Nppb (natriuretic peptide B) - Rat Genome Database
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Gene: Nppb (natriuretic peptide B) Rattus norvegicus
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Symbol: Nppb
Name: natriuretic peptide B
RGD ID: 3194
Description: Exhibits hormone activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cell population proliferation; and positive regulation of cGMP-mediated signaling. Localizes to several cellular components, including extracellular space; perinuclear region of cytoplasm; and transport vesicle. Used to study hypertension; hypertensive heart disease; myocardial infarction; polycystic kidney disease; and proteinuria. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); heart disease (multiple); hyperhomocysteinemia; and obesity. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B); PARTICIPATES IN brain natriuretic peptide signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Bnf; BNP; Brain natriuretic factor; brain natriuretic peptide; gamma-brain natriuretic peptide; iso-ANP; natriuretic peptide precursor B; natriuretic peptide precursor type B; natriuretic peptides B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nppbem2Mcwi   Nppbem4Mcwi  
Genetic Models: SS-Nppbem4Mcwi SS-Nppbem2Mcwi-/- SS-Nppbem2Mcwi
Is Marker For: Strains:   SD  
QTLs:   Bp100  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05164,796,176 - 164,797,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,796,185 - 164,797,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,454,278 - 168,455,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,062,348 - 165,063,650 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,072,535 - 165,073,838 (+)NCBI
Celera5156,698,873 - 156,700,175 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IEP,ISO)
adult respiratory distress syndrome  (ISO)
Animal Disease Models  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
aortic valve insufficiency  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Brain Injuries  (ISO)
Cardiac Output, High  (ISO)
Cardiomegaly  (IDA,IEP,ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
chronic kidney disease  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (IEP,ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Death  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Dyspnea  (ISO)
Eisenmenger Complex  (ISO)
end stage renal disease  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (IEP)
Familial Atrial Fibrillation 6  (ISO)
heart disease  (IEP,ISO)
hyperhomocysteinemia  (IEP)
hypertension  (IDA,IEP,ISO)
hypertensive heart disease  (IDA)
Hypertensive Nephropathy  (IMP)
hypokalemia  (ISO)
Hyponatremia  (ISO)
Hypotension  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Kawasaki disease  (ISO)
Left Ventricular Hypertrophy  (IDA,IEP,ISO)
liver cirrhosis  (ISO)
migraine  (ISO)
morbid obesity  (ISO)
myocardial infarction  (IEP,IMP,ISO)
Myocardial Reperfusion Injury  (IDA)
nephrosis  (IEP)
obesity  (IEP,ISO)
Pain  (ISO)
polycystic kidney disease  (IDA)
Postoperative Complications  (ISO)
proteinuria  (IMP)
pulmonary embolism  (ISO)
pulmonary hypertension  (IEP,ISO)
renal hypertension  (IEP,ISO)
sickle cell anemia  (ISO)
systolic heart failure  (ISO)
type 2 diabetes mellitus  (IEP,ISO)
ureteral obstruction  (ISO)
Vasovagal Syncope  (ISO)
Ventricular Dysfunction, Left  (IEP,ISO)
Ventricular Dysfunction, Right  (ISO)
Ventricular Remodeling  (ISO)
Ventricular Tachycardia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-noradrenaline  (ISO)
1,10-phenanthroline  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-(1,4-diazepane-1-sulfonyl)isoquinoline  (ISO)
5-azacytidine  (ISO)
acetylsalicylic acid  (EXP,ISO)
aflatoxin B1  (ISO)
aldosterone  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aspartame  (ISO)
atenolol  (EXP,ISO)
atorvastatin calcium  (ISO)
benazepril  (EXP)
benidipine  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
betaxolol  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
butyric acid  (EXP)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcitriol  (EXP)
Candesartan cilexetil  (EXP)
captopril  (EXP)
carvedilol  (EXP,ISO)
chromium atom  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin I  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
dantrolene  (EXP)
daunorubicin  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
digoxin  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
disulfiram  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxazosin  (EXP,ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP)
ethanol  (EXP,ISO)
famotidine  (EXP)
fasudil hydrochloride  (ISO)
febuxostat  (EXP)
fenofibrate  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
furan  (EXP)
gefitinib  (EXP)
gentamycin  (EXP)
glyburide  (EXP)
graphite  (EXP,ISO)
GW 501516  (EXP)
hydralazine  (EXP)
hydrochlorothiazide  (EXP)
idarubicin  (ISO)
indoxyl sulfate  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
lead nitrate  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
melatonin  (EXP)
melphalan  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
monocrotaline  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nebivolol  (ISO)
nickel sulfate  (ISO)
nifedipine  (EXP)
nitric oxide  (EXP)
nitroprusside  (ISO)
Olmesartan medoxomil  (EXP)
p-chloromercuribenzoic acid  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenylephrine  (EXP,ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
Plantamajoside  (EXP,ISO)
platycodin D  (EXP)
plumbagin  (EXP)
potassium chromate  (ISO)
pregabalin  (EXP)
progesterone  (EXP)
propranolol  (EXP)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP)
ramipril  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sirolimus  (EXP)
spironolactone  (ISO)
streptozocin  (EXP)
sunitinib  (EXP,ISO)
tacrolimus hydrate  (ISO)
telmisartan  (EXP,ISO)
Temocapril hydrochloride  (ISO)
tert-butyl hydroperoxide  (ISO)
thalidomide  (ISO)
thiabendazole  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
valsartan  (EXP,ISO)
verapamil  (ISO)
vitamin E  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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Additional References at PubMed
PMID:1652217   PMID:1660465   PMID:1672777   PMID:2525379   PMID:2525380   PMID:2528349   PMID:2673236   PMID:11410403   PMID:12562779   PMID:12727915   PMID:12941780   PMID:15837527  
PMID:15911064   PMID:16357805   PMID:16870210   PMID:17345093   PMID:17566658   PMID:17587490   PMID:17906112   PMID:18006556   PMID:18032399   PMID:18404982   PMID:18408131   PMID:18420944  
PMID:18499087   PMID:19139378   PMID:19721230   PMID:19752486   PMID:20108079   PMID:20559433   PMID:21951964   PMID:22474982   PMID:22547442   PMID:23382219   PMID:23454171   PMID:23497124  
PMID:24137001   PMID:24289757   PMID:24477916   PMID:25063069   PMID:25218476   PMID:25278510   PMID:25669688   PMID:25698234   PMID:25865156   PMID:26136529   PMID:26254181   PMID:26261563  
PMID:26838190   PMID:27162120   PMID:27228659   PMID:27443845   PMID:30221729   PMID:31766450  


