PPP1R10 (protein phosphatase 1 regulatory subunit 10) - Rat Genome Database

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Gene: PPP1R10 (protein phosphatase 1 regulatory subunit 10) Homo sapiens
Analyze
Symbol: PPP1R10
Name: protein phosphatase 1 regulatory subunit 10
RGD ID: 732967
HGNC Page HGNC:9284
Description: Enables RNA binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; and positive regulation of telomere maintenance. Located in nuclear body. Colocalizes with chromosome, telomeric region.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CAT53; FB19; HLA-C associated transcript 53; MHC class I region proline-rich protein CAT53; p99; phosphatase 1 nuclear targeting subunit; phosphatase nuclear targeting subunit; PNUTS; PP1-binding protein of 114 kDa; PP1R10; protein phosphatase 1, regulatory (inhibitor) subunit 10; putative protein phosphatase 1 nuclear targeting subunit; R111; serine/threonine-protein phosphatase 1 regulatory subunit 10; testis tissue sperm-binding protein Li 67n
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PPP1R10P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,600,413 - 30,617,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl630,600,413 - 30,618,612 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,568,190 - 30,585,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,676,161 - 30,692,999 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,676,161 - 30,692,999NCBI
Celera632,166,300 - 32,183,138 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,368,345 - 30,385,252 (-)NCBIHuRef
CHM1_1630,570,286 - 30,587,193 (-)NCBICHM1_1
T2T-CHM13v2.0630,464,593 - 30,481,424 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
acetaldehyde  (EXP)
acrylamide  (EXP)
aldrin  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (EXP)
bathocuproine disulfonic acid  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (EXP)
coumarin  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
D-mannitol  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
Diisodecyl phthalate  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
doxorubicin  (EXP)
elemental selenium  (EXP)
Enterolactone  (EXP)
enzyme inhibitor  (EXP)
flutamide  (ISO)
folic acid  (ISO)
furan  (ISO)
genistein  (EXP)
gentamycin  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (EXP)
L-methionine  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
leflunomide  (ISO)
methylmercury chloride  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-methylformamide  (ISO)
nickel atom  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pyrrolidine dithiocarbamate  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
selenium atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (EXP)
T-2 toxin  (EXP)
tamoxifen  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
vanadyl sulfate  (EXP)
vanillin  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin E  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA,IEA,ISO,ISS)
chromosome, telomeric region  (IDA)
nuclear body  (IBA,IDA)
nucleoplasm  (IDA)
nucleus  (IEA,TAS)
PTW/PP1 phosphatase complex  (IBA,IEA,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. Allen PB, etal., J Biol Chem 1998 Feb 13;273(7):4089-95.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8838313   PMID:8889548   PMID:9450550   PMID:9784381   PMID:10637318   PMID:12477932   PMID:12574161   PMID:12914669   PMID:14574404   PMID:15203218   PMID:15231748   PMID:15894402  
PMID:15907195   PMID:16009940   PMID:16964243   PMID:17081983   PMID:17318220   PMID:18360108   PMID:19293638   PMID:19429178   PMID:19851445   PMID:20360068   PMID:20372802   PMID:20516061  
PMID:20890310   PMID:21244100   PMID:21532586   PMID:21873635   PMID:22678362   PMID:22681889   PMID:22939629   PMID:23110726   PMID:23117887   PMID:23426265   PMID:23508102   PMID:23537643  
PMID:24270157   PMID:24332808   PMID:24366813   PMID:24462707   PMID:24591642   PMID:24711643   PMID:24981860   PMID:25147182   PMID:25281560   PMID:25544563   PMID:25921289   PMID:25959826  
PMID:26186194   PMID:26188041   PMID:26496610   PMID:26777405   PMID:27173435   PMID:27578752   PMID:27591855   PMID:27634302   PMID:27880917   PMID:28216226   PMID:28330616   PMID:28514442  
PMID:28825698   PMID:29180619   PMID:29507755   PMID:29509190   PMID:29656893   PMID:29669786   PMID:29764005   PMID:29884807   PMID:30158517   PMID:30190438   PMID:30344098   PMID:30585729  
PMID:30629181   PMID:30804502   PMID:31048545   PMID:31076518   PMID:31091453   PMID:31353912   PMID:31470122   PMID:31527615   PMID:31677974   PMID:31732153   PMID:32129710   PMID:32176628  
PMID:32203420   PMID:32377272   PMID:32416067   PMID:32538781   PMID:32908313   PMID:33306668   PMID:33916271   PMID:33961781   PMID:34048709   PMID:34079125   PMID:34373451   PMID:34795231  
PMID:35241646   PMID:35256949   PMID:35271311   PMID:35831314  


Genomics

Comparative Map Data
PPP1R10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,600,413 - 30,617,243 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl630,600,413 - 30,618,612 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,568,190 - 30,585,020 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,676,161 - 30,692,999 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,676,161 - 30,692,999NCBI
Celera632,166,300 - 32,183,138 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,368,345 - 30,385,252 (-)NCBIHuRef
CHM1_1630,570,286 - 30,587,193 (-)NCBICHM1_1
T2T-CHM13v2.0630,464,593 - 30,481,424 (-)NCBIT2T-CHM13v2.0
Ppp1r10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,227,404 - 36,243,175 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,227,326 - 36,243,175 (+)EnsemblGRCm39 Ensembl
GRCm381735,916,512 - 35,932,283 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,916,434 - 35,932,283 (+)EnsemblGRCm38mm10GRCm38
MGSCv371736,053,856 - 36,069,228 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,525,051 - 35,540,336 (+)NCBIMGSCv36mm8
Celera1739,426,148 - 39,441,526 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.77NCBI
Ppp1r10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2202,822,995 - 2,838,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl202,822,995 - 2,837,611 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx202,874,774 - 2,889,396 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0202,879,744 - 2,894,366 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0202,905,740 - 2,920,511 (-)NCBIRnor_WKY
Rnor_6.0203,329,677 - 3,344,286 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,329,677 - 3,344,286 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,427,600 - 5,441,809 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4202,940,605 - 2,984,636 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1202,970,906 - 2,984,624 (-)NCBI
Celera20248,977 - 263,595 (-)NCBICelera
Cytogenetic Map20p12NCBI
Ppp1r10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955583621,092 - 634,929 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955583621,380 - 635,595 (-)NCBIChiLan1.0ChiLan1.0
PPP1R10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1631,212,522 - 31,229,715 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,212,522 - 31,229,697 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0630,342,669 - 30,359,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PPP1R10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112416,533 - 434,777 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12417,680 - 427,799 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12554,183 - 572,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012560,665 - 578,919 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12560,666 - 578,721 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112417,222 - 435,469 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012486,514 - 504,753 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012556,330 - 574,575 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494633,911,200 - 33,928,070 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837277,618 - 286,515 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936837276,423 - 296,600 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,147,478 - 23,165,689 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,148,834 - 23,166,933 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,818,442 - 26,836,606 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.1NCBI
PPP1R10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,839,504 - 41,857,228 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1741,839,833 - 41,858,470 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604430,293,597 - 30,310,935 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475425,076,333 - 25,091,907 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475425,074,980 - 25,091,798 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPP1R10
