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Gene: PRAMEF5 (PRAME family member 5) Homo sapiens

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No known orthologs.

Symbol:

PRAMEF5

Name:

PRAME family member 5

RGD ID:

1603849

HGNC Page

HGNC:27995

Description:

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

PRAME family member 23; PRAMEF23; PRAMEF5L

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	13,254,198 - 13,263,435 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	13,254,198 - 13,263,435 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	13,108,514 - 13,117,751 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	13,232,406 - 13,241,644 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Cytogenetic Map	1	p36.21	NCBI
HuRef	1	12,037,906 - 12,044,726 (-)	NCBI		HuRef
CHM1_1	1	13,379,440 - 13,388,677 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	12,695,431 - 12,704,668 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF5	Human	chromosome 1p36 deletion syndrome		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Chromosome 1p36 deletion syndrome	ClinVar

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF5	Human	17beta-estradiol	affects expression	EXP		6480464	Estradiol affects the expression of PRAMEF5 mRNA	CTD	PMID:22574217
PRAMEF5	Human	all-trans-retinoic acid	increases expression	EXP		6480464	Tretinoin results in increased expression of PRAMEF5 mRNA	CTD	PMID:33167477
PRAMEF5	Human	butanal	increases expression	EXP		6480464	butyraldehyde results in increased expression of PRAMEF5 mRNA	CTD	PMID:26079696
PRAMEF5	Human	cadmium atom	decreases expression	EXP		6480464	Cadmium results in decreased expression of PRAMEF5 mRNA	CTD	PMID:24376830
PRAMEF5	Human	resveratrol	multiple interactions	EXP		6480464	[Plant Extracts co-treated with Resveratrol] results in decreased expression of PRAMEF5 mRNA	CTD	PMID:23557933
PRAMEF5	Human	valproic acid	increases methylation	EXP		6480464	Valproic Acid results in increased methylation of PRAMEF5 gene	CTD	PMID:29154799

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF5	Human	negative regulation of apoptotic process	involved_in	IEA	InterPro:IPR026271	150520179		InterPro	GO_REF:0000002
PRAMEF5	Human	negative regulation of cell differentiation	involved_in	IEA	InterPro:IPR026271	150520179		InterPro	GO_REF:0000002
PRAMEF5	Human	negative regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR026271	150520179		InterPro	GO_REF:0000002
PRAMEF5	Human	positive regulation of cell population proliferation	involved_in	IEA	InterPro:IPR026271	150520179		InterPro	GO_REF:0000002
PRAMEF5	Human	proteasome-mediated ubiquitin-dependent protein catabolic process	involved_in	IBA	PANTHER:PTN000368795 more ...	150520179		GO_Central	GO_REF:0000033

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF5	Human	Cul2-RING ubiquitin ligase complex	part_of	IBA	PANTHER:PTN000368795 more ...	150520179		GO_Central	GO_REF:0000033
PRAMEF5	Human	cytoplasm	is_active_in	IBA	MGI:1890541 more ...	150520179		GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
PRAMEF5	Human	ubiquitin-like ligase-substrate adaptor activity	enables	IBA	PANTHER:PTN000368795 more ...	150520179		GO_Central	GO_REF:0000033

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:12477932	PMID:16710414	PMID:21873635	PMID:26186194	PMID:28514442	PMID:33961781	PMID:35256949

