CEBPB (CCAAT enhancer binding protein beta) - Rat Genome Database

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Gene: CEBPB (CCAAT enhancer binding protein beta) Homo sapiens
Analyze
Symbol: CEBPB
Name: CCAAT enhancer binding protein beta
RGD ID: 736208
HGNC Page HGNC:1834
Description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Acts upstream of or within positive regulation of biomineral tissue development; positive regulation of sodium-dependent phosphate transport; and positive regulation of transcription by RNA polymerase II. Located in C/EBP complex; CHOP-C/EBP complex; and nucleoplasm. Biomarker of Alzheimer's disease; hepatocellular carcinoma; and rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: c/EBP beta; C/EBP-beta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer binding protein beta; CCAAT/enhancer-binding protein beta; CRP2; IL6DBP; interleukin 6-dependent DNA-binding protein; LAP; LIP; liver activator protein; liver-enriched inhibitory protein; liver-enriched transcriptional activator protein; MGC32080; NF-IL6; nuclear factor NF-IL6; nuclear factor of interleukin 6; TCF-5; TCF5; transcription factor 5; transcription factor C/EBP beta
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: BW184_H BW169_H BW175_H BW180_H BW172_H BW170_H BW183_H BW179_H BW186_H BW174_H BW176_H BW182_H BW185_H BW181_H BW171_H BW187_H BW173_H BW305_H BW312_H BW311_H BW306_H BW177_H BW178_H GLUCO192_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,190,583 - 50,192,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2050,190,830 - 50,192,668 (+)EnsemblGRCh38hg38GRCh38
GRCh372048,807,120 - 48,809,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,240,783 - 48,242,619 (+)NCBINCBI36Build 36hg18NCBI36
Build 342048,240,782 - 48,242,619NCBI
Celera2045,511,633 - 45,513,469 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2045,555,433 - 45,557,595 (+)NCBIHuRef
CHM1_12048,711,778 - 48,713,885 (+)NCBICHM1_1
T2T-CHM13v2.02051,960,086 - 51,962,193 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
(R)-adrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-acetamidofluorene  (ISO)
2-bromohexadecanoic acid  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
8-(4-chlorophenylthio)-cGMP  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-linolenic acid  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (EXP)
apigenin  (ISO)
aripiprazole  (EXP)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
astemizole  (ISO)
atrazine  (EXP,ISO)
Azaspiracid  (EXP)
azoxystrobin  (EXP)
baicalein  (ISO)
beauvericin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (EXP,ISO)
betulinic acid  (EXP,ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (EXP,ISO)
bucladesine  (ISO)
butylated hydroxyanisole  (ISO)
C60 fullerene  (ISO)
caffeine  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP,ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carboxy-PTIO  (EXP,ISO)
carmustine  (EXP)
ceruletide  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
choline  (EXP,ISO)
Chorionic gonadotropin  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
cortisol  (EXP)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
DDE  (EXP)
deguelin  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP,ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinous acid  (EXP)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
enniatin  (EXP)
entinostat  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
fenamidone  (ISO)
fenpyroximate  (EXP)
flavone  (ISO)
flavonoids  (ISO)
fluoranthene  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
geldanamycin  (ISO)
gemcitabine  (EXP)
gemfibrozil  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
geraniol  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycidol  (ISO)
glycyrrhizinic acid  (ISO)
GW 4064  (ISO)
herbimycin  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indirubin  (ISO)
indometacin  (EXP,ISO)
Iodine aqueous  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
isoniazide  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP,ISO)
L-serine  (EXP)
lactacystin  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
leflunomide  (EXP,ISO)
levofloxacin  (ISO)
linalool  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
MeIQx  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
Methylazoxymethanol acetate  (ISO)
methylmercury chloride  (EXP)
mifepristone  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Muraglitazar  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
naphthalenes  (ISO)
nickel dichloride  (EXP,ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitroprusside  (EXP,ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
oltipraz  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
panobinostat  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentane  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
picene  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
prostaglandin J2  (ISO)
pyrazinecarboxamide  (ISO)
pyrimidifen  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
raloxifene  (EXP)
