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Gene: RNF186-AS1 (RNF186 antisense RNA 1) Homo sapiens

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Symbol:

RNF186-AS1

Name:

RNF186 antisense RNA 1

RGD ID:

149735270

HGNC Page

HGNC:41127

Description:

Type:

ncrna (Ensembl: lncRNA)

RefSeq Status:

VALIDATED

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	19,814,409 - 19,819,502 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	19,814,354 - 19,819,502 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	20,140,902 - 20,145,995 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Cytogenetic Map	1	p36.13	NCBI
T2T-CHM13v2.0	1	19,637,797 - 19,642,889 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Variants in RNF186-AS1
37 total Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_019062.2(RNF186):c.39C>G (p.Ile13Met)	single nucleotide variant	not specified [RCV004228875]	Chr1:19815063 [GRCh38] Chr1:20141556 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.370G>A (p.Val124Met)	single nucleotide variant	not specified [RCV004129914]	Chr1:19814732 [GRCh38] Chr1:20141225 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.644G>T (p.Cys215Phe)	single nucleotide variant	not specified [RCV004132243]	Chr1:19814458 [GRCh38] Chr1:20140951 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.98C>G (p.Ser33Cys)	single nucleotide variant	not specified [RCV004194683]	Chr1:19815004 [GRCh38] Chr1:20141497 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.470C>T (p.Ala157Val)	single nucleotide variant	not specified [RCV004193908]	Chr1:19814632 [GRCh38] Chr1:20141125 [GRCh37] Chr1:1p36.13	likely benign
GRCh38/hg38 1p36.21-36.12(chr1:15385267-20980349)x1	copy number loss	See cases [RCV000051146]	Chr1:15385267..20980349 [GRCh38] Chr1:15711763..21306842 [GRCh37] Chr1:15584350..21179429 [NCBI36] Chr1:1p36.21-36.12	pathogenic
NM_019062.2(RNF186):c.457C>T (p.Arg153Trp)	single nucleotide variant	not specified [RCV004124250]	Chr1:19814645 [GRCh38] Chr1:20141138 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.608G>A (p.Arg203Gln)	single nucleotide variant	not specified [RCV004226183]	Chr1:19814494 [GRCh38] Chr1:20140987 [GRCh37] Chr1:1p36.13	likely benign
NM_019062.2(RNF186):c.152G>A (p.Arg51Gln)	single nucleotide variant	not specified [RCV004086158]	Chr1:19814950 [GRCh38] Chr1:20141443 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.653A>G (p.Gln218Arg)	single nucleotide variant	not specified [RCV004165881]	Chr1:19814449 [GRCh38] Chr1:20140942 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.679G>A (p.Ala227Thr)	single nucleotide variant	not specified [RCV004164021]	Chr1:19814423 [GRCh38] Chr1:20140916 [GRCh37] Chr1:1p36.13	uncertain significance
GRCh38/hg38 1p36.13-36.12(chr1:18347821-22512894)x1	copy number loss	See cases [RCV000053789]	Chr1:18347821..22512894 [GRCh38] Chr1:18674315..22839387 [GRCh37] Chr1:18546902..22711974 [NCBI36] Chr1:1p36.13-36.12	pathogenic
NM_019062.2(RNF186):c.20T>C (p.Leu7Pro)	single nucleotide variant	not specified [RCV004176920]	Chr1:19815082 [GRCh38] Chr1:20141575 [GRCh37] Chr1:1p36.13	likely benign
NM_019062.2(RNF186):c.515T>A (p.Phe172Tyr)	single nucleotide variant	not specified [RCV004323420]	Chr1:19814587 [GRCh38] Chr1:20141080 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.536G>A (p.Arg179Gln)	single nucleotide variant	not specified [RCV004214565]	Chr1:19814566 [GRCh38] Chr1:20141059 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.399C>A (p.His133Gln)	single nucleotide variant	not specified [RCV004165243]	Chr1:19814703 [GRCh38] Chr1:20141196 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.524C>T (p.Pro175Leu)	single nucleotide variant	not specified [RCV004190671]	Chr1:19814578 [GRCh38] Chr1:20141071 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.445C>A (p.His149Asn)	single nucleotide variant	not specified [RCV004166678]	Chr1:19814657 [GRCh38] Chr1:20141150 [GRCh37] Chr1:1p36.13	uncertain significance
GRCh38/hg38 1p36.13-36.12(chr1:19548795-20935131)x1	copy number loss	See cases [RCV000138079]	Chr1:19548795..20935131 [GRCh38] Chr1:19875289..21261624 [GRCh37] Chr1:19747876..21134211 [NCBI36] Chr1:1p36.13-36.12	likely pathogenic\|uncertain significance
NM_019062.2(RNF186):c.607C>T (p.Arg203Trp)	single nucleotide variant	not specified [RCV004297090]	Chr1:19814495 [GRCh38] Chr1:20140988 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.195C>G (p.Ile65Met)	single nucleotide variant	not specified [RCV004356515]	Chr1:19814907 [GRCh38] Chr1:20141400 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.40T>G (p.Ser14Ala)	single nucleotide variant	not specified [RCV004283271]	Chr1:19815062 [GRCh38] Chr1:20141555 [GRCh37] Chr1:1p36.13	uncertain significance
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3	copy number gain	Trisomy 12p [RCV003447845]	Chr1:99125..34026935 [GRCh38] Chr1:1p36.33-35.1	pathogenic
NM_019062.2(RNF186):c.205C>T (p.Leu69Phe)	single nucleotide variant	not specified [RCV004446551]	Chr1:19814897 [GRCh38] Chr1:20141390 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.283C>T (p.Leu95Phe)	single nucleotide variant	not specified [RCV004446553]	Chr1:19814819 [GRCh38] Chr1:20141312 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.358C>A (p.Pro120Thr)	single nucleotide variant	not specified [RCV004446554]	Chr1:19814744 [GRCh38] Chr1:20141237 [GRCh37] Chr1:1p36.13	uncertain significance
GRCh38/hg38 1p36.13(chr1:19093306-20063342)x1	copy number loss	See cases [RCV000053793]	Chr1:19093306..20063342 [GRCh38] Chr1:19419800..20389835 [GRCh37] Chr1:19292387..20262422 [NCBI36] Chr1:1p36.13	pathogenic
NM_019062.2(RNF186):c.298C>T (p.Arg100Cys)	single nucleotide variant	not specified [RCV004342430]	Chr1:19814804 [GRCh38] Chr1:20141297 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.338G>A (p.Cys113Tyr)	single nucleotide variant	not specified [RCV004255532]	Chr1:19814764 [GRCh38] Chr1:20141257 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.469G>A (p.Ala157Thr)	single nucleotide variant	not specified [RCV004255154]	Chr1:19814633 [GRCh38] Chr1:20141126 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.560C>T (p.Ala187Val)	single nucleotide variant	not specified [RCV004356516]	Chr1:19814542 [GRCh38] Chr1:20141035 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.380C>T (p.Ala127Val)	single nucleotide variant	not specified [RCV004446556]	Chr1:19814722 [GRCh38] Chr1:20141215 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.461G>A (p.Arg154His)	single nucleotide variant	not specified [RCV004446557]	Chr1:19814641 [GRCh38] Chr1:20141134 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.376C>T (p.Pro126Ser)	single nucleotide variant	not specified [RCV004446555]	Chr1:19814726 [GRCh38] Chr1:20141219 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.142A>G (p.Ser48Gly)	single nucleotide variant	not specified [RCV004665448]	Chr1:19814960 [GRCh38] Chr1:20141453 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.517A>C (p.Ile173Leu)	single nucleotide variant	not specified [RCV004665450]	Chr1:19814585 [GRCh38] Chr1:20141078 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.151C>T (p.Arg51Trp)	single nucleotide variant	not specified [RCV004665449]	Chr1:19814951 [GRCh38] Chr1:20141444 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.551T>A (p.Phe184Tyr)	single nucleotide variant	not specified [RCV004858470]	Chr1:19814551 [GRCh38] Chr1:20141044 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.534A>C (p.Leu178Phe)	single nucleotide variant	not specified [RCV004847516]	Chr1:19814568 [GRCh38] Chr1:20141061 [GRCh37] Chr1:1p36.13	uncertain significance
NM_019062.2(RNF186):c.230C>T (p.Thr77Ile)	single nucleotide variant	not specified [RCV004847515]	Chr1:19814872 [GRCh38] Chr1:20141365 [GRCh37] Chr1:1p36.13	uncertain significance

