PLA2G2D (phospholipase A2 group IID) - Rat Genome Database

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Gene: PLA2G2D (phospholipase A2 group IID) Homo sapiens
Analyze
Symbol: PLA2G2D
Name: phospholipase A2 group IID
RGD ID: 1320432
HGNC Page HGNC:9033
Description: Enables calcium-dependent phospholipase A2 activity. Involved in phosphatidylcholine metabolic process. Predicted to be located in extracellular region.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GIID sPLA2; group IID secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2D; phospholipase A2, group IID; PLA2IID; secretory phospholipase A2s; secretory-type PLA, stroma-associated homolog; sPLA2-IID; sPLA2S; SPLASH
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38120,111,939 - 20,119,536 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl120,111,939 - 20,119,566 (-)EnsemblGRCh38hg38GRCh38
GRCh37120,438,432 - 20,446,029 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,311,019 - 20,318,595 (-)NCBINCBI36Build 36hg18NCBI36
Build 34120,183,741 - 20,191,314NCBI
Celera118,761,553 - 18,769,129 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef118,684,974 - 18,691,890 (-)NCBIHuRef
CHM1_1120,548,848 - 20,555,764 (-)NCBICHM1_1
T2T-CHM13v2.0119,935,588 - 19,943,185 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9377118   PMID:9745929   PMID:10455175   PMID:10681567   PMID:11076863   PMID:12396716   PMID:12477932   PMID:12895207   PMID:12975309   PMID:15052324   PMID:15379211   PMID:15489334  
PMID:15489336   PMID:16002569   PMID:16188494   PMID:16381901   PMID:16710414   PMID:16897354   PMID:18405237   PMID:18958346   PMID:19365107   PMID:20056178   PMID:20237496   PMID:21873635  
PMID:22240557   PMID:22490726   PMID:23251661   PMID:23533611   PMID:24561123   PMID:26392224   PMID:33961781  


Genomics

Comparative Map Data
PLA2G2D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38120,111,939 - 20,119,536 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl120,111,939 - 20,119,566 (-)EnsemblGRCh38hg38GRCh38
GRCh37120,438,432 - 20,446,029 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36120,311,019 - 20,318,595 (-)NCBINCBI36Build 36hg18NCBI36
Build 34120,183,741 - 20,191,314NCBI
Celera118,761,553 - 18,769,129 (-)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef118,684,974 - 18,691,890 (-)NCBIHuRef
CHM1_1120,548,848 - 20,555,764 (-)NCBICHM1_1
T2T-CHM13v2.0119,935,588 - 19,943,185 (-)NCBIT2T-CHM13v2.0
Pla2g2d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394138,503,046 - 138,509,363 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4138,503,046 - 138,509,357 (+)EnsemblGRCm39 Ensembl
GRCm384138,775,735 - 138,782,052 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4138,775,735 - 138,782,046 (+)EnsemblGRCm38mm10GRCm38
MGSCv374138,331,650 - 138,338,058 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364138,047,811 - 138,054,219 (+)NCBIMGSCv36mm8
Celera4140,558,983 - 140,565,391 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.57NCBI
Pla2g2d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85156,299,374 - 156,305,816 (+)NCBIGRCr8
mRatBN7.25151,016,010 - 151,022,531 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5151,018,870 - 151,022,525 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5153,714,211 - 153,720,401 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05155,488,513 - 155,494,703 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05155,469,996 - 155,476,182 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05157,222,636 - 157,228,795 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5157,222,636 - 157,228,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05160,962,324 - 160,970,156 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45157,594,706 - 157,600,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15157,604,744 - 157,610,900 (+)NCBI
Celera5149,404,051 - 149,410,210 (+)NCBICelera
Cytogenetic Map5q36NCBI
Pla2g2d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955452736,600 - 743,806 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955452738,133 - 743,718 (-)NCBIChiLan1.0ChiLan1.0
PLA2G2D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21206,999,131 - 207,007,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11206,115,929 - 206,123,950 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0119,066,890 - 19,074,711 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1120,110,664 - 20,117,583 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl120,110,323 - 20,117,618 (-)Ensemblpanpan1.1panPan2
PLA2G2D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1278,739,826 - 78,745,839 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl278,739,769 - 78,745,920 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha275,253,368 - 75,260,612 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0279,305,947 - 79,313,189 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl279,305,982 - 79,313,914 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1276,125,252 - 76,132,491 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0277,131,831 - 77,139,073 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,202,771 - 78,210,014 (+)NCBIUU_Cfam_GSD_1.0
Pla2g2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505840,342,725 - 40,347,968 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364746,167,507 - 6,172,750 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364746,167,507 - 6,172,750 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G2D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl678,391,066 - 78,397,515 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1678,391,063 - 78,397,394 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2672,580,441 - 72,587,047 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G2D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120112,434,208 - 112,441,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20112,434,276 - 112,441,249 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660333,743,003 - 3,750,801 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g2d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247645,224,018 - 5,229,609 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247645,224,071 - 5,229,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G2D
8 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.21-36.12(chr1:15385267-20980349)x1 copy number loss See cases [RCV000051146] Chr1:15385267..20980349 [GRCh38]
Chr1:15711763..21306842 [GRCh37]
Chr1:15584350..21179429 [NCBI36]
Chr1:1p36.21-36.12		 pathogenic
GRCh38/hg38 1p36.21-36.12(chr1:13110797-20670207)x3 copy number gain See cases [RCV000051797] Chr1:13110797..20670207 [GRCh38]
Chr1:13178269..20996700 [GRCh37]
Chr1:13100856..20869287 [NCBI36]
Chr1:1p36.21-36.12		 pathogenic
GRCh38/hg38 1p36.13-36.12(chr1:18347821-22512894)x1 copy number loss See cases [RCV000053789] Chr1:18347821..22512894 [GRCh38]
Chr1:18674315..22839387 [GRCh37]
Chr1:18546902..22711974 [NCBI36]
Chr1:1p36.13-36.12		 pathogenic
