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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:34204
Term: 2,2',4,4'-tetrachlorobiphenyl
Definition: A tetrachlorobiphenyl that is biphenyl in which each of the phenyl groups is substituted at positions 2 and 4 by chlorines.
Chemical ID: MESH:C035976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingEXP 6480464CTD2 4 2' 4'-tetrachlorobiphenyl binds to AR protein

PMID:14565775
Armultiple interactionsISORGD:7356526480464CTD[aroclor 1260 co-treated with Chlorodiphenyl 54% Chlorine co-treated with 2 4 4'-trichlorobiphenyl co-treated with 2 4 2' 4'-tetrachlorobiphenyl co-treated with 3 4 5 3' 4'-pentachlorobiphenyl co-treated with 3 4 3' 4'-tetrachlorobiphenyl] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]

PMID:21295777
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