RGD Reference Report - Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension. - Rat Genome Database

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Endothelin-1 in children with acute poststreptococcal glomerulonephritis and hypertension.

Authors: Nicolaidou, P  Georgouli, H  Matsinos, Y  Psychou, F  Messaritaki, A  Gourgiotis, D  Zeis, P 
Citation: Nicolaidou P, etal., Pediatr Int. 2003 Feb;45(1):35-8.
RGD ID: 7248663
Pubmed: PMID:12654066   (View Abstract at PubMed)

BACKGROUND: Endothelin-1 (ET-1), the most potent vasoconstrictor peptide, is known to play a role in arterial hypertension. In patients with acute poststreptococcal glomerulonephritis (APSGN) an increase in the production of ET-1 is suspected due to damaged endothelium, platelet activation and increased thrombin production in the glomeruli. The aim of the present study was to investigate whether the levels of plasma ET-1 are elevated in children with APSGN. Furthermore, we examined the association between plasma ET-1 levels and blood pressure levels in the same children. METHODS: We studied 18 children (14 boys) with APSGN (mean age 7.44 to approximately 2.82 years). Fourteen healthy children served as controls. The following parameters were evaluated: plasma ET-1, plasma atrial natriuretic peptide (ANP), plasma renin (Rn), serum aldosterone (Aldo), creatinine clearance (Ccr) and fractional excretion of sodium (FENa). RESULTS: The mean plasma ET-1 concentrations were higher in patients with APSGN (3.39 to approximately 1.86 pg/mL) compared to controls (1.40 to approximately 0.15 pg/mL; P=0.0001). Patients with APSGN also had higher plasma ANP concentrations (41.67 to approximately 27.99 pg/mL) than the controls (22.80 to approximately 4.24 pg/mL; P=0.011). Plasma Rn concentrations were lower in patients (24.54 to approximately 16.34 microU/mL) compared to controls (56.76 to approximately 32.36 microU/mL; P=0.027). A positive correlation was found between ET-1 plasma concentrations and the height of systolic or diastolic blood pressure (r=0.57, P=0.013 and r=0.53, P=0.023, respectively). CONCLUSIONS: Our results suggest that increased plasma ET-1 concentrations may play an important role in the pathogenesis of hypertension in children with acute poststreptococcal glomerulonephritis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NPPAHumanglomerulonephritis  IEP associated with Streptococcal Infections and protein:increased expression:plasmaRGD 
NppaRatglomerulonephritis  ISONPPA (Homo sapiens)associated with Streptococcal Infections and protein:increased expression:plasmaRGD 
NppaMouseglomerulonephritis  ISONPPA (Homo sapiens)associated with Streptococcal Infections and protein:increased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nppa  (natriuretic peptide A)

Genes (Mus musculus)
Nppa  (natriuretic peptide type A)

Genes (Homo sapiens)
NPPA  (natriuretic peptide A)


Additional Information