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Gene: Mapk8 (mitogen-activated protein kinase 8) Mus musculus
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Description: Exhibits JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including cellular response to reactive oxygen species; positive regulation of cellular protein metabolic process; and protein phosphorylation. Localizes to several cellular components, including the basal dendrite; mitochondrion; and podosome. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; colorectal adenoma; rectal neoplasm; and type 2 diabetes mellitus. Is expressed in several structures, including central nervous system; future brain; genitourinary system; sensory organ; and submandibular gland. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; INTERACTS WITH (-)-anisomycin; (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI849689; c-Jun N-terminal kinase 1; JNK; JNK1; JNK1 beta1 protein kinase; MAP kinase 8; MAPK 8; mitogen activated protein kinase 8; Prkm8; protein kinase mitogen-activated 8; SAPK1; stress-activated protein kinase JNK1
Homo sapiens (human) : MAPK8 (mitogen-activated protein kinase 8)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mapk8 (mitogen-activated protein kinase 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapk8 (mitogen-activated protein kinase 8)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPK8 (mitogen-activated protein kinase 8)
Canis lupus familiaris (dog) : MAPK8 (mitogen-activated protein kinase 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapk8 (mitogen-activated protein kinase 8)
Sus scrofa (pig) : MAPK8 (mitogen-activated protein kinase 8)
Chlorocebus sabaeus (African green monkey) : MAPK8 (mitogen-activated protein kinase 8)
Heterocephalus glaber (naked mole-rat) : Mapk8 (mitogen-activated protein kinase 8)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1433,377,898 - 33,447,158 (-)Ensembl
GRCm381433,377,898 - 33,447,353 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371434,191,084 - 34,260,344 (-)NCBIGRCm37mm9NCBIm37
MGSCv361432,211,101 - 32,276,249 (-)NCBImm8
Celera1429,636,611 - 29,705,910 (-)NCBICelera
Cytogenetic Map14BNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences