MTOR (mechanistic target of rapamycin kinase) - Rat Genome Database

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Gene: MTOR (mechanistic target of rapamycin kinase) Homo sapiens
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Symbol: MTOR
Name: mechanistic target of rapamycin kinase
RGD ID: 68533
HGNC Page HGNC
Description: Enables several functions, including RNA polymerase III cis-regulatory region sequence-specific DNA binding activity; TFIIIC-class transcription factor complex binding activity; and identical protein binding activity. Involved in several processes, including cellular response to leucine; positive regulation of biosynthetic process; and positive regulation of cell migration. Acts upstream of or within negative regulation of macroautophagy and protein autophosphorylation. Located in endomembrane system; lysosomal membrane; and phagocytic vesicle. Part of TORC1 complex; TORC2 complex; and nuclear envelope. Implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Biomarker of congestive heart failure; high grade glioma; interstitial cystitis; and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein 1; FLJ44809; FRAP; FRAP1; FRAP2; mammalian target of rapamycin; mechanistic target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); RAFT1; rapamycin and FKBP12 target 1; rapamycin associated protein FRAP2; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR; SKS
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 treatment.
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl111,106,535 - 11,262,551 (-)EnsemblGRCh38hg38GRCh38
GRCh38111,106,535 - 11,273,497 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,166,592 - 11,322,608 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,089,179 - 11,245,153 (-)NCBINCBI36hg18NCBI36
Build 34111,100,857 - 11,256,830NCBI
Celera110,278,903 - 10,434,848 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef110,317,883 - 10,473,910 (-)NCBIHuRef
CHM1_1111,154,542 - 11,310,885 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adenocarcinoma  (EXP)
AIDS-Associated Nephropathy  (IMP,ISO)
autosomal dominant polycystic kidney disease  (IMP)
autosomal recessive polycystic kidney disease  (ISO)
Breast Neoplasms  (EXP,IAGP)
Burns  (ISO)
Cardiomegaly  (ISO)
CEBALID Syndrome  (IAGP)
Cerebral Hemorrhage  (ISO)
chondrosarcoma  (ISO)
Chronic Allograft Dysfunction  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (EXP)
Colorectal Neoplasms  (IAGP)
complex cortical dysplasia with other brain malformations  (EXP)
congestive heart failure  (IEP)
crescentic glomerulonephritis  (ISO)
Diabetes Mellitus, New-Onset after Transplantation  (IMP)
Diabetic Nephropathies  (IAGP,ISO)
Drug-Induced Dyskinesia  (ISO)
end stage renal disease  (ISO)
endocrine system disease  (EXP)
epilepsy  (IAGP)
exocrine pancreatic insufficiency  (EXP)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Familial Atrial Fibrillation 6  (IAGP)
Focal Cortical Dysplasia of Taylor  (IAGP)
gastric adenocarcinoma  (IAGP)
genetic disease  (IAGP)
glioblastoma  (EXP,IAGP)
Hemimegalencephaly  (IAGP)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (EXP)
Hepatomegaly  (EXP)
high grade glioma  (IEP)
Hyperalgesia  (ISO)
hypertension  (EXP,ISO)
Hypertriglyceridemia  (ISO)
idiopathic interstitial pneumonia  (IMP)
Inflammation  (ISO)
intellectual disability  (IAGP)
interstitial cystitis  (IEP)
kidney angiomyolipoma  (IMP)
Left Ventricular Hypertrophy  (EXP,ISO)
Lung Injury  (IMP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (EXP)
lung small cell carcinoma  (IAGP)
lupus nephritis  (ISO)
Lymphatic Metastasis  (EXP)
Macrocephaly  (IAGP)
Mammary Neoplasms, Experimental  (ISO)
mantle cell lymphoma  (EXP)
melanoma  (IAGP)
Mesothelioma  (EXP)
middle cerebral artery infarction  (ISO)
muscular atrophy  (ISO)
Muscular Dystrophy, Animal  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
obesity  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (EXP)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
papillary renal cell carcinoma  (IAGP)
Parkinsonism  (ISO)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
prostate cancer  (IDA)
Prostatic Neoplasms  (EXP)
pulmonary fibrosis  (EXP)
pulmonary hypertension  (ISO)
renal carcinoma  (IAGP)
renal cell carcinoma  (EXP,IAGP,IEP)
Renal Cell Carcinoma 1  (IAGP)
Retinal Neovascularization  (ISO)
Right Ventricular Hypertrophy  (ISO)
schizophrenia  (EXP,ISO)
Schnyder corneal dystrophy  (IAGP)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
skin melanoma  (IAGP)
small cell carcinoma  (EXP)
Smith-Kingsmore Syndrome  (IAGP)
Spinal Cord Injuries  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (IAGP)
status epilepticus  (ISO)
T-cell acute lymphoblastic leukemia  (EXP)
temporal lobe epilepsy  (ISO)
Temporomandibular Joint Disorders  (ISO)
toxic encephalopathy  (EXP)
transitional cell carcinoma  (IAGP)
type 2 diabetes mellitus  (IAGP,ISO)
ureteral obstruction  (ISO)
urinary bladder cancer  (ISO)
uterine cancer  (IAGP)
Uterine Cervical Neoplasms  (EXP,IAGP)
vascular dementia  (ISO)
visual epilepsy  (IAGP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-Tetrandrine  (EXP)
(-)-Arctigenin  (EXP)
(20S)-ginsenoside Rh2  (EXP)
(S)-nicotine  (EXP,ISO)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1,4-phenylenediamine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-chloroethanol  (ISO)
2-deoxy-D-glucose  (EXP)
20-hydroxyecdysone  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3-bromopyruvic acid  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4-hydroxynon-2-enal  (EXP)
4-nonylphenol  (ISO)
4-phenylbutyric acid  (EXP)
5'-S-methyl-5'-thioadenosine  (EXP)
5,6alpha-epoxy-5alpha-cholestan-3beta-ol  (ISO)
5-fluorouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (EXP,ISO)
acetaldehyde  (EXP)
acetylsalicylic acid  (EXP)
afimoxifene  (EXP)
AICA ribonucleotide  (EXP,ISO)
Ajugasterone C  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alpha-naphthoflavone  (EXP)
alternariol  (ISO)
amino acid  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
androst-4-ene-3,17-dione  (EXP)
antroquinonol  (EXP)
arachidonic acid  (EXP)
arecoline  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
Asiaticoside  (ISO)
astragaloside IV  (ISO)
atrazine  (ISO)
aucubin  (EXP)
Auriculasin  (EXP)
azathioprine  (EXP)
bafilomycin A1  (ISO)
baicalein  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-thujaplicin  (ISO)
betalain  (EXP)
betulin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
calix[6]arene  (EXP)
camptothecin  (EXP)
cannabidiol  (EXP)
capsaicin  (EXP)
carbon disulfide  (ISO)
carbon nanotube  (ISO)
carnosic acid  (EXP)
celastrol  (ISO)
cepharanthine  (EXP)
chicoric acid  (ISO)
chloroethene  (ISO)
chloroquine  (EXP,ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium(6+)  (EXP,ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
corticosterone  (ISO)
Corynoxine B  (EXP)
creatine  (ISO)
cucurbitacin E  (EXP,ISO)
curcumin  (EXP,ISO)
Curcumol  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
Dictamnine  (EXP)
dieckol  (EXP)
dieldrin  (EXP)
Dihydrotanshinone I  (EXP)
dimercaprol  (EXP)
dioscin  (EXP)
dioxygen  (EXP,ISO)
dodecanoic acid  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
