Nppb (natriuretic peptide type B) - Rat Genome Database

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Gene: Nppb (natriuretic peptide type B) Mus musculus
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Symbol: Nppb
Name: natriuretic peptide type B
RGD ID: 11004
MGI Page MGI
Description: Predicted to enable hormone activity and hormone receptor binding activity. Involved in several processes, including MAPK cascade; coronary vasculature development; and endothelial cell proliferation. Acts upstream of or within cardiac muscle hypertrophy in response to stress. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and extracellular space. Is expressed in heart; heart atrium; heart left ventricle; heart ventricle; and primitive ventricle. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA408272; B; BNF; BNP; brain natriuretic factor prohormone; brain natriuretic peptide; gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide precursor type B; natriuretic peptides B; preproBNP; proBNP; type-B natriuretic factor
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,070,264 - 148,071,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,070,245 - 148,071,662 (+)EnsemblGRCm39 Ensembl
GRCm384147,985,786 - 147,987,205 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,985,788 - 147,987,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,359,898 - 147,361,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,829,697 - 146,830,998 (+)NCBIMGSCv36mm8
Celera4150,250,201 - 150,251,617 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adult respiratory distress syndrome  (ISO)
Animal Disease Models  (ISO)
anti-basement membrane glomerulonephritis  (IDA)
aortic valve insufficiency  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Brain Injuries  (ISO)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
Charcot-Marie-Tooth disease type 2  (ISO)
chromosome 1p36 deletion syndrome  (ISO)
chronic kidney disease  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Death  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IMP,ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
Ehlers-Danlos syndrome kyphoscoliotic type 1  (ISO)
Eisenmenger Complex  (ISO)
end stage renal disease  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Familial Atrial Fibrillation 6  (ISO)
heart disease  (ISO)
High Cardiac Output  (ISO)
hyperhomocysteinemia  (ISO)
hypertension  (ISO)
hypertensive heart disease  (ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypokalemia  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Kawasaki disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
Metabolic Side Effects of Drugs and Substances  (ISO)
migraine  (ISO)
morbid obesity  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephrosis  (ISO)
obesity  (ISO)
Pain  (ISO)
polycystic kidney disease  (ISO)
Postoperative Complications  (ISO)
proteinuria  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
renal hypertension  (ISO)
sickle cell anemia  (ISO)
systolic heart failure  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Vasovagal Syncope  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Dysfunction, Right  (ISO)
Ventricular Remodeling  (IEP,ISO)
Ventricular Tachycardia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-noradrenaline  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (EXP,ISO)
aluminium phosphide  (ISO)
ammonium chloride  (ISO)
angiotensin II  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
arecoline  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
atenolol  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
bellidifolin  (EXP,ISO)
benazepril  (ISO)
benidipine  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
betaxolol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP,ISO)
bosentan  (ISO)
butyric acid  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
Candesartan cilexetil  (ISO)
captopril  (ISO)
carvedilol  (ISO)
chlorogenic acid  (ISO)
chlorpromazine  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
citronellal  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corilagin  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cucurbitacin I  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
dantrolene  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
dibromine  (ISO)
diethylstilbestrol  (ISO)
digoxin  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
diquat  (EXP)
disulfiram  (ISO)
donepezil hydrochloride  (EXP)
dorsomorphin  (ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
ellagic acid  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
ethanol  (EXP,ISO)
famotidine  (ISO)
fasudil  (EXP)
febuxostat  (ISO)
fenofibrate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gefitinib  (ISO)
gentamycin  (ISO)
glyburide  (ISO)
graphite  (EXP,ISO)
GW 501516  (ISO)
HET0016  (ISO)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
idarubicin  (ISO)
Ile(5)-angiotensin II  (ISO)
indole-3-acetic acid  (ISO)
indoxyl sulfate  (EXP,ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
lead nitrate  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
losartan  (ISO)
melatonin  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metoprolol  (ISO)
mirtazapine  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nebivolol  (ISO)
nickel sulfate  (ISO)
nifedipine  (ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nitroprusside  (ISO)
Olmesartan medoxomil  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (ISO)
Pentoxifylline  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP,ISO)
phenylhydrazine  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
Plantamajoside  (EXP,ISO)
platycodin D  (ISO)
plumbagin  (ISO)
potassium chromate  (ISO)
pregabalin  (ISO)
progesterone  (ISO)
propranolol  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
ramipril  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scutellarin  (EXP)
serpentine asbestos  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
spironolactone  (ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
Tanshinone I  (EXP)
telmisartan  (ISO)
Temocapril hydrochloride  (ISO)
tert-butyl hydroperoxide  (ISO)
thalidomide  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
verapamil  (ISO)
verteporfin  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, etal., Br J Pharmacol. 2009 Dec;158(7):1808-19. doi: 10.1111/j.1476-5381.2009.00461.x.