5 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR34Ahsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23426265

Predicted Target Of
Summary Value
Count of predictions:2167
Count of miRNA genes:975
Interacting mature miRNAs:1181
Transcripts:ENST00000376511, ENST00000461593, ENST00000468181, ENST00000473954, ENST00000476704, ENST00000484449, ENST00000496955
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SGC32149  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,568,239 - 30,568,341UniSTSGRCh37
Build 36630,676,218 - 30,676,320RGDNCBI36
Celera632,166,357 - 32,166,459RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,368,407 - 30,368,509UniSTS
Whitehead-RH Map6171.4UniSTS
SHGC-86293  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,576,877 - 30,577,192UniSTSGRCh37
Build 36630,684,856 - 30,685,171RGDNCBI36
Celera632,174,995 - 32,175,310RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,377,045 - 30,377,360UniSTS
TNG Radiation Hybrid Map616057.0UniSTS
GDB:305493  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3713109,337,950 - 109,338,490UniSTSGRCh37
GRCh3749,784,259 - 9,784,644UniSTSGRCh37
Build 3649,393,357 - 9,393,742RGDNCBI36
Celera1390,182,683 - 90,183,223UniSTS
Celera410,267,118 - 10,267,503RGD
Cytogenetic Map6p21.3UniSTS
Cytogenetic Map4p16.1UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map13q33.3UniSTS
HuRef1094,689,177 - 94,689,725UniSTS
HuRef49,118,664 - 9,119,049UniSTS
HuRef1389,930,866 - 89,931,406UniSTS
HuRef1841,116,019 - 41,116,347UniSTS
D17Ertd808e  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,568,197 - 30,568,512UniSTSGRCh37
Build 36630,676,176 - 30,676,491RGDNCBI36
Celera632,166,315 - 32,166,630RGD
HuRef630,368,365 - 30,368,680UniSTS
RH18166  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,568,303 - 30,568,519UniSTSGRCh37
Build 36630,676,282 - 30,676,498RGDNCBI36
Celera632,166,421 - 32,166,637RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,368,471 - 30,368,687UniSTS
GeneMap99-GB4 RH Map6118.61UniSTS
A007C28  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,573,711 - 30,573,953UniSTSGRCh37
Build 36630,681,690 - 30,681,932RGDNCBI36
Celera632,171,829 - 32,172,071RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,373,879 - 30,374,121UniSTS
GeneMap99-GB4 RH Map6117.14UniSTS
NCBI RH Map6476.0UniSTS
D6S484E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,584,504 - 30,584,586UniSTSGRCh37
Build 36630,692,483 - 30,692,565RGDNCBI36
Celera632,182,622 - 32,182,704RGD
Cytogenetic Map6p21.3UniSTS
HuRef630,384,672 - 30,384,754UniSTS
PPP1R10_1061  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,568,165 - 30,568,898UniSTSGRCh37
Build 36630,676,144 - 30,676,877RGDNCBI36
Celera632,166,283 - 32,167,016RGD
HuRef630,368,333 - 30,369,066UniSTS
SGC34051  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37630,572,823 - 30,573,800UniSTSGRCh37
Celera632,170,941 - 32,171,918UniSTS
Cytogenetic Map6p21.3UniSTS
HuRef630,372,991 - 30,373,968UniSTS
GeneMap99-GB4 RH Map6119.27UniSTS
Whitehead-RH Map6156.3UniSTS
RH16237  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6p21.3UniSTS
GeneMap99-GB4 RH Map6118.72UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2428 2325 1703 603 1776 445 4146 1691 3339 407 1447 1598 171 1201 2593 4
Low 6 659 21 19 173 19 209 502 372 11 2 10 3 195
Below cutoff 2 2 1 1 1 8 1 4 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001376195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_072994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_164780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_164781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011514722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB088097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB103603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB202094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ544537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BA000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC136294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC150310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU681199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX119957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX248507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX908728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD615451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR753328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR759778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000376511   ⟹   ENSP00000365694
