Pramel15 (PRAME like 15) - Rat Genome Database

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Gene: Pramel15 (PRAME like 15) Mus musculus
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Symbol: Pramel15
Name: PRAME like 15
RGD ID: 1620289
MGI Page MGI
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to several human genes including PRAMEF20 (PRAME family member 20).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: EG627009; Gm13125; Prame; PRAME family member 20; Pramef20; predicted gene 13125; RP23-231M4.5
RGD Orthologs
Human
Rat
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394144,099,330 - 144,104,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4144,099,330 - 144,104,530 (-)EnsemblGRCm39 Ensembl
GRCm384144,372,760 - 144,377,933 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4144,372,760 - 144,377,933 (-)EnsemblGRCm38mm10GRCm38
MGSCv374143,962,663 - 143,967,836 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364143,639,447 - 143,644,620 (-)NCBIMGSCv36mm8
MGSCv364141,694,228 - 141,699,541 (-)NCBIMGSCv36mm8
Celera4145,973,855 - 145,979,151 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map477.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21565611   PMID:21677750   PMID:21873635   PMID:27626380   PMID:30973865   PMID:31598710   PMID:38355793   PMID:39181896  


Genomics

Comparative Map Data
Pramel15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394144,099,330 - 144,104,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4144,099,330 - 144,104,530 (-)EnsemblGRCm39 Ensembl
GRCm384144,372,760 - 144,377,933 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4144,372,760 - 144,377,933 (-)EnsemblGRCm38mm10GRCm38
MGSCv374143,962,663 - 143,967,836 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364143,639,447 - 143,644,620 (-)NCBIMGSCv36mm8
MGSCv364141,694,228 - 141,699,541 (-)NCBIMGSCv36mm8
Celera4145,973,855 - 145,979,151 (-)NCBICelera
Cytogenetic Map4E1NCBI
cM Map477.98NCBI
PRAMEF20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38113,410,450 - 13,421,328 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl113,410,450 - 13,421,328 (+)EnsemblGRCh38hg38GRCh38
GRCh37113,736,907 - 13,747,803 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36113,609,494 - 13,620,390 (+)NCBINCBI36Build 36hg18NCBI36
Celera112,219,063 - 12,229,938 (+)NCBICelera
Cytogenetic Map1p36.21NCBI
HuRef112,253,404 - 12,264,251 (+)NCBIHuRef
CHM1_1113,535,692 - 13,546,570 (+)NCBICHM1_1
T2T-CHM13v2.0112,851,719 - 12,862,598 (+)NCBIT2T-CHM13v2.0
Pramef20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85161,454,398 - 161,458,874 (-)NCBIGRCr8
mRatBN7.25156,171,125 - 156,175,601 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5156,171,125 - 156,175,601 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.05162,406,599 - 162,411,066 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5162,406,599 - 162,411,063 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05166,097,294 - 166,101,846 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45162,746,264 - 162,750,628 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5154,474,742 - 154,479,271 (-)NCBICelera
Cytogenetic Map5q36NCBI
PRAMEF20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21213,494,300 - 213,506,635 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,745,084 - 212,760,561 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0112,006,813 - 12,010,964 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1113,553,798 - 13,564,608 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl113,553,798 - 13,564,608 (+)Ensemblpanpan1.1panPan2

Variants

.
Variants in Pramel15
344 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:45
Interacting mature miRNAs:45
Transcripts:ENSMUST00000121109
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001115077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL606926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000121109   ⟹   ENSMUSP00000112488
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4144,099,330 - 144,104,530 (-)Ensembl
GRCm38.p6 Ensembl4144,372,760 - 144,377,933 (-)Ensembl
RefSeq Acc Id: NM_001115077   ⟹   NP_001108549
RefSeq Status: INFERRED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394144,099,330 - 144,104,503 (-)NCBI
GRCm384144,372,760 - 144,377,933 (-)NCBI
Celera4145,973,855 - 145,979,151 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001108549 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000112488
  ENSMUSP00000112488.2
RefSeq Acc Id: NP_001108549   ⟸   NM_001115077
- UniProtKB: B1ARV6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000112488   ⟸   ENSMUST00000121109

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1ARV6-F1-model_v2 AlphaFold B1ARV6 1-477 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3712553 AgrOrtholog
Ensembl Genes ENSMUSG00000073721 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000121109 ENTREZGENE
  ENSMUST00000121109.3 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro L_dom-like UniProtKB/TrEMBL
  PRAME_domain UniProtKB/TrEMBL
  PRAME_family UniProtKB/TrEMBL
KEGG Report mmu:627009 UniProtKB/TrEMBL
MGD MGI:3712553 ENTREZGENE
NCBI Gene 627009 ENTREZGENE
PANTHER MELANOMA ANTIGEN PREFERENTIALLY EXPRESSED IN TUMORS UniProtKB/TrEMBL
  SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3 UniProtKB/TrEMBL
PhenoGen Pramel15 PhenoGen
PIRSF PRAME UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
UniProt B1ARV6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-19 Pramel15  PRAME like 15  Pramef20  PRAME family member 20  Symbol and/or name change 5135510 APPROVED
2017-05-23 Pramef20  PRAME family member 20  Gm13125  predicted gene 13125  Symbol and/or name change 5135510 APPROVED
2014-09-17 Gm13125  predicted gene 13125  EG627009  predicted gene, EG627009  Symbol and/or name change 5135510 APPROVED