erlotinib hydrochloride  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (EXP)
everolimus  (EXP,ISO)
fenvalerate  (ISO)
fingolimod hydrochloride  (EXP)
flavanones  (EXP)
flavokawain B  (EXP)
fluoxetine  (ISO)
fulvestrant  (EXP)
Fusaric acid  (ISO)
galangin  (EXP)
gefitinib  (EXP)
geraniol  (EXP)
gingerol  (EXP)
ginsenoside Rg1  (EXP,ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
gossypetin  (EXP)
graphene oxide  (EXP,ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
HU-308  (ISO)
hydrogen peroxide  (EXP,ISO)
icariin  (ISO)
icariside II  (EXP)
isoprenaline  (ISO)
ivermectin  (EXP)
kahweol  (EXP)
L-ascorbic acid 2-phosphate  (EXP)
lapatinib  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
letrozole  (EXP)
linsidomine  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
Lupiwighteone  (EXP)
LY294002  (EXP,ISO)
magnesium atom  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP)
mesalamine  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methyl caffeate  (EXP)
methylisothiazolinone  (EXP)
methyllycaconitine  (EXP)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
MK-2206  (EXP,ISO)
morin  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (ISO)
naringin  (ISO)
navitoclax  (EXP)
Neferine  (ISO)
niclosamide  (EXP)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitric oxide  (ISO)
nobiletin  (ISO)
Nonylphenol  (ISO)
ochratoxin A  (EXP)
oleanolic acid  (EXP)
oligopeptide  (EXP)
omacetaxine mepesuccinate  (EXP)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
p-cresol  (EXP)
paclitaxel  (EXP)
paeoniflorin  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (EXP)
PD 0325901  (ISO)
Pentoxifylline  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
perhexiline  (EXP)
perifosine  (ISO)
phenylarsine oxide  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidic acid  (EXP,ISO)
piclamilast  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
platycodin D  (EXP)
pravastatin  (EXP)
progesterone  (EXP,ISO)
promethazine  (EXP)
prostaglandin E2  (ISO)
puerarin  (EXP,ISO)
quercetin  (EXP,ISO)
radon atom  (EXP,ISO)
radon(0)  (EXP,ISO)
reactive oxygen species  (EXP)
Rebamipide  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (EXP)
ridaforolimus  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP)
Salidroside  (ISO)
sarpogrelate  (EXP)
SB 203580  (ISO)
SB 431542  (EXP)
selenium atom  (ISO)
serotonin  (EXP)
serpentine asbestos  (EXP)
Shikonin  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sonidegib  (ISO)
sorafenib  (EXP)
steviol  (ISO)
stevioside  (ISO)
stilbenoid  (EXP)
streptozocin  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
temozolomide  (EXP,ISO)
Temsirolimus  (EXP,ISO)
testosterone  (ISO)
tetrahydropalmatine  (EXP)
tetramethylpyrazine  (ISO)
theobromine  (ISO)
thioacetamide  (ISO)
Thiorphan  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP,ISO)
torin 1  (EXP)
trabectedin  (EXP)
trans-piceid  (EXP)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
trifluoperazine  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
ursolic acid  (EXP)
usnic acid  (EXP)
vancomycin  (ISO)
vorinostat  (EXP)
wortmannin  (EXP)
XL765  (ISO)
Y-27632  (EXP)
Yessotoxin  (EXP)
zearalenone  (ISO)
zidovudine  (ISO)
zinc oxide  (ISO)
zinc pyrithione  (EXP)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
'de novo' pyrimidine nucleobase biosynthetic process  (IEA)
activation of protein kinase B activity  (TAS)
anoikis  (NAS)
behavioral response to pain  (IEA)
brain development  (ISO)
cardiac cell development  (IEA)
cardiac muscle cell development  (IEA,ISO)