2. Ultrastructural changes, increased oxidative stress, inflammation, and altered cardiac hypertrophic gene expressions in heart tissues of rats exposed to incense smoke. Al-Attas OS, etal., Environ Sci Pollut Res Int. 2015 Jul;22(13):10083-93. doi: 10.1007/s11356-015-4212-5. Epub 2015 Feb 18.
3. N-terminal pro-B-type natriuretic peptide as an indicator of disease severity in a heterogeneous group of patients with chronic precapillary pulmonary hypertension. Andreassen AK, etal., Am J Cardiol. 2006 Aug 15;98(4):525-9. Epub 2006 Jun 28.
4. Prognostic role of B-type natriuretic peptide in patients with diabetes and acute decompensated heart failure. Aspromonte N, etal., Diabet Med. 2007 Feb;24(2):124-30.
5. Log-transformed plasma level of brain natriuretic peptide during the acute phase of Kawasaki disease is quantitatively associated with myocardial dysfunction. Bang S, etal., Korean J Pediatr. 2011 Aug;54(8):340-4. Epub 2011 Aug 31.
6. Cardioprotective role of growth/differentiation factor 1 in post-infarction left ventricular remodelling and dysfunction. Bao MW, etal., J Pathol. 2015 Jul;236(3):360-72. doi: 10.1002/path.4523. Epub 2015 Mar 30.
7. Impact of the Look AHEAD Intervention on NT-pro Brain Natriuretic Peptide in Overweight and Obese Adults With Diabetes. Bertoni AG, etal., Obesity (Silver Spring). 2011 Sep 29. doi: 10.1038/oby.2011.296.
8. Impact of obesity on the expression profile of natriuretic Peptide system in a rat experimental model. Cabiati M, etal., PLoS One. 2013 Aug 29;8(8):e72959. doi: 10.1371/journal.pone.0072959.
9. Long-term cardiac pro-B-type natriuretic peptide gene delivery prevents the development of hypertensive heart disease in spontaneously hypertensive rats. Cataliotti A, etal., Circulation. 2011 Mar 29;123(12):1297-305. Epub 2011 Mar 14.
10. Ventricular function and natriuretic peptides in sequentially combined models of hypertension. Cavallero S, etal., Am J Physiol Heart Circ Physiol. 2010 Apr;298(4):H1290-9. doi: 10.1152/ajpheart.00911.2009. Epub 2010 Feb 5.
11. Novel protein therapeutics for systolic heart failure: chronic subcutaneous B-type natriuretic peptide. Chen HH, etal., J Am Coll Cardiol. 2012 Dec 4;60(22):2305-12. doi: 10.1016/j.jacc.2012.07.056. Epub 2012 Nov 1.
12. Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy. Christoffersen TE, etal., Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1635-41. Epub 2005 Nov 4.
13. Serum levels of N--terminal proB--type natriuretic peptide in mechanically ventilated critically ill patients -- relation to tidal volume size and development of acute respiratory distress syndrome. Determann RM, etal., BMC Pulm Med. 2013 Jul 9;13(1):42.
14. B-type natriuretic peptide concentrations in contemporary Eisenmenger syndrome patients: predictive value and response to disease targeting therapy. Diller GP, etal., Heart. 2012 May;98(9):736-42. doi: 10.1136/heartjnl-2011-301522. Epub 2012 Mar 7.
