Pramel53 (PRAME like 53) - Rat Genome Database

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Gene: Pramel53 (PRAME like 53) Mus musculus
Analyze
Symbol: Pramel53
Name: PRAME like 53
RGD ID: 1623504
MGI Page MGI
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including PRAMEF1 (PRAME family member 1); PRAMEF10 (PRAME family member 10); and PRAMEF11 (PRAME family member 11).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EG622744; Gm6351; PRAME family member 8-like; predicted gene 6351
RGD Orthologs
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39594,168,420 - 94,229,054 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl594,224,244 - 94,228,794 (+)EnsemblGRCm39 Ensembl
GRCm38594,020,572 - 94,081,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl594,076,385 - 94,080,997 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl595,742,014 - 95,746,617 (+)EnsemblGRCm38mm10GRCm38
MGSCv37594,507,228 - 94,509,961 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36595,153,407 - 95,156,274 (+)NCBIMGSCv36mm8
Cytogenetic Map5E3NCBI
cM Map547.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Comparative Map Data
Pramel53
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39594,168,420 - 94,229,054 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl594,224,244 - 94,228,794 (+)EnsemblGRCm39 Ensembl
GRCm38594,020,572 - 94,081,042 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl594,076,385 - 94,080,997 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl595,742,014 - 95,746,617 (+)EnsemblGRCm38mm10GRCm38
MGSCv37594,507,228 - 94,509,961 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36595,153,407 - 95,156,274 (+)NCBIMGSCv36mm8
Cytogenetic Map5E3NCBI
cM Map547.29NCBI
Pramel53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81414,600,485 - 14,603,139 (+)NCBIGRCr8
mRatBN7.21414,589,069 - 14,591,723 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1414,585,574 - 14,591,723 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01416,015,792 - 16,018,566 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14512,711 - 515,365 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01415,943,251 - 15,946,025 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map14p22NCBI

Variants

.
Variants in Pramel53
86 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:189
Count of miRNA genes:168
Interacting mature miRNAs:174
Transcripts:ENSMUST00000101021, ENSMUST00000139102, ENSMUST00000139828
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000101011   ⟹   ENSMUSP00000098573
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl595,891,681 - 95,894,414 (+)Ensembl
Ensembl Acc Id: ENSMUST00000101021   ⟹   ENSMUSP00000098583
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl594,226,061 - 94,228,794 (+)Ensembl
Ensembl Acc Id: ENSMUST00000136313   ⟹   ENSMUSP00000114696
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl595,889,873 - 95,894,414 (+)Ensembl
Ensembl Acc Id: ENSMUST00000139102   ⟹   ENSMUSP00000115801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl594,224,244 - 94,228,314 (+)Ensembl
Ensembl Acc Id: ENSMUST00000139828   ⟹   ENSMUSP00000119594
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl594,224,244 - 94,228,794 (+)Ensembl
Ensembl Acc Id: ENSMUST00000154086   ⟹   ENSMUSP00000115998
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl595,889,873 - 95,893,934 (+)Ensembl
RefSeq Acc Id: NM_001406260   ⟹   NP_001393189
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39594,168,420 - 94,229,054 (+)NCBI
RefSeq Acc Id: NM_001406261   ⟹   NP_001393190
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39594,224,217 - 94,229,054 (+)NCBI
RefSeq Acc Id: XM_036165641   ⟹   XP_036021534
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39594,168,431 - 94,228,794 (+)NCBI
Sequence:
RefSeq Acc Id: XP_036021534   ⟸   XM_036165641
- Peptide Label: isoform X1
- UniProtKB: A0A0J9YUM1 (UniProtKB/TrEMBL),   A0AAG1GHQ8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000098573   ⟸   ENSMUST00000101011
Ensembl Acc Id: ENSMUSP00000119594   ⟸   ENSMUST00000139828
Ensembl Acc Id: ENSMUSP00000114696   ⟸   ENSMUST00000136313
Ensembl Acc Id: ENSMUSP00000098583   ⟸   ENSMUST00000101021
Ensembl Acc Id: ENSMUSP00000115801   ⟸   ENSMUST00000139102
Ensembl Acc Id: ENSMUSP00000115998   ⟸   ENSMUST00000154086
RefSeq Acc Id: NP_001393189   ⟸   NM_001406260
- Peptide Label: isoform 1
- UniProtKB: K9J7D1 (UniProtKB/TrEMBL),   A0A0J9YUM1 (UniProtKB/TrEMBL),   A0AAG1GHQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001393190   ⟸   NM_001406261
- Peptide Label: isoform 2
- UniProtKB: A0A571BEB7 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-K9J7D1-F1-model_v2 AlphaFold K9J7D1 1-481 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3647817 AgrOrtholog
Ensembl Genes ENSMUSG00000072814 Ensembl, UniProtKB/TrEMBL
  ENSMUSG00000072821 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSG00000095570 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000136313.3 UniProtKB/TrEMBL
  ENSMUST00000139102 ENTREZGENE
  ENSMUST00000139102.2 UniProtKB/TrEMBL
  ENSMUST00000139828 ENTREZGENE
  ENSMUST00000139828.3 UniProtKB/TrEMBL
  ENSMUST00000154086.8 UniProtKB/TrEMBL
  ENSMUST00000179972.2 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  PRAME_domain UniProtKB/TrEMBL
  PRAME_family UniProtKB/TrEMBL
MGD MGI:3647817 ENTREZGENE
NCBI Gene 622744 ENTREZGENE
PANTHER D5ERTD577E PROTEIN-RELATED UniProtKB/TrEMBL
  SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 UniProtKB/TrEMBL
PhenoGen Pramel53 PhenoGen
PIRSF PRAME UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
UniProt A0A0J9YUM1 ENTREZGENE
  A0A571BEB7 ENTREZGENE
  A0AAG1GHQ8 ENTREZGENE, UniProtKB/TrEMBL
  D3YXK9_MOUSE UniProtKB/TrEMBL
  K9J7D1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-08 Pramel53  PRAME like 53  Gm6351  predicted gene 6351  Symbol and/or name updated 27372883 PROVISIONAL