GRCh38/hg38 1p36.22-36.12(chr1:10556797-22557907)x1 copy number loss See cases [RCV000053760] Chr1:10556797..22557907 [GRCh38]
Chr1:10616854..22884400 [GRCh37]
Chr1:10539441..22756987 [NCBI36]
Chr1:1p36.22-36.12		 pathogenic
GRCh38/hg38 1p36.13-36.12(chr1:19548795-20935131)x1 copy number loss See cases [RCV000138079] Chr1:19548795..20935131 [GRCh38]
Chr1:19875289..21261624 [GRCh37]
Chr1:19747876..21134211 [NCBI36]
Chr1:1p36.13-36.12		 likely pathogenic|uncertain significance
Single allele complex Breast ductal adenocarcinoma [RCV000207058] Chr1:909238..24706269 [GRCh37]
Chr1:1p36.33-36.11		 uncertain significance
chr1:17555508-24706269 complex variant complex Breast ductal adenocarcinoma [RCV000207266] Chr1:17555508..24706269 [GRCh37]
Chr1:1p36.13-36.11		 uncertain significance
GRCh37/hg19 1p36.13-36.12(chr1:20067124-22537862)x1 copy number loss See cases [RCV000447314] Chr1:20067124..22537862 [GRCh37]
Chr1:1p36.13-36.12		 pathogenic
GRCh37/hg19 1p36.32-36.12(chr1:2749920-22564787)x1 copy number loss See cases [RCV000446470] Chr1:2749920..22564787 [GRCh37]
Chr1:1p36.32-36.12		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
NC_000001.10:g.(?_19199339)_(22987879_?)dup duplication Autosomal recessive early-onset Parkinson disease 6 [RCV003113320]|Congenital disorder of glycosylation type Ir [RCV003113321]|Hyperprolinemia type 2 [RCV003107740] Chr1:19199339..22987879 [GRCh37]
Chr1:1p36.13-36.12		 uncertain significance
GRCh37/hg19 1p36.13-36.12(chr1:16785250-23491592)x1 copy number loss 1p36.1 deletion syndrome [RCV001614471] Chr1:16785250..23491592 [GRCh37]
Chr1:1p36.13-36.12		 pathogenic
GRCh37/hg19 1p36.13-36.12(chr1:20100416-20549013)x3 copy number gain not provided [RCV001005074] Chr1:20100416..20549013 [GRCh37]
Chr1:1p36.13-36.12		 uncertain significance
GRCh37/hg19 1p36.13-36.12(chr1:17284906-21778495)x1 copy number loss not provided [RCV001259567] Chr1:17284906..21778495 [GRCh37]
Chr1:1p36.13-36.12		 pathogenic
GRCh37/hg19 1p36.21-36.12(chr1:16041431-21295864)x1 copy number loss not provided [RCV001259568] Chr1:16041431..21295864 [GRCh37]
Chr1:1p36.21-36.12		 pathogenic
NC_000001.10:g.(?_20208747)_(20503856_?)dup duplication not provided [RCV001372151] Chr1:20208747..20503856 [GRCh37]
Chr1:1p36.13-36.12		 uncertain significance
NC_000001.10:g.(?_19199339)_(24690861_?)dup duplication Deficiency of hydroxymethylglutaryl-CoA lyase [RCV003122155] Chr1:19199339..24690861 [GRCh37]
Chr1:1p36.13-36.11		 uncertain significance
NM_012400.4(PLA2G2D):c.133G>A (p.Gly45Ser) single nucleotide variant not provided [RCV004597640] Chr1:20116385 [GRCh38]
Chr1:20442878 [GRCh37]
Chr1:1p36.12		 likely benign
NM_012400.4(PLA2G2D):c.83T>G (p.Met28Arg) single nucleotide variant not specified [RCV004200865] Chr1:20116435 [GRCh38]
Chr1:20442928 [GRCh37]
Chr1:1p36.12		 uncertain significance
NM_012400.4(PLA2G2D):c.215A>G (p.Asp72Gly) single nucleotide variant not specified [RCV004143136] Chr1:20115584 [GRCh38]
Chr1:20442077 [GRCh37]
Chr1:1p36.12		 uncertain significance
NM_012400.4(PLA2G2D):c.398A>T (p.Tyr133Phe) single nucleotide variant not specified [RCV004134793] Chr1:20114154 [GRCh38]
Chr1:20440647 [GRCh37]
Chr1:1p36.12		 uncertain significance
NM_012400.4(PLA2G2D):c.425C>T (p.Thr142Ile) single nucleotide variant not specified [RCV004167652] Chr1:20114127 [GRCh38]
Chr1:20440620 [GRCh37]
Chr1:1p36.12		 uncertain significance
NC_000001.10:g.4481271_20530242del deletion Chromosome 1p36 deletion syndrome [RCV003159574] Chr1:4481271..20530242 [GRCh37]
Chr1:1p36.32-36.12		 pathogenic
