RGD Reference Report - Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents. - Rat Genome Database

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Diagnostic value of serum brain natriuretic peptide in syncope in children and adolescents.

Authors: Zhang, Q  Jin, H  Qi, J  Yan, H  Du, J 
Citation: Zhang Q, etal., Acta Paediatr. 2013 May;102(5):e210-4. doi: 10.1111/apa.12182. Epub 2013 Feb 21.
RGD ID: 7247623
Pubmed: PMID:23373852   (View Abstract at PubMed)
DOI: DOI:10.1111/apa.12182   (Journal Full-text)

AIM: This study was designed to evaluate the diagnostic value of B-type natriuretic peptide (BNP) in syncope in children and adolescents. METHODS: Serum BNP concentration was measured by electrochemiluminescence assay in 62 consecutive children and adolescents hospitalized for syncope. RESULTS: Of the 62 children and adolescents hospitalized for syncope, 39 had noncardiac syncope, of whom 37 (59.7%) had autonomic-mediated reflex syncope and two (3.2%) had syncope of unknown cause. Twenty-three patients (37.1%) had cardiac syncope: 11 of these had cardiac arrhythmias and 12 had structural cardiac/cardiopulmonary disease. Patients with cardiac syncope had significantly higher serum BNP than those with non-cardiac syncope (958.78 +/- 2443.41 pg/mL vs 31.05 +/- 22.64 pg/mL, p < 0.05). Logistic multivariate regression analysis revealed that urinary incontinence during syncopal episodes, ECG abnormalities and increased serum BNP levels were independent predictors of cardiac syncope. At a cut-off value of 40.65 pg/mL, serum BNP was associated with significant risk of a cardiac cause of syncope, with sensitivity of 73.9% and specificity of 70.0% for distinguishing cardiac syncope from noncardiac syncope. CONCLUSION: Serum BNP was helpful in differentiating cardiac syncope from noncardiac syncope in children and adolescents.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NPPBHumanVasovagal Syncope  IEP associated with Syncope and protein:increased expression:serum:RGD 
NppbRatVasovagal Syncope  ISONPPB (Homo sapiens)associated with Syncope and protein:increased expression:serum:RGD 
NppbMouseVasovagal Syncope  ISONPPB (Homo sapiens)associated with Syncope and protein:increased expression:serum:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nppb  (natriuretic peptide B)

Genes (Mus musculus)
Nppb  (natriuretic peptide type B)

Genes (Homo sapiens)
NPPB  (natriuretic peptide B)


Additional Information