Variants in PRAMEF5
24 total Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 1p36.31-36.13(chr1:6853513-17326813)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051795]\|See cases [RCV000051795]	Chr1:6853513..17326813 [GRCh38] Chr1:6913573..17685411 [GRCh37] Chr1:6836160..17557998 [NCBI36] Chr1:1p36.31-36.13	pathogenic
GRCh38/hg38 1p36.21-36.12(chr1:13110797-20670207)x3	copy number gain	See cases [RCV000051797]	Chr1:13110797..20670207 [GRCh38] Chr1:13178269..20996700 [GRCh37] Chr1:13100856..20869287 [NCBI36] Chr1:1p36.21-36.12	pathogenic
GRCh38/hg38 1p36.32-36.13(chr1:3006193-17688934)x1	copy number loss	See cases [RCV000053714]	Chr1:3006193..17688934 [GRCh38] Chr1:2922757..18015429 [GRCh37] Chr1:2912617..17888016 [NCBI36] Chr1:1p36.32-36.13	pathogenic
GRCh38/hg38 1p36.22-36.12(chr1:10556797-22557907)x1	copy number loss	See cases [RCV000053760]	Chr1:10556797..22557907 [GRCh38] Chr1:10616854..22884400 [GRCh37] Chr1:10539441..22756987 [NCBI36] Chr1:1p36.22-36.12	pathogenic
GRCh38/hg38 1p36.22-36.13(chr1:10621776-16520709)x1	copy number loss	See cases [RCV000053763]	Chr1:10621776..16520709 [GRCh38] Chr1:10681833..16847204 [GRCh37] Chr1:10604420..16719791 [NCBI36] Chr1:1p36.22-36.13	pathogenic
GRCh38/hg38 1p36.22-36.13(chr1:10809039-16422500)x1	copy number loss	See cases [RCV000053765]	Chr1:10809039..16422500 [GRCh38] Chr1:10869096..16748995 [GRCh37] Chr1:10791683..16621582 [NCBI36] Chr1:1p36.22-36.13	pathogenic
GRCh38/hg38 1p36.22-36.13(chr1:11121625-16324498)x1	copy number loss	See cases [RCV000053766]	Chr1:11121625..16324498 [GRCh38] Chr1:11181682..16650993 [GRCh37] Chr1:11104269..16523580 [NCBI36] Chr1:1p36.22-36.13	pathogenic
GRCh38/hg38 1p36.23-36.13(chr1:9034671-16441465)x1	copy number loss	See cases [RCV000053756]	Chr1:9034671..16441465 [GRCh38] Chr1:9094730..16767960 [GRCh37] Chr1:9017317..16640547 [NCBI36] Chr1:1p36.23-36.13	pathogenic
GRCh38/hg38 1p36.21-36.13(chr1:12724785-16034788)x1	copy number loss	See cases [RCV000137720]	Chr1:12724785..16034788 [GRCh38] Chr1:12784752..16361283 [GRCh37] Chr1:12707339..16233870 [NCBI36] Chr1:1p36.21-36.13	pathogenic
GRCh38/hg38 1p36.21(chr1:12627415-13993978)x3	copy number gain	See cases [RCV000138029]	Chr1:12627415..13993978 [GRCh38] Chr1:12687421..14320473 [GRCh37] Chr1:12610008..14193060 [NCBI36] Chr1:1p36.21	likely pathogenic
GRCh38/hg38 1p36.31-36.21(chr1:6303641-15799093)x1	copy number loss	See cases [RCV000137948]	Chr1:6303641..15799093 [GRCh38] Chr1:6363701..16125588 [GRCh37] Chr1:6286288..15998175 [NCBI36] Chr1:1p36.31-36.21	pathogenic\|likely benign
GRCh38/hg38 1p36.21(chr1:12852720-13330100)x1	copy number loss	See cases [RCV000139263]	Chr1:12852720..13330100 [GRCh38] Chr1:12912573..13448340 [GRCh37] Chr1:12835160..13320927 [NCBI36] Chr1:1p36.21	likely benign
GRCh38/hg38 1p36.22-36.21(chr1:9428538-15815791)x1	copy number loss	See cases [RCV000140873]	Chr1:9428538..15815791 [GRCh38] Chr1:9488597..16142286 [GRCh37] Chr1:9411184..16014873 [NCBI36] Chr1:1p36.22-36.21	pathogenic
GRCh38/hg38 1p36.22-36.21(chr1:11021751-15236671)x3	copy number gain	See cases [RCV000141823]	Chr1:11021751..15236671 [GRCh38] Chr1:11081808..15563167 [GRCh37] Chr1:11004395..15435754 [NCBI36] Chr1:1p36.22-36.21	likely pathogenic
GRCh38/hg38 1p36.22-36.21(chr1:10264397-15780840)x1	copy number loss	See cases [RCV000141438]	Chr1:10264397..15780840 [GRCh38] Chr1:10324455..16107335 [GRCh37] Chr1:10247042..15979922 [NCBI36] Chr1:1p36.22-36.21	pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:6554885-16056011)x3	copy number gain	See cases [RCV000142906]	Chr1:6554885..16056011 [GRCh38] Chr1:6614945..16382506 [GRCh37] Chr1:6537532..16255093 [NCBI36] Chr1:1p36.31-36.13	pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:5363826-18360302)x1	copy number loss	See cases [RCV000142771]	Chr1:5363826..18360302 [GRCh38] Chr1:5423886..18686796 [GRCh37] Chr1:5323746..18559383 [NCBI36] Chr1:1p36.31-36.13	pathogenic
