NOTCH1 (notch receptor 1) - Rat Genome Database

Name: NOTCH1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: NOTCH1 (notch receptor 1) Homo sapiens

Analyze

Symbol:

NOTCH1

Name:

notch receptor 1

RGD ID:

737367

HGNC Page

HGNC

Description:

Exhibits identical protein binding activity. Involved in several processes, including heart development; negative regulation of endothelial cell migration; and positive regulation of intracellular signal transduction. Localizes to MAML1-RBP-Jkappa- ICN1 complex and receptor complex. Implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Biomarker of cholangiocarcinoma and endometrial cancer.

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

AOS5; AOVD1; hN1; neurogenic locus notch homolog protein 1; notch 1; notch gene homolog 1, (drosophila); Notch homolog 1, translocation-associated; TAN1; translocation-associated notch protein TAN-1

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Notch1 (notch 1)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Notch1 (notch receptor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Notch1 (notch receptor 1)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	NOTCH1 (notch receptor 1)	NCBI	Ortholog
Canis lupus familiaris (dog):	NOTCH1 (notch receptor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Notch1 (notch receptor 1)	NCBI	Ortholog
Sus scrofa (pig):	NOTCH1 (notch receptor 1)	HGNC	Ensembl, NCBI, OrthoDB
Chlorocebus sabaeus (African green monkey):	NOTCH1 (notch receptor 1)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Notch1 (notch receptor 1)	NCBI	Ortholog
Other homologs ²
Mus musculus (house mouse):	Notch2 (notch 2)	HGNC	OrthoDB, OrthoMCL
Canis lupus familiaris (dog):	NOTCH2 (notch receptor 2)	HGNC	OrthoDB, OrthoMCL
Mus musculus (house mouse):	Notch3 (notch 3)	HGNC	OrthoMCL
Mus musculus (house mouse):	Notch4 (notch 4)	HGNC	OrthoMCL
Canis lupus familiaris (dog):	NOTCH4 (notch receptor 4)	HGNC	OrthoMCL
Rattus norvegicus (Norway rat):	Notch2 (notch receptor 2)	HGNC	OrthoDB
Sus scrofa (pig):	NOTCH2 (notch receptor 2)	HGNC	OrthoDB
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Notch1 (notch receptor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Notch1 (notch 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Danio rerio (zebrafish):	notch1a (notch receptor 1a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PhylomeDB\|TreeFam\|ZFIN)
Danio rerio (zebrafish):	notch1b (notch receptor 1b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PhylomeDB\|TreeFam\|ZFIN)
Caenorhabditis elegans (roundworm):	glp-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|Roundup\|TreeFam)
Drosophila melanogaster (fruit fly):	N	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PhylomeDB\|Roundup\|TreeFam)
Caenorhabditis elegans (roundworm):	lin-12	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PhylomeDB\|Roundup\|TreeFam)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	9	136,494,433 - 136,546,048 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	9	136,494,433 - 136,546,048 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	9	139,388,885 - 139,440,500 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	138,508,717 - 138,560,059 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	9	136,664,733 - 136,716,075	NCBI
Celera	9	109,903,340 - 109,955,631 (-)	NCBI
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	108,848,155 - 108,928,442 (-)	NCBI		HuRef
CHM1_1	9	139,537,619 - 139,588,846 (-)	NCBI		CHM1_1

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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