15. N-terminal-pro-brain natriuretic peptide, but not brain natriuretic peptide, is increased in patients with severe obesity. Fernandes F, etal., Braz J Med Biol Res. 2007 Feb;40(2):153-8.
16. Prognostic value of NT-proBNP in patients with severe COVID-19. Gao L, etal., Respir Res. 2020 Apr 15;21(1):83. doi: 10.1186/s12931-020-01352-w.
17. Long-term effects of B-type natriuretic peptide infusion after acute myocardial infarction in a rat model. George I, etal., J Cardiovasc Pharmacol. 2010 Jan;55(1):14-20.
18. Plasma pro-B-type natriuretic peptide in the general population: screening for left ventricular hypertrophy and systolic dysfunction. Goetze JP, etal., Eur Heart J. 2006 Dec;27(24):3004-10. Epub 2006 Nov 21.
19. Enhanced expression of DYRK1A in cardiomyocytes inhibits acute NFAT activation but does not prevent hypertrophy in vivo. Grebe C, etal., Cardiovasc Res. 2011 Jun 1;90(3):521-8. doi: 10.1093/cvr/cvr023. Epub 2011 Jan 27.
20. [Effects of buyang huanwu decoction on the sarcoplasmic reticulum calcium uptake in abdominal aortic constriction induced myocardial hypertrophic rats]. Gu YP, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 May;33(5):627-31.
21. Parallel gene expressions of IL-6 and BNP during cardiac hypertrophy complicated with diastolic dysfunction in spontaneously hypertensive rats. Haugen E, etal., Int J Cardiol. 2007 Jan 31;115(1):24-8. Epub 2006 Jun 8.
22. Studies on biochemical markers in cryoinfarction in rats. Hemalatha T, etal., Cryo Letters. 2006 Sep-Oct;27(5):311-8.
23. Hyperhomocysteinemia and myocardial expression of brain natriuretic peptide in rats. Herrmann M, etal., Clin Chem. 2007 Apr;53(4):773-80. Epub 2007 Feb 15.
24. B-type natriuretic peptide infusions in acute myocardial infarction. Hillock RJ, etal., Heart. 2008 May;94(5):617-22. Epub 2007 Jul 16.
25. Increased plasma levels and blunted effects of brain natriuretic peptide in rats with congestive heart failure. Hoffman A, etal., Am J Hypertens. 1991 Jul;4(7 Pt 1):597-601.
26. B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension. Holditch SJ, etal., Hypertension. 2015 Jul;66(1):199-210. doi: 10.1161/HYPERTENSIONAHA.115.05610. Epub 2015 May 11.
27. B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease. Holditch SJ, etal., Kidney Int. 2017 Sep;92(3):657-668. doi: 10.1016/j.kint.2017.02.017. Epub 2017 Apr 14.
28. Effects of brain natriuretic peptide on contraction and intracellular Ca2+ in ventricular myocytes from the streptozotocin-induced diabetic rat. Howarth FC, etal., Ann N Y Acad Sci. 2006 Nov;1084:155-65.
29. Regional cardiac expression and concentration of natriuretic peptides in patients with severe chronic heart failure. Hystad ME, etal., Acta Physiol Scand. 2001 Apr;171(4):395-403.
30. Molecular forms of human brain natriuretic peptide (BNP) in plasma of patients on hemodialysis (HD). Ishizaka Y, etal., Clin Nephrol. 1995 Apr;43(4):237-42.
31. B-type natriuretic peptide versus amino terminal pro-B type natriuretic peptide: selecting the optimal heart failure marker in patients with impaired kidney function. Jafri L, etal., BMC Nephrol. 2013 May 31;14:117. doi: 10.1186/1471-2369-14-117.
32. B-type natriuretic peptide and risk of contrast-induced acute kidney injury in acute ST-segment-elevation myocardial infarction: a substudy from the HORIZONS-AMI trial. Jarai R, etal., Circ Cardiovasc Interv. 2012 Dec;5(6):813-20. doi: 10.1161/CIRCINTERVENTIONS.112.972356. Epub 2012 Nov 27.
