FOSL1 (FOS like 1, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: FOSL1 (FOS like 1, AP-1 transcription factor subunit) Homo sapiens
Analyze
Symbol: FOSL1
Name: FOS like 1, AP-1 transcription factor subunit
RGD ID: 732196
HGNC Page HGNC
Description: Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription, initiation and positive regulation of pri-miRNA transcription by RNA polymerase II. Localizes to nucleoplasm. Biomarker of cervical squamous cell carcinoma and ductal carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FOS like 1, AP-1 trancription factor subunit; FOS like antigen 1; FOS-like antigen 1; FOS-like antigen-1; fos-related antigen 1; FRA; fra-1; FRA1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: FOSL1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1165,892,049 - 65,900,573 (-)EnsemblGRCh38hg38GRCh38
GRCh381165,892,049 - 65,900,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371165,659,520 - 65,668,016 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,416,268 - 65,424,573 (-)NCBINCBI36hg18NCBI36
Build 341165,416,267 - 65,424,573NCBI
Celera1162,983,599 - 62,991,910 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,986,283 - 61,994,593 (-)NCBIHuRef
CHM1_11165,544,021 - 65,552,418 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4-diaminotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-nitrotoluene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracene-1,8,9-triol  (ISO)
antimony(0)  (EXP)
antirheumatic drug  (EXP)
arachidonic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
asbestos  (ISO)
atazanavir sulfate  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzoic acid  (ISO)
beta-carotene  (ISO)
beta-naphthoflavone  (ISO)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
bromochloroacetic acid  (ISO)
butan-1-ol  (EXP)
butylated hydroxyanisole  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
capsaicin  (ISO)
carbofuran  (ISO)
carbon nanotube  (ISO)
catechol  (ISO)
chenodeoxycholic acid  (EXP)
chloroacetaldehyde  (EXP)
chlorpromazine  (EXP,ISO)
cholic acid  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (EXP)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
clozapine  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
D-glucose  (EXP,ISO)
DDT  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichromium trioxide  (EXP)
dicrotophos  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (EXP)
erythrosin B  (ISO)
ethanol  (EXP)
etoposide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
genistein  (ISO)
geraniol  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
graphite  (ISO)
haloperidol  (ISO)
hemin  (EXP)
hydroquinone  (EXP)
ifosfamide  (EXP)
indometacin  (EXP)
iron dichloride  (ISO)
iron trichloride  (ISO)
iron(III) nitrilotriacetate  (ISO)
isobutanol  (EXP)
isoprenaline  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP)
manganese(II) chloride  (ISO)
mechlorethamine  (EXP,ISO)
mercury atom  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
metacetamol  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
Mezerein  (ISO)
miconazole  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (EXP)
naphthalenes  (ISO)
nefazodone  (EXP)
neurotensin  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
niclosamide  (EXP)
nimustine  (EXP)
Nodularin  (EXP)
O-methyleugenol  (EXP)
okadaic acid  (EXP,ISO)
olanzapine  (ISO)
organoselenium compound  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
palytoxin  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (EXP)
perylene  (ISO)
phenacetin  (ISO)
phenol  (EXP)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picrotoxin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
rimonabant  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saccharin  (ISO)
SB 203580  (ISO)
SB 431542  (EXP)
serpentine asbestos  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
SKF 38393  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (ISO)
styrene oxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
tetradecane  (ISO)
tin(II) chloride (anhydrous)  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triacsin C  (EXP)
troglitazone  (ISO)
undecane  (ISO)
urethane  (EXP)
valsartan  (EXP)
vincaleukoblastine  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:2107490   PMID:8125298   PMID:8230424   PMID:8276409   PMID:8889549   PMID:8938448   PMID:9016559   PMID:9160889   PMID:9267807   PMID:9458721   PMID:9858769   PMID:10918580  
