PLA2G2D (phospholipase A2 group IID)

Gene: PLA2G2D (phospholipase A2 group IID) Chlorocebus sabaeus

Analyze

Symbol:

PLA2G2D

Name:

phospholipase A2 group IID

RGD ID:

18794796

Description:

ENCODES a protein that exhibits calcium ion binding (inferred); calcium-dependent phospholipase A2 activity (inferred); heparan sulfate proteoglycan binding (inferred); INVOLVED IN CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (ortholog); negative regulation of T cell activation (ortholog); negative regulation of T cell proliferation (ortholog); PARTICIPATES IN glycerophospholipid metabolic pathway; ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); chromosome 1p36 deletion syndrome (ortholog); congenital disorder of glycosylation Ir (ortholog); FOUND IN extracellular region (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

group IID secretory phospholipase A2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	112,434,208 - 112,441,215 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	112,434,276 - 112,441,249 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	3,743,003 - 3,750,801 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ISO)

chromosome 1p36 deletion syndrome (ISO)

congenital disorder of glycosylation Ir (ISO)

genetic disease (ISO)

hyperprolinemia type 2 (ISO)

Parkinson's disease 6 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arachidonic acid secretion (IEA)

CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (IEA,ISO)

lipid catabolic process (IEA)

lipid metabolic process (IEA)

negative regulation of T cell activation (IEA,ISO)

negative regulation of T cell proliferation (IEA,ISO)

phosphatidylcholine metabolic process (IEA)

phosphatidylethanolamine metabolic process (IEA)

phosphatidylglycerol metabolic process (IEA)

phospholipid metabolic process (IEA)

regulation of acute inflammatory response to antigenic stimulus (IEA)

Cellular Component

extracellular region (IEA)

membrane (IEA)

Molecular Function

calcium ion binding (IEA)

calcium-dependent phospholipase A2 activity (IEA)

heparan sulfate proteoglycan binding (IEA)

heparin binding (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

phospholipase A2 activity (IEA)

phospholipid binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

glycerophospholipid metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PLA2G2D
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	112,434,208 - 112,441,215 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	112,434,276 - 112,441,249 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	3,743,003 - 3,750,801 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

PLA2G2D
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	20,111,939 - 20,119,536 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	20,111,939 - 20,119,566 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	20,438,432 - 20,446,029 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	20,311,019 - 20,318,595 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	20,183,741 - 20,191,314	NCBI
Celera	1	18,761,553 - 18,769,129 (-)	NCBI		Celera
Cytogenetic Map	1	p36.12	NCBI
HuRef	1	18,684,974 - 18,691,890 (-)	NCBI		HuRef
CHM1_1	1	20,548,848 - 20,555,764 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	19,935,588 - 19,943,185 (-)	NCBI		T2T-CHM13v2.0

Pla2g2d
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	138,503,046 - 138,509,363 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	138,503,046 - 138,509,357 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	138,775,735 - 138,782,052 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	138,775,735 - 138,782,046 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	138,331,650 - 138,338,058 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	138,047,811 - 138,054,219 (+)	NCBI		MGSCv36	mm8
Celera	4	140,558,983 - 140,565,391 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	70.57	NCBI

Pla2g2d
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	156,299,374 - 156,305,816 (+)	NCBI		GRCr8
mRatBN7.2	5	151,016,010 - 151,022,531 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	151,018,870 - 151,022,525 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	153,714,211 - 153,720,401 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	155,488,513 - 155,494,703 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	155,469,996 - 155,476,182 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	157,222,636 - 157,228,795 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	157,222,636 - 157,228,791 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	160,962,324 - 160,970,156 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	157,594,706 - 157,600,865 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	157,604,744 - 157,610,900 (+)	NCBI
Celera	5	149,404,051 - 149,410,210 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Pla2g2d
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	736,600 - 743,806 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	738,133 - 743,718 (-)	NCBI	ChiLan1.0	ChiLan1.0

PLA2G2D
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	206,999,131 - 207,007,142 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	206,115,929 - 206,123,950 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	19,066,890 - 19,074,711 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	20,110,664 - 20,117,583 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	20,110,323 - 20,117,618 (-)	Ensembl	panpan1.1		panPan2

PLA2G2D
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	78,739,826 - 78,745,839 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	78,739,769 - 78,745,920 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	75,253,368 - 75,260,612 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	79,305,947 - 79,313,189 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	79,305,982 - 79,313,914 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	76,125,252 - 76,132,491 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	77,131,831 - 77,139,073 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	78,202,771 - 78,210,014 (+)	NCBI		UU_Cfam_GSD_1.0

Pla2g2d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	40,342,725 - 40,347,968 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	6,167,507 - 6,172,750 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	6,167,507 - 6,172,750 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLA2G2D
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	78,391,066 - 78,397,515 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	78,391,063 - 78,397,394 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	72,580,441 - 72,587,047 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Pla2g2d
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	5,224,018 - 5,229,609 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	5,224,071 - 5,229,603 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low	21	18	5
Below cutoff	12	2	16

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007980225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000017645 ⟹ ENSCSAP00000017119

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	112,434,276 - 112,441,249 (+)	Ensembl

RefSeq Acc Id:

XM_007980225 ⟹ XP_007978416

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	112,434,208 - 112,441,215 (+)	NCBI
Vero_WHO_p1.0	NW_023666033	3,743,003 - 3,750,801 (-)	NCBI