33. A new, fast and reliable radioimmunoassay of brain natriuretic peptide in human plasma. Reference values in healthy subjects and in patients with different diseases. Jensen KT, etal., Scand J Clin Lab Invest. 1997 Oct;57(6):529-40.
34. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
35. Altered regulation of nitric oxide and natriuretic peptide system in cisplatin-induced nephropathy. Kim CS, etal., Regul Pept. 2012 Feb 10;174(1-3):65-70. doi: 10.1016/j.regpep.2011.12.001. Epub 2011 Dec 28.
36. Increased plasma type B natriuretic peptide in the acute phase of Kawasaki disease. Kishimoto S, etal., Pediatr Int. 2011 Oct;53(5):736-41. doi: 10.1111/j.1442-200X.2011.03351.x.
37. A novel variable number of tandem repeat of the natriuretic peptide precursor B gene's 5'-flanking region is associated with essential hypertension among Japanese females. Kosuge K, etal., Int J Med Sci. 2007 May 16;4(3):146-52.
38. N-terminal pro-Brain Natriuretic Peptide and Risk of Diabetes. Lazo M, etal., Diabetes. 2013 Jun 3.
39. N-terminal pro-brain natriuretic peptide and renal insufficiency as predictors of mortality in pulmonary hypertension. Leuchte HH, etal., Chest. 2007 Feb;131(2):402-9.
40. Clinical and pathological investigation of severe COVID-19 patients. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
41. NT Pro BNP Plasma Level and Atrial Volume Are Linked to the Severity of Liver Cirrhosis. Licata A, etal., PLoS One. 2013 Aug 5;8(8):e68364. doi: 10.1371/journal.pone.0068364. Print 2013.
42. Development of cardiac hypertrophy by sunitinib in vivo and in vitro rat cardiomyocytes is influenced by the aryl hydrocarbon receptor signaling pathway. Maayah ZH, etal., Arch Toxicol. 2014 Mar;88(3):725-38. doi: 10.1007/s00204-013-1159-5. Epub 2013 Nov 19.
43. NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease. Machado RF, etal., Br J Haematol. 2011 Aug;154(4):512-20. doi: 10.1111/j.1365-2141.2011.08777.x. Epub 2011 Jun 21.
44. Transgenic overexpression of brain natriuretic peptide prevents the progression of diabetic nephropathy in mice. Makino H, etal., Diabetologia. 2006 Oct;49(10):2514-24. Epub 2006 Aug 18.
45. Experimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: a kidney-heart connection. Martin FL, etal., Am J Physiol Regul Integr Comp Physiol. 2012 Jan 15;302(2):R292-9. doi: 10.1152/ajpregu.00194.2011. Epub 2011 Nov 9.
46. Increased S100B serum levels in dilated cardiomyopathy patients. Mazzini GS, etal., J Card Fail. 2007 Dec;13(10):850-4.
47. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
48. MGDs mouse GO annotations MGD data from the GO Consortium
49. MGD IEA MGD IEA
50. Cardiorenal syndrome in hypertensive rats: microalbuminuria, inflammation and ventricular hypertrophy. Moubarak M, etal., Physiol Res. 2012 Mar 6;61(1):13-24. Epub 2011 Dec 20.
51. Increased human brain natriuretic peptide in congestive heart failure. Mukoyama M, etal., N Engl J Med. 1990 Sep 13;323(11):757-8.
52. NT-proANP and BNP in renovascular and in severe and mild essential hypertension. Mussalo H, etal., Kidney Blood Press Res. 2003;26(1):34-41.
53. Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload. Nakagawa O, etal., J Clin Invest. 1995 Sep;96(3):1280-7.
54. Natriuretic peptides for early prediction of acute kidney injury in community-acquired pneumonia. Nowak A, etal., Clin Chim Acta. 2013 Apr 18;419:67-72. doi: 10.1016/j.cca.2013.01.014. Epub 2013 Feb 13.
55. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
56. Relationship of brain natriuretic peptide with metabolic syndrome parameters: an observational study. Oztekin S, etal., Anadolu Kardiyol Derg. 2011 Dec;11(8):678-84. doi: 10.5152/akd.2011.188. Epub 2011 Oct 28.
57. Vitamin D receptor activation, left ventricular hypertrophy and myocardial fibrosis. Panizo S, etal., Nephrol Dial Transplant. 2013 Sep 7.
58. SNP rs198389 (T-381 C) polymorphism in the B-type natriuretic peptide gene promoter in patients with atherosclerotic renovascular hypertension. Poreba R, etal., Pol Arch Med Wewn. 2009 Apr;119(4):219-24.
59. Elevated N-terminal pro-brain natriuretic peptide is associated with increased mortality in patients with COVID-19: systematic review and meta-analysis. Pranata R, etal., Postgrad Med J. 2020 May 20. pii: postgradmedj-2020-137884. doi: 10.1136/postgradmedj-2020-137884.
60. B-type natriuretic peptide pretreatment attenuates heart ischemia-reperfusion injury in rats. Ren B, etal., Transplant Proc. 2010 Dec;42(10):4496-8.
61. Mouse MP Annotation Import Pipeline RGD automated import pipeline
62. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
63. B-type natriuretic peptides are reliable markers of cardiac strain in CKD pediatric patients. Rinat C, etal., Pediatr Nephrol. 2012 Apr;27(4):617-25. doi: 10.1007/s00467-011-2025-4. Epub 2011 Oct 27.
64. The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. Seidman CE, etal., Science 1984 Jul 20;225(4659):324-6.
65. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Shahid M, etal., Am J Physiol Heart Circ Physiol. 2016 Apr 15;310(8):H984-94. doi: 10.1152/ajpheart.00879.2015. Epub 2016 Feb 12.
66. Detection of membrane-bound guanylate cyclase activity in rat C6 glioma cells at different growth states following activation by natriuretic peptides. Sorci G, etal., Brain Res. 1995 Jun 12;683(1):51-8.
67. Overexpression of brain natriuretic peptide in mice ameliorates immune-mediated renal injury. Suganami T, etal., J Am Soc Nephrol. 2001 Dec;12(12):2652-63.
68. Posttranscriptional Control of BNP Gene Expression in Angiotensin II-Induced Hypertension. Suo M, etal., Hypertension 2002 Mar 1;39(3):803-8.
69. The association of brain natriuretic peptide and insulin resistance in obesity-related hypertension. Tekes S and Cikim AS, J Hum Hypertens. 2007 Jul;21(7):546-50. Epub 2007 Mar 29.
70. Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy: the CARDIGENE study. Tiret L, etal., J Am Coll Cardiol. 2000 Jan;35(1):29-35.
71. Upregulated neurohumoral factors are associated with left ventricular remodeling and poor prognosis in rats with monocrotaline-induced pulmonary arterial hypertension. Usui S, etal., Circ J. 2006 Sep;70(9):1208-15.
72. Serum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine. Uzar E, etal., Eur Rev Med Pharmacol Sci. 2011 Oct;15(10):1111-6.
73. Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat. Vahtola E, etal., J Hypertens. 2008 Feb;26(2):334-44.
74. The prognostic value of pro-B-Type natriuretic peptide in acute pulmonary embolism. Verschuren F, etal., Thromb Res. 2013 Jun;131(6):e235-9. doi: 10.1016/j.thromres.2013.03.009. Epub 2013 Apr 4.
75. Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy. Walther T, etal., J Mol Endocrinol. 2000 Jun;24(3):391-5.
76. N-terminal pro-B-type natriuretic peptide in patients with isolated traumatic brain injury: a prospective cohort study. Wu X, etal., J Trauma. 2011 Oct;71(4):820-5; discussion 825.
77. WY14643 improves left ventricular myocardial mitochondrial and systolic functions in obese rats under chronic persistent hypoxia via the PPARα pathway. Yan J, etal., Life Sci. 2021 Feb 1;266:118888. doi: 10.1016/j.lfs.2020.118888. Epub 2020 Dec 10.
