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Gene: PRAMEF8 (PRAME family member 8) Homo sapiens

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Symbol:

PRAMEF8

Name:

PRAME family member 8

RGD ID:

1604149

HGNC Page

HGNC:24074

Description:

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

PRAMEF24; putative PRAME family member 24

RGD Orthologs

Rat

Pig

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	13,281,304 - 13,285,137 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	13,281,304 - 13,285,137 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	13,607,700 - 13,611,533 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	13,259,233 - 13,263,352 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Cytogenetic Map	1	p36.21	NCBI
HuRef	1	12,098,043 - 12,102,162 (+)	NCBI		HuRef
CHM1_1	1	13,406,546 - 13,410,379 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	12,722,538 - 12,726,371 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF8	Human	chromosome 1p36 deletion syndrome		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Chromosome 1p36 deletion syndrome	ClinVar

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF8	Human	(+)-schisandrin B	multiple interactions	ISO	Pramef8 (Rattus norvegicus)	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRAMEF8 mRNA]	CTD	PMID:31150632
PRAMEF8	Human	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	Pramef8 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in decreased expression of PRAMEF8 mRNA	CTD	PMID:33387578
PRAMEF8	Human	acrylamide	increases expression	ISO	Pramef8 (Rattus norvegicus)	6480464	Acrylamide results in increased expression of PRAMEF8 mRNA	CTD	PMID:28959563
PRAMEF8	Human	aflatoxin B1	increases methylation	EXP		6480464	Aflatoxin B1 results in increased methylation of PRAMEF8 gene	CTD	PMID:27153756
PRAMEF8	Human	bisphenol A	decreases expression	ISO	Pramef8 (Rattus norvegicus)	6480464	bisphenol A results in decreased expression of PRAMEF8 mRNA	CTD	PMID:30816183 and PMID:32528016
PRAMEF8	Human	CGP 52608	multiple interactions	EXP		6480464	CGP 52608 promotes the reaction [RORA protein binds to PRAMEF8 gene]	CTD	PMID:28238834
PRAMEF8	Human	fipronil	multiple interactions	EXP		6480464	[fipronil co-treated with DEET] results in increased expression of PRAMEF8 mRNA	CTD	PMID:27091632
PRAMEF8	Human	fipronil	increases expression	EXP		6480464	fipronil results in increased expression of PRAMEF8 mRNA	CTD	PMID:27091632
PRAMEF8	Human	gentamycin	decreases expression	ISO	Pramef8 (Rattus norvegicus)	6480464	Gentamicins results in decreased expression of PRAMEF8 mRNA	CTD	PMID:33387578
PRAMEF8	Human	N,N-diethyl-m-toluamide	multiple interactions	EXP		6480464	[fipronil co-treated with DEET] results in increased expression of PRAMEF8 mRNA	CTD	PMID:27091632
PRAMEF8	Human	tebuconazole	decreases expression	EXP		6480464	tebuconazole results in decreased expression of PRAMEF8 mRNA	CTD	PMID:30458266
PRAMEF8	Human	tetrachloromethane	multiple interactions	ISO	Pramef8 (Rattus norvegicus)	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PRAMEF8 mRNA]	CTD	PMID:31150632
PRAMEF8	Human	tetrachloromethane	increases expression	ISO	Pramef8 (Rattus norvegicus)	6480464	Carbon Tetrachloride results in increased expression of PRAMEF8 mRNA	CTD	PMID:31150632
PRAMEF8	Human	thioacetamide	increases expression	ISO	Pramef8 (Rattus norvegicus)	6480464	Thioacetamide results in increased expression of PRAMEF8 mRNA	CTD	PMID:34492290
PRAMEF8	Human	vinclozolin	decreases expression	ISO	Pramef8 (Rattus norvegicus)	6480464	vinclozolin results in decreased expression of PRAMEF8 mRNA	CTD	PMID:23555832

