MIR4632 (microRNA 4632) - Rat Genome Database

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Gene: MIR4632 (microRNA 4632) Homo sapiens
Analyze
Symbol: MIR4632
Name: microRNA 4632
RGD ID: 5134041
HGNC Page HGNC:41593
Description: Enables mRNA base-pairing translational repressor activity. Involved in cellular response to platelet-derived growth factor stimulus; miRNA-mediated post-transcriptional gene silencing; and negative regulation of vascular associated smooth muscle cell proliferation. Located in extracellular space.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,191,713 - 12,191,773 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl112,191,713 - 12,191,773 (+)EnsemblGRCh38hg38GRCh38
GRCh37112,251,770 - 12,251,830 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p36.22NCBI
HuRef111,405,016 - 11,405,093 (+)NCBIHuRef
CHM1_1112,239,748 - 12,239,808 (+)NCBICHM1_1
T2T-CHM13v2.0111,735,843 - 11,735,903 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR4632Humanextracellular space located_inIDA 150520179 PMID:28701355BHF-UCLPMID:28701355
MIR4632Humanextracellular vesicle located_inHDA 150520179 PMID:28798470ARUK-UCLPMID:28798470

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
MIR4632HumanmRNA base-pairing translational repressor activity enablesIDA 150520179 PMID:28701355BHF-UCLPMID:28701355


#
Reference Title
Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
PMID:16381832   PMID:21199797   PMID:28701355   PMID:28798470   PMID:34157350  



.

1 to 10 of 27 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_001066.2(TNFRSF1B):c.720C>T (p.Ser240=) single nucleotide variant Malignant melanoma [RCV000064056] Chr1:12193031 [GRCh38]
Chr1:12253088 [GRCh37]
Chr1:12175675 [NCBI36]
Chr1:1p36.22		 not provided
GRCh38/hg38 1p36.23-36.21(chr1:9064492-12666744)x1 copy number loss See cases [RCV000133779] Chr1:9064492..12666744 [GRCh38]
Chr1:9124551..12726755 [GRCh37]
Chr1:9047138..12649342 [NCBI36]
Chr1:1p36.23-36.21		 pathogenic
GRCh38/hg38 1p36.23-36.22(chr1:8283694-12470133)x1 copy number loss See cases [RCV000135807] Chr1:8283694..12470133 [GRCh38]
Chr1:8343754..12530188 [GRCh37]
Chr1:8266341..12452775 [NCBI36]
Chr1:1p36.23-36.22		 pathogenic
GRCh38/hg38 1p36.33-36.22(chr1:844347-12470133)x1 copy number loss See cases [RCV000136695] Chr1:844347..12470133 [GRCh38]
Chr1:779727..12530188 [GRCh37]
Chr1:769590..12452775 [NCBI36]
Chr1:1p36.33-36.22		 pathogenic|likely pathogenic
GRCh38/hg38 1p36.32-36.21(chr1:4898439-12911913)x1 copy number loss See cases [RCV000137461] Chr1:4898439..12911913 [GRCh38]
Chr1:4958499..12971757 [GRCh37]
Chr1:4858359..12894344 [NCBI36]
Chr1:1p36.32-36.21		 pathogenic
GRCh38/hg38 1p36.31-36.21(chr1:6303641-15799093)x1 copy number loss See cases [RCV000137948] Chr1:6303641..15799093 [GRCh38]
Chr1:6363701..16125588 [GRCh37]
Chr1:6286288..15998175 [NCBI36]
Chr1:1p36.31-36.21		 pathogenic|likely benign
GRCh38/hg38 1p36.22-36.21(chr1:9428538-15815791)x1 copy number loss See cases [RCV000140873] Chr1:9428538..15815791 [GRCh38]
Chr1:9488597..16142286 [GRCh37]
Chr1:9411184..16014873 [NCBI36]
Chr1:1p36.22-36.21		 pathogenic
GRCh38/hg38 1p36.22-36.21(chr1:11021751-15236671)x3 copy number gain See cases [RCV000141823] Chr1:11021751..15236671 [GRCh38]
Chr1:11081808..15563167 [GRCh37]
Chr1:11004395..15435754 [NCBI36]
Chr1:1p36.22-36.21		 likely pathogenic
GRCh38/hg38 1p36.22-36.21(chr1:10264397-15780840)x1 copy number loss See cases [RCV000141438] Chr1:10264397..15780840 [GRCh38]
Chr1:10324455..16107335 [GRCh37]
Chr1:10247042..15979922 [NCBI36]
Chr1:1p36.22-36.21		 pathogenic
GRCh38/hg38 1p36.31-36.13(chr1:6554885-16056011)x3 copy number gain See cases [RCV000142906] Chr1:6554885..16056011 [GRCh38]
Chr1:6614945..16382506 [GRCh37]
Chr1:6537532..16255093 [NCBI36]
Chr1:1p36.31-36.13		 pathogenic
1 to 10 of 27 rows

Predicted Targets
Summary Value
Count of predictions:87708
Count of gene targets:22482
Count of transcripts:61178
Interacting mature miRNAs:hsa-miR-4632-3p, hsa-miR-4632-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
16 56 29 49 101 61 94 36 202 33 29 352 291 5 90 30 50 55 4



Ensembl Acc Id: ENST00000584158
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl112,191,713 - 12,191,773 (+)Ensembl
RefSeq Acc Id: NR_039775
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38112,191,713 - 12,191,773 (+)NCBI
GRCh37112,251,762 - 12,251,839 (+)ENTREZGENE
HuRef111,405,024 - 11,405,084 (+)NCBI
CHM1_1112,239,748 - 12,239,808 (+)NCBI
T2T-CHM13v2.0111,735,843 - 11,735,903 (+)NCBI
Sequence:


1 to 11 of 11 rows
Database
Acc Id
Source(s)
COSMIC MIR4632 COSMIC
Ensembl Genes ENSG00000263676 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000584158 ENTREZGENE
GTEx ENSG00000263676 GTEx
HGNC ID HGNC:41593 ENTREZGENE
Human Proteome Map MIR4632 Human Proteome Map
miRBase MI0017259 ENTREZGENE
NCBI Gene 100616438 ENTREZGENE
RNAcentral URS0000759A2A RNACentral
  URS000075A071 RNACentral
  URS000075A2F8 RNACentral
1 to 11 of 11 rows