Mapk8ip1 (mitogen-activated protein kinase 8 interacting protein 1) - Rat Genome Database

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Gene: Mapk8ip1 (mitogen-activated protein kinase 8 interacting protein 1) Rattus norvegicus
Analyze
Symbol: Mapk8ip1
Name: mitogen-activated protein kinase 8 interacting protein 1
RGD ID: 70937
Description: Enables MAP-kinase scaffold activity; identical protein binding activity; and protein kinase binding activity. Involved in negative regulation of JUN kinase activity; negative regulation of apoptotic process; and signal transduction. Located in cytosol; growth cone; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAPK8IP1 (mitogen-activated protein kinase 8 interacting protein 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-jun-amino-terminal kinase-interacting protein 1; IB-1; islet-brain-1; Jip-1; JIP-1-related protein; JIP1; JNK MAP kinase scaffold protein 1; JNK-interacting protein 1; JRP; Mapk8ip; mitogen activated protein kinase 8 interacting protein; mitogen-activated protein kinase 8-interacting protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2378,355,051 - 78,372,946 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl378,355,048 - 78,372,884 (-)Ensembl
Rnor_6.0381,295,023 - 81,304,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl381,295,024 - 81,304,181 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,998,491 - 88,016,191 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,781,504 - 76,790,661 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1376,677,932 - 76,687,089 (-)NCBI
Celera377,557,046 - 77,566,196 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. Bonny C, etal., J Biol Chem 1998 Jan 23;273(4):1843-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. c-Jun N-terminal kinase (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusion. Hayashi T, etal., Neurosci Lett. 2000 Apr 28;284(3):195-9.
5. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Kim AH, etal., Neuron 2002 Aug 15;35(4):697-709.
6. Molecular cloning of multiple splicing variants of JIP-1 preferentially expressed in brain. Kim IJ, etal., J Neurochem 1999 Apr;72(4):1335-43.
7. A unique set of SH3-SH3 interactions controls IB1 homodimerization. Kristensen O, etal., EMBO J. 2006 Feb 22;25(4):785-97. Epub 2006 Feb 2.
8. Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region. Li CH, etal., J Neurochem. 2005 Apr;93(2):290-8.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain. Pellet JB, etal., Eur J Neurosci. 2000 Feb;12(2):621-32.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Connexin26 is regulated in rat urothelium by the scaffold protein IB1/JIP-1. Tawadros T, etal., Cell Commun Adhes 2001;8(4-6):303-6.
18. Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein. Wilhelm M, etal., J Biol Chem. 2012 Jan 13;287(3):2247-56. doi: 10.1074/jbc.M111.269431. Epub 2011 Nov 28.
19. Regulation of stress-associated scaffold proteins JIP1 and JIP3 on the c-Jun NH2-terminal kinase in ischemia-reperfusion. Xu B, etal., Can J Physiol Pharmacol. 2010 Nov;88(11):1084-92. doi: 10.1139/y10-088.
20. Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia. Zhang QX, etal., Biochemistry. 2007 Apr 3;46(13):4006-16. Epub 2007 Mar 10.
21. Regulatory mechanisms of mitogen-activated kinase signaling. Zhang Y and Dong C, Cell Mol Life Sci. 2007 Nov;64(21):2771-89.