PMID:11431474   PMID:11708771   PMID:11912197   PMID:12209953   PMID:12371906   PMID:12424143   PMID:12477932   PMID:12692267   PMID:13679379   PMID:15025563   PMID:15342556   PMID:15489334  
PMID:15608675   PMID:15615716   PMID:15806162   PMID:15831677   PMID:16189514   PMID:16341674   PMID:16490785   PMID:16712791   PMID:17192200   PMID:17371847   PMID:17572495   PMID:17616677  
PMID:17872495   PMID:17882273   PMID:18096084   PMID:18098284   PMID:18172271   PMID:18288638   PMID:18435914   PMID:19060904   PMID:19160107   PMID:19274049   PMID:19384981   PMID:19453261  
PMID:19874574   PMID:19913121   PMID:19923172   PMID:20198886   PMID:20211142   PMID:20353950   PMID:20511396   PMID:20663135   PMID:21088499   PMID:21150319   PMID:21371080   PMID:21460858  
PMID:21516116   PMID:21526963   PMID:21558934   PMID:21640141   PMID:21673316   PMID:21708480   PMID:21822309   PMID:21840727   PMID:21873635   PMID:21874050   PMID:21937452   PMID:21969367  
PMID:21988832   PMID:22028113   PMID:22198213   PMID:22235402   PMID:22286759   PMID:22411068   PMID:22461694   PMID:22514348   PMID:22911824   PMID:23001043   PMID:23027619   PMID:23128233  
PMID:23275563   PMID:23301044   PMID:23483055   PMID:23625206   PMID:23661758   PMID:24029232   PMID:24084233   PMID:24604526   PMID:24652774   PMID:24658684   PMID:24927181   PMID:24952347  
PMID:25175497   PMID:25301070   PMID:25416956   PMID:25651840   PMID:25666264   PMID:25750173   PMID:26258633   PMID:26330014   PMID:26337460   PMID:26549498   PMID:26646695   PMID:26975631  
PMID:27002720   PMID:27134167   PMID:27144339   PMID:27220889   PMID:27685628   PMID:27816489   PMID:27882471   PMID:28049150   PMID:28169308   PMID:28192407   PMID:28220783   PMID:28232512  
PMID:28386843   PMID:28473536   PMID:28481878   PMID:28653890   PMID:28790303   PMID:29112457   PMID:29257201   PMID:29305863   PMID:29382358   PMID:29384218   PMID:29807388   PMID:29914371  
PMID:29993138   PMID:30318470   PMID:30471098   PMID:30563891   PMID:30575900   PMID:30782279   PMID:30804502   PMID:30807813   PMID:30935763   PMID:30990796   PMID:31015574   PMID:31248836  
PMID:31612408   PMID:31672492   PMID:31722399   PMID:31937587   PMID:32124141   PMID:32271412   PMID:32296183   PMID:32305558   PMID:32385348   PMID:32416067   PMID:32661324   PMID:32753701  
PMID:32814053   PMID:33533919  


Genomics

Candidate Gene Status
FOSL1 is a candidate Gene for QTL BMD9_H
Comparative Map Data
FOSL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1165,892,049 - 65,900,573 (-)EnsemblGRCh38hg38GRCh38
GRCh381165,892,049 - 65,900,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371165,659,520 - 65,668,016 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,416,268 - 65,424,573 (-)NCBINCBI36hg18NCBI36
Build 341165,416,267 - 65,424,573NCBI
Celera1162,983,599 - 62,991,910 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,986,283 - 61,994,593 (-)NCBIHuRef
CHM1_11165,544,021 - 65,552,418 (-)NCBICHM1_1
Fosl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,497,726 - 5,505,966 (+)NCBIGRCm39mm39
GRCm39 Ensembl195,497,575 - 5,505,974 (+)Ensembl
GRCm38195,447,698 - 5,455,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,447,547 - 5,455,946 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,447,698 - 5,455,938 (+)NCBIGRCm37mm9NCBIm37
MGSCv36195,447,698 - 5,455,938 (+)NCBImm8
Celera195,319,672 - 5,327,911 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.33NCBI
Fosl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,754,549 - 202,763,057 (+)NCBI
Rnor_6.0 Ensembl1220,826,560 - 220,835,066 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01220,826,560 - 220,835,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01227,755,887 - 227,764,393 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,090,612 - 208,099,118 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11208,244,064 - 208,252,571 (+)NCBI
Celera1200,290,637 - 200,299,144 (+)NCBICelera
Cytogenetic Map1q43NCBI
Fosl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,423,591 - 19,433,885 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,425,741 - 19,431,801 (+)NCBIChiLan1.0ChiLan1.0
FOSL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11164,581,841 - 64,589,300 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,581,841 - 64,589,304 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01161,252,513 - 61,261,032 (-)NCBIMhudiblu_PPA_v0panPan3
FOSL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,366,719 - 51,374,411 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,368,352 - 51,373,748 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,975,212 - 49,982,921 (+)NCBI
ROS_Cfam_1.01852,404,801 - 52,412,502 (+)NCBI
UMICH_Zoey_3.11851,504,866 - 51,512,571 (+)NCBI
UNSW_CanFamBas_1.01851,079,242 - 51,086,930 (+)NCBI
UU_Cfam_GSD_1.01851,868,548 - 51,876,244 (+)NCBI
Fosl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,199,963 - 7,206,564 (+)NCBI
SpeTri2.0NW_0049365993,642,504 - 3,649,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOSL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,430,153 - 6,436,173 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,430,158 - 6,436,173 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,534,085 - 5,540,201 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOSL1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,356,263 - 8,365,606 (+)NCBI
ChlSab1.1 Ensembl18,356,836 - 8,364,918 (+)Ensembl
Fosl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476720,519,054 - 20,525,311 (+)NCBI

Position Markers
RH80069  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,659,703 - 65,660,041UniSTSGRCh37
GRCh374129,077,675 - 129,078,010UniSTSGRCh37
Build 364129,297,125 - 129,297,460RGDNCBI36
Celera1162,983,610 - 62,983,948UniSTS
Celera4126,458,811 - 126,459,146RGD
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map11q13UniSTS
HuRef1161,986,294 - 61,986,632UniSTS
HuRef4124,809,194 - 124,809,529UniSTS
RH103273  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,659,828 - 65,659,995UniSTSGRCh37
Build 361165,416,404 - 65,416,571RGDNCBI36
Celera1162,983,735 - 62,983,902RGD
Cytogenetic Map11q13UniSTS
HuRef1161,986,419 - 61,986,586UniSTS
GeneMap99-GB4 RH Map11242.84UniSTS
D11S4907  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,669,783 - 65,669,895UniSTSGRCh37
Build 361165,426,359 - 65,426,471RGDNCBI36
Celera1162,993,696 - 62,993,810RGD
Cytogenetic Map11q13UniSTS
HuRef1161,996,379 - 61,996,493UniSTS
FOSL1_8776  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,659,610 - 65,660,435UniSTSGRCh37
Build 361165,416,186 - 65,417,011RGDNCBI36
Celera1162,983,517 - 62,984,342RGD
HuRef1161,986,201 - 61,987,026UniSTS
FOSL1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,660,253 - 65,660,346UniSTSGRCh37
Build 361165,416,829 - 65,416,922RGDNCBI36
Celera1162,984,160 - 62,984,253RGD
Cytogenetic Map11q13UniSTS
HuRef1161,986,844 - 61,986,937UniSTS
GeneMap99-GB4 RH Map11240.12UniSTS
NCBI RH Map11573.2UniSTS
G33132  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,661,857 - 65,661,941UniSTSGRCh37
Build 361165,418,433 - 65,418,517RGDNCBI36
Celera1162,985,765 - 62,985,849RGD
Cytogenetic Map11q13UniSTS
HuRef1161,988,448 - 61,988,532UniSTS
STS-H96643  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,659,890 - 65,660,059UniSTSGRCh37
GRCh374129,077,657 - 129,077,823UniSTSGRCh37
Build 364129,297,107 - 129,297,273RGDNCBI36
Celera4126,458,793 - 126,458,959RGD
Celera1162,983,797 - 62,983,966UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map4q28.2UniSTS
HuRef1161,986,481 - 61,986,650UniSTS
HuRef4124,809,176 - 124,809,342UniSTS
GeneMap99-GB4 RH Map11236.6UniSTS
NCBI RH Map11573.2UniSTS
STS-X16707  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371165,660,414 - 65,660,552UniSTSGRCh37
GRCh374129,077,164 - 129,077,302UniSTSGRCh37
Build 364129,296,614 - 129,296,752RGDNCBI36
Celera4126,458,300 - 126,458,438RGD
Celera1162,984,321 - 62,984,459UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map4q28.2UniSTS
HuRef1161,987,005 - 61,987,143UniSTS
HuRef4124,808,683 - 124,808,821UniSTS
GeneMap99-GB4 RH Map11242.84UniSTS
NCBI RH Map11573.2UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR34Chsa-miR-34c-5pOncomiRDBexternal_infoNANA23001043
MIR34Ahsa-miR-34a-5pMirtarbaseexternal_infoImmunoprecipitaion//Luciferase reporter assay//qRTFunctional MTI22198213
MIR34Ahsa-miR-34a-5pOncomiRDBexternal_infoNANA23001043
MIR34Ahsa-miR-34a-5pOncomiRDBexternal_infoNANA22198213
MIR138-2hsa-miR-138-5pOncomiRDBexternal_infoNANA21969367
MIR138-1hsa-miR-138-5pOncomiRDBexternal_infoNANA21969367

Predicted Target Of
Summary Value
Count of predictions:1847
Count of miRNA genes:636
Interacting mature miRNAs:692
Transcripts:ENST00000312562, ENST00000448083, ENST00000531493, ENST00000532401, ENST00000534222
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 6 3 1 1 5 2 8 1 7 15
Medium 588 739 340 69 305 42 1193 255 280 114 307 707 40 596 438
Low 1737 1999 1192 366 1445 253 3030 1656 2226 248 1066 857 117 607 2225 4