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF8	Human	negative regulation of apoptotic process	involved_in	IEA	InterPro:IPR026271	150520179		InterPro	GO_REF:0000002
PRAMEF8	Human	negative regulation of cell differentiation	involved_in	IEA	InterPro:IPR026271	150520179		InterPro	GO_REF:0000002
PRAMEF8	Human	negative regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR026271	150520179		InterPro	GO_REF:0000002
PRAMEF8	Human	positive regulation of cell population proliferation	involved_in	IEA	InterPro:IPR026271	150520179		InterPro	GO_REF:0000002
PRAMEF8	Human	proteasome-mediated ubiquitin-dependent protein catabolic process	involved_in	IBA	PANTHER:PTN000368795 more ...	150520179		GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF8	Human	Cul2-RING ubiquitin ligase complex	part_of	IBA	PANTHER:PTN000368795 more ...	150520179		GO_Central	GO_REF:0000033
PRAMEF8	Human	cytoplasm	is_active_in	IBA	MGI:1890541 more ...	150520179		GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF8	Human	ubiquitin-like ligase-substrate adaptor activity	enables	IBA	PANTHER:PTN000368795 more ...	150520179		GO_Central	GO_REF:0000033

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:12477932	PMID:16710414	PMID:21873635	PMID:25011449	PMID:33961781

PRAMEF8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	13,281,304 - 13,285,137 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	13,281,304 - 13,285,137 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	13,607,700 - 13,611,533 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	13,259,233 - 13,263,352 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Cytogenetic Map	1	p36.21	NCBI
HuRef	1	12,098,043 - 12,102,162 (+)	NCBI		HuRef
CHM1_1	1	13,406,546 - 13,410,379 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	12,722,538 - 12,726,371 (-)	NCBI		T2T-CHM13v2.0

Pramef8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	161,061,444 - 161,077,222 (+)	NCBI		GRCr8
mRatBN7.2	5	155,778,156 - 155,793,935 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	155,778,201 - 155,793,932 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	158,462,437 - 158,478,210 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	160,235,751 - 160,251,526 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	160,191,830 - 160,207,767 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	162,183,397 - 162,197,119 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	162,183,327 - 162,199,050 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	165,877,921 - 165,891,643 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	162,318,746 - 162,332,911 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	154,085,021 - 154,098,116 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

