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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:8093
Term: phenylephrine
Definition: A member of the class of the class of phenylethanolamines that is (1R)-2-(methylamino)-1-phenylethan-1-ol carrying an additional hydroxy substituent at position 3 on the phenyl ring.
Chemical ID: MESH:D010656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationEXP 6480464CTDPhenylephrine results in increased phosphorylation of MAPK8 proteinPMID:10727428 PMID:16385079
Mapk8multiple interactionsEXP 6480464CTDGLRX3 protein inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAPK8 protein affects the reaction [Phenylephrine results in decreased expression of KCNIP2 mRNA]; Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein; RGS2 protein promotes the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of MAPK8 protein]PMID:16385079 PMID:16517124 PMID:16809552
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