Genomics

Candidate Gene Status
Nppb is a candidate Gene for QTL Bp155
Comparative Map Data
Nppb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05164,796,176 - 164,797,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5164,796,185 - 164,797,531 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05168,454,278 - 168,455,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,062,348 - 165,063,650 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15165,072,535 - 165,073,838 (+)NCBI
Celera5156,698,873 - 156,700,175 (+)NCBICelera
Cytogenetic Map5q36NCBI
NPPB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl111,857,464 - 11,858,945 (-)EnsemblGRCh38hg38GRCh38
GRCh38111,857,464 - 11,858,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,917,521 - 11,918,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,840,108 - 11,841,579 (-)NCBINCBI36hg18NCBI36
Build 34111,851,789 - 11,853,254NCBI
Celera111,031,156 - 11,032,627 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef111,073,021 - 11,074,492 (-)NCBIHuRef
CHM1_1111,905,417 - 11,906,888 (-)NCBICHM1_1
Nppb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,070,264 - 148,071,662 (+)NCBIGRCm39mm39
GRCm384147,985,786 - 147,987,205 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4147,985,788 - 147,987,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,359,898 - 147,361,314 (+)NCBIGRCm37mm9NCBIm37
MGSCv364146,829,697 - 146,830,998 (+)NCBImm8
Celera4150,250,201 - 150,251,617 (+)NCBICelera
Cytogenetic Map4E1NCBI
cM Map478.57NCBI
Nppb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554862,054,775 - 2,056,130 (+)NCBIChiLan1.0ChiLan1.0
NPPB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,838,518 - 11,839,999 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl111,838,518 - 11,839,995 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0110,621,416 - 10,622,960 (-)NCBIMhudiblu_PPA_v0panPan3
NPPB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,395,844 - 84,397,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nppb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936474683,325 - 684,662 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPPB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,919,495 - 71,932,254 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,930,374 - 71,931,843 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,840,061 - 65,841,530 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPPB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120119,930,931 - 119,933,391 (+)NCBI
ChlSab1.1 Ensembl20119,932,021 - 119,933,197 (+)Ensembl
Nppb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248181,139,776 - 1,141,010 (+)NCBI

