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Gene: Lck (LCK proto-oncogene, Src family tyrosine kinase) Chinchilla lanigera

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Symbol:

Lck

Name:

LCK proto-oncogene, Src family tyrosine kinase

RGD ID:

8832511

Description:

ENCODES a protein that exhibits antigen binding (ortholog); ATPase binding (ortholog); CD4 receptor binding (ortholog); INVOLVED IN B cell receptor signaling pathway (ortholog); CD27 signaling pathway (ortholog); cell surface receptor signaling pathway (ortholog); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; ASSOCIATED WITH allergic conjunctivitis (ortholog); dilated cardiomyopathy (ortholog); human immunodeficiency virus infectious disease (ortholog); FOUND IN cell-cell junction (ortholog); cytoplasm (ortholog); endocytic vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lymphocyte-specific protein tyrosine kinase; tyrosine-protein kinase Lck

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	10,608,318 - 10,632,310 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	10,608,317 - 10,632,310 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic conjunctivitis (ISO)

dilated cardiomyopathy (ISO)

human immunodeficiency virus infectious disease (ISO)

immunodeficiency 22 (ISO)

retinal degeneration (ISO)

RETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES (ISO)

severe combined immunodeficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell receptor signaling pathway (ISO)

CD27 signaling pathway (ISO)

cell surface receptor signaling pathway (ISO)

Fc-gamma receptor signaling pathway (ISO)

gamma-delta T cell differentiation (ISO)

intracellular signal transduction (ISO)

intracellular zinc ion homeostasis (ISO)

peptidyl-tyrosine autophosphorylation (ISO)

peptidyl-tyrosine phosphorylation (ISO)

positive regulation of cysteine-type endopeptidase activity (ISO)

positive regulation of gamma-delta T cell differentiation (ISO)

positive regulation of gene expression (ISO)

positive regulation of heterotypic cell-cell adhesion (ISO)

positive regulation of intrinsic apoptotic signaling pathway (ISO)

positive regulation of leukocyte cell-cell adhesion (ISO)

positive regulation of T cell activation (ISO)

positive regulation of tyrosine phosphorylation of STAT protein (ISO)

positive regulation of uterine smooth muscle contraction (ISO)

protein autophosphorylation (ISO)

protein phosphorylation (ISO)

regulation of regulatory T cell differentiation (ISO)

regulation of T cell receptor signaling pathway (ISO)

release of sequestered calcium ion into cytosol (ISO)

response to aldosterone (ISO)

response to hydrogen peroxide (ISO)

response to mechanical stimulus (ISO)

response to metal ion (ISO)

response to xenobiotic stimulus (ISO)

response to zinc ion (ISO)

T cell activation (ISO)

T cell differentiation (ISO)

T cell receptor signaling pathway (ISO)

Cellular Component

cell-cell junction (ISO)

cytoplasm (ISO)

endocytic vesicle (ISO)

glutamatergic synapse (ISO)

immunological synapse (ISO)

membrane raft (ISO)

pericentriolar material (ISO)

plasma membrane (ISO)

postsynaptic specialization, intracellular component (ISO)

Molecular Function

antigen binding (ISO)

ATPase binding (ISO)

CD4 receptor binding (ISO)

CD8 receptor binding (ISO)

identical protein binding (ISO)

non-membrane spanning protein tyrosine kinase activity (ISO)

phosphatidylinositol 3-kinase binding (ISO)

phospholipase activator activity (ISO)

phospholipase binding (ISO)

phosphotyrosine residue binding (ISO)

protein antigen binding (ISO)

protein binding (ISO)

protein kinase binding (ISO)

protein phosphatase binding (ISO)

protein serine/threonine phosphatase activity (ISO)

protein tyrosine kinase activity (ISO)

protein-containing complex binding (ISO)

SH2 domain binding (ISO)

T cell receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway (ISO)

ephrin - ephrin receptor bidirectional signaling axis (ISO)

glypican signaling pathway (ISO)

interleukin-12 signaling pathway (ISO)

interleukin-2 signaling pathway (ISO)

nuclear factor kappa B signaling pathway (ISO)

phosphatidylinositol 3-kinase class I signaling pathway (ISO)

platelet-derived growth factor signaling pathway (ISO)

protein kinase C (PKC) signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Lck
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	10,608,318 - 10,632,310 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	10,608,317 - 10,632,310 (+)	NCBI	ChiLan1.0	ChiLan1.0

LCK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	32,251,265 - 32,286,165 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	32,251,244 - 32,286,165 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	32,716,866 - 32,751,766 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	32,489,427 - 32,524,353 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	32,386,024 - 32,420,854	NCBI
Celera	1	30,987,010 - 31,022,233 (+)	NCBI		Celera
Cytogenetic Map	1	p35.2	NCBI
HuRef	1	30,833,080 - 30,867,241 (+)	NCBI		HuRef
CHM1_1	1	32,832,435 - 32,867,211 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	32,109,169 - 32,144,081 (+)	NCBI		T2T-CHM13v2.0

