HSPG2 (heparan sulfate proteoglycan 2)

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Gene: HSPG2 (heparan sulfate proteoglycan 2) Homo sapiens

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Symbol:

HSPG2

Name:

heparan sulfate proteoglycan 2

RGD ID:

1351428

HGNC Page

HGNC:5273

Description:

Predicted to enable protease binding activity. Involved in negative regulation of amyloid fibril formation. Located in extracellular exosome and focal adhesion. Colocalizes with collagen-containing extracellular matrix. Implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Biomarker of carotid artery disease and hyperglycemia.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

basement membrane-specific heparan sulfate proteoglycan core protein; endorepellin (domain V region); heparan sulfate proteoglycan 2 (perlecan); HSPG; perlecan proteoglycan; PLC; PRCAN; Schwartz-Jampel syndrome 1 (chondrodystrophic myotonia); SJA; SJS; SJS1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Hspg2 (perlecan (heparan sulfate proteoglycan 2))	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Hspg2 (heparan sulfate proteoglycan 2)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Hspg2 (heparan sulfate proteoglycan 2)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	HSPG2 (heparan sulfate proteoglycan 2)	NCBI	Ortholog
Canis lupus familiaris (dog):	HSPG2 (heparan sulfate proteoglycan 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hspg2 (heparan sulfate proteoglycan 2)	NCBI	Ortholog
Sus scrofa (pig):	HSPG2 (heparan sulfate proteoglycan 2)	HGNC	EggNOG, Ensembl, NCBI, OrthoDB, Treefam
Chlorocebus sabaeus (green monkey):	HSPG2 (heparan sulfate proteoglycan 2)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Hspg2 (heparan sulfate proteoglycan 2)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Hspg2 (heparan sulfate proteoglycan 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hspg2 (perlecan (heparan sulfate proteoglycan 2))	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hspg2 (heparan sulfate proteoglycan 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid\|ZFIN)
Caenorhabditis elegans (roundworm):	unc-52	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	trol	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	hspg2.L	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	hspg2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	21,822,244 - 21,937,310 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	21,822,244 - 21,937,310 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	22,148,737 - 22,263,803 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	22,021,324 - 22,136,337 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	21,894,545 - 22,009,053	NCBI
Celera	1	20,471,674 - 20,545,742 (-)	NCBI		Celera
Cytogenetic Map	1	p36.12	NCBI
HuRef	1	20,392,206 - 20,466,222 (-)	NCBI		HuRef
CHM1_1	1	22,261,185 - 22,335,234 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	21,646,052 - 21,761,123 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Human Phenotype Annotations - HPO

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