reactive oxygen species  (EXP)
resveratrol  (ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rolipram  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
SB 203580  (EXP)
SB 431542  (EXP)
SCH 23390  (ISO)
sevoflurane  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sincalide  (ISO)
sodium arsenite  (EXP)
Soman  (ISO)
stavudine  (ISO)
streptozocin  (ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP)
tamibarotene  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP)
Tanshinone I  (ISO)
tebufenpyrad  (EXP)
telmisartan  (ISO)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
Tetramethylthiourea  (EXP)
thapsigargin  (EXP)
thifluzamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
torin 1  (EXP,ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (EXP,ISO)
undecane  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin D  (EXP)
vitamin E  (EXP)
zearalenone  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (TAS)
brown fat cell differentiation  (IEA)
cell differentiation  (IEA)
cellular response to amino acid stimulus  (IEA,ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to organic cyclic compound  (IEA,ISO)
defense response to bacterium  (IEA,ISS)
embryonic placenta development  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
granuloma formation  (ISS)
hepatocyte proliferation  (IEA,ISS)
immune response  (TAS)
inflammatory response  (TAS)
integrated stress response signaling  (IC)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,TAS)
liver development  (IEA,ISO)
liver regeneration  (IEA,ISS)
mammary gland epithelial cell differentiation  (IEA,ISO)
mammary gland epithelial cell proliferation  (IEA,ISO)
memory  (IEA,ISO)
myeloid cell development  (IC)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of T cell proliferation  (IEA,ISS)
negative regulation of transcription by RNA polymerase II  (IC,IEA,ISS)
neuron differentiation  (IEA,ISO)
ovarian follicle development  (IEA,ISS)
positive regulation of biomineral tissue development  (IDA,IMP)
positive regulation of cold-induced thermogenesis  (IEA,ISS)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (IDA,IEA,IMP)
positive regulation of fat cell differentiation  (IEA,ISS)
positive regulation of gene expression  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-4 production  (IEA,ISS)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of sodium-dependent phosphate transport  (IDA,IMP)
positive regulation of transcription by RNA polymerase II  (IC,IDA,IEA)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IDA)
regulation of cell differentiation  (IBA)
regulation of dendritic cell differentiation  (IEA)
regulation of DNA-templated transcription  (IDA,IEA)
regulation of interleukin-6 production  (IEA,ISO)
regulation of odontoblast differentiation  (IEA,ISS)
regulation of osteoclast differentiation  (IEA,ISS)
regulation of transcription by RNA polymerase II  (IBA,IC,IDA,IEA,ISS)
response to endoplasmic reticulum stress  (IDA)
response to lipopolysaccharide  (IEA)
T-helper 1 cell activation  (ISS)
transcription by RNA polymerase II  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. Cain DW, etal., J Immunol. 2013 Nov 1;191(9):4665-75. doi: 10.4049/jimmunol.1300581. Epub 2013 Sep 27.
2. Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling. Colangelo V, etal., J Neurosci Res. 2002 Nov 1;70(3):462-73.
3. Mammalian target of rapamycin regulates IL-10 and resistance to Pseudomonas aeruginosa corneal infection. Foldenauer ME, etal., J Immunol. 2013 Jun 1;190(11):5649-58. doi: 10.4049/jimmunol.1203094. Epub 2013 Apr 26.
4. Identification of a molecular signature of sarcopenia. Giresi PG, etal., Physiol Genomics. 2005 Apr 14;21(2):253-63. Epub 2005 Feb 1.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon. Gombart AF, etal., Blood 2001 May 1;97(9):2561-7.
7. IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway. Gong B, etal., Mol Immunol. 2013 Dec;56(4):619-29. doi: 10.1016/j.molimm.2013.06.016. Epub 2013 Aug 1.
8. CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. Greenbaum LE, etal., J Clin Invest 1998 Sep 1;102(5):996-1007.
9. CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis. Hayashida M, etal., Arthritis Rheum. 2009 Mar;60(3):708-16. doi: 10.1002/art.24332.
10. C/EBPbeta and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2alpha as the inducer in chondrocytes. Hirata M, etal., Hum Mol Genet. 2012 Mar 1;21(5):1111-23. doi: 10.1093/hmg/ddr540. Epub 2011 Nov 17.
11. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Jeschke MG, etal., Endocrinology. 2004 Sep;145(9):4084-93. Epub 2004 Jun 10.
12. CRE-mediated transcription is increased in Huntington's disease transgenic mice. Obrietan K and Hoyt KR, J Neurosci. 2004 Jan 28;24(4):791-6.
13. C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle. Penner G, etal., Am J Physiol Regul Integr Comp Physiol 2002 Feb;282(2):R439-44.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. C/EBP beta in rheumatoid arthritis: correlation with inflammation, not disease specificity. Pope RM, etal., Clin Immunol. 1999 Jun;91(3):271-82.
