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Gene: MYCN (MYCN proto-oncogene, bHLH transcription factor) Homo sapiens
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Symbol: MYCN
Name: MYCN proto-oncogene, bHLH transcription factor
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and kinase binding activity. Involved in negative regulation of gene expression and positive regulation of transcription by RNA polymerase II. Localizes to the nucleolus and nucleoplasm. Implicated in Feingold syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHe37; class E basic helix-loop-helix protein 37; MODED; MYCNOT; N-myc; N-myc proto-oncogene protein; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; NMYC; ODED; oncogene NMYC; pp65/67; v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
Orthologs:
Mus musculus (house mouse) : Mycn (v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mycn (MYCN proto-oncogene, bHLH transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mycn (MYCN proto-oncogene, bHLH transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : MYCN (MYCN proto-oncogene, bHLH transcription factor)
Canis lupus familiaris (dog) : MYCN (MYCN proto-oncogene, bHLH transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mycn (MYCN proto-oncogene, bHLH transcription factor)
Sus scrofa (pig) : MYCN (MYCN proto-oncogene, bHLH transcription factor)
Chlorocebus sabaeus (African green monkey) : MYCN (MYCN proto-oncogene, bHLH transcription factor)
Heterocephalus glaber (naked mole-rat) : Mycn (MYCN proto-oncogene, bHLH transcription factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl215,940,550 - 15,947,007 (+)EnsemblGRCh38hg38GRCh38
GRCh38215,940,550 - 15,947,004 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37216,080,683 - 16,087,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36215,998,134 - 16,004,580 (+)NCBINCBI36hg18NCBI36
Build 34216,032,643 - 16,037,721NCBI
Celera215,998,381 - 16,004,827 (+)NCBI
Cytogenetic Map2p24.3NCBI
HuRef215,934,021 - 15,938,396 (+)NCBIHuRef
CHM1_1216,010,346 - 16,016,915 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Cell Lines
Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MYCN
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344499
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.