cardiac muscle contraction  (IEA,ISO)
cardiac muscle tissue development  (IEA,ISO)
cell aging  (ISO)
cell projection organization  (IEA,ISO)
cellular response to amino acid starvation  (IDA)
cellular response to amino acid stimulus  (IDA)
cellular response to hypoxia  (IEA,ISS)
cellular response to leucine  (IDA)
cellular response to leucine starvation  (IDA)
cellular response to nutrient levels  (IEA,ISS)
cellular response to starvation  (IDA)
energy reserve metabolic process  (IEA,ISO)
germ cell development  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
heart valve morphogenesis  (IEA,ISO)
inflammatory response  (IEA)
long-term memory  (ISO)
lysosome organization  (IDA)
maternal process involved in female pregnancy  (ISO)
mRNA stabilization  (ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of autophagy  (IDA,IEA,IMP,ISO,ISS)
negative regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
negative regulation of cell size  (IEA,ISO)
negative regulation of cholangiocyte apoptotic process  (ISO)
negative regulation of iodide transmembrane transport  (ISO)
negative regulation of macroautophagy  (IBA,IDA,IEA)
negative regulation of muscle atrophy  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
neuronal action potential  (IEA)
nucleus localization  (IDA)
peptidyl-serine phosphorylation  (IDA,IEA,IMP,ISO,ISS)
peptidyl-threonine phosphorylation  (IEA,ISO)
phosphorylation  (IDA,IEA)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of cell death  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (ISO)
positive regulation of cellular protein metabolic process  (IEA)
positive regulation of cholangiocyte proliferation  (ISO)
positive regulation of cytoplasmic translational initiation  (TAS)
positive regulation of dendritic spine development  (ISO)
positive regulation of eating behavior  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of glial cell proliferation  (ISO)
positive regulation of granulosa cell proliferation  (ISO)
positive regulation of keratinocyte migration  (IMP)
positive regulation of lamellipodium assembly  (IEA,ISO)
positive regulation of lipid biosynthetic process  (IMP)
positive regulation of myotube differentiation  (IEA,ISO)
positive regulation of neurogenesis  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron maturation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oligodendrocyte differentiation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of phosphoprotein phosphatase activity  (TAS)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (IEA,ISO)
positive regulation of sensory perception of pain  (ISO)
positive regulation of skeletal muscle hypertrophy  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of transcription by RNA polymerase III  (IMP)
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I  (IMP)
positive regulation of translation  (IDA,ISO)
positive regulation of wound healing, spreading of epidermal cells  (IMP)
post-embryonic development  (IEA,ISO)
primary metabolic process  (IEA)
protein autophosphorylation  (IDA,ISO)
protein catabolic process  (TAS)
protein phosphorylation  (IDA,IEA,IMP,ISO)
regulation of actin cytoskeleton organization  (IMP)
regulation of autophagy  (IEA)
regulation of brown fat cell differentiation  (ISO)
regulation of carbohydrate metabolic process  (ISO)
regulation of carbohydrate utilization  (ISO)
regulation of cell growth  (IDA)
regulation of cell size  (IMP)
regulation of cellular macromolecule biosynthetic process  (IEA)
regulation of cellular response to heat  (TAS)
regulation of cellular response to stress  (IEA)
