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Gene: Nppb (natriuretic peptide B) Rattus norvegicus
Symbol: Nppb
Name: natriuretic peptide B
RGD ID: 3194
Description: Exhibits hormone activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cell population proliferation; and positive regulation of cGMP-mediated signaling. Localizes to several cellular components, including extracellular space; perinuclear region of cytoplasm; and transport vesicle. Used to study hypertension; hypertensive heart disease; myocardial infarction; polycystic kidney disease; and proteinuria. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); heart disease (multiple); hyperhomocysteinemia; and obesity. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B); PARTICIPATES IN brain natriuretic peptide signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
Also known as: Bnf; BNP; Brain natriuretic factor; brain natriuretic peptide; gamma-brain natriuretic peptide; iso-ANP; natriuretic peptide precursor B; natriuretic peptide precursor type B; natriuretic peptides B
Homo sapiens (human) : NPPB (natriuretic peptide B)  HGNC  Alliance
Mus musculus (house mouse) : Nppb (natriuretic peptide type B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppb (natriuretic peptide B)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPB (natriuretic peptide B)
Canis lupus familiaris (dog) : NPPB (natriuretic peptide B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppb (natriuretic peptide B)
Sus scrofa (pig) : NPPB (natriuretic peptide B)
Chlorocebus sabaeus (African green monkey) : NPPB (natriuretic peptide B)
Heterocephalus glaber (naked mole-rat) : Nppb (natriuretic peptide B)
more info ...
Allele / Splice: Nppbem2Mcwi   Nppbem4Mcwi  
Genetic Models: SS-Nppbem4Mcwi SS-Nppbem2Mcwi-/- SS-Nppbem2Mcwi
Is Marker For: Strains:   SD  
QTLs:   Bp100  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05164,796,176 - 164,797,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,796,185 - 164,797,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,454,278 - 168,455,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,062,348 - 165,063,650 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,072,535 - 165,073,838 (+)NCBI
Celera5156,698,873 - 156,700,175 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nppb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3194
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.