Lck
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	129,442,142 - 129,467,415 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	129,442,137 - 129,467,434 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	129,548,344 - 129,573,641 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	129,548,344 - 129,573,641 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	129,225,588 - 129,250,885 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	129,050,662 - 129,060,676 (-)	NCBI		MGSCv36	mm8
Celera	4	127,881,707 - 127,907,449 (-)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	63.26	NCBI

Lck
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	147,172,642 - 147,201,267 (-)	NCBI		GRCr8
mRatBN7.2	5	141,888,318 - 141,916,945 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	141,888,326 - 141,903,794 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	144,589,698 - 144,600,304 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	146,359,523 - 146,370,129 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	146,356,103 - 146,366,907 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	147,750,976 - 147,779,627 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	147,750,973 - 147,761,983 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	151,480,214 - 151,509,064 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	148,707,505 - 148,718,296 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	140,363,592 - 140,374,224 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

LCK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	194,540,879 - 194,576,384 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	193,662,224 - 193,697,739 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	31,560,229 - 31,572,391 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	32,567,712 - 32,579,923 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	32,565,739 - 32,579,923 (+)	Ensembl	panpan1.1		panPan2

LCK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	68,940,816 - 68,964,585 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	68,941,249 - 68,964,567 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	65,521,599 - 65,545,402 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	69,507,326 - 69,531,453 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	69,507,329 - 69,531,404 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	66,344,251 - 66,368,026 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	67,339,915 - 67,363,766 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	68,338,870 - 68,362,999 (-)	NCBI		UU_Cfam_GSD_1.0

Lck
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	49,480,227 - 49,489,329 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	15,305,050 - 15,313,668 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	15,293,115 - 15,314,072 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LCK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	88,719,881 - 88,745,914 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	88,719,886 - 88,745,922 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	82,843,255 - 82,852,667 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LCK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	100,582,718 - 100,618,041 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666033	16,070,565 - 16,104,978 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lck
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	15,472,685 - 15,495,351 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	15,469,582 - 15,495,351 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005395058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005395059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01044281	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01044282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01044283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01388405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000010895 ⟹ ENSCLAP00000010762

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955452	10,608,318 - 10,632,310 (+)	Ensembl

RefSeq Acc Id:

XM_005395058 ⟹ XP_005395115

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955452	10,608,318 - 10,632,310 (+)	NCBI

Sequence:

show sequence

GAAGTCGGGGTGGAACGTGGGCGCGGGGAGACAGGTGGTGGCTCCGACAGCAAGGGGAGCTGAG
CCGTGTCTGCGCAGCCACGCCAGGCCGGGAGGACCATGTGAATGGGCCGGGGGCCTCTCAGGCT
GGGCAGGGACCATGGGCTGTAGCTGCAGCTCAAACCCTGAAGATGACTGGATGGAAAACATCGA
TGTGTGCGAGAACTGCCATTATCCCATAGTCCCCCTGGACGGCAAGGCCACGCTTCTCTTGCGG
AATGGCTCTGAGGTACGGGATCCACTGGTCACCTACGAGGGCTCCAACCCACCAGCCTCTCCGC
TGCAAGACAACCTGGTTATCGCCCTGCACAGCTACGAGCCCTCGCACGACGGAGACCTGGGCTT
TGAGAAGGGCGAGCAGCTCCGCATCCTGGAGCAGAACGGCGAGTGGTGGAAGGCCCAGTCCCTG
ACCACGGGCCAGGAAGGTTTCATCCCCTTCAACTTCGTGGCCAAAGCGAATAGCCTGGAACCTG
AACCCTGGTTCTTCAAGAACCTGAGCCGCAAGGACGCAGAGCGACAGCTCCTGGCGCCGGGAAA
CACGCACGGCTCGTTCCTGATCCGAGAGAGCGAGAGCACCGCGGGATCGTTTTCGCTGTCGGTC
CGGGATTTCGACCAAAACCAGGGAGAGGTGGTGAAACATTACAAAATCCGTAACCTGGACAATG
GCGGCTTCTACATCTCCCCTCGCATCACTTTTCCCGGCCTGCACGAACTGGTCCGCCATTACAC
CAATGCTTCTGATGGTCTCTGCACGAGGTTGAGCCGCCCCTGCCAGACCCAGAAGCCCCAGAAG
CCGTGGTGGGAGGACGAGTGGGAGGTTCCCAGGGAGACGCTGAAGCTGGTGGAGCGGCTGGGGG
CCGGCCAGTTCGGGGAAGTGTGGATGGGGTACTACAACGGACACACGAAGGTGGCTGTGAAGAG
CCTGAAGCAGGGCAGCATGTCCCCCGACGCCTTCCTGGCGGAGGCCAACCTCATGAAGCAGCTG
CAGCACCAGCGGCTAGTCCGGCTCTACGCGGTGGTCACGCAGGAGCCCATCTACATCATCACCG
AGTACATGGAGAACGGGAGCCTGGTGGATTTTCTCAAAACCCCCCCGGGCATCAAGTTGACCAT
CAACAAACTCTTGGACATGGCAGCCCAAATTGCAGAGGGCATGGCATTCATCGAAGAGCGCAAT
TACATCCACCGTGACCTGCGGGCTGCCAACATCCTGGTGTCTGACACCCTGAGCTGCAAGATTG
CAGACTTTGGCTTAGCACGCCTCATCGAGGACAATGAGTACACAGCCAGGGAGGGGGCCAAATT
TCCCATTAAGTGGACAGCGCCAGAAGCCATTAACTATGGGACGTTCACTATCAAGTCGGACGTG
TGGTCTTTCGGGATCCTGCTGACGGAGATCGTTACCCACGGCCGCATCCCTTACCCAGGGATGA
CCAATCCTGAGGTAATTCAGAACCTGGAGCGAGGCTACCGCATGGTACAACCTGACAATTGTCC
AGAGGAACTGTACCAGCTCATGATGCTGTGCTGGAAGGAGCGCCCAGAGGACCGGCCCACCTTT
GACTACCTGCGTAGCGTGCTGGAGGACTTCTTCACGGCCACCGAGGGCCAATACCAGCCCCAGC
CTTGACAGGCCTCGCTGGCCTGTGCCCTGCCCCCATCTCACAACCCTGGCTTGGAGAGGGGGTG
TTTTGGTGTCACAGCCAAATGACCTGGGCACGATGGACTCTTCACGTGAACCTCACCAATGTGC
AACACGTGTCATGCACACACGTCCTGTAGTTGTGTGGGCTCTGTACACGTCTGACACATGTGGA
GCCTATGCATGTATGTTTTGGATACCATCTAAAGTATGTCTTTCTGGATGCTCTCATTTCCTGA
GAGCATGGAGAGGGGAGAGAAACCTGTGATTGACATCTGCTTCTGCTCCCCACTTTTCTTCTCT
CAGATTATGCTGAAGCTCACTGTGGGCTGGGGCGTTATCCTAATACCTCTGTGTGCTCCTCCAC
GGTGCCTGGCATGCGTCAGGAGCTCAATAAATGTCTTTGGATGTAGGGTGCACATTTCTCCACC
CCAA

hide sequence

RefSeq Acc Id:

XM_005395059 ⟹ XP_005395116

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955452	10,608,317 - 10,632,310 (+)	NCBI

Sequence:

show sequence

GGAAGTCGGGGTGGAACGTGGGCGCGGGGAGACAGGTGGTGGCTCCGACAGCAAGGGGAGCTGA
GCCGTGTCTGCGCAGCCACGCCAGGCCGGGAGGACCATGTGAATGGGCCGGGGGCCTCTCAGGC
TGGGCAGGGACCATGGGCTGTAGCTGCAGCTCAAACCCTGAAGATGACTGGATGGAAAACATCG
ATGTGTGCGAGAACTGCCATTATCCCATAGTCCCCCTGGACGGCAAGGCCACGCTTCTCTTGCG
GAATGGCTCTGAGGTACGGGATCCACTGGTCACCTACGAGGGCTCCAACCCACCAGCCTCTCCG
CTGCAAGACAACCTGGTTATCGCCCTGCACAGCTACGAGCCCTCGCACGACGGAGACCTGGGCT
TTGAGAAGGGCGAGCAGCTCCGCATCCTGGAGCAGAACGGCGAGTGGTGGAAGGCCCAGTCCCT
GACCACGGGCCAGGAAGGTTTCATCCCCTTCAACTTCGTGGCCAAAGCGAATAGCCTGGAACCT
GAACCCTGGTTCTTCAAGAACCTGAGCCGCAAGGACGCAGAGCGACAGCTCCTGGCGCCGGGAA
ACACGCACGGCTCGTTCCTGATCCGAGAGAGCGAGAGCACCGCGGGATCGTTTTCGCTGTCGGT
CCGGGATTTCGACCAAAACCAGGGAGAGGTGGTGAAACATTACAAAATCCGTAACCTGGACAAT
GGCGGCTTCTACATCTCCCCTCGCATCACTTTTCCCGGCCTGCACGAACTGGTCCGCCATTACA
CCAGGTACTACAACGGACACACGAAGGTGGCTGTGAAGAGCCTGAAGCAGGGCAGCATGTCCCC
CGACGCCTTCCTGGCGGAGGCCAACCTCATGAAGCAGCTGCAGCACCAGCGGCTAGTCCGGCTC
TACGCGGTGGTCACGCAGGAGCCCATCTACATCATCACCGAGTACATGGAGAACGGGAGCCTGG
TGGATTTTCTCAAAACCCCCCCGGGCATCAAGTTGACCATCAACAAACTCTTGGACATGGCAGC
CCAAATTGCAGAGGGCATGGCATTCATCGAAGAGCGCAATTACATCCACCGTGACCTGCGGGCT
GCCAACATCCTGGTGTCTGACACCCTGAGCTGCAAGATTGCAGACTTTGGCTTAGCACGCCTCA
TCGAGGACAATGAGTACACAGCCAGGGAGGGGGCCAAATTTCCCATTAAGTGGACAGCGCCAGA
AGCCATTAACTATGGGACGTTCACTATCAAGTCGGACGTGTGGTCTTTCGGGATCCTGCTGACG
GAGATCGTTACCCACGGCCGCATCCCTTACCCAGGGATGACCAATCCTGAGGTAATTCAGAACC
TGGAGCGAGGCTACCGCATGGTACAACCTGACAATTGTCCAGAGGAACTGTACCAGCTCATGAT
GCTGTGCTGGAAGGAGCGCCCAGAGGACCGGCCCACCTTTGACTACCTGCGTAGCGTGCTGGAG
GACTTCTTCACGGCCACCGAGGGCCAATACCAGCCCCAGCCTTGACAGGCCTCGCTGGCCTGTG
CCCTGCCCCCATCTCACAACCCTGGCTTGGAGAGGGGGTGTTTTGGTGTCACAGCCAAATGACC
TGGGCACGATGGACTCTTCACGTGAACCTCACCAATGTGCAACACGTGTCATGCACACACGTCC
TGTAGTTGTGTGGGCTCTGTACACGTCTGACACATGTGGAGCCTATGCATGTATGTTTTGGATA
CCATCTAAAGTATGTCTTTCTGGATGCTCTCATTTCCTGAGAGCATGGAGAGGGGAGAGAAACC
TGTGATTGACATCTGCTTCTGCTCCCCACTTTTCTTCTCTCAGATTATGCTGAAGCTCACTGTG
GGCTGGGGCGTTATCCTAATACCTCTGTGTGCTCCTCCACGGTGCCTGGCATGCGTCAGGAGCT
CAATAAATGTCTTTGGATGTAGGGTGCACATTTCTCCACCCCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005395115	(Get FASTA)	NCBI Sequence Viewer
	XP_005395116	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000010762
	ENSCLAP00000010762.1

RefSeq Acc Id:

XP_005395116 ⟸ XM_005395059

- Peptide Label:

isoform X2

- Sequence:

show sequence

MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLLLRNGSEVRDPLVTYEGSNPPASPLQDN
LVIALHSYEPSHDGDLGFEKGEQLRILEQNGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWF
FKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFY
ISPRITFPGLHELVRHYTRYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVV
TQEPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANIL
VSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVT
HGRIPYPGMTNPEVIQNLERGYRMVQPDNCPEELYQLMMLCWKERPEDRPTFDYLRSVLEDFFT
ATEGQYQPQP

hide sequence

RefSeq Acc Id:	XP_005395115 ⟸ XM_005395058
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2V5Z2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGCSCSSNPEDDWMENIDVCENCHYPIVPLDGKATLLLRNGSEVRDPLVTYEGSNPPASPLQDN LVIALHSYEPSHDGDLGFEKGEQLRILEQNGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWF FKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFY ISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQF GEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYME NGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFG LARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPE VIQNLERGYRMVQPDNCPEELYQLMMLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP hide sequence

Ensembl Acc Id:

ENSCLAP00000010762 ⟸ ENSCLAT00000010895

Protein Domains

Protein kinase SH2 SH3

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007429	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000010895	ENTREZGENE
	ENSCLAT00000010895.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom_sf	UniProtKB/TrEMBL
	Lck_SH2	UniProtKB/TrEMBL
	Lck_SH3	UniProtKB/TrEMBL
	Non-receptor_tyrosine_kinases	UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/TrEMBL
NCBI Gene	Lck	ENTREZGENE
PANTHER	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE LCK	UniProtKB/TrEMBL
Pfam	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50044	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
	SSF56112	UniProtKB/TrEMBL
UniProt	A0A8C2V5Z2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	Lck	LCK proto-oncogene, Src family tyrosine kinase		lymphocyte-specific protein tyrosine kinase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)