GWAS1574080_H QTL Report (Homo sapiens) - Rat Genome Database

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QTL Registration

QTL: GWAS1574080_H (serum alanine aminotransferase measurement QTL GWAS1574080 (human)) Homo sapiens

Symbol: GWAS1574080_H
Name: serum alanine aminotransferase measurement QTL GWAS1574080 (human)
RGD ID: 597478006
Trait: serum alanine aminotransferase measurement
Measurement Type: serum alanine aminotransferase activity level   (CMO:0000575)    
LOD Score: Not Available
P Value: 5.0E-9
Variance: Not Available
Position
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh38116,184,399 - 16,184,400RGD_MAPPER_PIPELINEGRCh38
GRCh37116,510,894 - 16,510,895RGD_MAPPER_PIPELINEGRCh37
Population Stats: Not Available
JBrowse: View Region in Genome Browser (JBrowse)
Model




Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1574080_HHumanserum alanine aminotransferase activity level  IAGPrs36086195405850206 GWAS_CATALOGPMID:33339817

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GWAS1574080_HHumanserum alanine aminotransferase measurement  IAGPrs36086195405850206 GWAS_CATALOGPMID:33339817

#
Reference Title
Reference Citation
1. RGD GWAS Catalog Import Pipeline RGD pipeline to import data from GWAS Catalog and create human variant and QTL records


The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
155632683LOC127267658H3K4me1 hESC enhancer GRCh37_chr1:16510785-1651128611618429016184791Human


Peak: (rs36086195)
Human AssemblyChrPosition (strand)Source
GRCh38116,184,399 - 16,184,400RGD_MAPPER_PIPELINE


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
597597727GWAS1654587_Hserum alanine aminotransferase measurement QTL GWAS1654587 (human)2e-13serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11618439916184400Human
597441817GWAS1537891_Hserum alanine aminotransferase measurement QTL GWAS1537891 (human)5e-10serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11618439916184400Human
597477652GWAS1573726_Hserum gamma-glutamyl transferase measurement QTL GWAS1573726 (human)7e-44serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)11618439916184400Human
597404307GWAS1500381_Haspartate aminotransferase measurement QTL GWAS1500381 (human)1e-39aspartate aminotransferase measurementblood aspartate aminotransferase activity level (CMO:0000580)11618439916184400Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
597598034GWAS1654894_Haspartate aminotransferase to alanine aminotransferase ratio QTL GWAS1654894 (human)6e-16aspartate aminotransferase to alanine aminotransferase ratioserum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio (CMO:0002245)11618439916184400Human
597599120GWAS1655980_Hserum alanine aminotransferase measurement QTL GWAS1655980 (human)2e-16serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)11618439916184400Human
597433164GWAS1529238_Hsex hormone-binding globulin measurement QTL GWAS1529238 (human)5e-44sex hormone-binding globulin measurement11618439916184400Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human