Sequence:

show sequence

CTCCATAAGAGTGAGGGCTGGGAGGGAGGGCTGGGCAAGCCTGGGTGGGGTGCATCTGATATAA
GGGGGCAGCCCGCATGGAAAGAGACTTCCAGCAGCTGCCTCCACTGCTGTCTGCTGGCATCATG
GAACTTGCCCTGCTGTGTGGGCTGGTGGTGATGGCTGGTGTGATTCCAATCCAGGGCGGGATCC
TGAACCTGAACAAGATGGTCAAGCAAGTGACTGGGAAAATGCCCCTTTTCTTCTACTGGCCCTA
CGGCTGTTACTGCGGACCAGGTGGCAGAGGCCAGCCCAAAGATGCCACGGACTGGTGCTGTCAG
ACCCATGACTGCTGCTACGACCACCTGAAGACCCACGGATGCTGCGTCCACACGGACCACTACA
GATACAGCTTTTCCCAGGGGGACATCCACTGCTCTGACAAGGGAAGCTGGTGTGAGCAGCAGCT
GTGTGCCTGTGACAAGGAGGTGGCCCTCTGCCTGAAGCGTAACCTGGACACCTACAAGAAGCGA
CTGCGTTTCTACTGGCGGCCCCGCTGCCAGGGGCAGACCCCTGGGTGCTAGAAGTCCACACCCT
CTACCCTGTTCCTCAGCATGGAGCTCCGGCATCCCCGCATCAGTATCTAACCTGAACCAGTCTG
GTTTTTCAAACACTCCGTGGGGAGGTAGTTCCAGCCTCCCCCGGAACCCCTACCAATGCCTTCT
AACCTTCTGAAGCTTTCCGAATCCTCCTAGTCGAGGCAGCAGCTGTGTCCTCTGGGGTGGATGG
GAATCTTGGGAGAAGCCCAAGCAAGGGAGCCCTCAGAGGTGGTGTTTGGACCAAAGCATTGGGG
TGGGGGGAGAGGTCTGCCGCTGTCCCCCACCTGCTGTCTCCCTGGTCCTTTCTCACCCCCTCCA
ATATAGTCTCGGAGCTACAACCGGAGCAGCCACTTTAAAGGGCAATATTGATTTTTCTGTCCAT
GTAACTCTCTCTCTTAAAATCTCAAGGCCCTCCACTGTCCTAAGACAAAGCCTCTCATAGGCGT
TGGGGACCCTGCACCGTCCGGCCATGTGACCTTCTCCCCAGGCAAGCTCTGAAGTCCCTGCAGG
TGGAGGCCATGCCTGTCTTAAACTCAGTTGCATCCCTGGTGCCCAAAACAACACTCAGAACCAA
GGAGCTCCGTAAATCCGTCTTGGGCGAAGCGCTAGACAAAGCCGCCAGCTCATATGGCTCCGGG
CACCAGAGCCTTGAGTACTTTCTCCTGACTCCAGGCGTCAGCTCAGGGTGAATTACAAGGGGCT
ACTGAATGGCTATTACTTTCATCACGACTGATCCCCATCTCCTCAGGGTCAAAGGGCTACTTTC
TGGAAGTCTCCCCGGGCTGACTCCTCCTCCCTGACTGCAAGGGCTCACTCCCTCCTCCAAGCTC
CCACAATGCTTCATGGCTCTGCTGCTGACCAAGCTTGGCCTAGAGTGGCAAATGGAATTTCTCT
GATCTCCCCCAACGAAACTGGAACCCTGAAGGACGGAGGCCATGTGTGTGCTGTCTCTGTTTCC
CCTGTTTCCCCACATACTGGGTGCTCAATTCATGCCTGTGAATGGAGTGAGCCCATAATGGATA
CACAAAGGTTGCAGCAGATGGTGTGGGTACCCCACCCAGATCCCCTCCAGGCCCAAGGCCCCTC
TCCCTGAGTGAGGCCAGGTGTTGGCAGCCAACTGCTCCAATCTGCCTCCTTCTCTTAAATATTG
CCCTGGTCTACAGGGAGCTGCCTGCCCCCCGCCCCACCTCTCCCACCAAGAGGCCACCTGTCAC
TCATGGCCAGGAGAGTCTGACACTATGGAGGGTACAACTGCCAGCTCCCCTGCCTCTGTGCAGG
ATTGTATGGGTGGAACGACACTCTCGAATTCCTCCTGGGATCGGGCTGAGGCCAGGCCTCTCCT
GGAACCACCTCTCTGCTTGGTCGGACCCCATGGCCTATTCAGTTTTCCTGGTTCCCTCACAGGT
TTCTCCAGAAAGTACTCCCTCAGTAAAGTATTTGCACAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007978416	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000017119
	ENSCSAP00000017119.1

RefSeq Acc Id:	XP_007978416 ⟸ XM_007980225
- UniProtKB:	A0A0D9S8D0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000017119 ⟸ ENSCSAT00000017645

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000000888	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017645.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.90.10	UniProtKB/TrEMBL
InterPro	PLipase_A2	UniProtKB/TrEMBL
	PLipase_A2_Asp_AS	UniProtKB/TrEMBL
	PLipase_A2_dom	UniProtKB/TrEMBL
	PLipase_A2_dom_sf	UniProtKB/TrEMBL
	PLipase_A2_His_AS	UniProtKB/TrEMBL
KEGG Report	csab:103225463	UniProtKB/TrEMBL
NCBI Gene	PLA2G2D	ENTREZGENE
PANTHER	GROUP IID SECRETORY PHOSPHOLIPASE A2	UniProtKB/TrEMBL
	PTHR11716	UniProtKB/TrEMBL
Pfam	Phospholip_A2_1	UniProtKB/TrEMBL
PRINTS	PHPHLIPASEA2	UniProtKB/TrEMBL
PROSITE	PA2_ASP	UniProtKB/TrEMBL
	PA2_HIS	UniProtKB/TrEMBL
SMART	PA2c	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48619	UniProtKB/TrEMBL
UniProt	A0A0D9S8D0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Annotations - SMPDB