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Gene: JAG1 (jagged canonical Notch ligand 1) Homo sapiens
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Symbol: JAG1
Name: jagged canonical Notch ligand 1
Description: Exhibits Notch binding activity and phospholipid binding activity. Involved in several processes, including circulatory system development; negative regulation of cell adhesion; and neuronal stem cell population maintenance. Localizes to plasma membrane. Colocalizes with membrane. Implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Biomarker of hepatocellular carcinoma; multiple sclerosis; osteoarthritis; and temporal arteritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGS; AGS1; AHD; Alagille syndrome; AWS; CD339; DCHE; HJ1; jagged 1; jagged 1 (Alagille syndrome); jagged1; JAGL1; MGC104644; protein jagged-1
Orthologs:
Mus musculus (house mouse) : Jag1 (jagged 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Jag1 (jagged canonical Notch ligand 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jag1 (jagged canonical Notch ligand 1)
Pan paniscus (bonobo/pygmy chimpanzee) : JAG1 (jagged canonical Notch ligand 1)
Canis lupus familiaris (dog) : JAG1 (jagged canonical Notch ligand 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jag1 (jagged canonical Notch ligand 1)
Sus scrofa (pig) : JAG1 (jagged canonical Notch ligand 1)
Chlorocebus sabaeus (African green monkey) : JAG1 (jagged canonical Notch ligand 1)
Heterocephalus glaber (naked mole-rat) : Jag1 (jagged canonical Notch ligand 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl2010,637,684 - 10,673,999 (-)EnsemblGRCh38hg38GRCh38
GRCh382010,637,684 - 10,673,999 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372010,618,332 - 10,654,694 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362010,566,334 - 10,602,590 (-)NCBINCBI36hg18NCBI36
Build 342010,566,333 - 10,602,590NCBI
Celera2010,688,304 - 10,724,650 (-)NCBI
Cytogenetic Map20p12.2NCBI
HuRef2010,569,771 - 10,606,135 (-)NCBIHuRef
CHM1_12010,618,904 - 10,655,234 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on JAG1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353888
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.