RGD Reference Report - NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease.

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NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease.
Authors:	Machado, RF Hildesheim, M Mendelsohn, L Remaley, AT Kato, GJ Gladwin, MT
Citation:	Machado RF, etal., Br J Haematol. 2011 Aug;154(4):512-20. doi: 10.1111/j.1365-2141.2011.08777.x. Epub 2011 Jun 21.
RGD ID:	5685653
Pubmed:	PMID:21689089 (View Abstract at PubMed)
PMCID:	PMC3206726 (View Article at PubMed Central)
DOI:	DOI:10.1111/j.1365-2141.2011.08777.x (Journal Full-text)
Epidemiological studies support a hypothesis that pulmonary hypertension (PH) is a common complication of sickle cell disease (SCD) that is associated with a high risk of death and evolves as a complication of haemolytic anaemia. This fundamental hypothesis has been recently challenged and remains controversial. In order to further test this hypothesis in a large and independent cohort of SCD patients we obtained plasma samples from the Cooperative Study of Sickle Cell Disease (CSSCD) for analysis of a biomarker, N-terminal-pro brain natriuretic peptide (NT-proBNP), which is elevated in the setting of pulmonary arterial and venous hypertension. A NT-pro-BNP value previously identified to predict PH in adults with SCD was used to determine the association between the risk of mortality in 758 CSSCD participants (428 children and 330 adults). An abnormally high NT-proBNP level >/=160ng/l was present in 27.6% of adult SCD patients. High levels were associated with markers of haemolytic anaemia, such as low haemoglobin level (P<0.001), high lactate dehydrogenase (P<0.001), and high total bilirubin levels (P<0.007). A NT-proBNP level >/=160ng/l was an independent predictor of mortality (RR 6.24, 95% CI 2.9-13.3, P<0.0001). These findings provide further support for an association between haemolytic anaemia and cardiovascular complications in this patient population.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
NPPB	Human	sickle cell anemia	severity	IEP			RGD
Nppb	Rat	sickle cell anemia	severity	ISO	NPPB (Homo sapiens)		RGD
Nppb	Mouse	sickle cell anemia	severity	ISO	NPPB (Homo sapiens)		RGD

Objects Annotated

Genes (Rattus norvegicus)

Nppb (natriuretic peptide B)

Genes (Mus musculus)

Nppb (natriuretic peptide type B)

Genes (Homo sapiens)

NPPB (natriuretic peptide B)

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NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease.