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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:165219
Term: PCB138
Definition: null
Chemical ID: MESH:C029790
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ardecreases expressionEXP 6480464CTD2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of AR proteinPMID:21673325
Armultiple interactionsEXP 6480464CTD2,2',3',4,4',5-hexachlorobiphenyl analog inhibits the reaction [Dihydrotestosterone binds to AR protein]; [2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of AR mRNAPMID:11906248 PMID:21190954
Armultiple interactionsISOAR (Homo sapiens)6480464CTD2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; 2,2',3',4,4',5-hexachlorobiphenyl inhibits the reaction [Metribolone results in increased activity of AR protein]PMID:18324785 PMID:21357386
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