Below cutoff 102 244 183 179 190 162 126 278 1208 56 72 32 18 1 1 125 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001300844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001300855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001300856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001300857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_125339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA120824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ297411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ297412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ297413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP006287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM764259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM846271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP222547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ937004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB123614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D14493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KU178408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S68214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X16707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000312562   ⟹   ENSP00000310170
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,892,049 - 65,900,388 (-)Ensembl
RefSeq Acc Id: ENST00000448083   ⟹   ENSP00000393302
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,892,049 - 65,900,419 (-)Ensembl
RefSeq Acc Id: ENST00000531493   ⟹   ENSP00000436276
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,892,474 - 65,900,419 (-)Ensembl
RefSeq Acc Id: ENST00000532401   ⟹   ENSP00000431594
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,892,645 - 65,900,419 (-)Ensembl
RefSeq Acc Id: ENST00000534222   ⟹   ENSP00000434350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1165,893,004 - 65,900,573 (-)Ensembl
RefSeq Acc Id: NM_001300844   ⟹   NP_001287773
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,892,049 - 65,900,388 (-)NCBI
CHM1_11165,544,021 - 65,552,418 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001300855   ⟹   NP_001287784
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,892,049 - 65,900,388 (-)NCBI
CHM1_11165,544,021 - 65,552,418 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001300856   ⟹   NP_001287785
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,892,049 - 65,900,388 (-)NCBI
CHM1_11165,544,021 - 65,552,418 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001300857   ⟹   NP_001287786
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,892,049 - 65,900,388 (-)NCBI
CHM1_11165,544,021 - 65,552,418 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005438   ⟹   NP_005429
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,892,049 - 65,900,388 (-)NCBI
GRCh371165,659,616 - 65,667,997 (-)NCBI
Build 361165,416,268 - 65,424,573 (-)NCBI Archive
HuRef1161,986,283 - 61,994,593 (-)ENTREZGENE
CHM1_11165,544,021 - 65,552,418 (-)NCBI
Sequence:
RefSeq Acc Id: NR_125339
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,892,049 - 65,900,545 (-)NCBI
CHM1_11165,544,021 - 65,552,418 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005429   ⟸   NM_005438
- Peptide Label: isoform 1
- UniProtKB: P15407 (UniProtKB/Swiss-Prot),   A0A0S2Z595 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001287786   ⟸   NM_001300857
- Peptide Label: isoform 5
- UniProtKB: P15407 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001287785   ⟸   NM_001300856
- Peptide Label: isoform 4
- UniProtKB: P15407 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001287773   ⟸   NM_001300844
- Peptide Label: isoform 2
- UniProtKB: P15407 (UniProtKB/Swiss-Prot),   E9PPX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001287784   ⟸   NM_001300855
- Peptide Label: isoform 3
- UniProtKB: P15407 (UniProtKB/Swiss-Prot),   E9PKL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000436276   ⟸   ENST00000531493
RefSeq Acc Id: ENSP00000431594   ⟸   ENST00000532401
RefSeq Acc Id: ENSP00000434350   ⟸   ENST00000534222
RefSeq Acc Id: ENSP00000310170   ⟸   ENST00000312562
RefSeq Acc Id: ENSP00000393302   ⟸   ENST00000448083
Protein Domains
bZIP

Promoters
RGD ID:6810008
Promoter ID:HG_ACW:12691
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Lymphoblastoid
Transcripts:FOSL1.EAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,415,134 - 65,415,634 (-)MPROMDB
RGD ID:6810007
Promoter ID:HG_ACW:12692
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:FOSL1.HAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,420,926 - 65,421,426 (-)MPROMDB