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection. Sahu SK, etal., PLoS Pathog. 2017 May 30;13(5):e1006410. doi: 10.1371/journal.ppat.1006410. eCollection 2017 May.
19. Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis. Saito H, etal., Mech Ageing Dev. 2003 Dec;124(10-12):1047-58. doi: 10.1016/j.mad.2003.08.002.
20. Age-dependent response of CCAAT/enhancer binding proteins following traumatic brain injury in mice. Sandhir R and Berman NE, Neurochem Int. 2010 Jan;56(1):188-93. doi: 10.1016/j.neuint.2009.10.002. Epub 2009 Oct 13.
21. Impairment of Hematopoietic Precursor Cell Activation during the Granulopoietic Response to Bacteremia in Mice with Chronic-Plus-Binge Alcohol Administration. Shi X, etal., Infect Immun. 2017 Oct 18;85(11). pii: IAI.00369-17. doi: 10.1128/IAI.00369-17. Print 2017 Nov.
22. C/EBPbeta Promotes Immunity to Oral Candidiasis through Regulation of beta-Defensins. Simpson-Abelson MR, etal., PLoS One. 2015 Aug 28;10(8):e0136538. doi: 10.1371/journal.pone.0136538. eCollection 2015.
23. Valproic acid attenuates skeletal muscle wasting by inhibiting C/EBPβ-regulated atrogin1 expression in cancer cachexia. Sun R, etal., Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C101-15. doi: 10.1152/ajpcell.00344.2015. Epub 2016 Apr 27.
24. The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing. Uematsu S, etal., J Immunol. 2007 Oct 15;179(8):5378-86. doi: 10.4049/jimmunol.179.8.5378.
25. Increased insulin receptor substrate-1 and enhanced skeletal muscle insulin sensitivity in mice lacking CCAAT/enhancer-binding protein beta. Wang L, etal., J Biol Chem 2000 May 12;275(19):14173-81.
26. Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBPbeta and NFkappaB cleavage. Wu SM, etal., J Pineal Res. 2016 Mar;60(2):142-54. doi: 10.1111/jpi.12295. Epub 2015 Dec 16.
27. Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming. Xiong L, etal., Nat Commun. 2019 Jan 18;10(1):335. doi: 10.1038/s41467-018-08245-z.
Additional References at PubMed
PMID:1314426   PMID:1427819   PMID:1518839   PMID:1535333   PMID:1547942   PMID:1638120   PMID:1741402   PMID:1840554   PMID:1884998   PMID:1934061   PMID:2112087   PMID:2253878  
PMID:7594592   PMID:7635140   PMID:7651415   PMID:7684005   PMID:7838705   PMID:7959007   PMID:8040336   PMID:8113688   PMID:8384717   PMID:8552662   PMID:8622667   PMID:8657121  
PMID:8662954   PMID:8855267   PMID:8972203   PMID:9032301   PMID:9139739   PMID:9169458   PMID:9343424   PMID:9495318   PMID:9506442   PMID:9545285   PMID:9553145   PMID:9570146  
PMID:9614188   PMID:9712049   PMID:9742105   PMID:9817600   PMID:9885903   PMID:10022857   PMID:10196196   PMID:10318842   PMID:10619021   PMID:10635333   PMID:10775602   PMID:10821850  
PMID:10921906   PMID:11018027   PMID:11024029   PMID:11158330   PMID:11257229   PMID:11452034   PMID:11466389   PMID:11500490   PMID:11580138   PMID:11596110   PMID:11668178   PMID:11684016  
PMID:11726507   PMID:11741938   PMID:11748221   PMID:11751971   PMID:11756662   PMID:11780052   PMID:11792321   PMID:11801594   PMID:11825899   PMID:11893744   PMID:11997389   PMID:12036869  
PMID:12071851   PMID:12095417   PMID:12151100   PMID:12161447   PMID:12167619   PMID:12177065   PMID:12202226   PMID:12202480   PMID:12213825   PMID:12242300   PMID:12367750   PMID:12393563  
PMID:12410800   PMID:12441050   PMID:12471036   PMID:12477932   PMID:12479114   PMID:12482935   PMID:12493739   PMID:12496392   PMID:12505790   PMID:12524424   PMID:12574125   PMID:12618752  
PMID:12631601   PMID:12665574   PMID:12670924   PMID:12692227   PMID:12706815   PMID:12707271   PMID:12748173   PMID:12773552   PMID:12810706   PMID:12821655   PMID:12825852   PMID:12847250  
PMID:12857754   PMID:12873812   PMID:12900520   PMID:12947119   PMID:12970736   PMID:14530280   PMID:14630807   PMID:14645007   PMID:14670999   PMID:14685163   PMID:14688407   PMID:14728809  
