Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Lck (LCK proto-oncogene, Src family tyrosine kinase) Rattus norvegicus
Symbol: Lck
Name: LCK proto-oncogene, Src family tyrosine kinase
RGD ID: 2994
Description: Exhibits antigen binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of uterine smooth muscle contraction; protein phosphorylation; and response to zinc ion. Localizes to several cellular components, including glutamatergic synapse; membrane raft; and postsynaptic specialization, intracellular component. Used to study allergic conjunctivitis and human immunodeficiency virus infectious disease. Human ortholog(s) of this gene implicated in immunodeficiency 22. Orthologous to human LCK (LCK proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; 7,12-dimethyltetraphene; acetamide.
Type: protein-coding
Also known as: Lck1; Lck_mapped; Lcktkr; lymphocyte cell-specific protein-tyrosine kinase; lymphocyte protein tyrosine kinase; lymphocyte protein tyrosine kinase (mapped); lymphocyte-specific protein tyrosine kinase; p56-LCK; proto-oncogene tyrosine-protein kinase LCK
Homo sapiens (human) : LCK (LCK proto-oncogene, Src family tyrosine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Lck (lymphocyte protein tyrosine kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05147,750,976 - 147,779,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5147,750,973 - 147,761,983 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05151,480,214 - 151,509,064 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45148,707,505 - 148,718,296 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5140,363,592 - 140,374,224 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Lck
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2994
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.