78. Clinical characteristics and outcomes of patients with severe covid-19 with diabetes. Yan Y, etal., BMJ Open Diabetes Res Care. 2020 Apr;8(1). pii: 8/1/e001343. doi: 10.1136/bmjdrc-2020-001343.
79. Plasma brain natriuretic peptide levels in normotensive noninsulin-dependent diabetic patients with microalbuminuria. Yano Y, etal., J Clin Endocrinol Metab. 1999 Jul;84(7):2353-6.
80. Increased plasma levels and effects of brain natriuretic peptide in experimental nephrosis. Yokota N, etal., Nephron. 1993;65(3):454-9.
81. B-type natriuretic peptide for prevention of contrast-induced nephropathy in patients with heart failure undergoing primary percutaneous coronary intervention. Zhang J, etal., Acta Radiol. 2010 Jul;51(6):641-8. doi: 10.3109/02841851.2010.486804.
82. Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents. Zhang Q, etal., Acta Paediatr. 2013 May;102(5):e210-4. doi: 10.1111/apa.12182. Epub 2013 Feb 21.
83. Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction. Zhang Y, etal., Biochim Biophys Acta. 2014 Feb;1842(2):232-44. doi: 10.1016/j.bbadis.2013.11.018. Epub 2013 Nov 23.
84. The clinical characteristics and outcomes of patients with diabetes and secondary hyperglycaemia with coronavirus disease 2019: A single-centre, retrospective, observational study in Wuhan. Zhang Y, etal., Diabetes Obes Metab. 2020 May 14. doi: 10.1111/dom.14086.
85. Inhibition of CYP1B1 ameliorates cardiac hypertrophy induced by uremic toxin. Zhang Y, etal., Mol Med Rep. 2020 Jan;21(1):393-404. doi: 10.3892/mmr.2019.10810. Epub 2019 Nov 11.
86. Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu. Zheng Y, etal., J Clin Virol. 2020 Jun;127:104366. doi: 10.1016/j.jcv.2020.104366. Epub 2020 Apr 10.
87. Brain natriuretic peptide is related to carotid plaques and predicts atherosclerosis in pre-dialysis patients with chronic kidney disease. Zhou W, etal., Eur J Intern Med. 2012 Sep;23(6):539-44. doi: 10.1016/j.ejim.2012.06.001. Epub 2012 Jun 24.
Additional References at PubMed
PMID:7769089   PMID:8097440   PMID:8135846   PMID:8182124   PMID:8603590   PMID:8877790   PMID:8877792   PMID:8889548   PMID:9482886   PMID:10021345   PMID:10349636   PMID:10733590  
PMID:10737768   PMID:10892744   PMID:11042159   PMID:11076861   PMID:11238910   PMID:11390666   PMID:11518254   PMID:11558681   PMID:12124219   PMID:12297046   PMID:12464436   PMID:12466305  
PMID:12477932   PMID:12484513   PMID:14499647   PMID:14599720   PMID:14633990   PMID:15196958   PMID:15464586   PMID:15489334   PMID:15902305   PMID:15939815   PMID:16141072   PMID:16141073  
PMID:16374517   PMID:16530167   PMID:16602821   PMID:17188849   PMID:17303760   PMID:17468400   PMID:17482496   PMID:17822384   PMID:17823376   PMID:18367637   PMID:18502258   PMID:18554416  
PMID:18628400   PMID:18816849   PMID:19015276   PMID:19275472   PMID:19346456   PMID:19399180   PMID:19401302   PMID:19411759   PMID:19483677   PMID:19487812   PMID:19622544   PMID:19670825  
PMID:19782130   PMID:19805191   PMID:19805384   PMID:20007915   PMID:20080568   PMID:20194497   PMID:20439457   PMID:20562099   PMID:20606005   PMID:20705924   PMID:20711735   PMID:21041952  
PMID:21267068   PMID:21270129   PMID:21289070   PMID:21421818   PMID:21633169   PMID:21768366   PMID:21839733   PMID:21873635   PMID:21880664   PMID:22090424   PMID:22267199   PMID:22403008  
PMID:22431517   PMID:22617407   PMID:22923619   PMID:23236519   PMID:23342106   PMID:23382219   PMID:23704570   PMID:23921644   PMID:23968980   PMID:24104878   PMID:24137001   PMID:24161931  
PMID:24312267   PMID:24344164   PMID:24391132   PMID:24438367   PMID:24585936   PMID:24717731   PMID:24840128   PMID:24887312   PMID:24938781   PMID:25071214   PMID:25123163   PMID:25332179  
PMID:25670795   PMID:25917834   PMID:26079807   PMID:26207612   PMID:26487682   PMID:26517044   PMID:26576636   PMID:26641069   PMID:27048739   PMID:27150455   PMID:27175010   PMID:27249171  
PMID:27249321   PMID:27346147   PMID:27357444   PMID:27385019   PMID:27721024   PMID:28159809   PMID:28188211   PMID:28390247   PMID:28447738   PMID:28476948   PMID:28732025   PMID:28771943  
PMID:28973536   PMID:29117561   PMID:29320742   PMID:29632206   PMID:29734386   PMID:29796691   PMID:30700554   PMID:30898653   PMID:30936179   PMID:31259610   PMID:31581792   PMID:31688894  
PMID:32212902   PMID:32248761   PMID:32324169   PMID:32804075   PMID:33107387   PMID:33245046   PMID:33663221   PMID:33763067   PMID:33805532   PMID:33898448   PMID:34329394   PMID:34333993  