1 to 10 of 26 rows


1 to 20 of 21 rows
Data has come from the GWAS Catalog   
The highlighted row represents the current QTL
QTL
GWAS Catalog Study
Disease Trait
Study Size
Risk Allele
Risk Allele Frequency
P Value
P Value MLOG
Peak Marker
Reported Odds Ratio or Beta-coefficient
Ontology Accession
PubMed
GWAS1574080_H GCST011352 Alanine aminotransferase levels 76,081 European ancestry individuals, 127,395 Japanese ancestry individuals ? NR 5E-9 8.302 rs36086195 0.0246 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:33339817
GWAS1654587_H GCST90479506 Alanine transaminase (ALT, maximum, inv-norm transformed) 115,123 African American or Afro-Caribbean individuals, 56,102 Hispanic or Latin American individuals, 6,054 East Asian ancestry individuals, 406,783 European ancestry individuals C 0.5262 2E-13 12.699 rs36086195 0.01861 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:39024449
GWAS1654791_H GCST90479511 Aspartate aminotransferase (AST, minimum, inv-norm transformed) 112,345 African American or Afro-Caribbean individuals, 54,221 Hispanic or Latin American individuals, 5,834 East Asian ancestry individuals, 389,315 European ancestry individuals C 0.5278 1E-15 15 rs36086195 0.02259 aspartate aminotransferase to alanine aminotransferase ratio (EFO:0010934)
 PMID:39024449
GWAS1654894_H GCST90479510 Aspartate aminotransferase (AST, mean, inv-norm transformed) 112,429 African American or Afro-Caribbean individuals, 54,250 Hispanic or Latin American individuals, 5,835 East Asian ancestry individuals, 389,192 European ancestry individuals C 0.5278 6E-16 15.222 rs36086195 0.02284 aspartate aminotransferase to alanine aminotransferase ratio (EFO:0010934)
 PMID:39024449
GWAS1655980_H GCST90479507 Alanine transaminase (ALT, mean, inv-norm transformed) 115,128 African American or Afro-Caribbean individuals, 56,001 Hispanic or Latin American individuals, 6,050 East Asian ancestry individuals, 406,803 European ancestry individuals C 0.5262 2E-16 15.699 rs36086195 0.0213 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:39024449
GWAS1491405_H GCST90239667 Non-HDL cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 5E-19 18.302 rs36086195 N/A non-high density lipoprotein cholesterol measurement (EFO:0005689)
 PMID:34887591
GWAS1494449_H GCST90239673 Total cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 3E-24 23.523 rs36086195 N/A total cholesterol measurement (EFO:0004574)
 PMID:34887591
GWAS1500381_H GCST90011899 Aspartate aminotransferase levels 389,565 European ancestry individuals T 0.58 1E-39 39 rs36086195 13.2 aspartate aminotransferase measurement (EFO:0004736)
 PMID:33547301
GWAS1525486_H GCST90012111 Sex hormone-binding globulin levels 370,125 European ancestry individuals T 0.580121 1E-35 35 rs36086195 0.0116575 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS1529238_H GCST90012109 Sex hormone-binding globulin levels 180,726 European ancestry men T 0.579078 5E-44 43.302 rs36086195 0.0167429 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS1529272_H GCST90012108 Sex hormone-binding globulin levels adjusted for BMI 180,094 European ancestry men T 0.579078 2E-52 51.699 rs36086195 0.017046 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS1529980_H GCST90012110 Sex hormone-binding globulin levels adjusted for BMI 368,929 European ancestry individuals T 0.580121 3E-43 42.523 rs36086195 0.0113699 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:32042192
GWAS1530030_H GCST90012113 Total testosterone levels 194,453 European ancestry men T 0.579073 2E-9 8.699 rs36086195 0.0188837 testosterone measurement (EFO:0004908)
 PMID:32042192
GWAS1537891_H GCST90129601 Chronic elevation of alanine aminotransferase (cALT) levels 95,472 European ancestry cases, 68,725 European ancestry controls, 23,977 African American cases, 13,387 African American controls, 7,650 Hispanic cases, 7,468 Hispanic controls, 1,088 Asian ancestry cases, 828 Asian ancestry controls C 0.475 5E-10 9.302 rs36086195 0.043 serum alanine aminotransferase measurement (EFO:0004735)
 PMID:35654975
GWAS1562414_H GCST006019 Gamma glutamyl transferase levels 118,309 Japanese ancestry individuals ? NR 1E-36 36 rs36086195 0.06774 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:29403010
GWAS1570221_H GCST012398 Calcium levels 305,349 European ancestry individuals T 0.5791 1E-15 15 rs36086195 0.001839 calcium measurement (EFO:0004838)
 PMID:33887147
GWAS1573726_H GCST011349 Gamma glutamyl transferase levels 76,081 European ancestry individuals, 127,395 Japanese ancestry individuals ? NR 7E-44 43.155 rs36086195 0.0682 serum gamma-glutamyl transferase measurement (EFO:0004532)
 PMID:33339817
GWAS1587204_H GCST90027091 Sex hormone-binding globulin levels 148,248 British ancestry men T 0.58 5E-17 16.302 rs36086195 0.66 sex hormone-binding globulin measurement (EFO:0004696)
 PMID:34321204
GWAS1592280_H GCST90239655 Low density lipoprotein cholesterol levels 40,963 South Asian ancestry individuals, 48,057 Hispanic individuals, 99,432 Admixed African or African ancestry individuals, 146,492 East Asian ancestry individuals, 1,320,016 European ancestry individuals ? NR 2E-22 21.699 rs36086195 N/A low density lipoprotein cholesterol measurement (EFO:0004611)
 PMID:34887591
GWAS1611122_H GCST90239819 Total testosterone levels 176,212 British ancestry men ? NR 1E-11 11 rs36086195 0.0219218 testosterone measurement (EFO:0004908)
 PMID:36653534
1 to 20 of 21 rows
Database
Acc Id
Source(s)
GWAS Catalog GCST011352 GWAS Catalog

Note Type Note Reference