CCND1 (cyclin D1) - Rat Genome Database

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Gene: CCND1 (cyclin D1) Homo sapiens
Symbol: CCND1
Name: cyclin D1
RGD ID: 68556
Description: Enables enzyme binding activity; proline-rich region binding activity; and transcription corepressor activity. Involved in several processes, including positive regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic cell cycle phase transition; and response to UV-A. Located in nucleoplasm. Part of cyclin-dependent protein kinase holoenzyme complex and transcription repressor complex. Implicated in several diseases, including carcinoma (multiple); colorectal cancer; hematologic cancer (multiple); invasive lobular carcinoma; and von Hippel-Lindau disease. Biomarker of several diseases, including carcinoma (multiple); cervix uteri carcinoma in situ; hematologic cancer (multiple); high grade glioma (multiple); and invasive lobular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL-1 oncogene; BCL1; D11S287E; G1/S-specific cyclin D1; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1169,641,156 - 69,654,474 (+)EnsemblGRCh38hg38GRCh38
GRCh381169,641,156 - 69,654,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371169,455,924 - 69,469,242 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361169,165,054 - 69,178,423 (+)NCBINCBI36hg18NCBI36
Build 341169,165,053 - 69,178,422NCBI
Celera1166,752,901 - 66,766,272 (+)NCBI
Cytogenetic Map11q13.3NCBI
HuRef1165,748,357 - 65,761,725 (+)NCBIHuRef
CHM1_11169,338,874 - 69,352,243 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (IEP)
acute myeloid leukemia  (IDA,IEP)
adenocarcinoma  (EXP)
adenoid cystic carcinoma  (EXP)
angiosarcoma  (EXP)
Animal Mammary Neoplasms  (EXP)
B-lymphoblastic leukemia/lymphoma  (ISO)
Bowen's Disease  (EXP)
Brain Neoplasms  (EXP)
Breast Neoplasms  (EXP,IAGP,IEP)
bronchiolo-alveolar adenocarcinoma  (IEP)
Burns  (ISO)
carcinoma  (EXP)
Cecal Neoplasms  (EXP)
cervix uteri carcinoma in situ  (IEP)
Chronic Hepatitis C  (IEP)
Colonic Neoplasms  (EXP)
colorectal cancer  (IAGP)
Colorectal Neoplasms  (EXP)
Disease Progression  (EXP)
ductal carcinoma in situ  (IEP)
Endometrial Neoplasms  (EXP,IEP)
Esophageal Neoplasms  (EXP)
esophagus squamous cell carcinoma  (EXP)
Experimental Liver Neoplasms  (EXP,ISO)
Experimental Neoplasms  (EXP)
Genomic Instability  (EXP)
head and neck squamous cell carcinoma  (EXP,IAGP)
hepatocellular carcinoma  (EXP,IAGP,ISO)
high grade glioma  (IAGP,IEP,ISO)
hyperparathyroidism  (EXP)
Hyperplasia  (EXP)
impotence  (ISO)
intellectual disability  (IAGP)
Intestinal Polyps  (EXP)
invasive lobular carcinoma  (IAGP,IEP)
Kidney Neoplasms  (EXP)
leukemia  (EXP)
Liver Neoplasms  (EXP)
lung adenocarcinoma  (IEP,IMP)
Lung Neoplasms  (EXP)
lung non-small cell carcinoma  (IAGP,IEP)
lung small cell carcinoma  (IAGP)
lung squamous cell carcinoma  (IEP)
malignant astrocytoma  (IEP)
Mammary Neoplasms, Experimental  (EXP,ISO)
mantle cell lymphoma  (EXP,IEP)
medulloblastoma  (ISO)
multiple myeloma  (EXP,IAGP,IEP)
Myocardial Ischemia  (EXP)
Nasopharyngeal Neoplasms  (IAGP)
Neoplasm Metastasis  (IEP)
Neoplastic Cell Transformation  (EXP)
non-Hodgkin lymphoma  (IAGP)
ovarian carcinoma  (IDA)
pancreatic adenocarcinoma  (IEP)
pancreatic cancer  (IDA,IMP,ISO)
pancreatic ductal adenocarcinoma  (IAGP,IEP)
pancreatic ductal carcinoma  (IEP)
Pancreatic Intraepithelial Neoplasia  (IEP)
pancreatic solid pseudopapillary carcinoma  (IEP)
papilloma  (EXP)
penile benign neoplasm  (IEP)
pre-malignant neoplasm  (EXP)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (EXP,ISO)
renal cell carcinoma  (IAGP,IEP)
Reperfusion Injury  (ISO)
Salivary Gland Neoplasms  (EXP)
squamous cell carcinoma  (EXP,IAGP)
status epilepticus  (ISO)
Stomach Neoplasms  (EXP)
thyroid gland papillary carcinoma  (IEP)
Thyroid Neoplasms  (EXP)
transitional cell carcinoma  (EXP,IEP)
urinary bladder cancer  (IEP)
Urologic Neoplasms  (EXP)
Uterine Cervical Neoplasms  (EXP,IAGP)
visual epilepsy  (ISO)
von Hippel-Lindau disease  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (EXP)
(-)-cotinine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20R)-protopanaxadiol  (EXP)
(20S)-ginsenoside Rh2  (EXP)
(R)-adrenaline  (EXP,ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
(Z)-ligustilide  (EXP)
1'-acetoxychavicol acetate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1,3-thiazolidine-2,4-dione  (EXP)
1,4-dithiothreitol  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-Dihydroxybenzophenone  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxy-17beta-estradiol  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-methoxy-17beta-estradiol  (EXP)
2-methoxyidazoxan  (ISO)
2-nitrofluorene  (ISO)
2-tert-butylhydroquinone  (EXP)