CCL22 (C-C motif chemokine ligand 22) - Rat Genome Database

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Gene: CCL22 (C-C motif chemokine ligand 22) Homo sapiens
Analyze
Symbol: CCL22
Name: C-C motif chemokine ligand 22
RGD ID: 1351526
HGNC Page HGNC:10621
Description: Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including arthritis (multiple); cervical squamous cell carcinoma; lung disease (multiple); pleural tuberculosis; and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A-152E5.1; ABCD-1; C-C motif chemokine 22; CC chemokine STCP-1; chemokine (C-C motif) ligand 22; DC/B-CK; macrophage-derived chemokine; MDC; MDC(1-69); MGC34554; SCYA22; small inducible cytokine A22; small inducible cytokine subfamily A (Cys-Cys), member 22; small-inducible cytokine A22; STCP-1; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,357,909 - 57,366,189 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,358,783 - 57,366,189 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,392,695 - 57,400,101 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,950,219 - 55,957,602 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,950,218 - 55,957,602NCBI
Celera1641,892,697 - 41,900,098 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,260,573 - 43,267,982 (+)NCBIHuRef
CHM1_11658,800,929 - 58,808,348 (+)NCBICHM1_1
T2T-CHM13v2.01663,153,028 - 63,161,306 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-phenylprop-2-enal  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (ISO)
acetohydrazide  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP)
allopurinol  (EXP)
alloxanthine  (EXP)
alpha-Zearalanol  (ISO)
ammonium chloride  (ISO)
aripiprazole  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
Bandrowski's base  (EXP)
barium sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
ceric oxide  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (EXP)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dopamine  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
ferric oxide  (EXP)
Fexofenadine hydrochloride  (EXP)
flavonoids  (ISO)
formaldehyde  (EXP)
fragrance  (EXP)
gentamycin  (ISO)
graphite  (ISO)
hydralazine  (EXP)
inulin  (ISO)
lipopolysaccharide  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (ISO)
mycophenolic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodimethylamine  (ISO)
naproxen  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP,ISO)
nifuroxazide  (EXP)
ozone  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
pevonedistat  (EXP)
prostaglandin E2  (EXP)
rac-lactic acid  (EXP)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sotorasib  (EXP)
sterigmatocystin  (ISO)
succimer  (ISO)
sumatriptan  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
toluene 2,4-diisocyanate  (ISO)
trametinib  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP)
vincristine  (EXP)
zearalenone  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA,TAS)
extracellular space  (IBA,IEA,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome. Bhorade SM, etal., Transplantation. 2010 Sep 15;90(5):540-6.
2. Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. Chiu BC, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):106-16. Epub 2003 Jan 10.
3. Expression of MDC/CCL22 and its receptor CCR4 in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Flytlie HA, etal., Cytokine. 2010 Jan;49(1):24-9. doi: 10.1016/j.cyto.2009.10.005. Epub 2009 Nov 25.
4. Mononuclear cell-infiltrate inhibition by blocking macrophage-derived chemokine results in attenuation of developing crescentic glomerulonephritis. Garcia GE, etal., Am J Pathol. 2003 Apr;162(4):1061-73.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammation. Gonzalo JA, etal., J Immunol. 1999 Jul 1;163(1):403-11.
7. CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis. Inoue T, etal., Eur Respir J. 2004 Jul;24(1):49-56.
8. Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. Jacobsen EA, etal., J Exp Med. 2008 Mar 17;205(3):699-710. Epub 2008 Mar 3.
9. Role of CCR4 ligands, CCL17 and CCL22, during Schistosoma mansoni egg-induced pulmonary granuloma formation in mice. Jakubzick C, etal., Am J Pathol. 2004 Oct;165(4):1211-21.
10. Expression of macrophage-derived chemokine (MDC)/CCL22 in human lung cancer. Nakanishi T, etal., Cancer Immunol Immunother. 2006 Nov;55(11):1320-9. Epub 2006 Feb 2.
11. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. Oh SB, etal., J Neurosci. 2001 Jul 15;21(14):5027-35.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Elevated expression of TARC (CCL17) and MDC (CCL22) in models of cigarette smoke-induced pulmonary inflammation. Ritter M, etal., Biochem Biophys Res Commun. 2005 Aug 19;334(1):254-62.