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl630,600,413 - 30,617,243 (-)Ensembl
RefSeq Acc Id: ENST00000461593
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl630,605,018 - 30,606,737 (-)Ensembl
RefSeq Acc Id: ENST00000468181
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl630,605,809 - 30,606,243 (-)Ensembl
RefSeq Acc Id: ENST00000473954
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl630,616,584 - 30,618,612 (-)Ensembl
RefSeq Acc Id: ENST00000476704
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl630,604,612 - 30,605,998 (-)Ensembl
RefSeq Acc Id: ENST00000484449
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl630,609,947 - 30,617,244 (-)Ensembl
RefSeq Acc Id: ENST00000496955
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl630,603,573 - 30,604,212 (-)Ensembl
RefSeq Acc Id: NM_001376195   ⟹   NP_001363124
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,600,413 - 30,617,243 (-)NCBI
T2T-CHM13v2.0630,464,593 - 30,481,424 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002714   ⟹   NP_002705
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,600,413 - 30,617,243 (-)NCBI
GRCh37630,568,177 - 30,585,084 (-)NCBI
Build 36630,676,161 - 30,692,999 (-)NCBI Archive
HuRef630,368,345 - 30,385,252 (-)NCBI
CHM1_1630,570,286 - 30,587,193 (-)NCBI
T2T-CHM13v2.0630,464,593 - 30,481,424 (-)NCBI
Sequence:
RefSeq Acc Id: NR_072994
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,600,413 - 30,617,243 (-)NCBI
HuRef630,368,345 - 30,385,252 (-)NCBI
CHM1_1630,570,286 - 30,587,193 (-)NCBI
T2T-CHM13v2.0630,464,593 - 30,481,424 (-)NCBI
Sequence:
RefSeq Acc Id: NR_164780
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,615,553 - 30,617,243 (-)NCBI
T2T-CHM13v2.0630,479,734 - 30,481,424 (-)NCBI
Sequence:
RefSeq Acc Id: NR_164781
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,615,553 - 30,617,243 (-)NCBI
T2T-CHM13v2.0630,479,734 - 30,481,424 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011514722   ⟹   XP_011513024
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,600,413 - 30,617,243 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002705   ⟸   NM_002714
- UniProtKB: O00405 (UniProtKB/Swiss-Prot),   Q96QC0 (UniProtKB/Swiss-Prot),   Q2L6I0 (UniProtKB/TrEMBL),   A0A1U9X8C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011513024   ⟸   XM_011514722
- Peptide Label: isoform X1
- UniProtKB: O00405 (UniProtKB/Swiss-Prot),   Q96QC0 (UniProtKB/Swiss-Prot),   Q2L6I0 (UniProtKB/TrEMBL),   A0A1U9X8C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001363124   ⟸   NM_001376195
- UniProtKB: O00405 (UniProtKB/Swiss-Prot),   A0A1U9X8C5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSP00000365694   ⟸   ENST00000376511
Protein Domains
C3H1-type   TFIIS N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96QC0-F1-model_v2 AlphaFold Q96QC0 1-940 view protein structure

Promoters
RGD ID:6872392
Promoter ID:EPDNEW_H9361
Type:initiation region
Name:PPP1R10_3
Description:protein phosphatase 1 regulatory subunit 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9362  EPDNEW_H9368  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,616,646 - 30,616,706EPDNEW
RGD ID:6872394
Promoter ID:EPDNEW_H9362
Type:initiation region
Name:PPP1R10_1
Description:protein phosphatase 1 regulatory subunit 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9361  EPDNEW_H9368  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38630,617,243 - 30,617,303EPDNEW
RGD ID:6813048
Promoter ID:HG_ACW:67925
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:PPP1R10.BAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,677,176 - 30,677,676 (-)MPROMDB
RGD ID:6804556
Promoter ID:HG_KWN:52834
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000256178
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,679,621 - 30,680,917 (-)MPROMDB
RGD ID:6804555
Promoter ID:HG_KWN:52835
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000256175,   OTTHUMT00000256176,   OTTHUMT00000256177
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,681,871 - 30,682,522 (-)MPROMDB
RGD ID:6803900
Promoter ID:HG_KWN:52837
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000396492,   NM_014046,   OTTHUMT00000076556,   OTTHUMT00000076583,   OTTHUMT00000076585,   OTTHUMT00000256174,   OTTHUMT00000256239,   UC010JSC.1,   UC010JSD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,692,981 - 30,693,667 (-)MPROMDB
RGD ID:6804554
Promoter ID:HG_KWN:52838