GRCh37/hg19 1p36.13-36.12(chr1:17291707-23016395)x4 copy number gain not provided [RCV003485339] Chr1:17291707..23016395 [GRCh37]
Chr1:1p36.13-36.12		 likely pathogenic
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3 copy number gain Trisomy 12p [RCV003447845] Chr1:99125..34026935 [GRCh38]
Chr1:1p36.33-35.1		 pathogenic
NM_012400.4(PLA2G2D):c.160G>A (p.Gly54Ser) single nucleotide variant not specified [RCV004511444] Chr1:20116358 [GRCh38]
Chr1:20442851 [GRCh37]
Chr1:1p36.12		 uncertain significance
NM_012400.4(PLA2G2D):c.145G>A (p.Gly49Arg) single nucleotide variant not specified [RCV004511443] Chr1:20116373 [GRCh38]
Chr1:20442866 [GRCh37]
Chr1:1p36.12		 uncertain significance
NM_012400.4(PLA2G2D):c.83T>C (p.Met28Thr) single nucleotide variant not specified [RCV004511445] Chr1:20116435 [GRCh38]
Chr1:20442928 [GRCh37]
Chr1:1p36.12		 uncertain significance
GRCh37/hg19 1p36.21-36.12(chr1:16194137-20561434)x1 copy number loss not specified [RCV003986551] Chr1:16194137..20561434 [GRCh37]
Chr1:1p36.21-36.12		 pathogenic
NM_012400.4(PLA2G2D):c.84G>A (p.Met28Ile) single nucleotide variant not specified [RCV004511446] Chr1:20116434 [GRCh38]
Chr1:20442927 [GRCh37]
Chr1:1p36.12		 uncertain significance
NM_012400.4(PLA2G2D):c.180G>A (p.Thr60=) single nucleotide variant not provided [RCV004585243] Chr1:20116338 [GRCh38]
Chr1:20442831 [GRCh37]
Chr1:1p36.12		 benign
GRCh37/hg19 1p36.32-36.12(chr1:4436802-22782007)x2 copy number loss not provided [RCV004577440] Chr1:4436802..22782007 [GRCh37]
Chr1:1p36.32-36.12		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1482
Count of miRNA genes:718
Interacting mature miRNAs:805
Transcripts:ENST00000375105
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298451OSTEAR17_HOsteoarthritis QTL 17 (human)2.40.0004Joint/bone inflammationosteoarthritis11125188105Human
1576329MYI9_HMyocardial infarction susceptibility QTL 9 (human)12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1298463BP9_HBlood pressure QTL 9 (human)3.9Blood pressurehypertension susceptibility1125188105Human
1576325MYI1_HMyocardial infarction susceptibility QTL 1 (human)11.681e-12Myocardial infarction susceptibilityearly-onset1758550333585503Human
1643380BW316_HBody weight QTL 316 (human)2.620.0002Body weightBMI1758550333585503Human

Markers in Region
D8S2279  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.12UniSTS
Cytogenetic Map15q13UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map21q21.3UniSTS
Cytogenetic Map3p22-p21.3UniSTS
Cytogenetic Map1q21.1UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map17q24.2UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map3p25.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map2q31.1UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map3p14.1UniSTS
Cytogenetic Map2q37.3UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map2q22.3UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map12q24.1UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map2p25.2UniSTS
Cytogenetic Map3p24.3UniSTS
Cytogenetic Map17q25.3UniSTS
Cytogenetic Map15q22.31UniSTS
Cytogenetic Map5q14UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map7q21.11UniSTS
Cytogenetic Map9q34.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map8q22.3UniSTS
Cytogenetic Map6p21.1-p12UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map7p21.3UniSTS
Cytogenetic Map4q12UniSTS
Cytogenetic Map22q11.22UniSTS
Cytogenetic Map11p13UniSTS
Cytogenetic Map1q12UniSTS
Cytogenetic Map8p23UniSTS
Cytogenetic Map11q13.2-q13.3UniSTS