PMID:34622152   PMID:34919054   PMID:34988124   PMID:34996942   PMID:35521669   PMID:35875660   PMID:36220812   PMID:36230906   PMID:36539111   PMID:36756875   PMID:36899856   PMID:37067297  
PMID:38196272   PMID:38226173   PMID:38382296   PMID:38395995   PMID:38522572   PMID:38877142   PMID:38950288   PMID:39239522   PMID:39304345  


Genomics

Comparative Map Data
Nppb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,070,264 - 148,071,662 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,070,245 - 148,071,662 (+)EnsemblGRCm39 Ensembl
GRCm384147,985,786 - 147,987,205 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,985,788 - 147,987,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,359,898 - 147,361,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364146,829,697 - 146,830,998 (+)NCBIMGSCv36mm8
Celera4150,250,201 - 150,251,617 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.57NCBI
NPPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,857,464 - 11,858,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,857,464 - 11,858,945 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,917,521 - 11,919,002 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,840,108 - 11,841,579 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,851,789 - 11,853,254NCBI
Celera111,031,156 - 11,032,627 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef111,073,021 - 11,074,492 (-)NCBIHuRef
CHM1_1111,905,417 - 11,906,888 (-)NCBICHM1_1
T2T-CHM13v2.0111,401,560 - 11,403,041 (-)NCBIT2T-CHM13v2.0
Nppb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85163,699,955 - 163,701,314 (+)NCBIGRCr8
mRatBN7.25158,416,813 - 158,418,175 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5158,416,866 - 158,418,168 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,133,613 - 161,134,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05162,961,436 - 162,962,738 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05162,917,783 - 162,919,085 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05164,796,176 - 164,797,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,796,185 - 164,797,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,454,278 - 168,455,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,062,348 - 165,063,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,072,535 - 165,073,838 (+)NCBI
Celera5156,698,873 - 156,700,175 (+)NCBICelera
Cytogenetic Map5q36NCBI
Nppb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554862,054,775 - 2,056,130 (+)NCBIChiLan1.0ChiLan1.0
NPPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,361,604 - 216,364,862 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,008,742 - 215,011,988 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0110,621,416 - 10,622,960 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,838,518 - 11,839,999 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,838,518 - 11,839,995 (-)Ensemblpanpan1.1panPan2
NPPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,395,844 - 84,397,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha280,929,289 - 80,930,932 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,060,368 - 85,062,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,060,271 - 85,073,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1281,809,597 - 81,811,239 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,809,514 - 82,811,156 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0283,872,280 - 83,873,924 (+)NCBIUU_Cfam_GSD_1.0
Nppb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,858,528 - 34,860,962 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474683,325 - 684,665 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936474683,325 - 684,662 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,930,382 - 71,932,254 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,930,374 - 71,931,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,840,061 - 65,841,530 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,930,931 - 119,933,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20119,932,021 - 119,933,197 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605423,799,168 - 23,801,437 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nppb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,139,776 - 1,141,010 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:95
Interacting mature miRNAs:100
Transcripts:ENSMUST00000103231