Single allele	complex	Breast ductal adenocarcinoma [RCV000207058]	Chr1:909238..24706269 [GRCh37] Chr1:1p36.33-36.11	uncertain significance
chr1:909238-16736132 complex variant	complex	Breast ductal adenocarcinoma [RCV000207094]	Chr1:909238..16736132 [GRCh37] Chr1:1p36.33-36.13	uncertain significance
GRCh37/hg19 1p36.33-36.21(chr1:746608-15077159)x1	copy number loss	See cases [RCV000240403]	Chr1:746608..15077159 [GRCh37] Chr1:1p36.33-36.21	pathogenic
GRCh37/hg19 1p36.32-36.12(chr1:2749920-22564787)x1	copy number loss	See cases [RCV000446470]	Chr1:2749920..22564787 [GRCh37] Chr1:1p36.32-36.12	pathogenic
GRCh37/hg19 1p36.21-36.13(chr1:13178371-19961858)x1	copy number loss	See cases [RCV000447987]	Chr1:13178371..19961858 [GRCh37] Chr1:1p36.21-36.13	pathogenic
GRCh37/hg19 1p36.22-36.21(chr1:11143298-13709344)x3	copy number gain	See cases [RCV000510407]	Chr1:11143298..13709344 [GRCh37] Chr1:1p36.22-36.21	uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3	copy number gain	See cases [RCV000510383]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)	copy number gain	See cases [RCV000510926]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.22-36.21(chr1:10722725-14267773)x1	copy number loss	See cases [RCV000512501]	Chr1:10722725..14267773 [GRCh37] Chr1:1p36.22-36.21	likely pathogenic
GRCh37/hg19 1p36.23-36.13(chr1:8850514-16272383)x1	copy number loss	See cases [RCV000512226]	Chr1:8850514..16272383 [GRCh37] Chr1:1p36.23-36.13	likely pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3	copy number gain	not provided [RCV000736305]	Chr1:82154..249218992 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3	copy number gain	not provided [RCV000736295]	Chr1:47851..249228449 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.21(chr1:12741240-15768304)x1	copy number loss	not provided [RCV000736409]	Chr1:12741240..15768304 [GRCh37] Chr1:1p36.21	uncertain significance
GRCh37/hg19 1p36.21(chr1:12975284-13706571)x1	copy number loss	not provided [RCV000748904]	Chr1:12975284..13706571 [GRCh37] Chr1:1p36.21	benign
GRCh37/hg19 1p36.21(chr1:13320708-13706571)x1	copy number loss	not provided [RCV000748905]	Chr1:13320708..13706571 [GRCh37] Chr1:1p36.21	benign
GRCh37/hg19 1p36.21(chr1:13321120-13695371)x1	copy number loss	not provided [RCV000748907]	Chr1:13321120..13695371 [GRCh37] Chr1:1p36.21	benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3	copy number gain	Global developmental delay [RCV000787285]	Chr1:103343285..103455144 [GRCh37] Chr1:1p36.22-21.1	uncertain significance
GRCh37/hg19 1p36.33-36.13(chr1:849466-17525065)x1	copy number loss	not provided [RCV001832902]	Chr1:849466..17525065 [GRCh37] Chr1:1p36.33-36.13	pathogenic
NC_000001.11:g.10115497_16283149dup	duplication	not specified [RCV002286386]	Chr1:10115497..16283149 [GRCh38] Chr1:1p36.22-36.13	likely pathogenic
GRCh37/hg19 1p36.31-36.13(chr1:6758933-19287770)x1	copy number loss	not provided [RCV002474779]	Chr1:6758933..19287770 [GRCh37] Chr1:1p36.31-36.13	pathogenic
NM_001013407.5(PRAMEF5):c.326G>C (p.Cys109Ser)	single nucleotide variant	not specified [RCV004115291]	Chr1:13260260 [GRCh38] Chr1:13111689 [GRCh37] Chr1:1p36.21	likely benign
NM_001013407.5(PRAMEF5):c.371G>C (p.Cys124Ser)	single nucleotide variant	not specified [RCV004216578]	Chr1:13260305 [GRCh38] Chr1:13111644 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.722A>G (p.His241Arg)	single nucleotide variant	not specified [RCV004188034]	Chr1:13260656 [GRCh38] Chr1:13111293 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.49C>G (p.Leu17Val)	single nucleotide variant	not specified [RCV004230249]	Chr1:13259317 [GRCh38] Chr1:13112632 [GRCh37] Chr1:1p36.21	likely benign
