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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:34581
Term: Bisphenol B
Definition: A bisphenol that has formula C16H18O2.
Chemical ID: MESH:C492482
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ardecreases activityISORGD:7356526480464CTDbisphenol B results in decreased activity of AR protein

PMID:24563381
Arincreases activityISORGD:7356526480464CTDbisphenol B results in increased activity of AR protein

PMID:30951782
Armultiple interactionsISORGD:7356526480464CTDbisphenol B inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein], bisphenol B inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein], bisphenol B inhibits the reaction [Testosterone binds to and results in increased activity of AR protein]

PMID:27561732, PMID:29392883, PMID:30582956
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.