PMID:14729647   PMID:14759369   PMID:14976428   PMID:15044620   PMID:15082764   PMID:15102854   PMID:15308669   PMID:15381907   PMID:15385533   PMID:15489334   PMID:15498874   PMID:15561713  
PMID:15688424   PMID:15710476   PMID:15751966   PMID:15762841   PMID:15775988   PMID:15777639   PMID:15777798   PMID:15778453   PMID:15785238   PMID:15870285   PMID:15878863   PMID:15879117  
PMID:16009338   PMID:16026328   PMID:16054042   PMID:16227626   PMID:16303757   PMID:16307770   PMID:16318580   PMID:16399783   PMID:16418324   PMID:16453302   PMID:16458921   PMID:16465418  
PMID:16511829   PMID:16563127   PMID:16608438   PMID:16651265   PMID:16709933   PMID:16785565   PMID:16820889   PMID:16959612   PMID:17031851   PMID:17111047   PMID:17203171   PMID:17251582  
PMID:17257825   PMID:17301242   PMID:17303761   PMID:17335903   PMID:17351148   PMID:17387179   PMID:17504763   PMID:17513780   PMID:17540774   PMID:17570496   PMID:17583490   PMID:17596295  
PMID:17616429   PMID:17620318   PMID:17652082   PMID:17675296   PMID:17705277   PMID:17724128   PMID:17785586   PMID:17921324   PMID:17928076   PMID:17989362   PMID:18025168   PMID:18182446  
PMID:18198130   PMID:18203738   PMID:18294142   PMID:18310298   PMID:18339625   PMID:18512730   PMID:18628207   PMID:18647749   PMID:18660489   PMID:18682709   PMID:18703796   PMID:18786141  
PMID:18809921   PMID:18820298   PMID:18852215   PMID:19014341   PMID:19029947   PMID:19043455   PMID:19064995   PMID:19088256   PMID:19109189   PMID:19116245   PMID:19126543   PMID:19133313  
PMID:19169276   PMID:19222842   PMID:19274049   PMID:19322201   PMID:19324970   PMID:19335620   PMID:19453261   PMID:19487031   PMID:19489038   PMID:19523687   PMID:19592659   PMID:19632992  
PMID:19641492   PMID:19652226   PMID:19690170   PMID:19717648   PMID:19723873   PMID:19733238   PMID:19734226   PMID:19747512   PMID:19806478   PMID:19811452   PMID:19903813   PMID:19962993  
PMID:20004457   PMID:20015877   PMID:20032975   PMID:20099975   PMID:20102225   PMID:20110283   PMID:20111005   PMID:20145198   PMID:20209087   PMID:20224108   PMID:20225273   PMID:20336759  
PMID:20351173   PMID:20385540   PMID:20452968   PMID:20460359   PMID:20562859   PMID:20583135   PMID:20605485   PMID:20638476   PMID:20690902   PMID:20699097   PMID:20702408   PMID:20726009  
PMID:20797423   PMID:20818427   PMID:20829347   PMID:20948428   PMID:20970301   PMID:21048943   PMID:21098707   PMID:21145827   PMID:21150337   PMID:21183071   PMID:21280222   PMID:21283634  
PMID:21302301   PMID:21303932   PMID:21308746   PMID:21326902   PMID:21343335   PMID:21344389   PMID:21345218   PMID:21389327   PMID:21447826   PMID:21471847   PMID:21545825   PMID:21558273  
PMID:21595849   PMID:21612443   PMID:21612582   PMID:21638299   PMID:21689417   PMID:21804532   PMID:21852335   PMID:21854628   PMID:21873635   PMID:21883217   PMID:21899882   PMID:21917825  
PMID:21980398   PMID:21988375   PMID:21998664   PMID:22013073   PMID:22080951   PMID:22152057   PMID:22242598   PMID:22260630   PMID:22374303   PMID:22379085   PMID:22422068   PMID:22538425  
PMID:22689263   PMID:22728165   PMID:22763786   PMID:22818222   PMID:22860016   PMID:22911498   PMID:22921787   PMID:22955269   PMID:23097472   PMID:23128233   PMID:23314288   PMID:23560079  
PMID:23711709   PMID:23741337   PMID:23770848   PMID:23782703   PMID:23915234   PMID:23955082   PMID:23955085   PMID:23966000   PMID:24043631   PMID:24086495   PMID:24086653   PMID:24128855  
PMID:24191285   PMID:24222641   PMID:24248464   PMID:24265756   PMID:24284203   PMID:24379003   PMID:24466171   PMID:24472318   PMID:24551078   PMID:24589738   PMID:24635384   PMID:24789216  
PMID:24912680   PMID:24994936   PMID:25177685   PMID:25184681   PMID:25192658   PMID:25229239   PMID:25335188   PMID:25382637   PMID:25391587   PMID:25403356   PMID:25451943   PMID:25453760  