14. Immunoreactivity profile of peripheral blood mononuclear cells from patients with ragweed-induced allergic rhinitis. Sun J, etal., Clin Exp Allergy. 2007 Jun;37(6):901-8.
15. CCL22 is involved in the recruitment of CD4+CD25 high T cells into tuberculous pleural effusions. Wu C, etal., Respirology. 2010 Apr;15(3):522-9. Epub 2010 Mar 19.
16. Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease. Ying S, etal., J Immunol. 2008 Aug 15;181(4):2790-8.
17. Macrophage derived chemokine (CCL22), thymus and activation-regulated chemokine (CCL17), and CCR4 in idiopathic pulmonary fibrosis. Yogo Y, etal., Respir Res. 2009 Aug 29;10:80.
18. Negative immune factors might predominate local tumor immune status and promote carcinogenesis in cervical carcinoma. Zhao M, etal., Virol J. 2017 Jan 13;14(1):5. doi: 10.1186/s12985-016-0670-8.
Additional References at PubMed
PMID:9151897   PMID:9312138   PMID:9381181   PMID:9430724   PMID:9691168   PMID:9743322   PMID:9826729   PMID:9933589   PMID:10493829   PMID:10861057   PMID:11241286   PMID:11352815  
PMID:11390394   PMID:11792124   PMID:11818437   PMID:11981828   PMID:12193695   PMID:12407016   PMID:12477932   PMID:12485447   PMID:12642832   PMID:12715916   PMID:12851650   PMID:12949249  
PMID:14718574   PMID:14747532   PMID:14962085   PMID:15067078   PMID:15113590   PMID:15187160   PMID:15210758   PMID:15489334   PMID:15714581   PMID:15813816   PMID:15944327   PMID:16343773  
PMID:16344560   PMID:16583210   PMID:16614259   PMID:17008059   PMID:17703412   PMID:17967467   PMID:17979978   PMID:18047937   PMID:18178833   PMID:18208895   PMID:18224687   PMID:18266834  
PMID:18271928   PMID:18287226   PMID:18435706   PMID:18515987   PMID:18547160   PMID:19175890   PMID:19244125   PMID:19258923   PMID:19298002   PMID:19371952   PMID:19756997   PMID:20002703  
PMID:20237496   PMID:20348247   PMID:20503287   PMID:20525891   PMID:20625996   PMID:21129807   PMID:21327296   PMID:21823987   PMID:21873635   PMID:21988832   PMID:22125604   PMID:22322668  
PMID:22975373   PMID:23106659   PMID:23180648   PMID:23265706   PMID:23268288   PMID:23340773   PMID:23383108   PMID:23782855   PMID:23898208   PMID:24124553   PMID:24254331   PMID:24397961  
PMID:25117529   PMID:25136780   PMID:25148803   PMID:25352172   PMID:25604093   PMID:25647263   PMID:25722218   PMID:25922986   PMID:25970596   PMID:26093920   PMID:26341115   PMID:26432403  
PMID:26827189   PMID:27152707   PMID:27499437   PMID:27634754   PMID:27811371   PMID:27863395   PMID:28039457   PMID:28381538   PMID:28383711   PMID:28501127   PMID:28514442   PMID:28898872  
PMID:29099057   PMID:29662241   PMID:29794410   PMID:29945324   PMID:30572845   PMID:30623804   PMID:30928379   PMID:30953706   PMID:31131048   PMID:31134686   PMID:31325403   PMID:31769216  
PMID:32060848   PMID:32179746   PMID:32296183   PMID:32480426   PMID:32725764   PMID:33264064   PMID:33597749   PMID:33961781   PMID:34781732   PMID:35962191   PMID:36224014   PMID:36792811  
PMID:37124725   PMID:37685890   PMID:38387281   PMID:38836681   PMID:38924414  


Genomics

Comparative Map Data
CCL22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,357,909 - 57,366,189 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,358,783 - 57,366,189 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,392,695 - 57,400,101 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,950,219 - 55,957,602 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,950,218 - 55,957,602NCBI
Celera1641,892,697 - 41,900,098 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,260,573 - 43,267,982 (+)NCBIHuRef
CHM1_11658,800,929 - 58,808,348 (+)NCBICHM1_1
T2T-CHM13v2.01663,153,028 - 63,161,306 (+)NCBIT2T-CHM13v2.0
Ccl22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,472,312 - 95,478,016 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,472,218 - 95,478,327 (+)EnsemblGRCm39 Ensembl
GRCm38894,745,684 - 94,751,388 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,745,590 - 94,751,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,269,584 - 97,275,288 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,634,719 - 97,640,828 (+)NCBIMGSCv36mm8
Celera899,073,978 - 99,079,588 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.75NCBI
