LOC127267729 (H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17201146-17201709) - Rat Genome Database

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Gene: LOC127267729 (H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17201146-17201709) Homo sapiens
Analyze
Symbol: LOC127267729
Name: H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:17201146-17201709
RGD ID: 155636979
Description: This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. An accessible chromatin subregion was used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. That subregion was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Jun 2023]
Type: biological-region
RefSeq Status: REVIEWED
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,874,651 - 16,875,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37117,201,146 - 17,201,709 (+)NCBIGRCh37GRCh37hg19GRCh37
T2T-CHM13v2.0116,685,079 - 16,685,642 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30033119   PMID:32094911  


Genomics


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human


Expression

RNA-SEQ Expression


Sequence



Additional Information

Database Acc Id Source(s)
COSMIC LOC127267729 COSMIC
GTEx LOC127267729 GTEx
Human Proteome Map LOC127267729 Human Proteome Map
NCBI Gene LOC127267729 ENTREZGENE