PMID:25609649   PMID:25613138   PMID:25699273   PMID:25720442   PMID:25738360   PMID:25740226   PMID:25766403   PMID:25767874   PMID:25772238   PMID:25784653   PMID:25811130   PMID:25940801  
PMID:25959126   PMID:25965830   PMID:26111340   PMID:26166436   PMID:26505752   PMID:26511475   PMID:26522356   PMID:26709824   PMID:26762974   PMID:26797706   PMID:26868909   PMID:26896926  
PMID:26968249   PMID:27011164   PMID:27067260   PMID:27339399   PMID:27433286   PMID:27495086   PMID:27522676   PMID:27572958   PMID:27590344   PMID:27609421   PMID:27659348   PMID:27663075  
PMID:27665842   PMID:27812542   PMID:27833915   PMID:28092463   PMID:28148901   PMID:28192407   PMID:28321907   PMID:28328949   PMID:28374767   PMID:28428115   PMID:28473536   PMID:28482072  
PMID:28566324   PMID:28581487   PMID:28754668   PMID:28760550   PMID:28942243   PMID:28977591   PMID:29098625   PMID:29111326   PMID:29117863   PMID:29169725   PMID:29172775   PMID:29209111  
PMID:29322786   PMID:29458145   PMID:29712898   PMID:29844126   PMID:30254053   PMID:30335837   PMID:30355436   PMID:30355733   PMID:30376994   PMID:30536410   PMID:30566668   PMID:30664211  
PMID:30754676   PMID:30804502   PMID:30894209   PMID:30945396   PMID:31042624   PMID:31356989   PMID:31364785   PMID:31379854   PMID:31415393   PMID:31471107   PMID:31527615   PMID:31614865  
PMID:31615122   PMID:31676720   PMID:31767145   PMID:31822355   PMID:32189359   PMID:32276639   PMID:32344865   PMID:32416067   PMID:32460775   PMID:32467529   PMID:32513696   PMID:32526700  
PMID:32632701   PMID:32652877   PMID:32795415   PMID:32971400   PMID:32989298   PMID:33147208   PMID:33232782   PMID:33582555   PMID:33660927   PMID:33663392   PMID:33757572   PMID:33892791  
PMID:33928605   PMID:33961781   PMID:33966038   PMID:34001062   PMID:34158346   PMID:34233190   PMID:34341514   PMID:34478711   PMID:34605942   PMID:34653294   PMID:35013218   PMID:35013251  
PMID:35077804   PMID:35137113   PMID:35196497   PMID:35198878   PMID:35199941   PMID:35365168   PMID:35831314  


Genomics

Comparative Map Data
CEBPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382050,190,583 - 50,192,690 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2050,190,830 - 50,192,668 (+)EnsemblGRCh38hg38GRCh38
GRCh372048,807,120 - 48,809,227 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362048,240,783 - 48,242,619 (+)NCBINCBI36Build 36hg18NCBI36
Build 342048,240,782 - 48,242,619NCBI
Celera2045,511,633 - 45,513,469 (+)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2045,555,433 - 45,557,595 (+)NCBIHuRef
CHM1_12048,711,778 - 48,713,885 (+)NCBICHM1_1
T2T-CHM13v2.02051,960,086 - 51,962,193 (+)NCBIT2T-CHM13v2.0
Cebpb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,530,835 - 167,532,352 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,530,835 - 167,532,338 (+)EnsemblGRCm39 Ensembl
GRCm382167,688,915 - 167,690,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,688,915 - 167,690,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv372167,514,415 - 167,515,918 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362167,380,120 - 167,381,623 (+)NCBIMGSCv36mm8
MGSCv362168,673,393 - 168,674,898 (+)NCBIMGSCv36mm8
Celera2173,629,112 - 173,630,498 (+)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.58NCBI
Cebpb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23156,398,035 - 156,399,466 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3156,397,052 - 156,399,473 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3160,193,187 - 160,194,618 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03168,692,267 - 168,693,698 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03166,433,973 - 166,435,404 (+)NCBIRnor_WKY
Rnor_6.03164,424,502 - 164,425,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3164,424,515 - 164,425,910 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03170,577,328 - 170,579,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,826,021 - 158,827,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,732,056 - 158,733,825 (+)NCBI