Additional References at PubMed
PMID:9235893   PMID:10574993   PMID:11238452   PMID:11562351   PMID:15345675   PMID:16301330   PMID:20816823   PMID:23825109   PMID:23963642   PMID:24478353   PMID:26665154   PMID:28886967  


Genomics

Comparative Map Data
Mapk8ip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2378,355,051 - 78,372,946 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl378,355,048 - 78,372,884 (-)Ensembl
Rnor_6.0381,295,023 - 81,304,181 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl381,295,024 - 81,304,181 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,998,491 - 88,016,191 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,781,504 - 76,790,661 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1376,677,932 - 76,687,089 (-)NCBI
Celera377,557,046 - 77,566,196 (-)NCBICelera
Cytogenetic Map3q24NCBI
MAPK8IP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381145,885,651 - 45,906,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1145,885,651 - 45,906,465 (+)EnsemblGRCh38hg38GRCh38
GRCh371145,907,202 - 45,928,016 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,863,778 - 45,884,592 (+)NCBINCBI36hg18NCBI36
Build 341145,863,777 - 45,884,591NCBI
Celera1146,054,811 - 46,075,621 (+)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1145,613,904 - 45,634,868 (+)NCBIHuRef
CHM1_11145,904,472 - 45,925,436 (+)NCBICHM1_1
T2T-CHM13v2.01146,041,587 - 46,062,395 (+)NCBI
Mapk8ip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39292,214,021 - 92,231,608 (-)NCBIGRCm39mm39
GRCm39 Ensembl292,214,021 - 92,231,608 (-)Ensembl
GRCm38292,383,671 - 92,401,346 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl292,383,676 - 92,401,263 (-)EnsemblGRCm38mm10GRCm38
MGSCv37292,223,837 - 92,241,420 (-)NCBIGRCm37mm9NCBIm37
MGSCv36292,184,519 - 92,202,102 (-)NCBImm8
Celera293,776,808 - 93,794,307 (-)NCBICelera
Cytogenetic Map2E1NCBI
Mapk8ip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554222,061,851 - 2,082,514 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554222,064,010 - 2,081,681 (-)NCBIChiLan1.0ChiLan1.0
MAPK8IP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11146,332,121 - 46,352,750 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,332,159 - 46,352,010 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01145,839,754 - 45,860,615 (+)NCBIMhudiblu_PPA_v0panPan3
MAPK8IP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11843,517,186 - 43,522,603 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1843,517,677 - 43,526,379 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1842,245,214 - 42,263,683 (-)NCBI
ROS_Cfam_1.01844,173,152 - 44,191,616 (-)NCBI
ROS_Cfam_1.0 Ensembl1844,173,163 - 44,192,012 (-)Ensembl
UMICH_Zoey_3.11843,657,404 - 43,675,863 (-)NCBI
UNSW_CanFamBas_1.01843,210,353 - 43,228,830 (-)NCBI
UU_Cfam_GSD_1.01843,942,641 - 43,961,111 (-)NCBI
Mapk8ip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494721,001,575 - 21,011,189 (-)NCBI
SpeTri2.0NW_0049365623,113,217 - 3,122,794 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK8IP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl216,564,257 - 16,584,768 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1216,562,687 - 16,584,763 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,929,057 - 17,949,520 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK8IP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,435,593 - 19,457,073 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl119,432,631 - 19,442,185 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038116,712,446 - 116,733,704 (-)NCBIVero_WHO_p1.0
Mapk8ip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247672,603,483 - 2,620,536 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247672,603,483 - 2,620,574 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH135410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2378,355,089 - 78,355,301 (+)MAPPERmRatBN7.2
Rnor_6.0381,295,062 - 81,295,273NCBIRnor6.0
Rnor_5.0387,998,530 - 87,998,741UniSTSRnor5.0
RGSC_v3.4376,781,543 - 76,781,754UniSTSRGSC3.4
Celera377,557,085 - 77,557,296UniSTS
RH 3.4 Map3707.2UniSTS
Cytogenetic Map3q24UniSTS
BE118974  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2378,360,791 - 78,360,986 (+)MAPPERmRatBN7.2
Rnor_6.0381,300,764 - 81,300,958NCBIRnor6.0
Rnor_5.0388,004,232 - 88,004,426UniSTSRnor5.0
RGSC_v3.4376,787,245 - 76,787,439UniSTSRGSC3.4
Celera377,562,787 - 77,562,981UniSTS
