RGD Reference Report - Increased S100B serum levels in dilated cardiomyopathy patients. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Increased S100B serum levels in dilated cardiomyopathy patients.

Authors: Mazzini, GS  Schaf, DV  Vinade, ER  Horowitz, E  Bruch, RS  Brunm, LM  Goncalves, CA  Bacal, F  Souza, DO  Portela, LV  Bordignon, S 
Citation: Mazzini GS, etal., J Card Fail. 2007 Dec;13(10):850-4.
RGD ID: 2324684
Pubmed: PMID:18068619   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cardfail.2007.07.009   (Journal Full-text)

BACKGROUND: The S100B protein is considered a biochemical marker for brain injuries. However, our group demonstrated that the isolated rat heart releases S100B. In this study, we investigated the serum levels of S100B in dilated cardiomyopathy (DCM) patients to evaluate its levels in heart disease. METHODS AND RESULTS: We selected DCM patients, excluding any condition that could influence S100B serum levels. Control individuals were sex and age matched. Both groups were submitted to clinical evaluation and echocardiography. We measured the S100B and NT-proBNP serum levels (expressed as median [interquartile range]). NT-proBNP levels in patients group (1462 pg/mL [426-3591]) were higher than in controls (35 pg/mL [29-55]), P < .001. S100B serum levels were higher in patients group (0.051 microg/L [0.022-0.144]) than in controls (0.017 microg/L [0.003-0.036]), P = .009. Additionally, we found a positive correlation between S100B and NT-proBNP serum levels only in patients group (Spearman's coefficient r = 0.534; P = .013). CONCLUSIONS: Although we cannot rule out the influence of S100B from brain, the positive correlation between S100B and NT-proBNP levels in DCM patients points to the myocardium as the main source for the rise in S100B serum levels.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NPPBHumandilated cardiomyopathy  IEP protein:increased expression:serumRGD 
NppbRatdilated cardiomyopathy  ISONPPB (Homo sapiens)protein:increased expression:serumRGD 
NppbMousedilated cardiomyopathy  ISONPPB (Homo sapiens)protein:increased expression:serumRGD 
S100BHumandilated cardiomyopathy  IEP protein:increased expression:serumRGD 
S100bRatdilated cardiomyopathy  ISOS100B (Homo sapiens)protein:increased expression:serumRGD 
S100bMousedilated cardiomyopathy  ISOS100B (Homo sapiens)protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nppb  (natriuretic peptide B)
S100b  (S100 calcium binding protein B)

Genes (Mus musculus)
Nppb  (natriuretic peptide type B)
S100b  (S100 protein, beta polypeptide, neural)

Genes (Homo sapiens)
NPPB  (natriuretic peptide B)
S100B  (S100 calcium binding protein B)


Additional Information