Ccl22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,263,589 - 10,270,359 (-)NCBIGRCr8
mRatBN7.21910,257,602 - 10,264,373 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,257,601 - 10,264,400 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,220,769 - 10,227,547 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,987,615 - 10,994,405 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,274,563 - 10,281,354 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,674,189 - 10,681,145 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,674,189 - 10,681,145 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,668,403 - 10,675,173 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,697,324 - 10,704,129 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,703,571 - 10,708,932 (-)NCBI
Celera1910,143,508 - 10,150,151 (-)NCBICelera
Cytogenetic Map19p13NCBI
Ccl22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,001,930 - 15,008,032 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,002,001 - 15,007,324 (+)NCBIChiLan1.0ChiLan1.0
CCL22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,826,127 - 66,834,428 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,746,907 - 72,755,202 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,631,861 - 37,640,208 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,765,370 - 56,770,650 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,765,367 - 56,771,213 (+)Ensemblpanpan1.1panPan2
CCL22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,039,650 - 59,045,519 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,040,539 - 59,045,625 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,669,094 - 55,674,886 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,577,991 - 59,583,780 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,579,632 - 59,583,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,409,552 - 56,415,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,417,248 - 57,423,037 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,310,530 - 58,316,323 (-)NCBIUU_Cfam_GSD_1.0
Ccl22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,151,805 - 50,156,642 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,432,505 - 9,436,240 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,432,505 - 9,436,240 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,296,637 - 19,302,737 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1619,296,726 - 19,301,506 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,265,026 - 17,294,055 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604733,012,741 - 33,018,986 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,694,735 - 28,700,827 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,694,879 - 28,700,711 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CCL22
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2		 pathogenic
GRCh38/hg38 16q12.2-21(chr16:55457477-63841622)x1 copy number loss See cases [RCV000133738] Chr16:55457477..63841622 [GRCh38]
Chr16:55491389..63875526 [GRCh37]
Chr16:54048890..62433027 [NCBI36]
Chr16:16q12.2-21		 pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3		 pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Breast ductal adenocarcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3		 uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Breast ductal adenocarcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2		 likely pathogenic|uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
GRCh37/hg19 16p11.2-q21(chr16:34197492-64509054)x3 copy number gain See cases [RCV000511791] Chr16:34197492..64509054 [GRCh37]
Chr16:16p11.2-q21		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2		 pathogenic
GRCh37/hg19 16q13-21(chr16:56950941-60203590)x1 copy number loss not provided [RCV000683823] Chr16:56950941..60203590 [GRCh37]
Chr16:16q13-21		 pathogenic|likely pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NM_002990.5(CCL22):c.118T>C (p.Tyr40His) single nucleotide variant not provided [RCV000948979] Chr16:57360481 [GRCh38]
Chr16:57360481..57360482 [GRCh38]
Chr16:57394393 [GRCh37]
Chr16:57394393..57394394 [GRCh37]
Chr16:16q21		 likely benign
GRCh37/hg19 16q12.2-21(chr16:53455650-64006604)x3 copy number gain not provided [RCV000848548] Chr16:53455650..64006604 [GRCh37]