RH 3.4 Map3708.4UniSTS
Cytogenetic Map3q24UniSTS
BF391846  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2378,362,388 - 78,362,579 (+)MAPPERmRatBN7.2
Rnor_6.0381,302,361 - 81,302,551NCBIRnor6.0
Rnor_5.0388,005,829 - 88,006,019UniSTSRnor5.0
RGSC_v3.4376,788,842 - 76,789,032UniSTSRGSC3.4
Celera377,564,377 - 77,564,567UniSTS
Cytogenetic Map3q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:433
Count of miRNA genes:199
Interacting mature miRNAs:251
Transcripts:ENSRNOT00000009725, ENSRNOT00000074106
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43 14 6 1 6 8 11 74 35 41 11 8
Low 3 43 35 18 35
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079746   ⟹   ENSRNOP00000074684
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl378,355,052 - 78,364,208 (-)Ensembl
Rnor_6.0 Ensembl381,295,024 - 81,304,181 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111802   ⟹   ENSRNOP00000089891
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl378,355,053 - 78,372,884 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117436   ⟹   ENSRNOP00000090670
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl378,355,048 - 78,372,884 (-)Ensembl
RefSeq Acc Id: NM_053777   ⟹   NP_446229
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2378,355,051 - 78,364,208 (-)NCBI
Rnor_6.0381,295,023 - 81,304,181 (-)NCBI
Rnor_5.0387,998,491 - 88,016,191 (-)NCBI
RGSC_v3.4376,781,504 - 76,790,661 (-)RGD
Celera377,557,046 - 77,566,196 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104100   ⟹   XP_038960028
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2378,355,051 - 78,372,901 (-)NCBI
RefSeq Acc Id: XM_039104101   ⟹   XP_038960029
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2378,355,051 - 78,364,457 (-)NCBI
RefSeq Acc Id: XM_039104102   ⟹   XP_038960030
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2378,355,051 - 78,372,946 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446229   ⟸   NM_053777
- UniProtKB: Q9R237 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074684   ⟸   ENSRNOT00000079746
RefSeq Acc Id: XP_038960030   ⟸   XM_039104102
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038960028   ⟸   XM_039104100
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960029   ⟸   XM_039104101
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000089891   ⟸   ENSRNOT00000111802
RefSeq Acc Id: ENSRNOP00000090670   ⟸   ENSRNOT00000117436
Protein Domains
PID   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R237-F1-model_v2 AlphaFold Q9R237 1-708 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70937 AgrOrtholog
BioCyc Gene G2FUF-48699 BioCyc
Ensembl Genes ENSRNOG00000058478 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074684 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000089891.1 UniProtKB/TrEMBL
  ENSRNOP00000090670 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079746 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000111802.1 UniProtKB/TrEMBL
  ENSRNOT00000117436 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro JIP1_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116457 UniProtKB/Swiss-Prot
NCBI Gene 116457 ENTREZGENE
Pfam PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapk8ip1 PhenoGen
PROSITE PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ABA5_RAT UniProtKB/TrEMBL
  JIP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B0VXR5 UniProtKB/Swiss-Prot
  O88979 UniProtKB/Swiss-Prot
  Q9R1H8 UniProtKB/Swiss-Prot
  Q9WVI5 UniProtKB/Swiss-Prot
  Q9WVI6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Mapk8ip1  mitogen-activated protein kinase 8 interacting protein 1  Mapk8ip  mitogen activated protein kinase 8 interacting protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Mapk8ip  mitogen activated protein kinase 8 interacting protein      Symbol and Name updated 629477 APPROVED
2003-03-12 Mapk8ip  mitogen activated protein kinase 8 interacting protein  Mapk8ip1  mitogen-activated protein kinase 8 interacting protein 1  Data Merged 628472 PROVISIONAL
2002-08-07 Mapk8ip1  mitogen-activated protein kinase 8 interacting protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-07-09 Mapk8ip  mitogen activated protein kinase 8 interacting protein      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a putative phosphotyrosine interaction domain, a helix-loop-helix domain, and an SH3 homologous region 70789
gene_expression mRNA expressed in brain and kidney 70789