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Gene: PRAME (preferentially expressed antigen in melanoma) Homo sapiens
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Symbol: PRAME
Name: preferentially expressed antigen in melanoma
Description: Exhibits retinoic acid receptor binding activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of retinoic acid receptor signaling pathway; and negative regulation of transcription, DNA-templated. Localizes to the nucleoplasm and plasma membrane. Implicated in myeloid leukemia. Biomarker of several diseases, including adenocarcinoma (multiple); hematologic cancer (multiple); melanoma (multiple); neuroblastoma; and osteosarcoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cancer/testis antigen 130; CT130; MAPE; melanoma antigen preferentially expressed in tumors; OIP-4; OIP4; opa-interacting protein 4; Opa-interacting protein OIP4; preferentially expressed antigen of melanoma
Orthologs:
Mus musculus (house mouse) : Prame (preferentially expressed antigen in melanoma)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prame (preferentially expressed antigen in melanoma)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prame (preferentially expressed antigen in melanoma)
Canis lupus familiaris (dog) : PRAME (preferentially expressed antigen in melanoma)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prame (preferentially expressed antigen in melanoma)
Sus scrofa (pig) : PRAME (preferentially expressed antigen in melanoma)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382222,547,696 - 22,559,361 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372222,890,123 - 22,901,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,220,123 - 21,231,696 (-)NCBINCBI36hg18NCBI36
Build 342221,214,677 - 21,226,104NCBI
Celera226,710,275 - 6,721,853 (-)NCBI
Cytogenetic Map22q11.22NCBI
HuRef225,860,683 - 5,871,798 (-)NCBIHuRef
CHM1_12222,902,166 - 22,913,831 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PRAME
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1349908
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.