NM_001013407.5(PRAMEF5):c.982C>G (p.Leu328Val)	single nucleotide variant	not specified [RCV004229827]	Chr1:13262662 [GRCh38] Chr1:13109287 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.1276C>G (p.Leu426Val)	single nucleotide variant	not specified [RCV004190774]	Chr1:13262956 [GRCh38] Chr1:13108993 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.482A>G (p.Asp161Gly)	single nucleotide variant	not specified [RCV004100390]	Chr1:13260416 [GRCh38] Chr1:13111533 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.964C>G (p.Gln322Glu)	single nucleotide variant	not specified [RCV004184214]	Chr1:13262644 [GRCh38] Chr1:13109305 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.1357T>C (p.Phe453Leu)	single nucleotide variant	not specified [RCV004132290]	Chr1:13263037 [GRCh38] Chr1:13108912 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.142C>T (p.Arg48Cys)	single nucleotide variant	not specified [RCV004227744]	Chr1:13259410 [GRCh38] Chr1:13112539 [GRCh37] Chr1:1p36.21	likely benign
NM_001013407.5(PRAMEF5):c.451G>A (p.Val151Ile)	single nucleotide variant	not specified [RCV004239206]	Chr1:13260385 [GRCh38] Chr1:13111564 [GRCh37] Chr1:1p36.21	likely benign
NM_001013407.5(PRAMEF5):c.1421G>A (p.Cys474Tyr)	single nucleotide variant	not specified [RCV004088972]	Chr1:13263101 [GRCh38] Chr1:13108848 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.437C>G (p.Pro146Arg)	single nucleotide variant	not specified [RCV004166429]	Chr1:13260371 [GRCh38] Chr1:13111578 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.1026A>C (p.Gln342His)	single nucleotide variant	not specified [RCV004103958]	Chr1:13262706 [GRCh38] Chr1:13109243 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.1234C>G (p.Leu412Val)	single nucleotide variant	not specified [RCV004241278]	Chr1:13262914 [GRCh38] Chr1:13109035 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.121A>C (p.Met41Leu)	single nucleotide variant	not specified [RCV004133874]	Chr1:13259389 [GRCh38] Chr1:13112560 [GRCh37] Chr1:1p36.21	likely benign
NM_001013407.5(PRAMEF5):c.958A>G (p.Ile320Val)	single nucleotide variant	not specified [RCV004188679]	Chr1:13262638 [GRCh38] Chr1:13109311 [GRCh37] Chr1:1p36.21	likely benign
NM_001013407.5(PRAMEF5):c.1026A>T (p.Gln342His)	single nucleotide variant	not specified [RCV004273864]	Chr1:13262706 [GRCh38] Chr1:13109243 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.524A>G (p.Lys175Arg)	single nucleotide variant	not specified [RCV004273401]	Chr1:13260458 [GRCh38] Chr1:13111491 [GRCh37] Chr1:1p36.21	uncertain significance
NC_000001.10:g.4481271_20530242del	deletion	Chromosome 1p36 deletion syndrome [RCV003159574]	Chr1:4481271..20530242 [GRCh37] Chr1:1p36.32-36.12	pathogenic
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3	copy number gain	Trisomy 12p [RCV003447845]	Chr1:99125..34026935 [GRCh38] Chr1:1p36.33-35.1	pathogenic
NM_001013407.5(PRAMEF5):c.803G>A (p.Cys268Tyr)	single nucleotide variant	not specified [RCV004512626]	Chr1:13260737 [GRCh38] Chr1:13111212 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.392A>C (p.Asn131Thr)	single nucleotide variant	not specified [RCV004512625]	Chr1:13260326 [GRCh38] Chr1:13111623 [GRCh37] Chr1:1p36.21	uncertain significance
GRCh37/hg19 1p36.32-36.12(chr1:4436802-22782007)x2	copy number loss	not provided [RCV004577440]	Chr1:4436802..22782007 [GRCh37] Chr1:1p36.32-36.12	pathogenic
NM_001013407.5(PRAMEF5):c.359T>C (p.Met120Thr)	single nucleotide variant	not specified [RCV004660076]	Chr1:13260293 [GRCh38] Chr1:13111656 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.737G>A (p.Arg246His)	single nucleotide variant	not specified [RCV004656402]	Chr1:13260671 [GRCh38] Chr1:13111278 [GRCh37] Chr1:1p36.21	uncertain significance
NM_001013407.5(PRAMEF5):c.368G>C (p.Gly123Ala)	single nucleotide variant	not specified [RCV004845789]	Chr1:13260302 [GRCh38] Chr1:13111647 [GRCh37] Chr1:1p36.21	uncertain significance