Cytogenetic Map13q14.1-q14.3UniSTS
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Cytogenetic Map14q32.13UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map16p13.1UniSTS
Cytogenetic Map7q31.3UniSTS
Cytogenetic Map20q13.2-q13.3UniSTS
Cytogenetic Map1p21.2UniSTS
Cytogenetic Map9q21.33UniSTS
Cytogenetic Map14q32.2UniSTS
Cytogenetic Map13q13.3UniSTS
Cytogenetic Map10p12.31UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map5q33.2UniSTS
Cytogenetic Map13q32.2UniSTS
Cytogenetic Map14q23.1UniSTS
Cytogenetic Map8q21.2UniSTS
Cytogenetic Map2q24.1UniSTS
Cytogenetic Map10q26.13UniSTS
Cytogenetic Map2q23.3UniSTS
Cytogenetic Map19p13.1UniSTS
Cytogenetic Map15q14-q15UniSTS
Cytogenetic Map1q42.13UniSTS
Cytogenetic Map14q31UniSTS
Cytogenetic Map7p21.1UniSTS
Cytogenetic Map8p12-p11UniSTS
Cytogenetic Map18p11.2UniSTS
Cytogenetic Map7p11.1UniSTS
Cytogenetic Map1q31-q32UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map3p21.32UniSTS
Cytogenetic Map2p24.2UniSTS
Cytogenetic Map2q33-q34UniSTS
Cytogenetic Map6q24.1UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map15q13.3UniSTS
Cytogenetic Map10q26.11UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map10q23.33UniSTS
Cytogenetic Map12p12.1UniSTS
Cytogenetic Map7p13-p12UniSTS
Cytogenetic MapXq25UniSTS
Cytogenetic Map17q11-q21UniSTS
Cytogenetic Map12q23UniSTS
Cytogenetic Map6p24-p22.3UniSTS
Cytogenetic Map14q23.2UniSTS
Cytogenetic Map7q31.1-q31.2UniSTS
Cytogenetic Map8q22.2UniSTS
Cytogenetic Map15q21.2UniSTS
Cytogenetic Map3p26.1-p25.1UniSTS
Cytogenetic Map5q35UniSTS
Cytogenetic Map3q13.2UniSTS
Cytogenetic Map4p15.2UniSTS
Cytogenetic Map6q16.3UniSTS
Cytogenetic Map17q24-q25UniSTS
Cytogenetic MapXq12UniSTS
Cytogenetic MapXq27.1UniSTS
Cytogenetic Map8q12.3UniSTS
Cytogenetic Map5q21.2UniSTS
Cytogenetic Map5q15UniSTS
Cytogenetic Map5q35.1UniSTS
Cytogenetic Map4q13.3UniSTS
Cytogenetic Map4q35.2UniSTS
Cytogenetic Map3p26.1UniSTS
Cytogenetic Map3p11.1UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map2q21.2UniSTS
Cytogenetic Map19p13.13UniSTS
Cytogenetic Map18q12.3UniSTS
Cytogenetic Map18p11.3UniSTS
Cytogenetic Map17q11.1UniSTS
Cytogenetic Map15q25.1UniSTS
Cytogenetic Map13q12.3UniSTS
Cytogenetic Map12q23.2UniSTS
Cytogenetic Map12q12-q13UniSTS
Cytogenetic Map12q14UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map2q32-q34UniSTS
Cytogenetic Map16q22.3UniSTS
Cytogenetic Map2p15-p13UniSTS
Cytogenetic MapXp11.4UniSTS
Cytogenetic Map19q13.33-q13.41UniSTS
Cytogenetic Map20p11UniSTS
Cytogenetic Map6q23-q24UniSTS
Cytogenetic Map2p12UniSTS
Cytogenetic Map2p13UniSTS
Cytogenetic Map13q11-q12UniSTS
Cytogenetic Map6p12.3-p11.2UniSTS
Cytogenetic Map6q16.1-q16.3UniSTS
Cytogenetic Map22q11UniSTS
Cytogenetic Map7q31.2UniSTS
Cytogenetic Map10q21.3UniSTS
Cytogenetic Map3q25.2UniSTS
Cytogenetic Map3p21.1-p14.3UniSTS
Cytogenetic Map6p12.1UniSTS
Cytogenetic Map3q23-q24UniSTS
Cytogenetic Map3q12UniSTS
Cytogenetic Map7q11.1UniSTS
Cytogenetic Map3q22.3UniSTS
Cytogenetic Map7q21.3UniSTS
Cytogenetic Map4q31.1UniSTS
Cytogenetic Map22q12-q13UniSTS
Cytogenetic Map4q23UniSTS
Cytogenetic MapXp22.12UniSTS
Cytogenetic Map6q16.1UniSTS
Cytogenetic Map13q14.13UniSTS
Cytogenetic Map18q21.3UniSTS
Cytogenetic Map9q33.2UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map4q28-q32UniSTS
Cytogenetic Map17q24.3UniSTS
Cytogenetic Map6p23UniSTS
Cytogenetic Map8p11UniSTS
Cytogenetic Map5q34UniSTS
Cytogenetic Map1q24.3UniSTS
Cytogenetic Map9q33.1UniSTS
Cytogenetic Map1q23.3UniSTS
Cytogenetic Map2p16.2UniSTS
Cytogenetic Map9q22.31UniSTS
