Ar (androgen receptor) - Rat Genome Database

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Gene: Ar (androgen receptor) Ictidomys tridecemlineatus
Analyze
Symbol: Ar
Name: androgen receptor
RGD ID: 12633879
Description: ENCODES a protein that exhibits androgen binding (ortholog); chromatin binding (ortholog); nuclear androgen receptor binding (ortholog); INVOLVED IN androgen receptor signaling pathway (ortholog); animal organ formation (ortholog); cellular response to follicle-stimulating hormone stimulus (ortholog); PARTICIPATES IN altered androgen signaling pathway; androgen signaling pathway; forkhead class A signaling pathway; ASSOCIATED WITH 46,XY sex reversal (ortholog); acute kidney failure (ortholog); alcohol dependence (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X49,717,252 - 49,882,487 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936635485,903 - 647,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936635485,903 - 647,820 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
46,XY sex reversal  (ISO)
acute kidney failure  (ISO)
alcohol dependence  (ISO)
alopecia  (ISO)
androgen insensitivity syndrome  (ISO)
Androgen Insensitivity Syndrome due to Coactivator Deficiency  (ISO)
aromatase excess syndrome  (ISO)
attention deficit hyperactivity disorder  (ISO)
autistic disorder  (ISO)
autosomal hemophilia A  (ISO)
Breast Neoplasms  (ISO)
castration-resistant prostate carcinoma  (ISO)
complete androgen insensitivity syndrome  (ISO)
conduct disorder  (ISO)
cryptorchidism  (ISO)
Denys-Drash syndrome  (ISO)
ductal carcinoma in situ  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fabry disease  (ISO)
factor VIII deficiency  (ISO)
Familial Prostate Cancer  (ISO)
Female Infertility  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
hepatocellular carcinoma  (ISO)
hypertension  (ISO)
hypospadias  (ISO)
Hypospadias 1, X-Linked  (ISO)
Insulin Resistance  (ISO)
invasive ductal carcinoma  (ISO)
Kennedy's disease  (ISO)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
Lubs Syndrome  (ISO)
Lung Neoplasms  (ISO)
Male Breast Neoplasms  (ISO)
male infertility  (ISO)
male reproductive system disease  (ISO)
malignant astrocytoma  (ISO)
Mayer-Rokitansky-Kuster-Hauser syndrome  (ISO)
metabolic dysfunction and alcohol associated liver disease  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
multicentric Castleman disease  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO)
oppositional defiant disorder  (ISO)
osteoporosis  (ISO)
Osteoporotic Fractures  (ISO)
ovarian cancer  (ISO)
partial androgen insensitivity syndrome  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Hereditary, X-Linked 3  (ISO)
Prostate Cancer, Somatic  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
Sarcopenia  (ISO)
spermatogenic failure 3  (ISO)
spermatogenic failure 57  (ISO)
spinal muscular atrophy  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (IEA,ISO)
animal organ formation  (IEA,ISO)
cellular response to estrogen stimulus  (IEA)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to steroid hormone stimulus  (IEA,ISO)
cellular response to testosterone stimulus  (IEA)
copulation  (ISO)
drinking behavior  (ISO)
epithelial cell differentiation involved in prostate gland development  (IEA,ISO)
epithelial cell morphogenesis  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
estrogen receptor signaling pathway  (IEA,ISO)
fertilization  (IEA,ISO)
gene expression  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
intracellular receptor signaling pathway  (IEA)
lateral sprouting involved in mammary gland duct morphogenesis  (IEA,ISO)
Leydig cell differentiation  (IEA,ISO)
liver regeneration  (ISO)
locomotion  (ISO)
male courtship behavior  (ISO)
male genitalia morphogenesis  (IEA,ISO)
male gonad development  (IEA,ISO)
male sex differentiation  (ISO)
male somatic sex determination  (IEA,ISO)
mammary gland alveolus development  (IEA,ISO)
MAPK cascade  (IEA,ISO)
membraneless organelle assembly  (IEA)
morphogenesis of an epithelial fold  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA)
negative regulation of integrin biosynthetic process  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
positive regulation of cell differentiation  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of epithelial cell proliferation involved in prostate gland development  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of hippocampal neuron apoptotic process  (ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of integrin biosynthetic process  (IEA)
positive regulation of intracellular estrogen receptor signaling pathway  (IEA,ISO)
positive regulation of locomotion  (ISO)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of miRNA transcription  (IEA)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of penile erection  (ISO)
positive regulation of phosphorylation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription by RNA polymerase III  (IEA)
prostate gland epithelium morphogenesis  (IEA,ISO)
prostate gland growth  (IEA,ISO)
prostate induction  (ISO)
regulation of developmental growth  (IEA,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of prostatic bud formation  (IEA,ISO)
regulation of protein localization to plasma membrane  (IEA)
regulation of systemic arterial blood pressure  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
reproductive behavior  (ISO)
reproductive structure development  (IEA,ISO)
reproductive system development  (IEA,ISO)
response to environmental enrichment  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to insulin  (ISO)
response to muscle activity  (ISO)
response to nicotine  (ISO)
response to steroid hormone  (ISO)
response to testosterone  (ISO)
seminiferous tubule development  (IEA,ISO)
single fertilization  (IEA,ISO)
skeletal muscle hypertrophy  (ISO)
spermatogenesis  (IEA,ISO)
tertiary branching involved in mammary gland duct morphogenesis  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component
axon  (ISO)
chromatin  (IEA)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
dendrite  (ISO)
nuclear matrix  (ISO)
nuclear speck  (IEA)
nucleus  (IEA,ISO)
plasma membrane  (IEA,ISO)
protein-containing complex  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X49,717,252 - 49,882,487 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936635485,903 - 647,932 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936635485,903 - 647,820 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X67,544,021 - 67,730,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX67,544,021 - 67,730,619 (+)EnsemblGRCh38hg38GRCh38
GRCh37X66,763,863 - 66,950,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X66,680,599 - 66,860,844 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X66,571,703 - 66,727,140NCBI
CeleraX67,112,960 - 67,293,967 (+)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX60,592,006 - 60,778,929 (+)NCBIHuRef
CHM1_1X66,656,369 - 66,842,989 (+)NCBICHM1_1
T2T-CHM13v2.0X65,973,852 - 66,160,479 (+)NCBIT2T-CHM13v2.0
Ar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X97,192,363 - 97,366,824 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX97,192,375 - 97,366,821 (+)EnsemblGRCm39 Ensembl
GRCm38X98,148,757 - 98,323,218 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX98,148,769 - 98,323,215 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X95,345,089 - 95,512,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X94,352,469 - 94,519,866 (+)NCBIMGSCv36mm8
CeleraX85,096,584 - 85,263,216 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.82NCBI
Ar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X67,135,317 - 67,304,476 (+)NCBIGRCr8
mRatBN7.2X63,104,771 - 63,273,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX63,104,771 - 63,273,925 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX64,593,944 - 64,763,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X68,094,494 - 68,263,645 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X65,655,236 - 65,824,382 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X67,656,253 - 67,828,998 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX67,656,253 - 67,829,026 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X68,533,662 - 68,705,929 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X85,949,507 - 86,119,199 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X86,022,798 - 86,192,491 (+)NCBI
CeleraX63,512,152 - 63,679,533 (+)NCBICelera
Cytogenetic MapXq22NCBI
Ar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554757,013,960 - 7,186,069 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554757,013,960 - 7,192,473 (+)NCBIChiLan1.0ChiLan1.0
AR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X67,131,384 - 67,317,580 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X67,134,984 - 67,321,183 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X56,722,828 - 56,909,004 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X66,790,419 - 66,975,921 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX66,791,081 - 66,969,357 (+)Ensemblpanpan1.1panPan2
AR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X51,969,785 - 52,167,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.12434,713,390 - 34,731,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX51,969,785 - 52,151,912 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX42,802,440 - 42,991,502 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X52,938,974 - 53,121,719 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX52,939,453 - 53,121,588 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X50,910,919 - 51,093,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X52,242,285 - 52,424,949 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X52,163,183 - 52,345,868 (+)NCBIUU_Cfam_GSD_1.0
AR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX53,609,176 - 53,800,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X53,609,113 - 53,806,778 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X60,313,281 - 60,504,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXq11-q13NCBI
AR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X57,380,587 - 57,553,613 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX57,380,611 - 57,546,776 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660834,772,253 - 4,943,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248913,138,848 - 3,329,459 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248913,135,824 - 3,330,487 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005335195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000022468   ⟹   ENSSTOP00000015265
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936635485,903 - 647,932 (-)Ensembl
RefSeq Acc Id: XM_005335195   ⟹   XP_005335252
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X49,717,252 - 49,882,487 (-)NCBI
SpeTri2.0NW_004936635485,903 - 647,820 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005335252 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000015265.1
RefSeq Acc Id: XP_005335252   ⟸   XM_005335195
- UniProtKB: I3MT20 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000015265   ⟸   ENSSTOT00000022468
Protein Domains
NR LBD   Nuclear receptor


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021280 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000022468.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/TrEMBL
InterPro Andrgn_rcpt UniProtKB/TrEMBL
  NHR-like_dom_sf UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/TrEMBL
  Nuclear_hormone_rcpt_NR3 UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/TrEMBL
NCBI Gene Ar ENTREZGENE
PANTHER ANDROGEN RECEPTOR UniProtKB/TrEMBL
  KNIRPS-RELATED PROTEIN-RELATED UniProtKB/TrEMBL
Pfam Androgen_recep UniProtKB/TrEMBL
  Hormone_recep UniProtKB/TrEMBL
  zf-C4 UniProtKB/TrEMBL
PRINTS ANDROGENR UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/TrEMBL
SMART HOLI UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF48508 UniProtKB/TrEMBL
UniProt I3MT20 ENTREZGENE, UniProtKB/TrEMBL