Predicted Target Of

	Summary Value
Count of predictions:	145
Count of miRNA genes:	132
Interacting mature miRNAs:	133
Transcripts:	ENST00000376168, ENST00000605221
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298451	OSTEAR17_H	Osteoarthritis QTL 17 (human)	2.4	0.0004	Joint/bone inflammation	osteoarthritis	11	1	25188105	Human
1576329	MYI9_H	Myocardial infarction susceptibility QTL 9 (human)	12		Myocardial infarction susceptibility	early-onset	1	7585503	33585503	Human
1298463	BP9_H	Blood pressure QTL 9 (human)	3.9		Blood pressure	hypertension susceptibility	1	1	25188105	Human
1576325	MYI1_H	Myocardial infarction susceptibility QTL 1 (human)	11.68	1e-12	Myocardial infarction susceptibility	early-onset	1	7585503	33585503	Human
1643380	BW316_H	Body weight QTL 316 (human)	2.62	0.0002	Body weight	BMI	1	7585503	33585503	Human

D1S3693

Human Assembly	Chr	Position (strand)	Source
Cytogenetic Map	16	q24.3	UniSTS
Cytogenetic Map	22	q13.1	UniSTS
Cytogenetic Map	3	p22	UniSTS
Cytogenetic Map	22	q12.1	UniSTS
Cytogenetic Map	20	q11.21	UniSTS
Cytogenetic Map	21	q22.3	UniSTS
Cytogenetic Map	17	q25.3	UniSTS
Cytogenetic Map	13	q34	UniSTS
Cytogenetic Map	1	q22-q23	UniSTS
Cytogenetic Map	1	p36.21	UniSTS
Cytogenetic Map	19	p13	UniSTS
Cytogenetic Map	8	p21.3	UniSTS
Cytogenetic Map	20	q13.33	UniSTS
Cytogenetic Map	11	q13.2	UniSTS
Cytogenetic Map	12	p13.3	UniSTS
Cytogenetic Map	15	q14	UniSTS
Cytogenetic Map	6	p25.2	UniSTS
Cytogenetic Map	X	p22.33	UniSTS
Cytogenetic Map	Y	p11.32	UniSTS
Cytogenetic Map	10	p15.3-p15.2	UniSTS
Cytogenetic Map	13	q14.13	UniSTS
Cytogenetic Map	17	p13.3	UniSTS
Cytogenetic Map	3	p22.3	UniSTS
Cytogenetic Map	2	q13	UniSTS
Cytogenetic Map	1	q32.3-q41	UniSTS
Cytogenetic Map	1	p13.3	UniSTS
Cytogenetic Map	11	q13.5	UniSTS
Cytogenetic Map	9	q34.11	UniSTS
Cytogenetic Map	1	p36.32	UniSTS
Cytogenetic Map	19	q13.42	UniSTS
Cytogenetic Map	11	q13	UniSTS
Cytogenetic Map	1	q32.1	UniSTS
Cytogenetic Map	22	q13.2	UniSTS
Cytogenetic Map	19	p13.3	UniSTS
Cytogenetic Map	17	q12	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system	sensory system
6	28	29	31	42	20	21	6	26	4	17	86	77	34	5	176	15	2


RefSeq Transcripts	NM_001013407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC244216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC101344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC130274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC130276	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX640550	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX649449	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000622421 ⟹ ENSP00000480122

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	13,254,198 - 13,263,435 (+)	Ensembl

RefSeq Acc Id:

NM_001013407 ⟹ NP_001013425

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	13,254,198 - 13,263,435 (+)	NCBI
GRCh37	1	13,359,819 - 13,369,057 (+)	RGD
Build 36	1	13,232,406 - 13,241,644 (+)	NCBI Archive
HuRef	1	12,037,906 - 12,044,726 (-)	NCBI
CHM1_1	1	13,379,440 - 13,388,677 (+)	NCBI
T2T-CHM13v2.0	1	12,695,431 - 12,704,668 (+)	NCBI