Cytogenetic Map9p24.3UniSTS
Cytogenetic Map7q35UniSTS
Cytogenetic Map1p36.2UniSTS
Cytogenetic Map11q22.3UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map1q22-q23UniSTS
Cytogenetic Map13q22.1UniSTS
Cytogenetic Map2q12.2UniSTS
Cytogenetic Map8p12UniSTS
Cytogenetic Map4q21UniSTS
Cytogenetic Map13q12.2UniSTS
Cytogenetic Map9q31-q33UniSTS
Cytogenetic Map6p24.1UniSTS
Cytogenetic Map1q23UniSTS
Cytogenetic Map11q12-q13UniSTS
Cytogenetic Map11q13.3UniSTS
Cytogenetic Map11q24.2UniSTS
Cytogenetic Map11q12.1UniSTS
Cytogenetic Map3p26UniSTS
Cytogenetic Map5q13UniSTS
Cytogenetic Map8p21UniSTS
Cytogenetic Map19q13.1-q13.2UniSTS
Cytogenetic Map1p33-p32UniSTS
Cytogenetic Map7q36.2UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map16p13.2UniSTS
Cytogenetic Map14q32UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map10q26.1UniSTS
Cytogenetic Map9q32-q33.3UniSTS
Cytogenetic Map9q22.1-q22.2UniSTS
Cytogenetic Map3q26.1-q26.2UniSTS
Cytogenetic Map5q31-q34UniSTS
Cytogenetic Map9q33-q34UniSTS
Cytogenetic Map5q11.2-q13.2UniSTS
Cytogenetic Map13q32UniSTS
Cytogenetic Map9q22.32UniSTS
Cytogenetic Map1p36.3UniSTS
Cytogenetic Map1p36.3-p36.2UniSTS
Cytogenetic Map4q28.1UniSTS
Cytogenetic Map5q22UniSTS
Cytogenetic Map12p11.21UniSTS
Cytogenetic MapXq13.3UniSTS
Cytogenetic Map9q31.3UniSTS
Cytogenetic Map3p26.3UniSTS
Cytogenetic Map2q11.1UniSTS
Cytogenetic Map21q11.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map15q26.2UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map10q25.3UniSTS
Cytogenetic Map20q11.23UniSTS
Cytogenetic Map20p12.1UniSTS
Cytogenetic Map2q31.1-q31.2UniSTS
Cytogenetic MapXp22.31UniSTS
Cytogenetic MapXp21.3UniSTS
Cytogenetic Map5q33.3UniSTS
Cytogenetic Map4q28.2UniSTS
Cytogenetic Map3p14.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map2q13UniSTS
Cytogenetic Map20q13.2UniSTS
Cytogenetic Map14q11.2-q12UniSTS
Cytogenetic Map3p24UniSTS
Cytogenetic Map12q23.3UniSTS
Cytogenetic Map11q24.3UniSTS
Cytogenetic Map11q14.3UniSTS
Cytogenetic Map10q25.2UniSTS
Cytogenetic Map3q25.1UniSTS
Cytogenetic Map8q13UniSTS
Cytogenetic Map1p22.2UniSTS
Cytogenetic Map3p22.3UniSTS
Cytogenetic Map18q11.1UniSTS
Cytogenetic Map8q23.3UniSTS
Cytogenetic Map15q24UniSTS
Cytogenetic Map11cen-q12UniSTS
Cytogenetic Map11q25UniSTS
Cytogenetic Map3p22.2UniSTS
Cytogenetic MapXp21.1UniSTS
Cytogenetic Map7q36UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map12q21UniSTS
Cytogenetic Map7p15UniSTS
Cytogenetic Map7q22-q31UniSTS
Cytogenetic Map11q22UniSTS
Cytogenetic Map5p15.3UniSTS
Cytogenetic Map20q13.3-qterUniSTS
Cytogenetic Map1p35-p34UniSTS
Cytogenetic Map4p13-p12UniSTS
Cytogenetic Map10q21-q22UniSTS
Cytogenetic Map4q22UniSTS
Cytogenetic Map7p13-p11.1UniSTS
Cytogenetic Map9q31-q34UniSTS
Cytogenetic Map7q21.1-q22UniSTS
Cytogenetic Map15q26.1UniSTS
Cytogenetic Map3q13.13-q13.2UniSTS
Cytogenetic MapXp22.13UniSTS
Cytogenetic Map13q12.12UniSTS
Cytogenetic Map13q14.2UniSTS
Cytogenetic Map12qUniSTS
Cytogenetic Map1pUniSTS
Cytogenetic Map16pUniSTS
Cytogenetic Map15qUniSTS
Cytogenetic Map7qUniSTS
Cytogenetic Map2qUniSTS
Cytogenetic Map5q13.1UniSTS
Cytogenetic Map11p14.1UniSTS
Cytogenetic Map4q32UniSTS
Cytogenetic Map2p22UniSTS
Cytogenetic Map5q14.3UniSTS
Cytogenetic Map10p12.1UniSTS
Cytogenetic Map5q23.2UniSTS
Cytogenetic Map2p24.1UniSTS
Cytogenetic Map8q24.13UniSTS
Cytogenetic Map12p13.32UniSTS
Cytogenetic Map9p21.1UniSTS
Cytogenetic Map9q34.2-q34.3UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
865 2159 1178 1020 2712 1053 1674 2 476 1551 328 1283 4413 4126 20 2147 581 1267 1123 151