LOC100516915
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	72,765,442 - 72,768,567 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	66,894,554 - 66,898,503 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 1p36.31-36.13(chr1:6853513-17326813)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]\|See cases [RCV000051795]	Chr1:6853513..17326813 [GRCh38] Chr1:6913573..17685411 [GRCh37] Chr1:6836160..17557998 [NCBI36] Chr1:1p36.31-36.13	pathogenic
GRCh38/hg38 1p36.21-36.12(chr1:13110797-20670207)x3	copy number gain	See cases [RCV000051797]	Chr1:13110797..20670207 [GRCh38] Chr1:13178269..20996700 [GRCh37] Chr1:13100856..20869287 [NCBI36] Chr1:1p36.21-36.12	pathogenic
GRCh38/hg38 1p36.32-36.13(chr1:3006193-17688934)x1	copy number loss	See cases [RCV000053714]	Chr1:3006193..17688934 [GRCh38] Chr1:2922757..18015429 [GRCh37] Chr1:2912617..17888016 [NCBI36] Chr1:1p36.32-36.13	pathogenic
GRCh38/hg38 1p36.22-36.12(chr1:10556797-22557907)x1	copy number loss	See cases [RCV000053760]	Chr1:10556797..22557907 [GRCh38] Chr1:10616854..22884400 [GRCh37] Chr1:10539441..22756987 [NCBI36] Chr1:1p36.22-36.12	pathogenic
GRCh38/hg38 1p36.22-36.13(chr1:10621776-16520709)x1	copy number loss	See cases [RCV000053763]	Chr1:10621776..16520709 [GRCh38] Chr1:10681833..16847204 [GRCh37] Chr1:10604420..16719791 [NCBI36] Chr1:1p36.22-36.13	pathogenic
GRCh38/hg38 1p36.22-36.13(chr1:10809039-16422500)x1	copy number loss	See cases [RCV000053765]	Chr1:10809039..16422500 [GRCh38] Chr1:10869096..16748995 [GRCh37] Chr1:10791683..16621582 [NCBI36] Chr1:1p36.22-36.13	pathogenic
GRCh38/hg38 1p36.22-36.13(chr1:11121625-16324498)x1	copy number loss	See cases [RCV000053766]	Chr1:11121625..16324498 [GRCh38] Chr1:11181682..16650993 [GRCh37] Chr1:11104269..16523580 [NCBI36] Chr1:1p36.22-36.13	pathogenic
GRCh38/hg38 1p36.23-36.13(chr1:9034671-16441465)x1	copy number loss	See cases [RCV000053756]	Chr1:9034671..16441465 [GRCh38] Chr1:9094730..16767960 [GRCh37] Chr1:9017317..16640547 [NCBI36] Chr1:1p36.23-36.13	pathogenic
GRCh38/hg38 1p36.21-36.13(chr1:12724785-16034788)x1	copy number loss	See cases [RCV000137720]	Chr1:12724785..16034788 [GRCh38] Chr1:12784752..16361283 [GRCh37] Chr1:12707339..16233870 [NCBI36] Chr1:1p36.21-36.13	pathogenic
GRCh38/hg38 1p36.21(chr1:12627415-13993978)x3	copy number gain	See cases [RCV000138029]	Chr1:12627415..13993978 [GRCh38] Chr1:12687421..14320473 [GRCh37] Chr1:12610008..14193060 [NCBI36] Chr1:1p36.21	likely pathogenic
GRCh38/hg38 1p36.31-36.21(chr1:6303641-15799093)x1	copy number loss	See cases [RCV000137948]	Chr1:6303641..15799093 [GRCh38] Chr1:6363701..16125588 [GRCh37] Chr1:6286288..15998175 [NCBI36] Chr1:1p36.31-36.21	pathogenic\|likely benign
GRCh38/hg38 1p36.21(chr1:12852720-13330100)x1	copy number loss	See cases [RCV000139263]	Chr1:12852720..13330100 [GRCh38] Chr1:12912573..13448340 [GRCh37] Chr1:12835160..13320927 [NCBI36] Chr1:1p36.21	likely benign
GRCh38/hg38 1p36.22-36.21(chr1:9428538-15815791)x1	copy number loss	See cases [RCV000140873]	Chr1:9428538..15815791 [GRCh38] Chr1:9488597..16142286 [GRCh37] Chr1:9411184..16014873 [NCBI36] Chr1:1p36.22-36.21	pathogenic
GRCh38/hg38 1p36.22-36.21(chr1:11021751-15236671)x3	copy number gain	See cases [RCV000141823]	Chr1:11021751..15236671 [GRCh38] Chr1:11081808..15563167 [GRCh37] Chr1:11004395..15435754 [NCBI36] Chr1:1p36.22-36.21	likely pathogenic
GRCh38/hg38 1p36.22-36.21(chr1:10264397-15780840)x1	copy number loss	See cases [RCV000141438]	Chr1:10264397..15780840 [GRCh38] Chr1:10324455..16107335 [GRCh37] Chr1:10247042..15979922 [NCBI36] Chr1:1p36.22-36.21	pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:6554885-16056011)x3	copy number gain	See cases [RCV000142906]	Chr1:6554885..16056011 [GRCh38] Chr1:6614945..16382506 [GRCh37] Chr1:6537532..16255093 [NCBI36] Chr1:1p36.31-36.13	pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:5363826-18360302)x1	copy number loss	See cases [RCV000142771]	Chr1:5363826..18360302 [GRCh38] Chr1:5423886..18686796 [GRCh37] Chr1:5323746..18559383 [NCBI36] Chr1:1p36.31-36.13	pathogenic