Sequence:

show sequence

GACCCAAAGTCTTCAAGCCTGGAGTTCCTGCTTGGTTCTTCCTGAGGACTGAGCACCTTCTAGACTACATCCAGATCTGTTTTCCCTGCAGATTCGTGAAGATGAGCATCCGGACTCCACCCAGACTC
CTGGAGCTTGCAGGGCGGAGCCTGCTGAGGGACCAAGCCTTGGCCATGTCCACCCTGGAGGAGCTGCCCACAGAACTTTTCCCCCCACTGTTCATGGAGGCCTTCAGCAGGAGACGCTGTGAGGCCCT
GAAGCTGATGGTGCAGGCCTGGCCCTTCCGCCGCCTCCCTCTGAGGCCTCTGATAAAGATGCCTTGTCTGGAGGCCTTCCAAGCTGTGCTCGATGGGCTGGATGCACTGCTTACCCAAGGGGTTCATC
CCAGGAGGTGGAAACTTCAAGTGCTGGATTTACAGGATGTCTGTGAGAACTTCTGGATGGTTTGGTCTGAAGCTATGGCCCATGGGTGCTTCCTCAATGCCAAGAGGAACAAAAAACCAGTGCAGGAC
TGTCCAAGGATGAGAGGACAGCAGCCCTTGACTGTGTTCGTAGAACTTTGGCTCAAGAACAGGACTCTGGATGAATACCTCACCTGCCTCCTTCTATGGGTCAAGCAGAGGAAAGATTTACTACACCT
GTGCTGTAAGAAGCTGAAAATTTTGGGAATGCCCTTCCGCAATATCAGAAGCATCCTGAAAATGGTGAACCTAGACTGTATCCAGGAGGTGGAAGTGAATTGCAAGTGGGTACTGCCCATCCTGACAC
AGTTTACCCCATACCTGGGCCACATGAGGAATCTTCAGAAGCTCGTTCTCTCCCACATGGATGTCTCTCGCTACGTTTCCCCAGAGCAGAAGAAGGAGATTGTTACCCAGTTCACCACTCAGTTCCTC
AAGCTGTGCTGCCTCCAAAAGCTTTCTATGAACTCTGTTTCTTTCCTCGAAGGCCACCTGGACCAGCTGCTCAGCTGTCTGAAGACCTCGTTAAAGGTCCTCACAATAACTAACTGTGTGCTTTTGGA
ATCAGACTTGAAGCATCTATCCCAGTGCCCGAGTATCAGTCAACTAAAGACCCTGGACCTGAGTGGCATCAGACTGACCAATTACAGTCTTGTGCCTCTCCAAATTCTCCTAGAAAAAGTTGCAGCCA
CCCTTGAGTACCTGGATTTAGATGACTGTGGCATCATAGACTCCCAAGTCAACGCCATCCTGCCTGCCCTGAGCCGCTGCTTTGAGCTCAACACCTTCAGCTTCTGTGGAAATCCCATCTCCATGGCC
ACCCTGGAGAACCTGCTGAGCCACACAATCATACTCAAAAACTTATGCGTGGAGCTGTATCCTGCCCCCCGGGAGAGTTATGATGCTGATGGTACTCTCTGCTGGAGCAGATTTCCTCAAATTAGGGC
TGAGCTGATGAAGAGAGTGAGGGACTTAAGGCACCCCAAGAGGATCTTGTTCTGTACTGACTGCTGCCCTGACTGTGGCAACAGGTCATTTTATGACCTGGAGGCAGATCAATGCTGCTGTTGAATGC
CTGCCTATTTGGGTGGATATGTCAAACGCTTTCTTCTGGACACTTGGAAACTAAAACCTAGGTCTTAGGTACATCCTATAGGGAGCACAGAACCCATCATTTCACACATGGGCTCTGAAAGTGGGAAA
GGAAAGGTGATCAAGCAGGGGCAGGACTTGGGGGAAGTGTTGCCATGGATTCGATGGGACTTTGGGGACCTGTGTCCTGTAGAGTGGAAAATGGGAATTTGAATGTCTAGAGTGGAGGCTTGAGAATA
CTTGAGGGAGTTACTCTTGGATGCATGGTTGTAAAGAAACAATCAGAAATAAAGGAAAACTGAG

hide sequence


Protein RefSeqs	NP_001013425	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI01345	(Get FASTA)	NCBI Sequence Viewer
	AAI30275	(Get FASTA)	NCBI Sequence Viewer
	AAI30277	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000478534.2
	ENSP00000480122
	ENSP00000480122.1
	ENSP00000482418.1
	ENSP00000488527.1
GenBank Protein	Q5TYX0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001013425 ⟸ NM_001013407

