Pramel44 (PRAME like 44) - Rat Genome Database

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Pathways
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Gene: Pramel44 (PRAME like 44) Mus musculus
Analyze
No known orthologs.
Symbol: Pramel44
Name: PRAME like 44
RGD ID: 2299746
MGI Page MGI
Description: Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including PRAMEF1 (PRAME family member 1); PRAMEF10 (PRAME family member 10); and PRAMEF11 (PRAME family member 11).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 624507; Gm42117; Gm6509; PRAME family member 8-like; predicted gene 6509; predicted gene, 42117; predicted gene, 624507; uncharacterized protein LOC108169097
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39594,734,267 - 94,774,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl594,770,074 - 94,774,605 (+)EnsemblGRCm39 Ensembl
GRCm38594,586,408 - 94,626,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl594,623,979 - 94,626,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv37595,053,038 - 95,055,771 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Cytogenetic Map5E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
triptonide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635   PMID:26694250  


Genomics

Variants

.
Variants in Pramel44
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:96
Interacting mature miRNAs:97
Transcripts:ENSMUST00000098286
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse
10043993Hbnr10_mHeligmosomoides bakeri nematode resistance 10 (mouse)Not determined572418876106419011Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
25314315Mlh1fc4_mMLH1 foci count 4 (mouse)574460661132528839Mouse
13506928Recrq8_mrecombination rate in male meiosis QTL 8 (mouse)574460661132528839Mouse
4141124Dshv2_mdorsal hippocampal volume 2 (mouse)Not determined57531534898019803Mouse
1357431Cia27_mcollagen induced arthritis 27 (mouse)Not determined575315348120018629Mouse
4141438Skmw13_mskeletal muscle weight 13 (mouse)Not determined576190263110190479Mouse
4141505Chlq14_mcirculating hormone level QTL 14 (mouse)Not determined576280786110280917Mouse
1300986Hdlq2_mHDL QTL 2 (mouse)Not determined576280786110280917Mouse
1301691Cdcs10_mcytokine deficiency colitis susceptibility 10 (mouse)Not determined576280786110280917Mouse
1301829Thyls2_mthymic lymphoma susceptibility 2 (mouse)Not determined576445064110445225Mouse
1301713Dbsty2_mdiabesity 2 (mouse)Not determined576445064110445225Mouse
13464249Ahl16_mage related hearing loss, early onset 16 (mouse)576445064110445225Mouse
1300931Cocrb6_mcocaine related behavior 6 (mouse)Not determined576445064110445225Mouse
12910784Pwgrq15_mpost-weaning growth rate QTL 15 (mouse)57717582397658215Mouse
12910816Ogrq2_moverall growth rate QTL 2 (mouse)57717582397658215Mouse
10401246Bglu13_mblood glucose level 13 (mouse)Not determined579539640113539786Mouse
10755524Mono1_mmonocyte differential 1 (mouse)580849259114849259Mouse
1301419Cypr3_mcytokine production 3 (mouse)Not determined581019649115019803Mouse
10401245Bglu18_mblood glucose level 18 (mouse)Not determined582838468116838597Mouse
13464242Ahl17_mage related hearing loss, early onset 17 (mouse)582838468116838597Mouse
10043958Chldq12_mcholesterol and HDL QTL 12 (mouse)Not determined587386871121387065Mouse
1301126Bwem1_mbody weight day 30 males 1 (mouse)Not determined587386871121387065Mouse
13464241Ahl18_mage related hearing loss, early onset 18 (mouse)587386871121387065Mouse
1300801Drb2_mdopamine receptor binding 2 (mouse)Not determined587386871121387065Mouse
1301399Cpfd3_mcerebellum pattern fissures (mouse)Not determined587386871121387065Mouse
1357725Eae39_mexperimental allergic encephalomyelitis 39 (mouse)Not determined589418876118864028Mouse
1300968Skts4_mskin tumor susceptibility 4 (mouse)Not determined589418876124238239Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
11049562Lmr24f_mleishmaniasis resistance 24f (mouse)590320962124321041Mouse
1301457Cfsw2_mcystic fibrosis survival to weaning 2 (mouse)Not determined590561006124561151Mouse
1300993Hycdc_mhypercapnic duty cycle (mouse)Not determined590561006124561151Mouse
9587780Afw16_mabdominal fat weight QTL 16 (mouse)Not determined592830166126830285Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001378724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC124589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000098286   ⟹   ENSMUSP00000095887
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl594,771,872 - 94,774,380 (+)Ensembl
GRCm38.p6 Ensembl594,624,013 - 94,626,521 (+)Ensembl
RefSeq Acc Id: ENSMUST00000201552   ⟹   ENSMUSP00000144354
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl594,770,074 - 94,774,605 (+)Ensembl
GRCm38.p6 Ensembl594,623,979 - 94,626,848 (+)Ensembl
RefSeq Acc Id: NM_001378724   ⟹   NP_001365653
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39594,734,267 - 94,774,707 (+)NCBI
GRCm38594,586,408 - 94,626,848 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001365653 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000144354
  ENSMUSP00000144354.2
Reference Protein Sequences
RefSeq Acc Id: NP_001365653   ⟸   NM_001378724
- UniProtKB: A0A0J9YUV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000095887   ⟸   ENSMUST00000098286
RefSeq Acc Id: ENSMUSP00000144354   ⟸   ENSMUST00000201552

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0J9YUV1-F1-model_v2 AlphaFold A0A0J9YUV1 1-481 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3779602 AgrOrtholog
Ensembl Genes ENSMUSG00000094195 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000201552 ENTREZGENE
  ENSMUST00000201552.3 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  PRAME_family UniProtKB/TrEMBL
MGD MGI:3779602 ENTREZGENE
NCBI Gene Gm6509 ENTREZGENE
PANTHER D5ERTD577E PROTEIN-RELATED UniProtKB/TrEMBL
  SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 UniProtKB/TrEMBL
PhenoGen Pramel44 PhenoGen
PIRSF PRAME UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
UniProt A0A0J9YUV1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-19 Pramel44  PRAME like 44  Gm6509  predicted gene 6509  Symbol and/or name change 5135510 APPROVED
2020-03-12 Gm6509  predicted gene 6509  Gm42117  predicted gene, 42117  Data merged from RGD:10036518 737654 PROVISIONAL