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298451	OSTEAR17_H	Osteoarthritis QTL 17 (human)	2.4	0.0004	Joint/bone inflammation	osteoarthritis	11	1	25188105	Human
1576329	MYI9_H	Myocardial infarction susceptibility QTL 9 (human)	12		Myocardial infarction susceptibility	early-onset	1	7585503	33585503	Human
597378874	GWAS1474948_H	ulcerative colitis QTL GWAS1474948 (human)		7e-09	ulcerative colitis		1	19816373	19816374	Human
597402369	GWAS1498443_H	ulcerative colitis QTL GWAS1498443 (human)		6e-39	ulcerative colitis		1	19816373	19816374	Human
597360481	GWAS1456555_H	ankylosing spondylitis, psoriasis, ulcerative colitis, Crohn's disease, sclerosing cholangitis QTL GWAS1456555 (human)		1e-24	intestine integrity trait (VT:0010554)		1	19816373	19816374	Human
597376736	GWAS1472810_H	ulcerative colitis QTL GWAS1472810 (human)		3e-08	ulcerative colitis		1	19816373	19816374	Human
1298463	BP9_H	Blood pressure QTL 9 (human)	3.9		Blood pressure	hypertension susceptibility	1	1	25188105	Human
1576325	MYI1_H	Myocardial infarction susceptibility QTL 1 (human)	11.68	1e-12	Myocardial infarction susceptibility	early-onset	1	7585503	33585503	Human
1643380	BW316_H	Body weight QTL 316 (human)	2.62	0.0002	Body weight	BMI	1	7585503	33585503	Human

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NR_186008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AL391883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000454736

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	19,814,354 - 19,819,502 (+)	Ensembl

RefSeq Acc Id:

NR_186008

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	19,814,409 - 19,819,502 (+)	NCBI
T2T-CHM13v2.0	1	19,637,797 - 19,642,889 (+)	NCBI

Database	Acc Id	Source(s)
COSMIC	RNF186-AS1	COSMIC
Ensembl Genes	ENSG00000235434	Ensembl, ENTREZGENE
Ensembl Transcript	ENST00000454736	ENTREZGENE
GTEx	ENSG00000235434	GTEx
HGNC ID	HGNC:41127	ENTREZGENE
Human Proteome Map	RNF186-AS1	Human Proteome Map
NCBI Gene	RNF186-AS1	ENTREZGENE
RNAcentral	URS00002E1BD5	RNACentral
	URS00026A1E9C	RNACentral

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-05-31	RNF186-AS1	RNF186 antisense RNA 1	RNF186-AS1	RNF186 antisense RNA 1	Data merged from RGD:16556227	737654	PROVISIONAL
2021-07-05	RNF186-AS1	RNF186 antisense RNA 1	AL391883.1	novel transcript	Symbol and/or name change	19259463	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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