Single allele	complex	Breast ductal adenocarcinoma [RCV000207058]	Chr1:909238..24706269 [GRCh37] Chr1:1p36.33-36.11	uncertain significance
chr1:909238-16736132 complex variant	complex	Breast ductal adenocarcinoma [RCV000207094]	Chr1:909238..16736132 [GRCh37] Chr1:1p36.33-36.13	uncertain significance
GRCh37/hg19 1p36.33-36.21(chr1:746608-15077159)x1	copy number loss	See cases [RCV000240403]	Chr1:746608..15077159 [GRCh37] Chr1:1p36.33-36.21	pathogenic
GRCh37/hg19 1p36.32-36.12(chr1:2749920-22564787)x1	copy number loss	See cases [RCV000446470]	Chr1:2749920..22564787 [GRCh37] Chr1:1p36.32-36.12	pathogenic
GRCh37/hg19 1p36.21-36.13(chr1:13178371-19961858)x1	copy number loss	See cases [RCV000447987]	Chr1:13178371..19961858 [GRCh37] Chr1:1p36.21-36.13	pathogenic
GRCh37/hg19 1p36.22-36.21(chr1:11143298-13709344)x3	copy number gain	See cases [RCV000510407]	Chr1:11143298..13709344 [GRCh37] Chr1:1p36.22-36.21	uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3	copy number gain	See cases [RCV000510383]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)	copy number gain	See cases [RCV000510926]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.22-36.21(chr1:10722725-14267773)x1	copy number loss	See cases [RCV000512501]	Chr1:10722725..14267773 [GRCh37] Chr1:1p36.22-36.21	likely pathogenic
GRCh37/hg19 1p36.23-36.13(chr1:8850514-16272383)x1	copy number loss	See cases [RCV000512226]	Chr1:8850514..16272383 [GRCh37] Chr1:1p36.23-36.13	likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3	copy number gain	not provided [RCV000736295]	Chr1:47851..249228449 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3	copy number gain	not provided [RCV000736305]	Chr1:82154..249218992 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.21(chr1:12741240-15768304)x1	copy number loss	not provided [RCV000736409]	Chr1:12741240..15768304 [GRCh37] Chr1:1p36.21	uncertain significance
GRCh37/hg19 1p36.21(chr1:12975284-13706571)x1	copy number loss	not provided [RCV000748904]	Chr1:12975284..13706571 [GRCh37] Chr1:1p36.21	benign
GRCh37/hg19 1p36.21(chr1:13320708-13706571)x1	copy number loss	not provided [RCV000748905]	Chr1:13320708..13706571 [GRCh37] Chr1:1p36.21	benign
GRCh37/hg19 1p36.21(chr1:13321120-13695371)x1	copy number loss	not provided [RCV000748907]	Chr1:13321120..13695371 [GRCh37] Chr1:1p36.21	benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3	copy number gain	Global developmental delay [RCV000787285]	Chr1:103343285..103455144 [GRCh37] Chr1:1p36.22-21.1	uncertain significance
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3	copy number gain	Trisomy 12p [RCV003447845]	Chr1:99125..34026935 [GRCh38] Chr1:1p36.33-35.1	pathogenic
GRCh37/hg19 1p36.33-36.13(chr1:849466-17525065)x1	copy number loss	not provided [RCV001832902]	Chr1:849466..17525065 [GRCh37] Chr1:1p36.33-36.13	pathogenic
NC_000001.11:g.10115497_16283149dup	duplication	not specified [RCV002286386]	Chr1:10115497..16283149 [GRCh38] Chr1:1p36.22-36.13	likely pathogenic
GRCh37/hg19 1p36.31-36.13(chr1:6758933-19287770)x1	copy number loss	not provided [RCV002474779]	Chr1:6758933..19287770 [GRCh37] Chr1:1p36.31-36.13	pathogenic
NC_000001.10:g.4481271_20530242del	deletion	Chromosome 1p36 deletion syndrome [RCV003159574]	Chr1:4481271..20530242 [GRCh37] Chr1:1p36.32-36.12	pathogenic
GRCh37/hg19 1p36.32-36.12(chr1:4436802-22782007)x2	copy number loss	not provided [RCV004577440]	Chr1:4436802..22782007 [GRCh37] Chr1:1p36.32-36.12	pathogenic