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:OTTHUMT00000256173
Position:
Human AssemblyChrPosition (strand)Source
Build 36630,694,006 - 30,694,506 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p22.3-21.33(chr6:18120520-30767516)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052180]|See cases [RCV000052180] Chr6:18120520..30767516 [GRCh38]
Chr6:18120751..30735293 [GRCh37]
Chr6:18228730..30843272 [NCBI36]
Chr6:6p22.3-21.33
pathogenic
GRCh38/hg38 6p25.2-21.33(chr6:3224310-30657190)x3 copy number gain See cases [RCV000138956] Chr6:3224310..30657190 [GRCh38]
Chr6:3224544..30624967 [GRCh37]
Chr6:3169543..30732946 [NCBI36]
Chr6:6p25.2-21.33
pathogenic
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32
uncertain significance
NM_002714.4(PPP1R10):c.635-3C>T single nucleotide variant not provided [RCV000973564] Chr6:30606246 [GRCh38]
Chr6:30574023 [GRCh37]
Chr6:6p21.33
benign
NM_002714.4(PPP1R10):c.285A>G (p.Leu95=) single nucleotide variant not provided [RCV000884601] Chr6:30608824 [GRCh38]
Chr6:30576601 [GRCh37]
Chr6:6p21.33
benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_002714.4(PPP1R10):c.2052C>T (p.Gly684=) single nucleotide variant not provided [RCV001690148] Chr6:30602597 [GRCh38]
Chr6:30570374 [GRCh37]
Chr6:6p21.33
benign
NC_000006.11:g.28005012_31683185del deletion Megacolon [RCV001290055] Chr6:28005012..31683185 [GRCh37]
Chr6:6p22.1-21.33
likely pathogenic
NM_002714.4(PPP1R10):c.1295C>T (p.Ala432Val) single nucleotide variant Generalized muscle weakness [RCV002283353] Chr6:30604221 [GRCh38]
Chr6:30571998 [GRCh37]
Chr6:6p21.33
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9284 AgrOrtholog
COSMIC PPP1R10 COSMIC
Ensembl Genes ENSG00000204569 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000206489 UniProtKB/Swiss-Prot
  ENSG00000227804 UniProtKB/Swiss-Prot
  ENSG00000230995 UniProtKB/Swiss-Prot
  ENSG00000231737 UniProtKB/Swiss-Prot
  ENSG00000235291 UniProtKB/Swiss-Prot
  ENSG00000238104 UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000365694 ENTREZGENE
  ENSP00000365694.2 UniProtKB/Swiss-Prot
  ENSP00000373080.4 UniProtKB/Swiss-Prot
  ENSP00000389299.2 UniProtKB/Swiss-Prot
  ENSP00000407181.2 UniProtKB/Swiss-Prot
  ENSP00000407310.2 UniProtKB/Swiss-Prot
  ENSP00000413554.2 UniProtKB/Swiss-Prot
  ENSP00000416060.2 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000376511 ENTREZGENE
  ENST00000376511.7 UniProtKB/Swiss-Prot
  ENST00000383586.8 UniProtKB/Swiss-Prot
  ENST00000420949.6 UniProtKB/Swiss-Prot
  ENST00000424446.6 UniProtKB/Swiss-Prot
  ENST00000426299.6 UniProtKB/Swiss-Prot
  ENST00000429597.6 UniProtKB/Swiss-Prot
  ENST00000449113.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.930.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000204569 GTEx
  ENSG00000206489 GTEx
  ENSG00000227804 GTEx
  ENSG00000230995 GTEx
  ENSG00000231737 GTEx
  ENSG00000235291 GTEx
  ENSG00000238104 GTEx
HGNC ID HGNC:9284 ENTREZGENE
Human Proteome Map PPP1R10 Human Proteome Map
InterPro TFIIS/CRSP70_N_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFIIS/LEDGF_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TFIIS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5514 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5514 ENTREZGENE
OMIM 603771 OMIM
Pfam Med26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33612 PharmGKB
PROSITE TFIIS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TFS2N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47676 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1U9X8C5 ENTREZGENE
  O00405 ENTREZGENE
  PP1RA_HUMAN UniProtKB/Swiss-Prot
  Q2L6I0 ENTREZGENE, UniProtKB/TrEMBL
  Q58F28_HUMAN UniProtKB/TrEMBL
  Q96QC0 ENTREZGENE
UniProt Secondary A0A1U9X8C5 UniProtKB/TrEMBL
  O00405 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PPP1R10  protein phosphatase 1 regulatory subunit 10    protein phosphatase 1, regulatory subunit 10  Symbol and/or name change 5135510 APPROVED
2012-07-13 PPP1R10  protein phosphatase 1, regulatory subunit 10  PPP1R10  protein phosphatase 1, regulatory subunit 10  Symbol and/or name change 5135510 APPROVED
2011-10-11 PPP1R10  protein phosphatase 1, regulatory subunit 10  PPP1R10  protein phosphatase 1, regulatory (inhibitor) subunit 10  Symbol and/or name change 5135510 APPROVED
2011-08-17 PPP1R10  protein phosphatase 1, regulatory (inhibitor) subunit 10  PPP1R10  protein phosphatase 1, regulatory (inhibitor) subunit 10  Symbol and/or name change 5135510 APPROVED