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Gene: BCL2 (BCL2 apoptosis regulator) Homo sapiens
Symbol: BCL2
Name: BCL2 apoptosis regulator
RGD ID: 733100
Description: Exhibits several functions, including BH3 domain binding activity; enzyme binding activity; and protein heterodimerization activity. Involved in several processes, including apoptotic signaling pathway; negative regulation of apoptotic process; and positive regulation of B cell proliferation. Localizes to several cellular components, including mitochondrial outer membrane; nucleus; and pore complex. Implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; prostate cancer; and urinary bladder cancer. Biomarker of several diseases, including cervix uteri carcinoma in situ; ductal carcinoma in situ; hematologic cancer (multiple); nasopharynx carcinoma; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; b-cell leukemia/lymphoma 2; Bcl-2; Bcl-2a; Bcl-2ß; BCL2, apoptosis regulator; PPP1R50; protein phosphatase 1, regulatory subunit 50
Mus musculus (house mouse) : Bcl2 (B cell leukemia/lymphoma 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bcl2 (BCL2, apoptosis regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bcl2 (BCL2 apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : BCL2 (BCL2 apoptosis regulator)
Canis lupus familiaris (dog) : BCL2 (BCL2 apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bcl2 (BCL2 apoptosis regulator)
Sus scrofa (pig) : BCL2 (BCL2 apoptosis regulator)
Chlorocebus sabaeus (African green monkey) : BCL2 (BCL2 apoptosis regulator)
Heterocephalus glaber (naked mole-rat) : Bcl2 (BCL2 apoptosis regulator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1863,123,346 - 63,320,128 (-)EnsemblGRCh38hg38GRCh38
GRCh381863,123,346 - 63,320,280 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371860,790,579 - 60,987,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361858,941,559 - 59,137,593 (-)NCBINCBI36hg18NCBI36
Build 341858,941,558 - 59,136,910NCBI
Celera1857,509,356 - 57,706,116 (-)NCBI
Cytogenetic Map18q21.33NCBI
HuRef1857,487,199 - 57,684,751 (-)NCBIHuRef
CHM1_11860,786,149 - 60,982,536 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)