RGD ID:6788945
Promoter ID:HG_KWN:13370
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005438
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,424,174 - 65,424,674 (-)MPROMDB
RGD ID:6851402
Promoter ID:EP73501
Type:initiation region
Name:HS_FOSL1
Description:FOS-like antigen 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361165,424,466 - 65,424,526EPD
RGD ID:7221083
Promoter ID:EPDNEW_H16287
Type:initiation region
Name:FOSL1_1
Description:FOS like 1, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16288  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,900,388 - 65,900,448EPDNEW
RGD ID:7221085
Promoter ID:EPDNEW_H16288
Type:initiation region
Name:FOSL1_2
Description:FOS like 1, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H16287  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381165,900,613 - 65,900,673EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.1(chr11:65881597-65893890)x3 copy number gain See cases [RCV000051909] Chr11:65881597..65893890 [GRCh38]
Chr11:65649068..65661361 [GRCh37]
Chr11:65405644..65417937 [NCBI36]
Chr11:11q13.1
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh38/hg38 11q13.1-13.2(chr11:65741431-67705669)x1 copy number loss See cases [RCV000142881] Chr11:65741431..67705669 [GRCh38]
Chr11:65508902..67473140 [GRCh37]
Chr11:65265478..67229716 [NCBI36]
Chr11:11q13.1-13.2
pathogenic
GRCh37/hg19 11q13.1-13.2(chr11:64501919-67129258)x3 copy number gain See cases [RCV000511632] Chr11:64501919..67129258 [GRCh37]
Chr11:11q13.1-13.2
likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_005438.5(FOSL1):c.573C>A (p.Ser191Arg) single nucleotide variant not provided [RCV000881510] Chr11:65893129 [GRCh38]
Chr11:65660600 [GRCh37]
Chr11:11q13.1
benign
NM_005438.5(FOSL1):c.795T>C (p.Ser265=) single nucleotide variant not provided [RCV000923161] Chr11:65892907 [GRCh38]
Chr11:65660378 [GRCh37]
Chr11:11q13.1
benign
GRCh37/hg19 11q13.1-13.2(chr11:65138976-67574402) copy number gain not provided [RCV000767601] Chr11:65138976..67574402 [GRCh37]
Chr11:11q13.1-13.2
pathogenic
NC_000011.9:g.(?_65633902)_(66115026_?)dup duplication Autosomal recessive cutis laxa type 1B [RCV000798155] Chr11:65866431..66347555 [GRCh38]
Chr11:65633902..66115026 [GRCh37]
Chr11:11q13.1-13.2
uncertain significance
NM_005438.5(FOSL1):c.525G>A (p.Pro175=) single nucleotide variant not provided [RCV000969604] Chr11:65893177 [GRCh38]
Chr11:65660648 [GRCh37]
Chr11:11q13.1
benign
NC_000011.9:g.(?_65633902)_(66115026_?)dup duplication Autosomal recessive cutis laxa type 1B [RCV001305354] Chr11:65633902..66115026 [GRCh37]
Chr11:11q13.1-13.2
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13718 AgrOrtholog
COSMIC FOSL1 COSMIC
Ensembl Genes ENSG00000175592 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000310170 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000393302 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000431594 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000434350 UniProtKB/TrEMBL
  ENSP00000436276 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENST00000312562 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000448083 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000531493 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000532401 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000534222 UniProtKB/TrEMBL
GTEx ENSG00000175592 GTEx
HGNC ID HGNC:13718 ENTREZGENE
Human Proteome Map FOSL1 Human Proteome Map
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fra1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8061 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 8061 ENTREZGENE
OMIM 136515 OMIM
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28214 PharmGKB
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0S2Z595 ENTREZGENE, UniProtKB/TrEMBL
  E9PKL5 ENTREZGENE, UniProtKB/TrEMBL
  E9PPX2 ENTREZGENE, UniProtKB/TrEMBL
  E9PQT6_HUMAN UniProtKB/TrEMBL
  FOSL1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B4DR11 UniProtKB/Swiss-Prot
  Q6FG51 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-31 FOSL1  FOS like 1, AP-1 transcription factor subunit  FOSL1  FOS like 1, AP-1 trancription factor subunit  Symbol and/or name change 5135510 APPROVED
2016-05-10 FOSL1  FOS like 1, AP-1 trancription factor subunit  FOSL1  FOS like antigen 1  Symbol and/or name change 5135510 APPROVED
2016-01-19 FOSL1  FOS like antigen 1  FOSL1  FOS-like antigen 1  Symbol and/or name change 5135510 APPROVED