Celera3154,977,150 - 154,977,588 (+)NCBICelera
Cytogenetic Map3q42NCBI
Cebpb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554458,060,432 - 8,061,289 (-)NCBIChiLan1.0ChiLan1.0
CEBPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v02046,533,163 - 46,535,282 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CEBPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,661,294 - 36,663,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,661,616 - 36,662,656 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,905,196 - 35,907,045 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02437,368,136 - 37,369,976 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2437,368,234 - 37,369,274 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,608,936 - 36,610,792 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,742,145 - 36,743,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02437,285,911 - 37,287,750 (+)NCBIUU_Cfam_GSD_1.0
CEBPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,722,426 - 51,724,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,722,633 - 51,723,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21758,041,640 - 58,042,680 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CEBPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1213,780,538 - 13,782,639 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl213,781,160 - 13,782,194 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,211,871 - 62,213,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cebpb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,368,349 - 5,369,377 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,367,808 - 5,369,686 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CEBPB
1 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR421hsa-miR-421Tarbaseexternal_infoSequencingPOSITIVE
MIR34Ahsa-miR-34a-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayNon-Functional MTI20598588
MIR34Ahsa-miR-34a-5pTarbaseexternal_infoReporter GeneNEGATIVE
MIR155hsa-miR-155-5pOncomiRDBexternal_infoNANA19711427
MIR155hsa-miR-155-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18299402
MIR155hsa-miR-155-5pMirtarbaseexternal_infoMicroarray//qRT-PCR//Western blotFunctional MTI19193853
MIR155hsa-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19596814
MIR155hsa-miR-155-5pMirtarbaseexternal_infoELISA//Immunoblot//Immunocytochemistry//ImmunofluoFunctional MTI19887047

Predicted Target Of
Summary Value
Count of predictions:536
Count of miRNA genes:296
Interacting mature miRNAs:318
Transcripts:ENST00000303004
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D20S728  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372048,808,846 - 48,809,049UniSTSGRCh37
Build 362048,242,253 - 48,242,456RGDNCBI36
Celera2045,513,103 - 45,513,306RGD
Cytogenetic Map20q13.1UniSTS
HuRef2045,557,214 - 45,557,417UniSTS
RH17476  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372048,809,028 - 48,809,172UniSTSGRCh37
Build 362048,242,435 - 48,242,579RGDNCBI36
Celera2045,513,285 - 45,513,429RGD
Cytogenetic Map20q13.1UniSTS
HuRef2045,557,396 - 45,557,540UniSTS
GeneMap99-GB4 RH Map20304.82UniSTS
NCBI RH Map20516.4UniSTS
STS-H26183  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map20q13.1UniSTS
GeneMap99-GB4 RH Map20301.01UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 38 38 2 13 1
Medium 2427 2892 1719 622 1486 464 4354 2149 3033 369 1385 1601 170 1204 2787 4
Low 7 60 4 1 425 1 2 43 685 50 57 9 4 1 1 1 1