Position Markers
D5Wox33  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05164,794,256 - 164,794,600NCBIRnor6.0
Rnor_5.05168,452,358 - 168,452,702UniSTSRnor5.0
RGSC_v3.45165,060,375 - 165,060,719UniSTSRGSC3.4
Celera5156,696,900 - 156,697,244UniSTS
Cytogenetic Map5q36UniSTS
RH130424  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05164,796,730 - 164,797,367NCBIRnor6.0
Rnor_5.05168,454,832 - 168,455,469UniSTSRnor5.0
RGSC_v3.45165,062,849 - 165,063,486UniSTSRGSC3.4
Celera5156,699,374 - 156,700,011UniSTS
Cytogenetic Map5q36UniSTS
RH 3.4 Map51105.8UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)547745646167946134Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)561612600168109659Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)584963058173504662Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5128687766173687766Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5131077716173707219Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132551937173707219Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133943857173707219Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133943857173707219Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5134197905173707219Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5134712342173707219Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5134712342173707219Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5136354114173707219Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136640731173707219Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138154677172402610Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5142307322173707219Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5142309061173707219Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149029982173687766Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5149568588167739697Rat
631263Cm24Cardiac mass QTL 243.5heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)5149832180164807402Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5150360936167946134Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5157212422167739539Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5157319671171194163Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5157319671173707219Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5161084664173707219Rat
631498Bp100Blood pressure QTL 1004.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5164797538164808407Rat


Related Rat Strains
The following Strains have been annotated to Nppb
SD


Genetic Models
This gene Nppb is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:221
Count of miRNA genes:132
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000010779
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 43
Low 12 4 8 4 1 1 2 2 8 1
Below cutoff 20 16 4 16 7 7 17 11 18 1 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010779   ⟹   ENSRNOP00000010778
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5164,796,185 - 164,797,531 (+)Ensembl
RefSeq Acc Id: NM_031545   ⟹   NP_113733
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05164,796,229 - 164,797,531 (+)NCBI
Rnor_5.05168,454,278 - 168,455,640 (+)NCBI
RGSC_v3.45165,062,348 - 165,063,650 (+)RGD
Celera5156,698,873 - 156,700,175 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239376   ⟹   XP_006239438
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05164,796,176 - 164,797,538 (+)NCBI
Rnor_5.05168,454,278 - 168,455,640 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113733   ⟸   NM_031545
- Peptide Label: precursor
- UniProtKB: P13205 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239438   ⟸   XM_006239376
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000010778   ⟸   ENSRNOT00000010779

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694253
Promoter ID:EPDNEW_R4778
Type:single initiation site
Name:Nppb_1
Description:natriuretic peptide B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05164,796,205 - 164,796,265EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3194 AgrOrtholog
Ensembl Genes ENSRNOG00000008141 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000010778 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010779 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Natr_peptide UniProtKB/Swiss-Prot
  Natr_peptide_CS UniProtKB/Swiss-Prot
  Natriuretic_peptide_brain UniProtKB/Swiss-Prot
KEGG Report rno:25105 UniProtKB/Swiss-Prot
NCBI Gene 25105 ENTREZGENE
Pfam ANP UniProtKB/Swiss-Prot
PharmGKB NPPB RGD
PhenoGen Nppb PhenoGen
PRINTS BNATPEPTIDE UniProtKB/Swiss-Prot
PROSITE NATRIURETIC_PEPTIDE UniProtKB/Swiss-Prot
SMART NAT_PEP UniProtKB/Swiss-Prot
UniGene Rn.3835 ENTREZGENE
UniProt ANFB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Nppb  natriuretic peptide B  Nppb  natriuretic peptide precursor B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-10 Nppb  natriuretic peptide precursor B  Nppb  natriuretic peptide precursor type B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-10-23 Nppb  natriuretic peptide precursor type B      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization secreted by cardiac myocytes 728927
gene_disease upregulated in congestive heart failure and hypertension 70484
gene_disease expression increased in patients with heart failure 70484
gene_expression expressed in myocardial cells 70484
gene_process regulates blood pressure and fluid homeostasis 61490
gene_process regulates blood pressure and fluid homeostasis 70484