Chr16:16q12.2-21		 uncertain significance
Single allele duplication not provided [RCV001542388] Chr16:46385317..61223349 [GRCh38]
Chr16:16q11.2-21		 pathogenic
GRCh37/hg19 16q13-21(chr16:57292407-59103985)x1 copy number loss not provided [RCV001259855] Chr16:57292407..59103985 [GRCh37]
Chr16:16q13-21		 uncertain significance
NM_002990.5(CCL22):c.131G>A (p.Arg44His) single nucleotide variant not specified [RCV004609901] Chr16:57360494 [GRCh38]
Chr16:57394406 [GRCh37]
Chr16:16q21		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46503968-90155062)x3 copy number gain not provided [RCV002221458] Chr16:46503968..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
NC_000016.9:g.(?_56226148)_(58768132_?)del deletion Bardet-Biedl syndrome [RCV003119976]|Early infantile epileptic encephalopathy with suppression bursts [RCV003109791] Chr16:56226148..58768132 [GRCh37]
Chr16:16q12.2-21		 pathogenic
NC_000016.9:g.(?_57016057)_(58768132_?)del deletion not provided [RCV003122679] Chr16:57016057..58768132 [GRCh37]
Chr16:16q13-21		 pathogenic
Single allele deletion not provided [RCV002266766] Chr16:53818483..57631312 [GRCh38]
Chr16:16q12.2-21		 pathogenic
GRCh37/hg19 16q11.2-21(chr16:46503573-62203182)x3 copy number gain not provided [RCV002472562] Chr16:46503573..62203182 [GRCh37]
Chr16:16q11.2-21		 pathogenic
NM_002990.5(CCL22):c.143G>A (p.Arg48His) single nucleotide variant not specified [RCV004207537] Chr16:57360506 [GRCh38]
Chr16:57394418 [GRCh37]
Chr16:16q21		 uncertain significance
NM_002990.5(CCL22):c.112C>T (p.Arg38Cys) single nucleotide variant not specified [RCV004093468] Chr16:57360475 [GRCh38]
Chr16:57394387 [GRCh37]
Chr16:16q21		 uncertain significance
NM_002990.5(CCL22):c.142C>T (p.Arg48Cys) single nucleotide variant not specified [RCV004201577] Chr16:57360505 [GRCh38]
Chr16:57394417 [GRCh37]
Chr16:16q21		 uncertain significance
GRCh37/hg19 16q12.2-22.1(chr16:55329260-67180113)x1 copy number loss not specified [RCV003987196] Chr16:55329260..67180113 [GRCh37]
Chr16:16q12.2-22.1		 pathogenic
NM_002990.5(CCL22):c.37G>A (p.Val13Ile) single nucleotide variant not specified [RCV004430551] Chr16:57358853 [GRCh38]
Chr16:57392765 [GRCh37]
Chr16:16q21		 likely benign
NM_002990.5(CCL22):c.113G>A (p.Arg38His) single nucleotide variant not specified [RCV004430550] Chr16:57360476 [GRCh38]
Chr16:57394388 [GRCh37]
Chr16:16q21		 uncertain significance
NM_002990.5(CCL22):c.125G>A (p.Arg42His) single nucleotide variant not specified [RCV004604763] Chr16:57360488 [GRCh38]
Chr16:57394400 [GRCh37]
Chr16:16q21		 uncertain significance
NC_000016.9:g.(?_48799549)_(70756330_?)dup duplication Chromosome 16q12 duplication syndrome [RCV004595820] Chr16:48799549..70756330 [GRCh37]
Chr16:16q12.1-22.1		 likely pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR34Ahsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22975373
MIR34Ahsa-miR-34a-5pOncomiRDBexternal_infoNANA22975373

Predicted Target Of
Summary Value
Count of predictions:1621
Count of miRNA genes:810
Interacting mature miRNAs:895
Transcripts:ENST00000219235
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407236468GWAS885444_Hapolipoprotein A 1 measurement QTL GWAS885444 (human)2e-12apolipoprotein A 1 measurementblood apolipoprotein AI level (CMO:0000520)165735882157358822Human
407273618GWAS922594_Hasthma QTL GWAS922594 (human)3e-08asthma165736095057360951Human
406914935GWAS563911_Hsystemic lupus erythematosus QTL GWAS563911 (human)1e-08systemic lupus erythematosus165735832957358330Human
407143224GWAS792200_Hmultiple sclerosis QTL GWAS792200 (human)0.000002multiple sclerosis165735832957358330Human
407344442GWAS993418_Hhigh density lipoprotein cholesterol measurement QTL GWAS993418 (human)3e-15high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)165735882157358822Human
406892126GWAS541102_HC-C motif chemokine 22 measurement QTL GWAS541102 (human)4e-32chemokine amount (VT:0008721)165736048157360482Human

Markers in Region
CCL22_3302  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371657,399,281 - 57,400,108UniSTSGRCh37
Build 361655,956,782 - 55,957,609RGDNCBI36
Celera1641,899,277 - 41,900,104RGD
HuRef1643,267,161 - 43,267,988UniSTS
D10S16   No map positions available.