Below cutoff 3 1 2 1 1 1 10 5 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF289608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF350408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL161937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW025406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY193834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU753628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D63161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB457615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ161481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M98056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000303004   ⟹   ENSP00000305422
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2050,190,830 - 50,192,668 (+)Ensembl
RefSeq Acc Id: NM_001285878   ⟹   NP_001272807
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382050,190,583 - 50,192,690 (+)NCBI
HuRef2045,555,433 - 45,557,595 (+)NCBI
CHM1_12048,711,778 - 48,713,885 (+)NCBI
T2T-CHM13v2.02051,960,086 - 51,962,193 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001285879   ⟹   NP_001272808
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382050,190,583 - 50,192,690 (+)NCBI
HuRef2045,555,433 - 45,557,595 (+)NCBI
CHM1_12048,711,778 - 48,713,885 (+)NCBI
T2T-CHM13v2.02051,960,086 - 51,962,193 (+)NCBI
Sequence:
RefSeq Acc Id: NM_005194   ⟹   NP_005185
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382050,190,830 - 50,192,668 (+)NCBI
GRCh372048,807,120 - 48,809,227 (+)NCBI
Build 362048,240,783 - 48,242,619 (+)NCBI Archive
HuRef2045,555,433 - 45,557,595 (+)NCBI
CHM1_12048,711,778 - 48,713,885 (+)NCBI
T2T-CHM13v2.02051,960,333 - 51,962,171 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001272807 (Get FASTA)   NCBI Sequence Viewer  
  NP_001272808 (Get FASTA)   NCBI Sequence Viewer  
  NP_005185 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH05132 (Get FASTA)   NCBI Sequence Viewer  
  AAH07538 (Get FASTA)   NCBI Sequence Viewer  
  AAH21931 (Get FASTA)   NCBI Sequence Viewer  
  AAL55792 (Get FASTA)   NCBI Sequence Viewer  
  AAN86350 (Get FASTA)   NCBI Sequence Viewer  
  AHM26727 (Get FASTA)   NCBI Sequence Viewer  
  AHM26728 (Get FASTA)   NCBI Sequence Viewer  
  AHM26729 (Get FASTA)   NCBI Sequence Viewer  
  AHM26730 (Get FASTA)   NCBI Sequence Viewer  
  AHM26731 (Get FASTA)   NCBI Sequence Viewer  
  AHM26732 (Get FASTA)   NCBI Sequence Viewer  
  AHM26733 (Get FASTA)   NCBI Sequence Viewer  
  AHM26734 (Get FASTA)   NCBI Sequence Viewer  
  AHM26735 (Get FASTA)   NCBI Sequence Viewer  
  AHM26736 (Get FASTA)   NCBI Sequence Viewer  
  AHM26737 (Get FASTA)   NCBI Sequence Viewer  
  AHM26738 (Get FASTA)   NCBI Sequence Viewer  
  AHM26739 (Get FASTA)   NCBI Sequence Viewer  
  AHM26740 (Get FASTA)   NCBI Sequence Viewer  
  AHM26741 (Get FASTA)   NCBI Sequence Viewer  
  AHM26742 (Get FASTA)   NCBI Sequence Viewer  
  AHM26743 (Get FASTA)   NCBI Sequence Viewer  
  AHM26744 (Get FASTA)   NCBI Sequence Viewer  
  AHM26745 (Get FASTA)   NCBI Sequence Viewer  
  AHM26746 (Get FASTA)   NCBI Sequence Viewer  
  AHM26747 (Get FASTA)   NCBI Sequence Viewer  
  AHM26748 (Get FASTA)   NCBI Sequence Viewer  
  AHM26749 (Get FASTA)   NCBI Sequence Viewer  
  AHM26750 (Get FASTA)   NCBI Sequence Viewer  
  AHM26751 (Get FASTA)   NCBI Sequence Viewer  
  AHM26752 (Get FASTA)   NCBI Sequence Viewer  
  AHM26753 (Get FASTA)   NCBI Sequence Viewer  
  AHM26754 (Get FASTA)   NCBI Sequence Viewer  
  AHM26755 (Get FASTA)   NCBI Sequence Viewer  
  AHM26756 (Get FASTA)   NCBI Sequence Viewer  
  AHM26757 (Get FASTA)   NCBI Sequence Viewer  
  AHM26758 (Get FASTA)   NCBI Sequence Viewer  
  BAA09637 (Get FASTA)   NCBI Sequence Viewer  
  BAF84225 (Get FASTA)   NCBI Sequence Viewer  
  CAA36794 (Get FASTA)   NCBI Sequence Viewer  
  EAW75629 (Get FASTA)   NCBI Sequence Viewer  
  P17676 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_005185   ⟸   NM_005194
- Peptide Label: isoform a
- UniProtKB: Q9H4Z5 (UniProtKB/Swiss-Prot),   P17676 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001272807   ⟸   NM_001285878
- Peptide Label: isoform b
