GWAS1160518_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1160518_H (left ventricular function, response to anthracycline-based chemotherapy QTL GWAS1160518 (human)) Homo sapiens

Symbol: GWAS1160518_H
Name: left ventricular function, response to anthracycline-based chemotherapy QTL GWAS1160518 (human)
RGD ID: 597064444
Trait: left ventricular function, response to anthracycline-based chemotherapy
Measurement Type: time constant of left ventricular pressure decay   (CMO:0001747)    
LOD Score: Not Available
P Value: 7.0E-7
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38113,866,181 - 13,866,182RGD_MAPPER_PIPELINEGRCh38
GRCh37114,192,676 - 14,192,677RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model




Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1160518_HHumantime constant of left ventricular pressure decay  IAGPrs7542939405850206 GWAS_CATALOGPMID:28542097

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1160518_HHumanleft ventricular function  IAGPrs7542939405850206 GWAS_CATALOGPMID:28542097
GWAS1160518_HHumanresponse to anthracycline-based chemotherapy  IAGPrs7542939405850206 GWAS_CATALOGPMID:28542097

#
Reference Title
Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records



Peak: (rs7542939)
Human AssemblyChrPosition (strand)Source
GRCh38113,866,181 - 13,866,182RGD_MAPPER_PIPELINE


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
597064444GWAS1160518_Hleft ventricular function, response to anthracycline-based chemotherapy QTL GWAS1160518 (human)0.0000007left ventricular function, response to anthracycline-based chemotherapytime constant of left ventricular pressure decay (CMO:0001747)11386618113866182Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human



Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL
GWAS Catalog Study
Disease Trait
Study Size
Risk Allele
Risk Allele Frequency
P Value
P Value MLOG
Peak Marker
Reported Odds Ratio or Beta-coefficient
Ontology Accession
PubMed
GWAS1160518_H GCST004353 Left ventricular function change in anthracycline treatment 337 European ancestry individuals, 30 African American individuals, 1 Asian individual, 4 Latino individuals, 13 individuals A NR 7E-7 6.155 rs7542939 4.97 left ventricular function (EFO:0004295)
response to anthracycline-based chemotherapy (EFO:0005257)
 PMID:28542097
Database
Acc Id
Source(s)
GWAS Catalog GCST004353 GWAS Catalog

Note Type Note Reference