DAXX (death domain associated protein) - Rat Genome Database

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Pathways
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Gene: DAXX (death domain associated protein) Pan paniscus
Analyze
Symbol: DAXX
Name: death domain associated protein
RGD ID: 11855379
Description: ENCODES a protein that exhibits JUN kinase binding (ortholog); kinesin binding (ortholog); molecular condensate scaffold activity (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cell population proliferation (ortholog); cellular response to hydrogen peroxide (ortholog); PARTICIPATES IN aldosterone signaling pathway; histone modification pathway; p53 signaling pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); appendiceal neoplasm (ortholog); autosomal dominant intellectual developmental disorder 5 (ortholog); FOUND IN cell body (ortholog); cell cortex (ortholog); chromosome, centromeric region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: death domain-associated protein 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,796,450 - 47,801,452 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,668,130 - 43,673,132 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,890,846 - 32,895,307 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,004,362 - 34,008,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,004,543 - 34,008,717 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (IEA)
apoptotic process  (IEA)
apoptotic signaling pathway  (ISO)
cell population proliferation  (ISO)
cellular response to cadmium ion  (IEA)
cellular response to copper ion  (IEA)
cellular response to diamide  (IEA)
cellular response to heat  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to sodium arsenite  (IEA)
cellular response to tumor necrosis factor  (ISO)
cellular response to type II interferon  (ISO)
cellular response to unfolded protein  (IEA)
chromatin organization  (IEA)
chromatin remodeling  (IEA)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
JNK cascade  (IEA)
mitotic cytokinesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cellular response to hypoxia  (ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of myotube differentiation  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron intrinsic apoptotic signaling pathway in response to oxidative stress  (IEA)
nucleosome assembly  (IEA)
PML body organization  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein phosphorylation  (IEA)
positive regulation of transcription by RNA polymerase II  (ISO)
protein localization to chromatin  (ISO)
regulation of apoptotic process  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (IEA)
regulation of multicellular organism growth  (ISO)
regulation of protein ubiquitination  (IEA)
response to metal ion  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DAXX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,796,450 - 47,801,452 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,668,130 - 43,673,132 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,890,846 - 32,895,307 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1634,004,362 - 34,008,819 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,004,543 - 34,008,717 (-)Ensemblpanpan1.1panPan2
DAXX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,318,558 - 33,322,959 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl633,318,558 - 33,323,016 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,286,335 - 33,290,736 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,394,367 - 33,398,682 (-)NCBINCBI36Build 36hg18NCBI36
Build 34633,394,380 - 33,398,682NCBI
Celera634,840,701 - 34,845,159 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef633,027,906 - 33,032,806 (-)NCBIHuRef
CHM1_1633,288,251 - 33,292,710 (-)NCBICHM1_1
T2T-CHM13v2.0633,139,920 - 33,144,321 (-)NCBIT2T-CHM13v2.0
Daxx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,128,379 - 34,134,564 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,128,388 - 34,134,564 (+)EnsemblGRCm39 Ensembl
GRCm381733,909,404 - 33,915,590 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,909,414 - 33,915,590 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,046,443 - 34,052,534 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,520,055 - 33,526,038 (+)NCBIMGSCv36mm8
Celera1736,662,421 - 36,668,513 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Daxx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,971,973 - 4,978,062 (-)NCBIGRCr8
mRatBN7.2204,970,090 - 4,976,145 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,970,092 - 4,975,843 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,693,494 - 5,699,246 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0205,055,239 - 5,060,991 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,535,985 - 5,541,725 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,480,103 - 5,485,962 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,480,103 - 5,485,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,538,715 - 7,544,538 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,121,854 - 5,127,601 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,122,244 - 5,126,875 (-)NCBI
Celera206,554,093 - 6,559,840 (-)NCBICelera
Cytogenetic Map20p12NCBI
Daxx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,869,572 - 1,873,050 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,869,692 - 1,874,041 (-)NCBIChiLan1.0ChiLan1.0
DAXX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,755,960 - 2,760,687 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,755,960 - 2,761,340 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,836,834 - 2,841,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,087,394 - 3,092,130 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,087,394 - 3,091,799 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,754,580 - 2,759,316 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,835,893 - 2,840,633 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,910,802 - 2,915,532 (-)NCBIUU_Cfam_GSD_1.0
Daxx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,409,877 - 38,414,723 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,546,036 - 25,550,392 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,546,091 - 25,550,390 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAXX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,676,856 - 29,681,110 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,676,854 - 29,681,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,180,626 - 34,184,902 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAXX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,754,227 - 38,758,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,754,280 - 38,759,071 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,153,334 - 33,157,792 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Daxx
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,505,386 - 23,509,241 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,504,465 - 23,509,034 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000032262   ⟹   ENSPPAP00000009619
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl634,004,543 - 34,008,717 (-)Ensembl
RefSeq Acc Id: XM_008960642   ⟹   XP_008958890
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,796,450 - 47,801,452 (-)NCBI
NHGRI_mPanPan1643,668,130 - 43,673,132 (-)NCBI
Mhudiblu_PPA_v0632,890,846 - 32,895,302 (-)NCBI
PanPan1.1634,004,362 - 34,008,819 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034961845   ⟹   XP_034817736
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,796,450 - 47,801,432 (-)NCBI
NHGRI_mPanPan1643,668,130 - 43,673,112 (-)NCBI
Mhudiblu_PPA_v0632,890,846 - 32,895,307 (-)NCBI
RefSeq Acc Id: XM_055113466   ⟹   XP_054969441
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,796,450 - 47,800,542 (-)NCBI
NHGRI_mPanPan1643,668,130 - 43,672,222 (-)NCBI
RefSeq Acc Id: XM_055113467   ⟹   XP_054969442
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,796,450 - 47,800,519 (-)NCBI
NHGRI_mPanPan1643,668,130 - 43,672,199 (-)NCBI
RefSeq Acc Id: XM_063604820   ⟹   XP_063460890
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2547,796,450 - 47,800,924 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008958890 (Get FASTA)   NCBI Sequence Viewer  
  XP_034817736 (Get FASTA)   NCBI Sequence Viewer  
  XP_054969441 (Get FASTA)   NCBI Sequence Viewer  
  XP_054969442 (Get FASTA)   NCBI Sequence Viewer  
  XP_063460890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000009619.1
Reference Protein Sequences
RefSeq Acc Id: XP_008958890   ⟸   XM_008960642
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034817736   ⟸   XM_034961845
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000009619   ⟸   ENSPPAT00000032262
RefSeq Acc Id: XP_054969441   ⟸   XM_055113466
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054969442   ⟸   XM_055113467
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063460890   ⟸   XM_063604820
- Peptide Label: isoform X1
Protein Domains
Daxx histone-binding   Daxx N-terminal Rassf1C-interacting


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028039 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032262.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.810 UniProtKB/TrEMBL
  1.20.58.2170 UniProtKB/TrEMBL
InterPro DAXX_histone_binding UniProtKB/TrEMBL
  DAXX_histone_binding_sf UniProtKB/TrEMBL
  Daxx_N UniProtKB/TrEMBL
  Daxx_N_sf UniProtKB/TrEMBL
NCBI Gene DAXX ENTREZGENE
PANTHER DEATH DOMAIN-ASSOCIATED PROTEIN 6 UniProtKB/TrEMBL
  DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX UniProtKB/TrEMBL
Pfam Daxx UniProtKB/TrEMBL
  DAXX_hist_bd UniProtKB/TrEMBL
UniProt A0A2R9A2V7_PANPA UniProtKB/TrEMBL