- UniProtKB: P17676 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001272808   ⟸   NM_001285879
- Peptide Label: isoform c
- UniProtKB: P17676 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000305422   ⟸   ENST00000303004
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17676-F1-model_v2 AlphaFold P17676 1-345 view protein structure

Promoters
RGD ID:6798593
Promoter ID:HG_KWN:39800
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000079672,   UC002XVH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362048,240,041 - 48,242,352 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 20q13.13-13.2(chr20:49731076-51202566)x1 copy number loss See cases [RCV000052767] Chr20:49731076..51202566 [GRCh38]
Chr20:48347613..49819103 [GRCh37]
Chr20:47781020..49252510 [NCBI36]
Chr20:20q13.13-13.2
pathogenic
GRCh38/hg38 20q13.13-13.2(chr20:49947237-55875406)x3 copy number gain See cases [RCV000053037] Chr20:49947237..55875406 [GRCh38]
Chr20:48563774..54450462 [GRCh37]
Chr20:47997181..53883869 [NCBI36]
Chr20:20q13.13-13.2
pathogenic
GRCh38/hg38 20q13.12-13.33(chr20:44787704-64277321)x3 copy number gain See cases [RCV000053035] Chr20:44787704..64277321 [GRCh38]
Chr20:43416345..62908674 [GRCh37]
Chr20:42849759..62379118 [NCBI36]
Chr20:20q13.12-13.33
pathogenic
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20q13.13-13.2(chr20:49989123-51495645)x1 copy number loss See cases [RCV000137268] Chr20:49989123..51495645 [GRCh38]
Chr20:48605660..50112183 [GRCh37]
Chr20:48039067..49545590 [NCBI36]
Chr20:20q13.13-13.2
likely pathogenic
GRCh37/hg19 20q13.13-13.2(chr20:47682662-49884981)x1 copy number loss See cases [RCV000167570] Chr20:47682662..49884981 [GRCh37]
Chr20:20q13.13-13.2
likely pathogenic
GRCh37/hg19 20q13.13-13.2(chr20:47627844-52045480)x1 copy number loss See cases [RCV000511555] Chr20:47627844..52045480 [GRCh37]
Chr20:20q13.13-13.2
pathogenic
GRCh37/hg19 20q13.13-13.2(chr20:47726521-50427649)x1 copy number loss See cases [RCV000511416] Chr20:47726521..50427649 [GRCh37]
Chr20:20q13.13-13.2
likely pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
Single allele duplication not provided [RCV000677941] Chr20:46962638..50647699 [GRCh37]
Chr20:20q13.13-13.2
uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
NM_005194.4(CEBPB):c.45G>A (p.Pro15=) single nucleotide variant not provided [RCV000921331] Chr20:50191078 [GRCh38]
Chr20:48807615 [GRCh37]
Chr20:20q13.13
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1834 AgrOrtholog
COSMIC CEBPB COSMIC
Ensembl Genes ENSG00000172216 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000305422 ENTREZGENE
  ENSP00000305422.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000303004 ENTREZGENE
  ENST00000303004.5 UniProtKB/Swiss-Prot
GTEx ENSG00000172216 GTEx
HGNC ID HGNC:1834 ENTREZGENE
Human Proteome Map CEBPB Human Proteome Map
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C/EBP_chordates UniProtKB/Swiss-Prot
KEGG Report hsa:1051 UniProtKB/Swiss-Prot
NCBI Gene 1051 ENTREZGENE
OMIM 189965 OMIM
Pfam bZIP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26377 PharmGKB
PIRSF CCAAT/enhancer-binding UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CEBPB_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q9BSC0_HUMAN UniProtKB/TrEMBL
  Q9H4Z5 ENTREZGENE
  W8SNU6_HUMAN UniProtKB/TrEMBL
  W8SNV5_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8K671 UniProtKB/Swiss-Prot
  Q96IH2 UniProtKB/Swiss-Prot
  Q9H4Z5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-02-27 CEBPB  CCAAT enhancer binding protein beta    CCAAT/enhancer binding protein beta  Symbol and/or name change 5135510 APPROVED
2016-01-12 CEBPB  CCAAT/enhancer binding protein beta    CCAAT/enhancer binding protein (C/EBP), beta  Symbol and/or name change 5135510 APPROVED
2011-08-16 CEBPB  CCAAT/enhancer binding protein (C/EBP), beta  CEBPB  CCAAT/enhancer binding protein (C/EBP), beta  Symbol and/or name change 5135510 APPROVED