Sequence


Ensembl Acc Id: ENST00000375105   ⟹   ENSP00000364246
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl120,111,939 - 20,119,536 (-)Ensembl
Ensembl Acc Id: ENST00000617227   ⟹   ENSP00000482871
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl120,112,657 - 20,119,566 (-)Ensembl
RefSeq Acc Id: NM_001271814   ⟹   NP_001258743
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38120,111,939 - 20,119,536 (-)NCBI
HuRef118,684,974 - 18,691,890 (-)NCBI
CHM1_1120,548,848 - 20,555,764 (-)NCBI
T2T-CHM13v2.0119,935,588 - 19,943,185 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012400   ⟹   NP_036532
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38120,111,939 - 20,119,536 (-)NCBI
GRCh37120,439,143 - 20,446,059 (-)NCBI
Build 36120,311,019 - 20,318,595 (-)NCBI Archive
HuRef118,684,974 - 18,691,890 (-)NCBI
CHM1_1120,548,848 - 20,555,764 (-)NCBI
T2T-CHM13v2.0119,935,588 - 19,943,185 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036532   ⟸   NM_012400
- Peptide Label: isoform 1 precursor
- UniProtKB: B1AEL9 (UniProtKB/Swiss-Prot),   A8K2Z1 (UniProtKB/Swiss-Prot),   A0A087WZT4 (UniProtKB/Swiss-Prot),   Q9UK01 (UniProtKB/Swiss-Prot),   Q9UNK4 (UniProtKB/Swiss-Prot),   B2R4P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001258743   ⟸   NM_001271814
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9UNK4 (UniProtKB/Swiss-Prot),   A0A087WZT4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000364246   ⟸   ENST00000375105
Ensembl Acc Id: ENSP00000482871   ⟸   ENST00000617227
Protein Domains
Phospholipase A2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UNK4-F1-model_v2 AlphaFold Q9UNK4 1-145 view protein structure

Promoters
RGD ID:6854360
Promoter ID:EPDNEW_H344
Type:multiple initiation site
Name:PLA2G2D_2
Description:phospholipase A2 group IID
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H348  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38120,119,536 - 20,119,596EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9033 AgrOrtholog
COSMIC PLA2G2D COSMIC
Ensembl Genes ENSG00000117215 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000375105 ENTREZGENE
  ENST00000375105.8 UniProtKB/Swiss-Prot
  ENST00000617227 ENTREZGENE
  ENST00000617227.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000117215 GTEx
HGNC ID HGNC:9033 ENTREZGENE
Human Proteome Map PLA2G2D Human Proteome Map
InterPro PLipase_A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:26279 UniProtKB/Swiss-Prot
NCBI Gene 26279 ENTREZGENE
OMIM 605630 OMIM
PANTHER GROUP IID SECRETORY PHOSPHOLIPASE A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHOLIPASE A2 FAMILY MEMBER UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam Phospholip_A2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33363 PharmGKB
PRINTS PHPHLIPASEA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA2_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PA2c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Phospholipase A2, PLA2 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A087WZT4 ENTREZGENE
  A8K2Z1 ENTREZGENE
  B1AEL9 ENTREZGENE
  B2R4P7 ENTREZGENE, UniProtKB/TrEMBL
  PA2GD_HUMAN UniProtKB/Swiss-Prot
  Q9UK01 ENTREZGENE
  Q9UNK4 ENTREZGENE
UniProt Secondary A0A087WZT4 UniProtKB/Swiss-Prot
  A8K2Z1 UniProtKB/Swiss-Prot
  B1AEL9 UniProtKB/Swiss-Prot
  Q9UK01 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PLA2G2D  phospholipase A2 group IID    phospholipase A2, group IID  Symbol and/or name change 5135510 APPROVED