RGD Reference Report - N-terminal pro-Brain Natriuretic Peptide and Risk of Diabetes. - Rat Genome Database

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N-terminal pro-Brain Natriuretic Peptide and Risk of Diabetes.

Authors: Lazo, M  Young, JH  Brancati, FL  Coresh, J  Whelton, S  Ndumele, CE  Hoogeveen, R  Ballantyne, CM  Selvin, E 
Citation: Lazo M, etal., Diabetes. 2013 Jun 3.
RGD ID: 7246907
Pubmed: PMID:23733199   (View Abstract at PubMed)
PMCID: PMC3749338   (View Article at PubMed Central)
DOI: DOI:10.2337/db13-0478   (Journal Full-text)

Brain natriuretic peptide (BNP) has an established role in cardiovascular disease. However, recent animal studies suggest direct metabolic effects of BNP. To determine the association of BNP with the risk of diabetes, we conducted a prospective analysis of participants from the Atherosclerosis Risk in Communities (ARIC) Study. We included 7,822 men and women without history of diabetes, cardiovascular disease or reduced kidney function at baseline. At baseline, N-terminal (NT)-proBNP, a cleavage product of BNP, was inversely associated with adiposity, fasting glucose, insulin, and cholesterol, but positively associated with blood pressure and C-reactive protein levels. During a median follow-up of 12 years, 1740 participants reported a new diagnosis of diabetes or medication use for diabetes. Baseline quartiles of NT-proBNP were inversely associated with diabetes risk, even after multivariable adjustment including fasting glucose. The adjusted HRs for diabetes were 1.0 (reference), 0.84 (95%CI 0.74- 0.96), 0.79 (95%CI 0.68- 0.90) and 0.75 (95%CI 0.64-0.87) for the 1st, 2nd, 3rd and 4th quartiles of baseline NT-proBNP, respectively (p-for-trend<0.001). This inverse association was robust across sex, race and obesity subgroups. Our results extend animal studies and support a direct and important metabolic role of BNP in humans.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetes mellitus onsetIEP 7246907 RGD 
diabetes mellitus onsetISONPPB (Homo sapiens)7246907; 7246907 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nppb  (natriuretic peptide B)

Genes (Mus musculus)
Nppb  (natriuretic peptide type B)

Genes (Homo sapiens)
NPPB  (natriuretic peptide B)


Additional Information