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Gene: Clcnkb (chloride voltage-gated channel Kb) Rattus norvegicus
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Symbol: Clcnkb
Name: chloride voltage-gated channel Kb
Description: Exhibits chloride channel activity. Involved in chloride transport. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Orthologous to several human genes including CLCNKB (chloride voltage-gated channel Kb); INTERACTS WITH (4-chloro-2-methylphenoxy)acetic acid; 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: chloride channel K1-like; chloride channel K2; chloride channel Kb; chloride channel protein ClC-Kb; chloride channel, voltage-sensitive Kb; clC-K2; ClC-K2L; Clck2; Clcnk1l
Orthologs:
Homo sapiens (human) : CLCNKB (chloride voltage-gated channel Kb)  HGNC  Alliance
Mus musculus (house mouse) : Clcnkb (chloride channel, voltage-sensitive Kb)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CLCNKB (chloride voltage-gated channel Kb)
Canis lupus familiaris (dog) : CLCNKA (chloride voltage-gated channel Ka)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05159,950,384 - 159,973,576 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05163,670,926 - 163,694,123 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,294,294 - 160,305,991 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15160,304,482 - 160,316,179 (-)NCBI
Celera5152,071,911 - 152,083,591 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Clcnkb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628639
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.