NPPA (natriuretic peptide A) - Rat Genome Database

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Gene: NPPA (natriuretic peptide A) Canis lupus familiaris
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Symbol: NPPA
Name: natriuretic peptide A
RGD ID: 12252074
Description: ENCODES a protein that exhibits hormone activity (ortholog); neuropeptide hormone activity (ortholog); neuropeptide receptor binding (ortholog); INVOLVED IN cardiac muscle hypertrophy in response to stress (ortholog); cell growth involved in cardiac muscle cell development (ortholog); cellular response to angiotensin (ortholog); PARTICIPATES IN atrial natriuretic peptide signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); adenocarcinoma (ortholog); FOUND IN brush border (ortholog); glycinergic synapse (ortholog); mast cell granule (ortholog); INTERACTS WITH (R)-adrenaline; (R)-noradrenaline; dexamethasone
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ANF; ANP; atrial natriuretic factor; atrial natriuretic factor prohormone; atrial natriuretic peptide; atrial natriuretic peptide prohormone; atriopeptigen; cardiodilatin; CDD; natriuretic peptide precursor A; natriuretic peptides A; preproANF; preproANP; preproCDD-ANF; prepronatriodilatin; proANF; proANP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,406,317 - 84,408,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,396,073 - 84,408,385 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,939,561 - 80,941,359 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,071,241 - 85,073,039 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,819,847 - 81,821,645 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,819,771 - 82,821,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,882,545 - 83,884,343 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
aortic valve insufficiency  (ISO)
atrial standstill 1  (ISO)
atrial standstill 2  (ISO)
brain ischemia  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic kidney disease  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
coronary stenosis  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diastolic heart failure  (ISO)
dilated cardiomyopathy  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Atrial Fibrillation 6  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
heart disease  (ISO)
Hypercapnia  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypotension  (ISO)
Hypoxia  (ISO)
intrinsic cardiomyopathy  (ISO)
Kidney Reperfusion Injury  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Lung Neoplasms  (ISO)
melanoma  (ISO)
Metabolic Side Effects of Drugs and Substances  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Neoplasm Metastasis  (ISO)
nephrosis  (ISO)
obesity  (ISO)
Pain  (ISO)
patent ductus arteriosus  (ISO)
peritonitis  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renal hypertension  (ISO)
Right Ventricular Hypertrophy  (ISO)
Skin Neoplasms  (ISO)
small cell carcinoma  (ISO)
Stroke  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Urination Disorders  (ISO)
vascular dementia  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel diameter maintenance  (IEA)
cardiac muscle hypertrophy in response to stress  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cellular response to angiotensin  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to mechanical stimulus  (ISO)
cGMP biosynthetic process  (IBA,IEA,ISO,ISS)
cGMP-mediated signaling  (IBA,IEA,ISO)
female pregnancy  (ISS)
negative regulation of blood pressure  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of collecting lymphatic vessel constriction  (ISO)
negative regulation of epidermal growth factor receptor signaling pathway  (ISO)
negative regulation of systemic arterial blood pressure  (IBA,IEA,ISO)
neuropeptide signaling pathway  (IBA,IEA)
positive regulation of cardiac muscle contraction  (ISO)
positive regulation of cGMP-mediated signaling  (ISO)
positive regulation of heart rate  (ISO)
positive regulation of histamine secretion by mast cell  (ISO)
positive regulation of potassium ion export across plasma membrane  (ISO)
protein folding  (ISO)
receptor guanylyl cyclase signaling pathway  (IBA,IEA,ISO,ISS)
regulation of atrial cardiac muscle cell membrane repolarization  (ISO)
regulation of blood pressure  (ISS)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
response to 3-methylcholanthrene  (ISO)
response to hypoxia  (ISO)
response to insulin  (ISO)
signal transduction  (IEA)
sodium ion export across plasma membrane  (ISO)
synaptic signaling via neuropeptide  (ISO)
system process  (IEA)
vasodilation  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:2934062   PMID:15838287   PMID:17338155   PMID:18681918   PMID:19585255   PMID:21835711   PMID:22301074   PMID:22578688   PMID:30032202  


Genomics

Comparative Map Data
NPPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,406,317 - 84,408,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,396,073 - 84,408,385 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,939,561 - 80,941,359 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,071,241 - 85,073,039 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,819,847 - 81,821,645 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,819,771 - 82,821,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,882,545 - 83,884,343 (+)NCBIUU_Cfam_GSD_1.0
NPPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,845,709 - 11,847,783 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,845,709 - 11,848,345 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,905,766 - 11,907,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,828,363 - 11,830,422 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,840,041 - 11,842,101NCBI
Celera111,019,389 - 11,021,472 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,060,823 - 11,062,905 (-)NCBIHuRef
CHM1_1111,893,660 - 11,895,736 (-)NCBICHM1_1
T2T-CHM13v2.0111,389,795 - 11,391,868 (-)NCBIT2T-CHM13v2.0
Nppa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,085,179 - 148,086,531 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,085,179 - 148,086,536 (+)EnsemblGRCm39 Ensembl
GRCm384148,000,722 - 148,002,074 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,000,722 - 148,002,079 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,374,855 - 147,376,176 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,844,546 - 146,845,867 (+)NCBIMGSCv36mm8
Celera4150,267,117 - 150,268,440 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.66NCBI
Nppa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,712,184 - 163,713,493 (+)NCBIGRCr8
mRatBN7.25158,429,042 - 158,430,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,429,042 - 158,430,351 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,145,793 - 161,147,102 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,973,730 - 162,975,039 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,930,077 - 162,931,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,808,407 - 164,809,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,808,323 - 164,809,705 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,466,309 - 168,467,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,074,518 - 165,075,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,084,713 - 165,086,000 (+)NCBI
Celera5156,710,885 - 156,712,194 (+)NCBICelera
RH 3.4 Map51106.6RGD
Cytogenetic Map5q36NCBI
Nppa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,060,735 - 2,063,003 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,061,196 - 2,062,805 (+)NCBIChiLan1.0ChiLan1.0
NPPA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,375,951 - 216,382,131 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,021,064 - 215,023,807 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,608,025 - 10,610,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,825,072 - 11,827,452 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,825,072 - 11,827,373 (-)Ensemblpanpan1.1panPan2
Nppa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,846,575 - 34,848,291 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936474671,362 - 673,610 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,918,845 - 71,921,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,919,557 - 71,921,345 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,829,057 - 65,830,990 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,942,412 - 119,946,211 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,944,532 - 119,945,917 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,811,217 - 23,814,235 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nppa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,147,974 - 1,148,927 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,147,654 - 1,149,722 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NPPA
36 total Variants

Expression


Sequence


RefSeq Acc Id: ENSCAFT00000026188   ⟹   ENSCAFP00000024316
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,396,073 - 84,408,385 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000026190   ⟹   ENSCAFP00000024318
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,406,317 - 84,408,115 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000082103   ⟹   ENSCAFP00000053231
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl284,406,317 - 84,407,306 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003487   ⟹   ENSCAFP00845002767
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003490   ⟹   ENSCAFP00845002768
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl285,060,271 - 85,062,005 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003501   ⟹   ENSCAFP00845002777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl285,071,241 - 85,073,039 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845003507   ⟹   ENSCAFP00845002782
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl285,071,241 - 85,072,230 (+)Ensembl
RefSeq Acc Id: NM_001313851   ⟹   NP_001300780
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1284,406,317 - 84,408,115 (+)NCBI
Dog10K_Boxer_Tasha280,939,561 - 80,941,359 (+)NCBI
ROS_Cfam_1.0285,071,241 - 85,073,039 (+)NCBI
UMICH_Zoey_3.1281,819,847 - 81,821,645 (+)NCBI
UNSW_CanFamBas_1.0282,819,771 - 82,821,568 (+)NCBI
UU_Cfam_GSD_1.0283,882,545 - 83,884,343 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001300780   ⟸   NM_001313851
- Peptide Label: precursor
- UniProtKB: P07499 (UniProtKB/Swiss-Prot),   A0A8C0NNC8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000053231   ⟸   ENSCAFT00000082103
RefSeq Acc Id: ENSCAFP00000024316   ⟸   ENSCAFT00000026188
RefSeq Acc Id: ENSCAFP00000024318   ⟸   ENSCAFT00000026190
RefSeq Acc Id: ENSCAFP00845002782   ⟸   ENSCAFT00845003507
RefSeq Acc Id: ENSCAFP00845002777   ⟸   ENSCAFT00845003501
RefSeq Acc Id: ENSCAFP00845002768   ⟸   ENSCAFT00845003490
RefSeq Acc Id: ENSCAFP00845002767   ⟸   ENSCAFT00845003487


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016539 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00030016767 UniProtKB/TrEMBL
  ENSCAFG00040005849 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00805002757 UniProtKB/Swiss-Prot
  ENSCAFG00845001994 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026188.5 UniProtKB/TrEMBL
  ENSCAFT00000026190.5 UniProtKB/Swiss-Prot
  ENSCAFT00000082103.2 UniProtKB/TrEMBL
  ENSCAFT00030031168.1 UniProtKB/TrEMBL
  ENSCAFT00040010954.1 UniProtKB/TrEMBL
  ENSCAFT00040010974.1 UniProtKB/Swiss-Prot
  ENSCAFT00040010994.1 UniProtKB/TrEMBL
  ENSCAFT00805005044 UniProtKB/Swiss-Prot
  ENSCAFT00845003487.1 UniProtKB/TrEMBL
  ENSCAFT00845003501 ENTREZGENE
  ENSCAFT00845003501.1 UniProtKB/Swiss-Prot
  ENSCAFT00845003507.1 UniProtKB/TrEMBL
InterPro Natr_peptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natriuretic_peptide_atrial UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natriuretic_peptide_brain UniProtKB/TrEMBL
KEGG Report cfa:608289 UniProtKB/Swiss-Prot
NCBI Gene NPPA ENTREZGENE
PANTHER ATRIAL NATRIURETIC FACTOR PRECURSOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NATRIURETIC PEPTIDES A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NATRIURETIC PEPTIDES B UniProtKB/TrEMBL
Pfam ANP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ANATPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BNATPEPTIDE UniProtKB/TrEMBL
  NATPEPTIDES UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NAT_PEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0NNC8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Q7W5_CANLF UniProtKB/TrEMBL
  A0A8C0QEJ9_CANLF UniProtKB/TrEMBL
  A0A8I3MJH6_CANLF UniProtKB/TrEMBL
  A0A8I3MJW9_CANLF UniProtKB/TrEMBL
  A0A8P0NI44_CANLF UniProtKB/TrEMBL
  A0A8P0P2U9_CANLF UniProtKB/TrEMBL
  ANF_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:43925 ENTREZGENE