D22S958  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map14q23-q24UniSTS
Cytogenetic Map16q13UniSTS
Cytogenetic Map22q13.1-q13.2UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map6q16.3UniSTS
Cytogenetic Map3q27.2UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map10q24.1UniSTS
D2S1254  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19p13UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map16q13UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map11q25UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map4q12UniSTS
D10S16  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map1p36.33UniSTS
Cytogenetic Map16q24.1UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map17p11.2UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map5q23.3-q31.1UniSTS
Cytogenetic Map7q32UniSTS
Cytogenetic Map1q21-q23UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map2q11.2-q12UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map1p36.21UniSTS
Cytogenetic Map3p22UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map9p13.3-p12UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic Map14q24.3UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map5q21-q22UniSTS
Cytogenetic Map2p22.1UniSTS
Cytogenetic Map1q32.3UniSTS
Cytogenetic Map1p36.11UniSTS
Cytogenetic Map18q12UniSTS
Cytogenetic Map19q13.41UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map3q27.3UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map2p15UniSTS
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map7q21.13UniSTS
Cytogenetic Map1p33UniSTS
Cytogenetic Map1p35.1UniSTS
Cytogenetic Map9q22.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map22q13.31-q13.33UniSTS
Cytogenetic Map1q24.1UniSTS
Cytogenetic Map7q32.2UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map1q42.11UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map11q24UniSTS
Cytogenetic Map2q11.2-q12.1UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map19q13.1UniSTS
Cytogenetic Map19p13UniSTS
Cytogenetic Map8p11.21UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map5q31.1UniSTS
Cytogenetic Map17q22.2UniSTS
Cytogenetic Map18q21UniSTS
Cytogenetic Map11q14.2UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map4q34UniSTS
Cytogenetic Map2p22-p21UniSTS
Cytogenetic Map10q26.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map11q13.4UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map1p36.23UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map8p21.2UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map14q32.12UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1p36.31UniSTS
Cytogenetic Map1p32.3UniSTS
Cytogenetic MapXq26.3UniSTS
Cytogenetic Map8p23.1UniSTS
Cytogenetic Map6q13UniSTS
Cytogenetic Map3p21.31UniSTS
Cytogenetic Map9p13.2UniSTS
Cytogenetic Map17q25UniSTS
Cytogenetic Map9q22.2UniSTS
Cytogenetic Map14q32.33UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map13q12.11UniSTS
Cytogenetic Map16p13.13UniSTS
Cytogenetic Map11p15.4UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map11q12.3UniSTS
Cytogenetic Map22q13UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map11p15.3-p15.1UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map10q22.2UniSTS
Cytogenetic Map17p13.3UniSTS
Cytogenetic Map7p22.3UniSTS
Cytogenetic Map3p21UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map1q42.3UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map16p11.2UniSTS
Cytogenetic Map1q25UniSTS
Cytogenetic Map15q11.2UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map3q26UniSTS
Cytogenetic Map12p12.1-p11.2UniSTS
Cytogenetic Map11q23.1UniSTS
Cytogenetic Map13q14.11UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map10q11.22UniSTS
Cytogenetic Map5p12UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map9q21.13UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic MapXq23UniSTS
Cytogenetic Map2p21UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map16q13UniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map10q23-q24UniSTS
Cytogenetic Map20p13UniSTS
Cytogenetic Map7q31UniSTS
Cytogenetic Map6q23.3UniSTS
Cytogenetic MapXp22.2UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map4q35.1UniSTS
Cytogenetic Map3q21.3UniSTS
Cytogenetic Map5q12.3UniSTS
Cytogenetic Map6q25.1UniSTS
Cytogenetic Map14q24.1UniSTS
Cytogenetic Map2q33.2UniSTS
