IEA)
platelet-derived growth factor signaling pathway  (ISO)
Reelin signaling pathway  (ISO)
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathway  (IEA)
Rho/Rac/Cdc42 mediated signaling pathway  (ISO)
sphingosine 1-phosphate signaling pathway  (ISO)
syndecan signaling pathway  (ISO)
Toll-like receptor signaling pathway  (IEA)
toxoplasmosis pathway  (IEA)
Trail mediated signaling pathway  (ISO)
tuberculosis pathway  (IEA)
type 2 diabetes mellitus pathway  (IEA)
Wnt signaling pathway  (IEA)
Wnt signaling, non-canonical pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal brain development  (IAGP)
abnormal cerebral hemisphere morphology  (IAGP)
abnormal chemokine level  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal embryonic neuroepithelial layer differentiation  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal epidermal layer morphology  (IAGP)
abnormal epidermis stratum basale morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal eyelid morphology  (IAGP)
abnormal fat cell morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal fungiform papillae morphology  (IAGP)
abnormal gluconeogenesis  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal glycogen homeostasis  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lens morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal lung development  (IAGP)
abnormal macrophage differentiation  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal nephron morphology  (IAGP)
abnormal neural tube morphology  (IAGP)
abnormal retinal outer nuclear layer morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal tongue epithelium morphology  (IAGP)
abnormal tongue morphology  (IAGP)
absent brain ventricles  (IAGP)
absent keratohyalin granules  (IAGP)
atherosclerotic lesions  (IAGP)
cardiac fibrosis  (IAGP)
decreased body length  (IAGP)
decreased body weight  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased cardiomyocyte apoptosis  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating growth hormone level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased circulating insulin-like growth factor I level  (IAGP)
decreased circulating leptin level  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased food intake  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased hair follicle number  (IAGP)
decreased hindbrain apoptosis  (IAGP)
decreased inflammatory response  (IAGP)
decreased insulin secretion  (IAGP)
decreased keratinocyte migration  (IAGP)
decreased lean body mass  (IAGP)
decreased liver triglyceride level  (IAGP)
decreased liver weight  (IAGP)
decreased macrophage cell number  (IAGP)
decreased macrophage cytokine production  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
decreased percent body fat/body weight  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased subcutaneous adipose tissue amount  (IAGP)
decreased susceptibility to diet-induced hepatic steatosis  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
decreased T cell apoptosis  (IAGP)
decreased T cell proliferation  (IAGP)
decreased total body fat amount  (IAGP)
delayed intestine development  (IAGP)
dilated heart  (IAGP)
dilated renal tubules  (IAGP)
early eyelid opening  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
exencephaly  (IAGP)
eyelids open at birth  (IAGP)
impaired macrophage chemotaxis  (IAGP)
improved glucose tolerance  (IAGP)
incomplete rostral neuropore closure  (IAGP)
increased b-wave amplitude  (IAGP)
increased cardiomyocyte apoptosis  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating triiodothyronine level  (IAGP)
increased embryonic neuroepithelium apoptosis  (IAGP)
increased epididymal fat pad weight  (IAGP)
increased fibroblast apoptosis  (IAGP)
increased fibroblast cell migration  (IAGP)
increased forebrain apoptosis  (IAGP)
increased hindbrain apoptosis  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased lung tumor incidence  (IAGP)
increased oxygen consumption  (IAGP)
increased respiratory quotient  (IAGP)
increased response of heart to induced stress  (IAGP)
increased retinal cone cell number  (IAGP)
increased retinal rod cell number  (IAGP)
increased T cell proliferation  (IAGP)
infertility  (IAGP)
pallor  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
respiratory distress  (IAGP)
retina coloboma  (IAGP)
small lens  (IAGP)
small pancreatic islets  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin epidermis  (IAGP)
weight loss  (IAGP)
References

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