- UniProtKB:

A4FU31 (UniProtKB/Swiss-Prot), A2BDD6 (UniProtKB/Swiss-Prot), A0A087WWD0 (UniProtKB/Swiss-Prot), A6NMV5 (UniProtKB/Swiss-Prot), Q5TYX0 (UniProtKB/Swiss-Prot), B7ZW04 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSIRTPPRLLELAGRSLLRDQALAMSTLEELPTELFPPLFMEAFSRRRCEALKLMVQAWPFRRLPLRPLIKMPCLEAFQAVLDGLDALLTQGVHPRRWKLQVLDLQDVCENFWMVWSEAMAHGCFLNA
KRNKKPVQDCPRMRGQQPLTVFVELWLKNRTLDEYLTCLLLWVKQRKDLLHLCCKKLKILGMPFRNIRSILKMVNLDCIQEVEVNCKWVLPILTQFTPYLGHMRNLQKLVLSHMDVSRYVSPEQKKEI
VTQFTTQFLKLCCLQKLSMNSVSFLEGHLDQLLSCLKTSLKVLTITNCVLLESDLKHLSQCPSISQLKTLDLSGIRLTNYSLVPLQILLEKVAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFS
FCGNPISMATLENLLSHTIILKNLCVELYPAPRESYDADGTLCWSRFPQIRAELMKRVRDLRHPKRILFCTDCCPDCGNRSFYDLEADQCCC

hide sequence

Ensembl Acc Id:

ENSP00000480122 ⟸ ENST00000622421

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5TYX0-F1-model_v2	AlphaFold	Q5TYX0	1-476	view protein structure

Database	Acc Id	Source(s)
COSMIC	PRAMEF5	COSMIC
Ensembl Genes	ENSG00000270601	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSG00000276420	UniProtKB/Swiss-Prot
	ENSG00000282424	UniProtKB/Swiss-Prot
	ENSG00000283150	UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000618079.5	UniProtKB/Swiss-Prot
	ENST00000621481.4	UniProtKB/Swiss-Prot
	ENST00000622421	ENTREZGENE
	ENST00000622421.3	UniProtKB/Swiss-Prot
	ENST00000633074.1	UniProtKB/Swiss-Prot
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000270601	GTEx
	ENSG00000276420	GTEx
	ENSG00000282424	GTEx
	ENSG00000283150	GTEx
HGNC ID	HGNC:27995	ENTREZGENE
Human Proteome Map	PRAMEF5	Human Proteome Map
InterPro	LRR_dom_sf	UniProtKB/Swiss-Prot
	PRAME_domain	UniProtKB/Swiss-Prot
	PRAME_family	UniProtKB/Swiss-Prot
KEGG Report	hsa:343068	UniProtKB/Swiss-Prot
NCBI Gene	343068	ENTREZGENE
PANTHER	PRAME FAMILY MEMBER 11-RELATED	UniProtKB/Swiss-Prot
	SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3	UniProtKB/Swiss-Prot
PharmGKB	PA142671142	PharmGKB
PIRSF	PRAME	UniProtKB/Swiss-Prot
Superfamily-SCOP	RNI-like	UniProtKB/Swiss-Prot
UniProt	A0A087WWD0	ENTREZGENE
	A2BDD6	ENTREZGENE
	A4FU31	ENTREZGENE
	A6NMV5	ENTREZGENE
	B7ZW04	ENTREZGENE, UniProtKB/TrEMBL
	PRAM5_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A0A087WWD0	UniProtKB/Swiss-Prot
	A2BDD6	UniProtKB/Swiss-Prot
	A4FU31	UniProtKB/Swiss-Prot
	A6NMV5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-05	PRAMEF5	PRAME family member 5	PRAMEF23	PRAME family member 23	Data merged from RGD:2300353	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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Imported Disease Annotations - ClinVar