NPPB (natriuretic peptide B) - Rat Genome Database

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Gene: NPPB (natriuretic peptide B) Chlorocebus sabaeus
Analyze
Symbol: NPPB
Name: natriuretic peptide B
RGD ID: 18650116
Description: ENCODES a protein that exhibits hormone activity (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cardiac muscle hypertrophy in response to stress (ortholog); cell growth involved in cardiac muscle cell development (ortholog); PARTICIPATES IN brain natriuretic peptide signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adult respiratory distress syndrome (ortholog); Animal Disease Models (ortholog); FOUND IN extracellular space (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: natriuretic peptides B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,930,931 - 119,933,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,932,021 - 119,933,197 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,799,168 - 23,801,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adult respiratory distress syndrome  (ISO)
Animal Disease Models  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aortic valve insufficiency  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Brain Injuries  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic kidney disease  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Death  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Eisenmenger Complex  (ISO)
end stage renal disease  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Atrial Fibrillation 6  (ISO)
heart disease  (ISO)
High Cardiac Output  (ISO)
hyperhomocysteinemia  (ISO)
hypertension  (ISO)
hypertensive heart disease  (ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypokalemia  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Kawasaki disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Metabolic Side Effects of Drugs and Substances  (ISO)
migraine  (ISO)
morbid obesity  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephrosis  (ISO)
obesity  (ISO)
Pain  (ISO)
polycystic kidney disease  (ISO)
Postoperative Complications  (ISO)
proteinuria  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
renal hypertension  (ISO)
sickle cell anemia  (ISO)
systolic heart failure  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Vasovagal Syncope  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Dysfunction, Right  (ISO)
Ventricular Remodeling  (ISO)
Ventricular Tachycardia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NPPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,930,931 - 119,933,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,932,021 - 119,933,197 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,799,168 - 23,801,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NPPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,857,464 - 11,858,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,857,464 - 11,858,945 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,917,521 - 11,919,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,840,108 - 11,841,579 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,851,789 - 11,853,254NCBI
Celera111,031,156 - 11,032,627 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,073,021 - 11,074,492 (-)NCBIHuRef
CHM1_1111,905,417 - 11,906,888 (-)NCBICHM1_1
T2T-CHM13v2.0111,401,560 - 11,403,041 (-)NCBIT2T-CHM13v2.0
Nppb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,070,264 - 148,071,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,070,245 - 148,071,662 (+)EnsemblGRCm39 Ensembl
GRCm384147,985,786 - 147,987,205 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,985,788 - 147,987,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,359,898 - 147,361,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,829,697 - 146,830,998 (+)NCBIMGSCv36mm8
Celera4150,250,201 - 150,251,617 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.57NCBI
Nppb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,699,955 - 163,701,314 (+)NCBIGRCr8
mRatBN7.25158,416,813 - 158,418,175 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,416,866 - 158,418,168 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,133,613 - 161,134,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,961,436 - 162,962,738 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,917,783 - 162,919,085 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,796,176 - 164,797,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,796,185 - 164,797,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,454,278 - 168,455,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,062,348 - 165,063,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,072,535 - 165,073,838 (+)NCBI
Celera5156,698,873 - 156,700,175 (+)NCBICelera
Cytogenetic Map5q36NCBI
Nppb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554862,054,775 - 2,056,130 (+)NCBIChiLan1.0ChiLan1.0
NPPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,361,604 - 216,364,862 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,008,742 - 215,011,988 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,621,416 - 10,622,960 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,838,518 - 11,839,999 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,838,518 - 11,839,995 (-)Ensemblpanpan1.1panPan2
NPPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,395,844 - 84,397,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,929,289 - 80,930,932 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,060,368 - 85,062,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,809,597 - 81,811,239 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,809,514 - 82,811,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,872,280 - 83,873,924 (+)NCBIUU_Cfam_GSD_1.0
Nppb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,858,528 - 34,860,962 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474683,325 - 684,665 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474683,325 - 684,662 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,930,382 - 71,932,254 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,930,374 - 71,931,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,840,061 - 65,841,530 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nppb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,139,776 - 1,141,010 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSCSAT00000017731   ⟹   ENSCSAP00000017203
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl20119,932,021 - 119,933,197 (+)Ensembl
RefSeq Acc Id: XM_037985035   ⟹   XP_037840963
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605423,799,168 - 23,801,437 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037840963 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017203.1
Ensembl Acc Id: ENSCSAP00000017203   ⟸   ENSCSAT00000017731
RefSeq Acc Id: XP_037840963   ⟸   XM_037985035
- UniProtKB: A0A0D9S8L4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000803 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017731.1 UniProtKB/TrEMBL
InterPro Natr_peptide UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/TrEMBL
  Natriuretic_peptide UniProtKB/TrEMBL
  Natriuretic_peptide_brain UniProtKB/TrEMBL
KEGG Report csab:103225595 UniProtKB/TrEMBL
NCBI Gene NPPB ENTREZGENE
PANTHER ATRIAL NATRIURETIC FACTOR PRECURSOR UniProtKB/TrEMBL
  NATRIURETIC PEPTIDES B UniProtKB/TrEMBL
Pfam ANP UniProtKB/TrEMBL
PRINTS BNATPEPTIDE UniProtKB/TrEMBL
PROSITE NATRIURETIC_PEPTIDE UniProtKB/TrEMBL
SMART NAT_PEP UniProtKB/TrEMBL
UniProt A0A0D9S8L4 ENTREZGENE, UniProtKB/TrEMBL