Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: NPPB (natriuretic peptide B) Homo sapiens
Analyze
Symbol: NPPB
Name: natriuretic peptide B
Description: Exhibits hormone receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cGMP biosynthetic process; and receptor guanylyl cyclase signaling pathway. Localizes to the protein-containing complex. Implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Biomarker of several diseases, including Kawasaki disease; artery disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and kidney failure (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BNP; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B; natriuretic peptides B; natriuretic protein
Orthologs:
Mus musculus (house mouse) : Nppb (natriuretic peptide type B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nppb (natriuretic peptide B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppb (natriuretic peptide B)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPB (natriuretic peptide B)
Canis lupus familiaris (dog) : NPPB (natriuretic peptide B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppb (natriuretic peptide B)
Sus scrofa (pig) : NPPB (natriuretic peptide B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,857,464 - 11,858,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,917,521 - 11,918,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,840,108 - 11,841,579 (-)NCBINCBI36hg18NCBI36
Build 34111,851,789 - 11,853,254NCBI
Celera111,031,156 - 11,032,627 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef111,073,021 - 11,074,492 (-)NCBIHuRef
CHM1_1111,905,417 - 11,906,888 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NPPB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69139
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.