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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:91642
Term: 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester
Definition: A benzoate ester that has formula C16H22O3.
Chemical ID: MESH:C060446
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Armultiple interactionsISOAR (Homo sapiens)6480464CTDhomosalate binds to and results in decreased activity of AR protein; homosalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone results in increased activity of AR protein]PMID:12730620 PMID:15537743 PMID:18324785 PMID:24004914
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