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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:5141
Term: fomepizole
Definition: A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Chemical ID: MESH:C010238
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8affects bindingISORGD:7322726480464CTDFomepizole binds to MAPK8 protein

PMID:30903181
Mapk8multiple interactionsISORGD:7322726480464CTDFomepizole inhibits the reaction [Acetaminophen results in increased phosphorylation of and affects the localization of MAPK8 protein]

PMID:30903181
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.