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
12738431Lfibq20_mliver fibrosis QTL 20 (mouse)4144699835148907426Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse

Markers in Region
RH124694  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS
Nppb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384147,986,009 - 147,986,997UniSTSGRCm38
MGSCv374147,360,118 - 147,361,106UniSTSGRCm37
Celera4150,250,421 - 150,251,409UniSTS
Cytogenetic Map4E2UniSTS
cM Map476.5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001287348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006538627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB039044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB039052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL714013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU609640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK128345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK332585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D16497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D19444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D82049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S58667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000103231   ⟹   ENSMUSP00000099521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4148,070,245 - 148,071,662 (+)Ensembl
GRCm38.p6 Ensembl4147,985,788 - 147,987,205 (+)Ensembl
RefSeq Acc Id: NM_001287348   ⟹   NP_001274277
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,070,357 - 148,071,662 (+)NCBI
GRCm384147,985,900 - 147,987,205 (+)NCBI
Celera4150,250,200 - 150,251,617 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008726   ⟹   NP_032752
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,070,357 - 148,071,662 (+)NCBI
GRCm384147,985,900 - 147,987,205 (+)NCBI
MGSCv374147,359,898 - 147,361,314 (+)RGD
Celera4150,250,200 - 150,251,617 (+)NCBI
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006538627   ⟹   XP_006538690
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394148,070,264 - 148,071,662 (+)NCBI
GRCm384147,985,786 - 147,987,205 (+)NCBI
Sequence:
RefSeq Acc Id: NP_032752   ⟸   NM_008726
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P40753 (UniProtKB/Swiss-Prot),   Q54AE9 (UniProtKB/TrEMBL),   O55086 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006538690   ⟸   XM_006538627
- Peptide Label: isoform X1
- UniProtKB: O55086 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274277   ⟸   NM_001287348
- Peptide Label: isoform 2 preproprotein
- UniProtKB: O55086 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000099521   ⟸   ENSMUST00000103231

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P40753-F1-model_v2 AlphaFold P40753 1-121 view protein structure

Promoters
RGD ID:6835763
Promoter ID:MM_KWN:40791
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000023693,   UC008VTP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364147,359,801 - 147,360,301 (+)MPROMDB
RGD ID:6885486
Promoter ID:EPDNEW_M6194
Type:multiple initiation site
Name:Nppb_1
Description:Mus musculus natriuretic peptide type B , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384147,985,900 - 147,985,960EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97368 AgrOrtholog
Ensembl Genes ENSMUSG00000029019 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000103231 ENTREZGENE
  ENSMUST00000103231.5 UniProtKB/Swiss-Prot
InterPro Natr_peptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natr_peptide_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natriuretic_peptide UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Natriuretic_peptide_brain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18158 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97368 ENTREZGENE
NCBI Gene 18158 ENTREZGENE
PANTHER ATRIAL NATRIURETIC FACTOR PRECURSOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NATRIURETIC PEPTIDES B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ANP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NPPB RGD
PhenoGen Nppb PhenoGen
PRINTS BNATPEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART NAT_PEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ANFB_MOUSE UniProtKB/Swiss-Prot
  O55086 ENTREZGENE, UniProtKB/TrEMBL
  P40753 ENTREZGENE
  Q54AE9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Nppb  natriuretic peptide type B  Nppb  natriuretic peptide precursor type B  Symbol and/or name change 5135510 APPROVED