Gene: Nppb (natriuretic peptide B) Rattus norvegicus
Symbol: Nppb
Name: natriuretic peptide B
Description: ENCODES a protein that exhibits hormone activity; hormone receptor binding (ortholog); signaling receptor binding (ortholog); INVOLVED IN cell growth involved in cardiac muscle cell development; cellular response to mechanical stimulus; heart development; PARTICIPATES IN brain natriuretic peptide signaling pathway; ASSOCIATED WITH cardiac hypertrophy; hypertension; prolonged QT interval; ASSOCIATED WITH acute kidney failure; Cardiomegaly; congestive heart failure; FOUND IN cytoplasm; extracellular space; nucleus; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl
Type: protein-coding
Also known as: Bnf; BNP; Brain natriuretic factor; brain natriuretic peptide; gamma-brain natriuretic peptide; iso-ANP; natriuretic peptide precursor B; natriuretic peptide precursor type B; natriuretic peptides B
Homo sapiens (human) : NPPB (natriuretic peptide B)  HGNC  Alliance
Mus musculus (house mouse) : Nppb (natriuretic peptide type B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppb (natriuretic peptide B)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPB (natriuretic peptide B)
Canis lupus familiaris (dog) : NPPB (natriuretic peptide B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppb (natriuretic peptide B)
more info ...
Allele / Splice: Nppbem2Mcwi   Nppbem4Mcwi  
Genetic Models: SS-Nppbem2Mcwi SS-Nppbem4Mcwi
Is Marker For: Strains:   SD  
QTLs:   Bp100  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05164,796,176 - 164,797,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05168,454,278 - 168,455,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,062,348 - 165,063,650 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,072,535 - 165,073,838 (+)NCBI
Celera5156,698,873 - 156,700,175 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nppb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3194
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2018-05-29
Status: ACTIVE