Cytogenetic Map20q13.13UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic Map15q24.1UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map8q23.1UniSTS
Cytogenetic Map2q14.3UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map21q22.11UniSTS
Cytogenetic Map5p15.1UniSTS
Cytogenetic Map15q13.1UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map8p21.3UniSTS
Cytogenetic Map1p31.1UniSTS
Cytogenetic Map17qterUniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map12q22UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic MapXp22.33UniSTS
Cytogenetic MapYp11.32UniSTS
Cytogenetic Map14q24.2UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map10p11.23UniSTS
Cytogenetic Map15q15.2UniSTS
Cytogenetic Map8p21.1UniSTS
Cytogenetic Map22q12.2UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map6p21.31UniSTS
Cytogenetic Map10q23.1UniSTS
Cytogenetic Map1p36.2UniSTS
Cytogenetic Map2p16.1UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map17q23.3UniSTS
Cytogenetic Map12q13.13UniSTS
Cytogenetic Map20q12-q13.12UniSTS
Cytogenetic Map3q26.33UniSTS
Cytogenetic Map5q31.2-q34UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map5q35.3UniSTS
Cytogenetic MapXq13-q21UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map1pter-q31.3UniSTS
Cytogenetic Map15q21.1UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic MapXq13.1UniSTS
Cytogenetic Map3p23-p21UniSTS
Cytogenetic Map11q22-q23UniSTS
Cytogenetic Map1p34.1UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map7p22.1UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map10q11.21UniSTS
Cytogenetic Map16q22UniSTS
Cytogenetic Map2q24UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map3q13.13UniSTS
Cytogenetic Map19p12UniSTS
Cytogenetic Map16p13.1UniSTS
Cytogenetic Map19q13.11UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map10p12.31UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map8q21.2UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map8p11.2UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1p36.1-p34UniSTS
Cytogenetic Map4p13UniSTS
Cytogenetic Map7q31.1-q31.2UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map15q21.1-q21.2UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic Map7q36.1UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map3p11.1UniSTS
Cytogenetic Map15q21.3UniSTS
Cytogenetic Map13q12UniSTS
Cytogenetic Map12q23.2UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic MapXq21UniSTS
Cytogenetic Map15q15UniSTS
Cytogenetic Map4q25UniSTS
Cytogenetic Map3q22.1UniSTS
Cytogenetic Map1q25.2UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map15q24.2UniSTS
Cytogenetic Map2p14UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map6p21UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map17p13UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map21q22.13UniSTS
Cytogenetic Map6p21.1UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map1p21UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map8p11.23UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map9q33.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map12q15UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map7q22.3UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map4q35UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map16p13.12UniSTS
Cytogenetic Map9q34.1UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map3p23UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map12p13UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map4p15.3UniSTS
Cytogenetic Map2q33.1UniSTS
Cytogenetic Map15q15.1UniSTS
Cytogenetic Map1p32-p31UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map2q33.3UniSTS
Cytogenetic Map8p22UniSTS
Cytogenetic Map22q11.23UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.3UniSTS
Cytogenetic Map12q14.2UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic Map12q13.11UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map9q34.11UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map6q22.32UniSTS
Cytogenetic Map5q15UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3p25.1UniSTS
Cytogenetic Map3q27.1UniSTS
Cytogenetic Map2q36.1UniSTS
Cytogenetic Map2q37UniSTS
Cytogenetic Map19q13.31UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map10q22.1UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map16q23.2UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map18q21.1UniSTS
Cytogenetic Map12q12-q13UniSTS
Cytogenetic Map9p22.3UniSTS
Cytogenetic Map6p21.2UniSTS
Cytogenetic Map6p22.1UniSTS
Cytogenetic Map11p15.1UniSTS
Cytogenetic Map19qterUniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map12q14.1UniSTS
Cytogenetic Map7p11UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map16p12.3UniSTS
Cytogenetic Map3q29UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map17pUniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map2p13.2UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map20q13.12UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map17p13.1UniSTS
Cytogenetic Map14q23.3UniSTS
Cytogenetic Map3q26.2UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1152 2180 2314 1852 4158 1567 2209 4 559 1738 401 2204 6149 5693 48 2922 787 1559 1543 170

Sequence


Ensembl Acc Id: ENST00000219235   ⟹   ENSP00000219235
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1657,358,783 - 57,366,189 (+)Ensembl
RefSeq Acc Id: NM_002990   ⟹   NP_002981
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,358,783 - 57,366,189 (+)NCBI
GRCh371657,392,695 - 57,400,102 (+)ENTREZGENE
Build 361655,950,219 - 55,957,602 (+)NCBI Archive
HuRef1643,260,573 - 43,267,982 (+)ENTREZGENE
CHM1_11658,800,929 - 58,808,348 (+)NCBI
T2T-CHM13v2.01663,153,902 - 63,161,306 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047434449   ⟹   XP_047290405
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,357,925 - 57,366,189 (+)NCBI
RefSeq Acc Id: XM_047434450   ⟹   XP_047290406
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,357,909 - 57,366,189 (+)NCBI
RefSeq Acc Id: XM_054313599   ⟹   XP_054169574
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01663,153,188 - 63,161,306 (+)NCBI
RefSeq Acc Id: XM_054313600   ⟹   XP_054169575
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01663,153,028 - 63,161,306 (+)NCBI
RefSeq Acc Id: NP_002981   ⟸   NM_002990
- Peptide Label: precursor
- UniProtKB: A0N0Q6 (UniProtKB/Swiss-Prot),   B2R4W2 (UniProtKB/Swiss-Prot),   O00626 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000219235   ⟸   ENST00000219235
RefSeq Acc Id: XP_047290406   ⟸   XM_047434450
- Peptide Label: isoform X2
- UniProtKB: O00626 (UniProtKB/Swiss-Prot),   A0N0Q6 (UniProtKB/Swiss-Prot),   B2R4W2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047290405   ⟸   XM_047434449
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054169575   ⟸   XM_054313600
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054169574   ⟸   XM_054313599
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O00626-F1-model_v2 AlphaFold O00626 1-93 view protein structure

Promoters
RGD ID:6792892
Promoter ID:HG_KWN:23892
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000257328
Position:
Human AssemblyChrPosition (strand)Source
Build 361655,949,356 - 55,950,307 (+)MPROMDB
RGD ID:7232317
Promoter ID:EPDNEW_H21905
Type:initiation region
Name:CCL22_1
Description:C-C motif chemokine ligand 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381657,358,783 - 57,358,843EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10621 AgrOrtholog
COSMIC CCL22 COSMIC
Ensembl Genes ENSG00000102962 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000219235 ENTREZGENE
  ENST00000219235.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot
GTEx ENSG00000102962 GTEx
HGNC ID HGNC:10621 ENTREZGENE
Human Proteome Map CCL22 Human Proteome Map
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot
  Chemokine_CC_CS UniProtKB/Swiss-Prot
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot
  Interleukin_8-like_sf UniProtKB/Swiss-Prot
KEGG Report hsa:6367 UniProtKB/Swiss-Prot
NCBI Gene 6367 ENTREZGENE
OMIM 602957 OMIM
PANTHER PTHR12015 UniProtKB/Swiss-Prot
  PTHR12015:SF102 UniProtKB/Swiss-Prot
Pfam IL8 UniProtKB/Swiss-Prot
PharmGKB PA35553 PharmGKB
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot
SMART SCY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot
UniProt A0N0Q6 ENTREZGENE
  B2R4W2 ENTREZGENE
  CCL22_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0N0Q6 UniProtKB/Swiss-Prot
  B2R4W2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 CCL22  C-C motif chemokine ligand 22    chemokine (C-C motif) ligand 22  Symbol and/or name change 5135510 APPROVED