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Gene: ACSL4 (acyl-CoA synthetase long chain family member 4) Homo sapiens
Symbol: ACSL4
Name: acyl-CoA synthetase long chain family member 4
RGD ID: 1344693
Description: Exhibits arachidonate-CoA ligase activity; long-chain fatty acid-CoA ligase activity; and very long-chain fatty acid-CoA ligase activity. Involved in several processes, including long-chain fatty acid metabolic process; negative regulation of prostaglandin secretion; and positive regulation of cell growth. Localizes to several cellular components, including endoplasmic reticulum; lipid droplet; and mitochondria-associated endoplasmic reticulum membrane. Implicated in intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACS4; acyl-CoA synthetase 4; acyl-CoA synthetase long-chain family member 4; arachidonate--CoA ligase; FACL4; fatty-acid-Coenzyme A ligase, long-chain 4; LACS 4; LACS4; lignoceroyl-CoA synthase; long-chain acyl-CoA synthetase 4; long-chain fatty-acid-Coenzyme A ligase 4; long-chain-fatty-acid--CoA ligase 4; mental retardation, X-linked 63; mental retardation, X-linked 68; MRX63; MRX68
Mus musculus (house mouse) : Acsl4 (acyl-CoA synthetase long-chain family member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Acsl4 (acyl-CoA synthetase long-chain family member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acsl4 (acyl-CoA synthetase long chain family member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Canis lupus familiaris (dog) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acsl4 (acyl-CoA synthetase long chain family member 4)
Sus scrofa (pig) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Chlorocebus sabaeus (African green monkey) : ACSL4 (acyl-CoA synthetase long chain family member 4)
Heterocephalus glaber (naked mole-rat) : Acsl4 (acyl-CoA synthetase long chain family member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 EnsemblX109,624,244 - 109,733,403 (-)EnsemblGRCh38hg38GRCh38
GRCh38X109,641,335 - 109,733,325 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X108,884,564 - 108,976,621 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X108,771,220 - 108,863,277 (-)NCBINCBI36hg18NCBI36
Build 34X108,690,710 - 108,782,764NCBI
CeleraX109,364,202 - 109,456,256 (-)NCBI
Cytogenetic MapXq23NCBI
HuRefX98,507,227 - 98,598,360 (-)NCBIHuRef
CHM1_1X108,795,825 - 108,887,899 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ACSL4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344693
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.