regulation of circadian rhythm  (IEA,ISS)
regulation of fatty acid beta-oxidation  (ISO)
regulation of glycogen biosynthetic process  (ISO)
regulation of GTPase activity  (IEA,ISO)
regulation of locomotor rhythm  (IEA,ISS)
regulation of macroautophagy  (TAS)
regulation of membrane permeability  (IEA,ISO)
regulation of myelination  (IEA,ISO)
regulation of osteoclast differentiation  (IEA,ISS)
regulation of protein kinase activity  (IEA,ISO)
regulation of protein kinase B signaling  (IEA,ISO)
regulation of protein phosphorylation  (IEA,ISO)
regulation of response to food  (ISO)
regulation of signal transduction by p53 class mediator  (TAS)
regulation of translation at synapse, modulating synaptic transmission  (ISO)
response to activity  (ISO)
response to amino acid  (IDA,IEA,ISO)
response to cocaine  (ISO)
response to heat  (IEA)
response to insulin  (IEA,ISO)
response to morphine  (ISO)
response to nutrient  (IMP)
response to nutrient levels  (IDA)
rhythmic process  (IEA)
ruffle organization  (IEA,ISO)
social behavior  (ISO)
spinal cord development  (ISO)
T-helper 1 cell lineage commitment  (IEA)
TOR signaling  (IEA,IMP,NAS)
TORC1 signaling  (IBA,IDA,IMP)
visual learning  (ISO)
voluntary musculoskeletal movement  (IEA,ISO)
wound healing  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal corpus callosum morphology  (IAGP)
Abnormal facial shape  (IAGP)
Adult onset  (IAGP)
Allergy  (IAGP)
Asthma  (IAGP)
Astrocytosis  (IAGP)
Autistic behavior  (IAGP)
Autosomal dominant inheritance  (IAGP)
Cafe-au-lait spot  (IAGP)
Capillary malformation  (IAGP)
Cognitive impairment  (IAGP)
Cortical dysplasia  (IAGP)
Cryptorchidism  (IAGP)
Curly hair  (IAGP)
Cutaneous melanoma  (IAGP)
Decreased circulating IgA level  (IAGP)
Deep palmar crease  (IAGP)
Deep plantar creases  (IAGP)
Depressed nasal bridge  (IAGP)
Diastasis recti  (IAGP)
Downslanted palpebral fissures  (IAGP)
Feeding difficulties  (IAGP)
Focal cortical dysplasia type II  (IAGP)
Focal impaired awareness seizure  (IAGP)
Focal white matter lesions  (IAGP)
Focal-onset seizure  (IAGP)
Frontal bossing  (IAGP)
Gait disturbance  (IAGP)
Generalized hypotonia  (IAGP)
Generalized-onset seizure  (IAGP)
Glioblastoma multiforme  (IAGP)
Global developmental delay  (IAGP)
Hemangioma  (IAGP)
Hemimegalencephaly  (IAGP)
Hemiparesis  (IAGP)
High forehead  (IAGP)
Hyperactivity  (IAGP)
Hypertelorism  (IAGP)
Hypoglycemia  (IAGP)
Hypopigmented skin patches  (IAGP)
Hypospadias  (IAGP)
Hypotonia  (IAGP)
Infantile onset  (IAGP)
Intellectual disability  (IAGP)
Intellectual disability, severe  (IAGP)
Intestinal polyp  (IAGP)
Lactose intolerance  (IAGP)
Large for gestational age  (IAGP)
Long philtrum  (IAGP)
Macrocephaly  (IAGP)
Megalencephaly  (IAGP)
Midface retrusion  (IAGP)
Neonatal hypoglycemia  (IAGP)
Neoplasm of the breast  (IAGP)
Neoplasm of the large intestine  (IAGP)
Neurological speech impairment  (IAGP)
Open mouth  (IAGP)
Perisylvian polymicrogyria  (IAGP)
Pes planus  (IAGP)
Polymicrogyria  (IAGP)
Prominent forehead  (IAGP)
Protuberant abdomen  (IAGP)
Rhizomelia  (IAGP)
Seizure  (IAGP)
Short chin  (IAGP)
Short distal phalanx of finger  (IAGP)
Short nose  (IAGP)
Short proximal phalanx of finger  (IAGP)
Smooth philtrum  (IAGP)
Somatic mutation  (IAGP)
Specific learning disability  (IAGP)
Sporadic  (IAGP)
Strabismus  (IAGP)
Thin upper lip vermilion  (IAGP)
Thoracic hypoplasia  (IAGP)
Thrombocytopenia  (IAGP)
Transitional cell carcinoma of the bladder  (IAGP)
Umbilical hernia  (IAGP)
Ventriculomegaly  (IAGP)
Wide anterior fontanel  (IAGP)
Wide mouth  (IAGP)
References

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