Predicted Target Of

	Summary Value
Count of predictions:	153
Count of miRNA genes:	148
Interacting mature miRNAs:	150
Transcripts:	ENST00000357367
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298451	OSTEAR17_H	Osteoarthritis QTL 17 (human)	2.4	0.0004	Joint/bone inflammation	osteoarthritis	11	1	25188105	Human
1576329	MYI9_H	Myocardial infarction susceptibility QTL 9 (human)	12		Myocardial infarction susceptibility	early-onset	1	7585503	33585503	Human
1298463	BP9_H	Blood pressure QTL 9 (human)	3.9		Blood pressure	hypertension susceptibility	1	1	25188105	Human
1576325	MYI1_H	Myocardial infarction susceptibility QTL 1 (human)	11.68	1e-12	Myocardial infarction susceptibility	early-onset	1	7585503	33585503	Human
1643380	BW316_H	Body weight QTL 316 (human)	2.62	0.0002	Body weight	BMI	1	7585503	33585503	Human

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
64	81	163	153	166	130	158	69	53	65	103	354	310	8	147	25	251	83	4


RefSeq Transcripts	NM_001012276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017001269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054328621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054331979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054336534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC244216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC140755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC144565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX470067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000357367 ⟹ ENSP00000349931

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	13,281,304 - 13,285,137 (-)	Ensembl

Ensembl Acc Id:

ENST00000614831 ⟹ ENSP00000484204

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	13,281,302 - 13,285,174 (-)	Ensembl

Ensembl Acc Id:

ENST00000621519 ⟹ ENSP00000484753

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	13,281,304 - 13,284,169 (-)	Ensembl

RefSeq Acc Id:

NM_001012276 ⟹ NP_001012276

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	13,281,304 - 13,285,137 (-)	NCBI
GRCh37	1	13,386,646 - 13,390,765 (-)	RGD
Build 36	1	13,259,233 - 13,263,352 (-)	NCBI Archive
HuRef	1	12,098,043 - 12,102,162 (+)	RGD
CHM1_1	1	13,406,546 - 13,410,379 (-)	NCBI
T2T-CHM13v2.0	1	12,722,538 - 12,726,371 (-)	NCBI

Sequence:

show sequence

TCTGAGAGATCCCAGCACCCTACAAACTGAGTCCAGATCTGAGTTTTCCCTTGCAGATTCATCAAGATGAGCATCAGGGCCCCACCCAGACTCCTGGAGCTGGCAAGGCAGAGGCTGCTGAGGGACCA
GGCCTTGGCCATCTCCACCATGGAGGAGCTGCCCAGGGAGCTCTTCCCCACACTGTTCATGGAGGCCTTCAGCAGGAGACGCTGTGAAACCCTGAAAACAATGGTGCAGGCCTGGCCTTTCACCCGCC
TCCCTCTAGGGTCCCTGATGAAGTCGCCTCATCTGGAGTCATTAAAATCTGTGCTGGAAGGGGTTGATGTGCTGTTGACCCAAGAGGTTCGCCCCAGGCAGTCAAAACTTCAAGTGCTGGACTTGAGG
AATGTGGATGAGAACTTCTGCGACATATTTTCTGGAGCTACTGCATCCTTCCCGGAGGCTCTGAGTCAGAAGCAAACAGCAGATAACTGTCCAGGGACAGGCAGGCAGCAGCCATTCATGGTGTTCAT
AGACCTTTGTCTCAAGAACAGGACACTAGATGAATGCCTCACCCACCTCTTAGAGTGGGGCAAGCAGAGAAAAGGCTTACTGCATGTGTGTTGCAAGGAGCTGCAGGTTTTTGGAATGCCCATCCACA
GTATCATAGAGGTCCTGAACATGGTGGAGCTTGACTGTATCCAGGAGGTGGAAGTGTGCTGCCCCTGGGAGCTGTCCACTCTTGTGAAGTTTGCCCCTTACCTGGGCCAGATGAGGAATCTCCGCAAA
CTTGTTCTCTTCAACATCCGTGCATCTGCCTGCATTCCCCCAGACAACAAGGGGCAGTTCATTGCCCGATTCACCTCTCAGTTCCTCAAGCTGGACTATTTCCAGAATCTGTCTATGCACTCCGTCTC
TTTCCTCGAAGGCCACCTGGACCAGCTGCTCAGGTGTCTCCAGGCCTCCTTGGAGATGGTCGTTATGACCGACTGCCTGCTGTCAGAGTCGGACTTGAAGCATCTCTCTTGGTGCCCGAGCATCCGTC
AATTAAAGGAGCTGGACCTGAGGGGTGTCACGCTGACCCATTTCAGCCCTGAGCCCCTCACAGGTCTGCTGGAGCAAGTTGTGGCCACCCTGCAGACCCTGGACTTAGAGGACTGTGGGATCATGGAT
TCCCAACTCAGCGCCATCCTGCCTGTCCTGAGCCGCTGCTCCCAGCTCAGCACCTTCAGCTTCTGTGGGAACCTCATCTCCATGGCTGCCCTTGAGAACCTGCTGCGCCACACCGTCGGGCTGAGCAA
GCTAAGCCTGGAGCTGTATCCTGCCCCTCTGGAGAGTTATGACACCCAGGGAGCTCTCTGCTGGGGGAGATTTGCTGAACTTGGGGCTGAGCTGATGAACACACTGAGGGACTTAAGGCAGCCCAAGA
TCATTGTGTTCTGCACCGTCCCCTGCCCTCGCTGTGGCATCAGGGCCTCCTATGACCTGGAGCCCAGTCACTGCCTCTGTTGAATGCCTGCCATCAGGGTGGATATATTTCAAGCTTTCTTCTGGTCA
TTTCGGAGCTGAAACCTAGGCC

hide sequence

RefSeq Acc Id:

XM_017001269 ⟹ XP_016856758

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	13,281,304 - 13,284,153 (-)	NCBI

Sequence:

show sequence

CTGAGAGTGATGCCTTTTCTCTGGATTTGTCCTCTAGAGTTTTCCCTTGCAGATTCATCAAGAT
GAGCATCAGGGCCCCACCCAGACTCCTGGAGCTGGCAAGGCAGAGGCTGCTGAGGGACCAGGCCTTGGCCATCTCCACCATGGAGGAGCTGCCCAGGGAGCTCTTCCCCACACTGTTCATGGAGGCCT
TCAGCAGGAGACGCTGTGAAACCCTGAAAACAATGGTGCAGGCCTGGCCTTTCACCCGCCTCCCTCTAGGGTCCCTGATGAAGTCGCCTCATCTGGAGTCATTAAAATCTGTGCTGGAAGGGGTTGAT
GTGCTGTTGACCCAAGAGGTTCGCCCCAGGCAGTCAAAACTTCAAGTGCTGGACTTGAGGAATGTGGATGAGAACTTCTGCGACATATTTTCTGGAGCTACTGCATCCTTCCCGGAGGCTCTGAGTCA
GAAGCAAACAGCAGATAACTGTCCAGGGACAGGCAGGCAGCAGCCATTCATGGTGTTCATAGACCTTTGTCTCAAGAACAGGACACTAGATGAATGCCTCACCCACCTCTTAGAGTGGGGCAAGCAGA
GAAAAGGCTTACTGCATGTGTGTTGCAAGGAGCTGCAGGTTTTTGGAATGCCCATCCACAGTATCATAGAGGTCCTGAACATGGTGGAGCTTGACTGTATCCAGGAGGTGGAAGTGTGCTGCCCCTGG
GAGCTGTCCACTCTTGTGAAGTTTGCCCCTTACCTGGGCCAGATGAGGAATCTCCGCAAACTTGTTCTCTTCAACATCCGTGCATCTGCCTGCATTCCCCCAGACAACAAGGGGCAGTTCATTGCCCG
ATTCACCTCTCAGTTCCTCAAGCTGGACTATTTCCAGAATCTGTCTATGCACTCCGTCTCTTTCCTCGAAGGCCACCTGGACCAGCTGCTCAGGTGTCTCCAGGCCTCCTTGGAGATGGTCGTTATGA
CCGACTGCCTGCTGTCAGAGTCGGACTTGAAGCATCTCTCTTGGTGCCCGAGCATCCGTCAATTAAAGGAGCTGGACCTGAGGGGTGTCACGCTGACCCATTTCAGCCCTGAGCCCCTCACAGGTCTG
CTGGAGCAAGTTGTGGCCACCCTGCAGACCCTGGACTTAGAGGACTGTGGGATCATGGATTCCCAACTCAGCGCCATCCTGCCTGTCCTGAGCCGCTGCTCCCAGCTCAGCACCTTCAGCTTCTGTGG
GAACCTCATCTCCATGGCTGCCCTTGAGAACCTGCTGCGCCACACCGTCGGGCTGAGCAAGCTAAGCCTGGAGCTGTATCCTGCCCCTCTGGAGAGTTATGACACCCAGGGAGCTCTCTGCTGGGGGA
GATTTGCTGAACTTGGGGCTGAGCTGATGAACACACTGAGGGACTTAAGGCAGCCCAAGATCATTGTGTTCTGCACCGTCCCCTGCCCTCGCTGTGGCATCAGGGCCTCCTATGACCTGGAGCCCAGT
CACTGCCTCTGTTGAATGCCTGCCATCAGGGTGGATATATTTCAAGCTTTCTTCTGGTCATTTCGGAGCTGAAACCTAGGCCATGAGTGCATGTTAAAGGGAGCACAGACCCATCGTTTCAAATGCCT
CCTCAGTGTGAATGGGAAAGGAATGAGGATGCAGG

hide sequence

RefSeq Acc Id:

XM_054336534 ⟹ XP_054192509

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	1	12,722,538 - 12,725,387 (-)	NCBI


Protein RefSeqs	NP_001012276	(Get FASTA)	NCBI Sequence Viewer
	XP_016856758	(Get FASTA)	NCBI Sequence Viewer
	XP_054184596	(Get FASTA)	NCBI Sequence Viewer
	XP_054187834	(Get FASTA)	NCBI Sequence Viewer
	XP_054187954	(Get FASTA)	NCBI Sequence Viewer
	XP_054192509	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI40756	(Get FASTA)	NCBI Sequence Viewer
	AAI44566	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000349931
	ENSP00000349931.2
	ENSP00000478860.1
	ENSP00000480509.1
	ENSP00000484753
	ENSP00000484753.1
	ENSP00000488367.1
	ENSP00000488817.1
	ENSP00000488892.1
	ENSP00000490581.1
	ENSP00000490790.1
GenBank Protein	Q5VWM4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001012276 ⟸ NM_001012276

- UniProtKB:

A6NMC2 (UniProtKB/Swiss-Prot), B7ZMI5 (UniProtKB/Swiss-Prot), Q5VWM4 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGATASFPEALS
QKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNIRASACIPPDNKGQFIA
RFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFC
GNLISMAALENLLRHTVGLSKLSLELYPAPLESYDTQGALCWGRFAELGAELMNTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC

hide sequence

RefSeq Acc Id:	XP_016856758 ⟸ XM_017001269
- Peptide Label:	isoform X1
- UniProtKB:	A6NMC2 (UniProtKB/Swiss-Prot), B7ZMI5 (UniProtKB/Swiss-Prot), Q5VWM4 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSIRAPPRLLELARQRLLRDQALAISTMEELPRELFPTLFMEAFSRRRCETLKTMVQAWPFTRLPLGSLMKSPHLESLKSVLEGVDVLLTQEVRPRQSKLQVLDLRNVDENFCDIFSGATASFPEALS QKQTADNCPGTGRQQPFMVFIDLCLKNRTLDECLTHLLEWGKQRKGLLHVCCKELQVFGMPIHSIIEVLNMVELDCIQEVEVCCPWELSTLVKFAPYLGQMRNLRKLVLFNIRASACIPPDNKGQFIA RFTSQFLKLDYFQNLSMHSVSFLEGHLDQLLRCLQASLEMVVMTDCLLSESDLKHLSWCPSIRQLKELDLRGVTLTHFSPEPLTGLLEQVVATLQTLDLEDCGIMDSQLSAILPVLSRCSQLSTFSFC GNLISMAALENLLRHTVGLSKLSLELYPAPLESYDTQGALCWGRFAELGAELMNTLRDLRQPKIIVFCTVPCPRCGIRASYDLEPSHCLC hide sequence

Ensembl Acc Id:

ENSP00000484753 ⟸ ENST00000621519

Ensembl Acc Id:

ENSP00000484204 ⟸ ENST00000614831

Ensembl Acc Id:

ENSP00000349931 ⟸ ENST00000357367

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5VWM4-F1-model_v2	AlphaFold	Q5VWM4	1-474	view protein structure

Database	Acc Id	Source(s)
COSMIC	PRAMEF8	COSMIC
Ensembl Genes	ENSG00000182330	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSG00000278021	UniProtKB/Swiss-Prot
	ENSG00000282583	UniProtKB/Swiss-Prot
	ENSG00000283387	UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000357367	ENTREZGENE
	ENST00000357367.7	UniProtKB/Swiss-Prot
	ENST00000611408.1	UniProtKB/Swiss-Prot
	ENST00000616484.4	UniProtKB/Swiss-Prot
	ENST00000621519	ENTREZGENE
	ENST00000621519.5	UniProtKB/Swiss-Prot
	ENST00000631760.1	UniProtKB/Swiss-Prot
	ENST00000632222.1	UniProtKB/Swiss-Prot
	ENST00000632952.1	UniProtKB/Swiss-Prot
	ENST00000636073.2	UniProtKB/Swiss-Prot
	ENST00000637989.2	UniProtKB/Swiss-Prot
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000182330	GTEx
	ENSG00000278021	GTEx
	ENSG00000282583	GTEx
	ENSG00000283387	GTEx
HGNC ID	HGNC:24074	ENTREZGENE
Human Proteome Map	PRAMEF8	Human Proteome Map
InterPro	LRR_dom_sf	UniProtKB/Swiss-Prot
	PRAME_domain	UniProtKB/Swiss-Prot
	PRAME_family	UniProtKB/Swiss-Prot
KEGG Report	hsa:391002	UniProtKB/Swiss-Prot
NCBI Gene	391002	ENTREZGENE
PANTHER	PRAME FAMILY MEMBER 7-RELATED	UniProtKB/Swiss-Prot
	SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3	UniProtKB/Swiss-Prot
PharmGKB	PA142671145	PharmGKB
PIRSF	PRAME	UniProtKB/Swiss-Prot
Superfamily-SCOP	RNI-like	UniProtKB/Swiss-Prot
UniProt	A6NMC2	ENTREZGENE
	B7ZMI5	ENTREZGENE
	PRAM8_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A6NMC2	UniProtKB/Swiss-Prot
	B7ZMI5	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar