RGD Reference Report - Atrial natriuretic factor blocks the high-threshold Ca2+ current and increases K+ current in fetal single ventricular cells. - Rat Genome Database

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Atrial natriuretic factor blocks the high-threshold Ca2+ current and increases K+ current in fetal single ventricular cells.

Authors: Bkaily, G  Perron, N  Wang, S  Sculptoreanu, A  Jacques, D  Menard, D 
Citation: Bkaily G, etal., J Mol Cell Cardiol. 1993 Nov;25(11):1305-16.
RGD ID: 10047161
Pubmed: (View Article at PubMed) PMID:8301666

The effect of atriopeptin III (ANF) was studied on K+, Ca2+ and Na+ currents of single heart cells of 10-day-old chick embryos and 17- to 20-week old human fetuses. ANF III (2 x 10(-9) M) greatly decreased the basal and cAMP prestimulated high-threshold (IL) Ca2+ current without affecting the low-threshold Ca2+ current (IT) or the TTX-sensitive fast inward Na+ current. ANF III was also found to increase the delayed outward K+ currents (IK) in a dose-dependent fashion (10(-10) to 10(-7) M). The effects of ANF III on IK and IL were reversible upon washout of this hormone. Increasing intracellular guanosine 3',5'-cyclic monophosphate (cGMP) blocked IL but had no effect on IK. These results suggested that ANF regulated one type of Ca2+ current and the delayed outward K+ current in single heart cells. The effects of ANF on IL (but not on IK) could be due in part to the increased [cGMP]i levels or to an unknown signal transduction that is stimulated by this hormone.

Annotation

Objects Annotated

Genes (Rattus norvegicus)
Nppa  (natriuretic peptide A)


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