RGD Reference Report - The natriuretic peptide (ovCNP-39) from platypus (Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release. - Rat Genome Database

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The natriuretic peptide (ovCNP-39) from platypus (Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release.

Authors: de Plater, G M  Martin, R L  Milburn, P J 
Citation: de Plater GM, etal., Toxicon. 1998 Jun;36(6):847-57.
RGD ID: 13461752
Pubmed: PMID:9663691   (View Abstract at PubMed)

In this study we characterise the ability of a C-type natriuretic peptide from platypus (Ornithorhynchus anatinus) venom (ovCNP-39) to relax the rat uterus in vitro and we investigate the possibility that ovCNP-39 contributes to the acute effects of envenomation, which include oedema, pain and erythema. We have found that both ovCNP-39 and the endogenous C-type natriuretic peptide, CNP-22, produce oedema in the rat paw and release histamine from rat peritoneal mast cells. Two synthetic peptides, ovCNP-39(1-17) and ovCNP-39(18-39), corresponding to the N- and C-termini, respectively, are equipotent histamine releasers, suggesting that ovCNP-39 and other natriuretic peptides do not act through conventional natriuretic peptide receptors on mast cells.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NppaRatpositive regulation of histamine secretion by mast cell involved_inIDA PMID:9663691UniProt 
NppcRatpositive regulation of mast cell degranulation involved_inIDA PMID:9663691UniProt 
NppcRatpositive regulation of uterine smooth muscle relaxation involved_inIDA PMID:9663691UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Nppa  (natriuretic peptide A)
Nppc  (natriuretic peptide C)


Additional Information